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Modeling For Prediction Of Radiation Induced Toxicity To Improve Therapeutic Ratio In The Modern Radiation Therapy Era
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Book Synopsis Modeling for Prediction of Radiation-Induced Toxicity to Improve Therapeutic Ratio in the Modern Radiation Therapy Era by : Ester Orlandi
Download or read book Modeling for Prediction of Radiation-Induced Toxicity to Improve Therapeutic Ratio in the Modern Radiation Therapy Era written by Ester Orlandi and published by Frontiers Media SA. This book was released on 2021-07-27 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modelling Radiotherapy Side Effects by : Tiziana Rancati
Download or read book Modelling Radiotherapy Side Effects written by Tiziana Rancati and published by CRC Press. This book was released on 2019-06-11 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: The treatment of a patient with radiation therapy is planned to find the optimal way to treat a tumour while minimizing the dose received by the surrounding normal tissues. In order to better exploit the possibilities of this process, the availability of accurate and quantitative knowledge of the peculiar responses of the different tissues is of paramount importance. This book provides an invaluable tutorial for radiation oncologists, medical physicists, and dosimetrists involved in the planning optimization phase of treatment. It presents a practical, accessible, and comprehensive summary of the field’s current research and knowledge regarding the response of normal tissues to radiation. This is the first comprehensive attempt to do so since the publication of the QUANTEC guidelines in 2010. Features: Addresses the lack of systemization in the field, providing educational materials on predictive models, including methods, tools, and the evaluation of uncertainties Collects the combined effects of features, other than dose, in predicting the risk of toxicity in radiation therapy Edited by two leading experts in the field
Book Synopsis Stereotactic Body Radiation Therapy by : Simon S. Lo
Download or read book Stereotactic Body Radiation Therapy written by Simon S. Lo and published by Springer Science & Business Media. This book was released on 2012-08-28 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.
Book Synopsis Machine Learning in Radiation Oncology by : Issam El Naqa
Download or read book Machine Learning in Radiation Oncology written by Issam El Naqa and published by Springer. This book was released on 2015-06-19 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a complete overview of the role of machine learning in radiation oncology and medical physics, covering basic theory, methods, and a variety of applications in medical physics and radiotherapy. An introductory section explains machine learning, reviews supervised and unsupervised learning methods, discusses performance evaluation, and summarizes potential applications in radiation oncology. Detailed individual sections are then devoted to the use of machine learning in quality assurance; computer-aided detection, including treatment planning and contouring; image-guided radiotherapy; respiratory motion management; and treatment response modeling and outcome prediction. The book will be invaluable for students and residents in medical physics and radiation oncology and will also appeal to more experienced practitioners and researchers and members of applied machine learning communities.
Book Synopsis Molecular Targeted Radiosensitizers by : Henning Willers
Download or read book Molecular Targeted Radiosensitizers written by Henning Willers and published by Springer Nature. This book was released on 2020-08-10 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.
Book Synopsis Advances in Radiation Oncology by : Jeffrey Y.C. Wong
Download or read book Advances in Radiation Oncology written by Jeffrey Y.C. Wong and published by Springer. This book was released on 2017-04-20 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concisely reviews important advances in radiation oncology, providing practicing radiation oncologists with a fundamental understanding of each topic and an appreciation of its significance for the future of radiation oncology. It explores in detail the impact of newer imaging modalities, such as multiparametric magnetic resonance imaging (MRI) and positron emission tomography (PET) using fluorodeoxyglucose (FDG) and other novel agents, which deliver improved visualization of the physiologic and phenotypic features of a given cancer, helping oncologists to provide more targeted radiotherapy and assess the response. Due consideration is also given to how advanced technologies for radiation therapy delivery have created new treatment options for patients with localized and metastatic disease, highlighting the increasingly important role of image-guided radiotherapy in treating systemic and oligometastatic disease. Further topics include the potential value of radiotherapy in enhancing immunotherapy thanks to the broader immune-stimulatory effects, how cancer stem cells and the tumor microenvironment influence response, and the application of mathematical and systems biology methods to radiotherapy.
Book Synopsis Adaptive Radiation Therapy by : X. Allen Li
Download or read book Adaptive Radiation Therapy written by X. Allen Li and published by CRC Press. This book was released on 2011-01-27 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern medical imaging and radiation therapy technologies are so complex and computer driven that it is difficult for physicians and technologists to know exactly what is happening at the point-of-care. Medical physicists responsible for filling this gap in knowledge must stay abreast of the latest advances at the intersection of medical imaging and radiation therapy. This book provides medical physicists and radiation oncologists current and relevant information on Adaptive Radiation Therapy (ART), a state-of-the-art approach that uses a feedback process to account for patient-specific anatomic and/or biological changes, thus delivering highly individualized radiation therapy for cancer patients. The book should also benefit medical dosimetrists and radiation therapists. Adaptive Radiation Therapy describes technological and methodological advances in the field of ART, as well as initial clinical experiences using ART for selected anatomic sites. Divided into three sections (radiobiological basis, current technologies, and clinical applications), the book covers: Morphological and biological biomarkers for patient-specific planning Design and optimization of treatment plans Delivery of IMRT and IGRT intervention methodologies of ART Management of intrafraction variations, particularly with respiratory motion Quality assurance needed to ensure the safe delivery of ART ART applications in several common cancer types / anatomic sites The technology and methodology for ART have advanced significantly in the last few years and accumulated clinical data have demonstrated the need for ART in clinical settings, assisted by the wide application of intensity modulated radiation therapy (IMRT) and image-guided radiation therapy (IGRT). This book shows the real potential for supplying every patient with individualized radiation therapy that is maximally accurate and precise.
Book Synopsis Personalization in Modern Radiation Oncology: Predictions, Prognosis and Survival by : Francesco Cellini
Download or read book Personalization in Modern Radiation Oncology: Predictions, Prognosis and Survival written by Francesco Cellini and published by Frontiers Media SA. This book was released on 2022-12-01 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Big Data in Radiation Oncology by : Jun Deng
Download or read book Big Data in Radiation Oncology written by Jun Deng and published by CRC Press. This book was released on 2019-03-07 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big Data in Radiation Oncology gives readers an in-depth look into how big data is having an impact on the clinical care of cancer patients. While basic principles and key analytical and processing techniques are introduced in the early chapters, the rest of the book turns to clinical applications, in particular for cancer registries, informatics, radiomics, radiogenomics, patient safety and quality of care, patient-reported outcomes, comparative effectiveness, treatment planning, and clinical decision-making. More features of the book are: Offers the first focused treatment of the role of big data in the clinic and its impact on radiation therapy. Covers applications in cancer registry, radiomics, patient safety, quality of care, treatment planning, decision making, and other key areas. Discusses the fundamental principles and techniques for processing and analysis of big data. Address the use of big data in cancer prevention, detection, prognosis, and management. Provides practical guidance on implementation for clinicians and other stakeholders. Dr. Jun Deng is a professor at the Department of Therapeutic Radiology of Yale University School of Medicine and an ABR board certified medical physicist at Yale-New Haven Hospital. He has received numerous honors and awards such as Fellow of Institute of Physics in 2004, AAPM Medical Physics Travel Grant in 2008, ASTRO IGRT Symposium Travel Grant in 2009, AAPM-IPEM Medical Physics Travel Grant in 2011, and Fellow of AAPM in 2013. Lei Xing, Ph.D., is the Jacob Haimson Professor of Medical Physics and Director of Medical Physics Division of Radiation Oncology Department at Stanford University. His research has been focused on inverse treatment planning, tomographic image reconstruction, CT, optical and PET imaging instrumentations, image guided interventions, nanomedicine, and applications of molecular imaging in radiation oncology. Dr. Xing is on the editorial boards of a number of journals in radiation physics and medical imaging, and is recipient of numerous awards, including the American Cancer Society Research Scholar Award, The Whitaker Foundation Grant Award, and a Max Planck Institute Fellowship.
Book Synopsis Cell'Cell Interactions by : Sean P. Colgan
Download or read book Cell'Cell Interactions written by Sean P. Colgan and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: A versatile collection of readily reproducible cell-cell interaction assays for uncovering cellular interactions at the molecular level, both in vitro and in vivo. The protocols cover a diverse set of cell-cell interaction models in both normal and pathological states, are readily adaptable to nearly any cell type and organ system, and include primary data and outcome analysis. In addition, the protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Book Synopsis Imbalanced Classification with Python by : Jason Brownlee
Download or read book Imbalanced Classification with Python written by Jason Brownlee and published by Machine Learning Mastery. This book was released on 2020-01-14 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imbalanced classification are those classification tasks where the distribution of examples across the classes is not equal. Cut through the equations, Greek letters, and confusion, and discover the specialized techniques data preparation techniques, learning algorithms, and performance metrics that you need to know. Using clear explanations, standard Python libraries, and step-by-step tutorial lessons, you will discover how to confidently develop robust models for your own imbalanced classification projects.
Book Synopsis Radiation Myelopathy by : Timothy Schultheiss
Download or read book Radiation Myelopathy written by Timothy Schultheiss and published by Springer Nature. This book was released on 2022-08-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers every aspect of radiation myelopathy and considers the evidence from all species in which it has been studied. The historical and current understanding of the pathogenesis of this rare but devastating injury is first discussed. The evidence regarding the role of a variety of factors in radiation myelopathy is then reviewed. Readers will find detailed information on the impacts of total radiation dose, radiation volume, dose fractionation, hyper fractionation, age, anatomic level, comorbidities, radiation modifiers, other therapies, and retreatment of the spinal cord. Given the similarity of the pathogenesis of radiation myelopathy in humans and experimental animals, the potential for cross-species modelling of dose response is explored, with attention to relevant species differences. Treatment of the condition is also fully considered. New theories are presented regarding retreatment, small volume response, and the final step in white matter necrosis. The final chapter addresses the medicolegal issues elicited by radiation myelopathy, which is often the result of treatment error. Radiation Myelopathy will be of high value for radiation oncologists, radiation physicists, dosimetrists, biologists, neurologists, medical oncologists, and attorneys.
Book Synopsis Accuracy Requirements and Uncertainties in Radiotherapy by : International Atomic Energy Agency
Download or read book Accuracy Requirements and Uncertainties in Radiotherapy written by International Atomic Energy Agency and published by . This book was released on 2017-04-12 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accuracy requirements in radiation oncology have been defined in multiple publications; however, these have been based on differing radiation technologies. In the meantime, the uncertainties in radiation dosimetry reference standards have been reduced and more detailed patient outcome data are available. No comprehensive literature on accuracy and uncertainties in radiotherapy has been published so far. The IAEA has therefore developed a new international consensus document on accuracy requirements and uncertainties in radiation therapy, to promote safer and more effective patient treatments. This publication addresses accuracy and uncertainty issues related to the vast majority of radiotherapy departments including both external beam radiotherapy and brachytherapy. It covers clinical, radiobiological, dosimetric, technical and physical aspects.
Book Synopsis Radiation Pathology by : Luis Felipe Fajardo
Download or read book Radiation Pathology written by Luis Felipe Fajardo and published by Oxford University Press. This book was released on 2001-01-25 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiation Pathology is an up-to-date compendium of the effects of ionizing radiation on human tissues. It will be of great value to radiation oncologists, pathologists, and other professionals. The early chapters deal with basic science: physics, radiobiology, genetics, etc. The circumstances of human exposures (therapeutic, accidental, warfare) are then considered in the light of extensive epidemiological data. Acute radiation syndromes and radiation cardiogenesis are described in detail, including recent information on mechanisms of oncogenesis. For the benefit of readers who are not radiation oncologists, two chapters outline the current uses of radiation in therapy and in diagnosis, including the various applications of radionuclides. The bulk of the text deals with radiopathology and its morphologic expression. An overview orients the reader and classifies the main types of lesions. The chapters on specific organs or organ systems are consistently divided into sections to facilitate rapid retrieval of information on: normal structure, tolerance doses, experimental studies, morphology and pathogenesis, and clinical manifestations. The authors' lucid, well-organized descriptions will inform radiation oncologists about the types of injury to be expected, and will guide pathologists in making differential diagnoses.
Book Synopsis Radiation Toxicity: A Practical Medical Guide by : William Small
Download or read book Radiation Toxicity: A Practical Medical Guide written by William Small and published by Springer Science & Business Media. This book was released on 2006 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiation Toxicity: A Practical Guide brings together renowned authors from leading cancer centers. Radiation, medical and surgical oncologists, nursing professionals, and members of radiation oncology teams will find this book an important reference.
Book Synopsis Basic Clinical Radiobiology by : Michael C. Joiner
Download or read book Basic Clinical Radiobiology written by Michael C. Joiner and published by CRC Press. This book was released on 2018-08-28 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Builds on success and reputation of previous editions Draws on the considerable teaching experience of an international author team, most notably the US and European Editors The gold-standard European text for training, adopted by ESTRO as a course book, as a text for the Royal College of Radiologists' radiobiology exam and by courses in the US Highly illustrated with new, 2 colour illustrations Clear and concise style, appropriate for trainees and also practising radiation oncologists requiring a ready reference to the subject Includes new chapters on stem cells, tissue response and the meeting point of meeting point of radiotherapy, radiobiology and physics
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309457971 Total Pages :145 pages Book Rating :4.3/5 (94 download)
Book Synopsis The Drug Development Paradigm in Oncology by : National Academies of Sciences, Engineering, and Medicine
Download or read book The Drug Development Paradigm in Oncology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-02-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.
