Mitochondrial Intoxication

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Mitochondrial Intoxication

Author : Marcos Roberto de Oliveira
Publisher : Elsevier
ISBN 13 : 0323884636
Total Pages : 800 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Mitochondrial Intoxication by : Marcos Roberto de Oliveira

Download or read book Mitochondrial Intoxication written by Marcos Roberto de Oliveira and published by Elsevier. This book was released on 2022-11-30 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease. - Features a wide range of toxicants and their effects on mitochondrial physiology - Covers molecular markers of mitochondrial intoxication - Includes case studies that illustrate the health impacts of toxicity upon mitochondria - Considers future directions regarding the study of mitochondrial intoxication

Mitochondrial Physiology and Vegetal Molecules

Author : Marcos Roberto de Oliveira
Publisher : Academic Press
ISBN 13 : 0128215836
Total Pages : 808 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Mitochondrial Physiology and Vegetal Molecules by : Marcos Roberto de Oliveira

Download or read book Mitochondrial Physiology and Vegetal Molecules written by Marcos Roberto de Oliveira and published by Academic Press. This book was released on 2021-07-14 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health provides a comprehensive overview of mitochondrial physiology throughout the human life span, as well as the effect of molecules of vegetal origin on mitochondrial health. The editor has lined up a team of worldwide experts to cover the most exciting and high-impact advancements of research in this area. This book is structured into two parts that provide a balance of both foundational and applied content. Part I provides an overview of mitochondrial physiology including its structure, dynamics, biogenesis, membranes, DNA transcription, and translation in the mitochondria. Part I also covers other themes such as apoptosis. Part II then covers the effect of specific vegetable-derived molecules on mitochondrial health, including anthocyanins, caffeine, cannabinoids, carnosic and rosmarinic acids, citrus flavonoids, polyphenols, pterostilbene, resveratrol, and sulforaphane, among others. Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health is a complete resource for researchers in this exciting field. Its comprehensive coverage makes it particularly interesting to bioscience researchers willing to understand the foundations of mitochondrial physiology throughout the human life span. Clinician researchers, MDs, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the health effects of vegetal origin molecules on the organelle. - Contains detailed information on plant products and their effect on mitochondria - Proposes therapies and reviews mechanisms of absorption at the cellular level - Discusses the limited bioavailability of plant molecules/compounds in the human organism - Includes coverage of specific conditions such as Sports and affective disorders, among others - Presents the protective effects of plant products in mitochondrial health through all stages of life

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Drug-Induced Mitochondrial Dysfunction

Author : James A. Dykens
Publisher : Wiley-Interscience
ISBN 13 : 9780470111314
Total Pages : 0 pages
Book Rating : 4.1/5 (113 download)

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Book Synopsis Drug-Induced Mitochondrial Dysfunction by : James A. Dykens

Download or read book Drug-Induced Mitochondrial Dysfunction written by James A. Dykens and published by Wiley-Interscience. This book was released on 2008-09-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Author : Yvonne Will
Publisher : John Wiley & Sons
ISBN 13 : 1119329744
Total Pages : 816 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants by : Yvonne Will

Download or read book Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants written by Yvonne Will and published by John Wiley & Sons. This book was released on 2018-03-23 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Mitochondrial Dysfunction and Nanotherapeutics

Author : Marcos Roberto de Oliveira
Publisher : Academic Press
ISBN 13 : 0323886183
Total Pages : 602 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Mitochondrial Dysfunction and Nanotherapeutics by : Marcos Roberto de Oliveira

Download or read book Mitochondrial Dysfunction and Nanotherapeutics written by Marcos Roberto de Oliveira and published by Academic Press. This book was released on 2021-07-15 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span. This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies. - Contains detailed information on mitochondrial dysfunction - Reviews our current understanding of the role of mitochondria in aging - Includes coverage of specific conditions, including sports and affective disorders, among others - Discusses mitochondria targeted delivery of therapeutic compounds

Alcohol Intoxication and Withdrawal I

Author : Milton M. Gross
Publisher : Springer Science & Business Media
ISBN 13 : 1468432346
Total Pages : 417 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Alcohol Intoxication and Withdrawal I by : Milton M. Gross

Download or read book Alcohol Intoxication and Withdrawal I written by Milton M. Gross and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contributions to this volume clearly indicate the momentum, quality, liveliness and diversity of the research effort being di rected toward deepening our understanding of tqe alcohol withdrawal syndrome. This area of study has gained increasing interest and attention to the point where it seemed reasonable to devote a spe cial section to it at the 30th International Congress for Alcoholism and Drug Dependence in Amsterdam in September, 1972. Our goal was to share our most recent findings and stimulate others to join in the effort. With few exceptions, the papers in this publication present new data. It had been hoped that the volume would appear by the end of 1972. However, the eagerness of many of the contributors to extend their investigations made this target date impossible. Several of the papers were not presented in the section but were presented elsewhere in the Congress. However, because of their particular relevance to the topic they have been included with the generous consent of the authors.

Mitochondrial Biology and Experimental Therapeutics

Author : Paulo J. Oliveira
Publisher : Springer
ISBN 13 : 3319733443
Total Pages : 696 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Mitochondrial Biology and Experimental Therapeutics by : Paulo J. Oliveira

Download or read book Mitochondrial Biology and Experimental Therapeutics written by Paulo J. Oliveira and published by Springer. This book was released on 2018-03-21 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Author : Yvonne Will
Publisher : John Wiley & Sons
ISBN 13 : 1119329736
Total Pages : 813 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants by : Yvonne Will

Download or read book Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants written by Yvonne Will and published by John Wiley & Sons. This book was released on 2018-03-21 with total page 813 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Toxic Effects of Mercury

Author : Shabnum Nabi
Publisher : Springer
ISBN 13 : 8132219228
Total Pages : 265 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis Toxic Effects of Mercury by : Shabnum Nabi

Download or read book Toxic Effects of Mercury written by Shabnum Nabi and published by Springer. This book was released on 2014-07-25 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mercury is widespread in our environment. Methylmercury, an organic form of mercury, can accumulate in the aquatic food chain and lead to high concentrations in predatory fish. When consumed by humans, contaminated fish represent a public health risk. Toxic Effects of Mercury intends to facilitate among its readers the understanding of the importance of mercury pollution in the environment and the health consequences associated with exposure to this metal. The knowledge on methylmercury (MeHg) toxicity collected over the years is undoubtedly robust creating an impression all that is to be learnt about this metal has already been accomplished. However, in large measure, past knowledge has merely laid the ground for interesting questions that have yet to be fully addressed and concepts have yet to be deciphered. One of my major goals was to make a valiant attempt to include state-of-the-art information on the mechanisms of mercury toxicity, describing its effects on cultured cellular systems as well as in whole living organisms, starting from the lessons learned from the tragic events in Minamata Bay, Japan. A special focus of the book is on the neurotoxic effects of MeHg. An understanding at the cellular level is necessary to gather information on the structural and functional alterations induced by MeHg and how they possibly become unmasked and evident at the behavioral level, 32 chapters of the book have been organised having these considerations in mind. This book will provide state-of-the-art information to the graduate students training in toxicology, risk assessors, researchers and medical providers at large. It is aimed to bring the readers updated information on contemporary issues associated with exposure to methylmercury, from its effects on stem cells and neurons to population studies. It is a valuable resource for individuals interested in the public health effects and regulation of mercury. The report provides an excellent example of the implications of decisions in the risk assessment process for a larger audience and is written with the hope that the information will provide better understanding of the mercury problems which confront us.

Advances in Mitochondrial Medicine

Author : Roberto Scatena
Publisher : Springer Science & Business Media
ISBN 13 : 9400728689
Total Pages : 459 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Advances in Mitochondrial Medicine by : Roberto Scatena

Download or read book Advances in Mitochondrial Medicine written by Roberto Scatena and published by Springer Science & Business Media. This book was released on 2012-02-09 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.

Toxicology of Cyanides and Cyanogens

Author : Alan H. Hall
Publisher : John Wiley & Sons
ISBN 13 : 1118628942
Total Pages : 369 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Toxicology of Cyanides and Cyanogens by : Alan H. Hall

Download or read book Toxicology of Cyanides and Cyanogens written by Alan H. Hall and published by John Wiley & Sons. This book was released on 2015-10-13 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basic and applied toxicology of cyanides and cyanogens has widespread commercial, occupational, environmental, clinical, forensic, military, and public health implications. This book provides a detailed and updated reference describing the properties, uses, general and human toxicology, clinical recognition, diagnosis and medical management, and countermeasures is therefore required in academic, medical, occupational, environmental, medico-legal, regulatory, emergency response, and military arenas. Edited by a world-renowned team of experts from academia, defense and industry, this book will be an invaluable reference for professionals, researchers and students in cyanide and cyanogens.

Photobiomodulation in the Brain

Author : Michael R. Hamblin
Publisher : Academic Press
ISBN 13 : 0128153067
Total Pages : 658 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Photobiomodulation in the Brain by : Michael R. Hamblin

Download or read book Photobiomodulation in the Brain written by Michael R. Hamblin and published by Academic Press. This book was released on 2019-07-13 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photobiomodulation in the Brain: Low-Level Laser (Light) Therapy in Neurology and Neuroscience presents the fundamentals of photobiomodulation and the diversity of applications in which light can be implemented in the brain. It will serve as a reference for future research in the area, providing the basic foundations readers need to understand photobiomodulation's science-based evidence, practical applications and related adaptations to specific therapeutic interventions. The book covers the mechanisms of action of photobiomodulation to the brain, and includes chapters describing the pre-clinical studies and clinical trials that have been undertaken for diverse brain disorders, including traumatic events, degenerative diseases and psychiatric disorders. - Provides a much-needed reference on photobiomodulation with an unprecedented focus on the brain and its disorders - Features a body of world-renowned editors and chapter authors that promote research, policy and funding - Discusses the recent and rapid accumulation of literature in this area of research and the shift towards the use of non-invasive techniques in therapy

Mechanisms of Drug Toxicity

Author : H. Rašková
Publisher : Elsevier
ISBN 13 : 1483157202
Total Pages : 113 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Mechanisms of Drug Toxicity by : H. Rašková

Download or read book Mechanisms of Drug Toxicity written by H. Rašková and published by Elsevier. This book was released on 2013-10-22 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.

Mitochondria as a Key Intracellular Target of Thallium Toxicity

Author : Sergey Korotkov
Publisher : Academic Press
ISBN 13 : 0323955320
Total Pages : 280 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Mitochondria as a Key Intracellular Target of Thallium Toxicity by : Sergey Korotkov

Download or read book Mitochondria as a Key Intracellular Target of Thallium Toxicity written by Sergey Korotkov and published by Academic Press. This book was released on 2022-06-01 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria as a Key Intracellular Target of Thallium Toxicity presents a new hypothesis that explains the decrease in antioxidant defense of thallium poisoning and proposes a new model for studying the transport of inorganic cations across the inner mitochondrial membrane. Readers will learn about the toxicity of thallium and its compounds, the toxicology of thallium, the toxic thallium effects on cells, and the effects of thallium on mitochondria. In addition, the book lists the pathways and mechanisms of thallium transport into cells and mitochondria, including information on toxicity that has been analyzed at both the cellular and subcellular levels. The increase in human contact with the toxic trace element thallium is associated with industry development, the release of metal into the environment from various rocks, and the use of special isotope techniques for studying the vascular bed. - Highlights the differences between the toxic effect of thallium and the action of other heavy metals on cells and mitochondria - Explains why the toxicity of thallium in experiments in vivo is higher than that of bivalent heavy metals - Discusses the applied in vitro model when searching for new inhibitors of the mitochondrial permeability transition pore

Steatohepatitis (NASH and ASH)

Author : U. Leuschner
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387695
Total Pages : 410 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Steatohepatitis (NASH and ASH) by : U. Leuschner

Download or read book Steatohepatitis (NASH and ASH) written by U. Leuschner and published by Springer Science & Business Media. This book was released on 2001-05-31 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the proceedings of the Falk Symposium No. 121 on 'Steatohepatitis (NASH and ASH)', held in Den Haag, The Netherlands, on October 14-15, 2000. The histological features of what we now call non-alcoholic steatohepatitis were described as early as 1962 by the Honorary President of the Symposium, Professor Herbert Thaler, from Vienna. Others followed, and in 1980 Jürgen Ludwig, one of the speakers of this symposium, introduced the name `non-alcoholic steatohepatitis' or NASH. In a Consensus Symposium organized by the National Institute of Health (NIH) in Washington, USA, in December 1998, NASH was recognized as one of the most common liver diseases in Western countries when viral hepatitis and heavy alcohol consumption were excluded. ASH, or alcoholic steatohepatitis, is more common than NASH, since alcohol is omnipresent in Western as well as Eastern cultures. Histologically NASH and ASH are similar or even identical. Morphological findings range from fatty degeneration to inflammation and fibrosis, and may end up in liver cirrhosis. In spite of the well-defined morphological features, our knowledge of epidemiology, aetiology, and pathogenesis is full of gaps, especially for NASH. Therefore, it is the purpose of this book to show the state of the art, to discuss recent scientific data, and to suggest possible treatment strategies, hoping to stimulate clinicians as well as scientists.

Alcohol Abuse and Liver Disease

Author : Andrea DiMartini
Publisher : John Wiley & Sons
ISBN 13 : 1118887298
Total Pages : 264 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Alcohol Abuse and Liver Disease by : Andrea DiMartini

Download or read book Alcohol Abuse and Liver Disease written by Andrea DiMartini and published by John Wiley & Sons. This book was released on 2016-03-21 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: For people with alcohol excess and liver disease, successful management must be two-fold with management of both their psychological/physical addiction to alcohol and their liver disease. Alcohol Abuse and liver disease, with its joint focus on hepatology and psychiatry, provides both hepatologists and psychiatrists of all levels with a practical, concise and didactic guide to the investigation and clinical management of those with alcohol-related problems. Edited by a practicing hepatologist in the UK and a practising specialist in psychiatry/substance abuse in the US, it covers areas such as: • Risk factors for alcoholic liver disease • Interaction of alcohol with other co-morbidities • Clinical assessment of alcohol intake • Detoxification and management of withdrawal • Psychotherapeutic and pharmaceutical interventions • Treatment of liver disease Key points, management diagrams and high-quality images are all be supported by the very latest in clinical guidelines from the major hepatology and psychiatry societies such as the APA, EPA, AASLD and EASL. With increasing emphasis on multi-disciplinary speciality care in this area, this is the ideal tool to consult in order to provide the best care possible care for what are very challenging patients to manage.