MIPs and Their Roles in the Exchange of Metalloids

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Publisher : Springer Science & Business Media
ISBN 13 : 1441963154
Total Pages : 158 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis MIPs and Their Roles in the Exchange of Metalloids by : Thomas P. Jahn

Download or read book MIPs and Their Roles in the Exchange of Metalloids written by Thomas P. Jahn and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixteen years have passed since human aquaporin-1 (AQP1) was discovered as the first water channel, facilitating trans-membrane water fluxes. Subsequent years of research showed that the water channel AQP1 was only the tip of an iceberg; the iceberg itself being the ubiquitous super family of membrane intrinsic proteins (MIPs) that facilitate trans-membrane transport of water and an increasing number of small, water-soluble and uncharged compounds. Here we introduce you to the superfamily of MIPs and provide a summary about our gradually refined understanding of the phylogenetic relationship of its members. This volume is dedicated to the metalloids, a recently discovered group of substrates for a number of specific MIPs in a diverse spectrum of organisms. Particular focus is given to the essential boron, the beneficial silicon and the highly toxic arsenic. The respective MIP isoforms that facilitate the transport of these metalloids include members from several clades of the phylogenetic tree, suggesting that metalloid transport is an ancient function within this family of channel proteins. Among all the various substrates that have been shown to be transported by MIPs, metalloids take an outstanding position. While water transport seems to be a common function of many MIPs, single isoforms in plants have been identified as being crucially important for the uptake of boric acid as well as silicic acid. Here, the function seems not to be redundant, as mutations in those genes render plants deficient in boron and silicon, respectively.

MIPs and Their Roles in the Exchange of Metalloids

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Author :
Publisher : Springer
ISBN 13 : 9781493941001
Total Pages : 145 pages
Book Rating : 4.9/5 (41 download)

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Book Synopsis MIPs and Their Roles in the Exchange of Metalloids by : Thomas P. Jahn

Download or read book MIPs and Their Roles in the Exchange of Metalloids written by Thomas P. Jahn and published by Springer. This book was released on 2016-08-23 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixteen years have passed since human aquaporin-1 (AQP1) was discovered as the first water channel, facilitating trans-membrane water fluxes. Subsequent years of research showed that the water channel AQP1 was only the tip of an iceberg; the iceberg itself being the ubiquitous super family of membrane intrinsic proteins (MIPs) that facilitate trans-membrane transport of water and an increasing number of small, water-soluble and uncharged compounds. Here we introduce you to the superfamily of MIPs and provide a summary about our gradually refined understanding of the phylogenetic relationship of its members. This volume is dedicated to the metalloids, a recently discovered group of substrates for a number of specific MIPs in a diverse spectrum of organisms. Particular focus is given to the essential boron, the beneficial silicon and the highly toxic arsenic. The respective MIP isoforms that facilitate the transport of these metalloids include members from several clades of the phylogenetic tree, suggesting that metalloid transport is an ancient function within this family of channel proteins. Among all the various substrates that have been shown to be transported by MIPs, metalloids take an outstanding position. While water transport seems to be a common function of many MIPs, single isoforms in plants have been identified as being crucially important for the uptake of boric acid as well as silicic acid. Here, the function seems not to be redundant, as mutations in those genes render plants deficient in boron and silicon, respectively.

Aquaporins in Health and Disease

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Author :
Publisher : CRC Press
ISBN 13 : 149870784X
Total Pages : 356 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Aquaporins in Health and Disease by : Graca Soveral

Download or read book Aquaporins in Health and Disease written by Graca Soveral and published by CRC Press. This book was released on 2018-10-30 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology. The studies have also shown aquaporins as potential drug targets and targets for improving crop properties. Written by an international group of contributors at the forefront of the field, Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery presents the latest research advances in aquaporins and other major intrinsic protein (MIP) channels. The first section of the book describes the general concepts of aquaporin channel function, genomic research, structure-function analysis of aquaporins and glycerol facilitators, and regulation by gating and trafficking, including yeast aquaporin regulation and function. The second section discusses the physiological and pathophysiological roles of aquaporins in humans and microbes. The final section covers the development of inhibitors of aquaporin function. The book’s epilogue offers future perspectives and directions, mainly in the area of aquaporin-based diagnostics and therapeutics. Stimulating future research on this important protein family, this book facilitates a paradigm shift in the understanding and roles of aquaporin membrane proteins in all biological settings. It encourages scientists to develop novel approaches for the treatment of human diseases based on aquaporin function or dysfunction.

Progress in Adhesion and Adhesives, Volume 4

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Publisher : John Wiley & Sons
ISBN 13 : 1119625254
Total Pages : 458 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Progress in Adhesion and Adhesives, Volume 4 by : K. L. Mittal

Download or read book Progress in Adhesion and Adhesives, Volume 4 written by K. L. Mittal and published by John Wiley & Sons. This book was released on 2019-07-11 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: A solid collection of interdisciplinary review articles on the latest developments in adhesion science and adhesives technology With the ever-increasing amount of research being published, it is a Herculean task to be fully conversant with the latest research developments in any field, and the arena of adhesion and adhesives is no exception. Thus, topical review articles provide an alternate and very efficient way to stay abreast of the state-of-the-art in many subjects representing the field of adhesion science and adhesives. Based on the success of the preceding volumes in this series "Progress in Adhesion and Adhesives"), the present volume comprises 9 review articles published in Volume 6 (2018) of Reviews of Adhesion and Adhesives. The subject of these reviews fall into the following general areas: 1. Adhesion to wood and wood bonds 2. Adhesive joints 3. Adhesion in microelectronic packaging 4. Surface modification 5. Contact angle, wettability and surface free energy. The topics covered include: Adhesion phenomena in microelectronic packaging; adhesives for wood and lignocellulosic materials; adhesion to wood and lignocellulosic materials; adhesively bonded lap joints having bi-adhesive and modulus-graded bondlines; adhesion between compounded elastomers; applications of contact angle measurements in pharmaceuticals and foods; oxygen or ammonia plasma treatment of polyolefin surfaces; surface free energy determination of powders and particles; wood bonds; and dispersion adhesion forces between macroscopic objects.

Metal and Nutrient Transporters in Abiotic Stress

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Publisher : Academic Press
ISBN 13 : 0128179562
Total Pages : 272 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Metal and Nutrient Transporters in Abiotic Stress by : Aryadeep Roychoudhury

Download or read book Metal and Nutrient Transporters in Abiotic Stress written by Aryadeep Roychoudhury and published by Academic Press. This book was released on 2021-04-08 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal and Nutrient Transporters in Abiotic Stress focuses on the different forms of environmental stress related to heavy metal, metalloid and nutrient deficiency that have the potential to inflict major damages to crop plants, leading to a massive decrease in crop yield and productivity. The book presents the current state of knowledge of the biochemical and molecular regulation of several classes of membrane transporters related to the uptake of metals/metalloids and nutrient elements during different stresses and their probable mechanisms of operation in plant stress tolerance. Metal and Nutrient Transporters in Abiotic Stress provides a comprehensive discussion that will help in mitigating multiple forms of stresses utilizing transporter proteins. Edited by leading experts and written by a global team of knowledgeable contributors, this book will further stimulate research in the field of transporter proteins and will foster further interests for researchers, academicians and scientists worldwide. It is complimented by its companion book titled Transporters and Plant Osmotic Stress. Focuses exclusively on metal and nutrient transporters involved in multiple environmental stresses in plants Explains exploiting transporters in crop improvement programs through transgenic technology against different stresses such as heavy metal, metalloid and nutrient deficiency Serves as an important source of information in the field of abiotic stress

Aquaporins: Dynamic Role and Regulation

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Publisher : Frontiers Media SA
ISBN 13 : 2889452891
Total Pages : 185 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Aquaporins: Dynamic Role and Regulation by : Rupesh K. Deshmukh

Download or read book Aquaporins: Dynamic Role and Regulation written by Rupesh K. Deshmukh and published by Frontiers Media SA. This book was released on 2017-10-10 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaporins (AQPs), a class of integral membrane proteins, form channels facilitating movement of water and many other solutes. In solute transport systems of all living organisms including plants, animals and fungi, AQPs play a vital role. Plants contain a much higher number of AQP genes compared to animals, the likely consequence of genome duplication events and higher ploidy levels. As a result of duplication and subsequent diversification, plant AQPs have evolved several subfamilies with very diverse functions. Plant AQPs are highly selective for specific solutes because of their unique structural features. For instance, ar/R selectivity filters and NPA domains have been found to be key elements in governing solute permeability through the AQP channels. Combination of conserved motifs and specific amino acids influencing pore morphology appears to regulate the permeability of specific solutes such as water, urea, CO2, H2O2, boric acid, silicic acid and many more. The discovery of novel AQPs has been accelerated over the last few years with the increasing availability of genomic and transcriptomic data. The expanding number of well characterised AQPs provides opportunities to understand factors influencing water transport, nutritional uptake, and elemental balance. Homology-based search tools and phylogenetic analyses offer efficient strategies for AQP identification. Subsequent characterization can be based on different approaches involving proteomics, genomics, and transcriptomic tools. The combination of these technological advances make it possible to efficiently study the inter-dependency of AQPs, regulation through phosphorylation and reversible phosphorylation, networking with other transporters, structural features, pH gating systems, trafficking and degradation. Several studies have supported the role of AQPs in differential phenotypic responses to abiotic and biotic stress in plants. Crop improvement programs aiming for the development of cultivars with higher tolerance against stresses like drought, flooding, salinity and many biotic diseases, can explore and exploit the finely tuned AQP-regulated transport system. For instance, a promising approach in crop breeding programs is the utilization of genetic variation in AQPs for the development of stress tolerant cultivars. Similarly, transgenic and mutagenesis approaches provide an opportunity to better understand the AQP transport system with subsequent applications for the development of climate-smart drought-tolerant cultivars. The contributions to this Frontiers in Plant Science Research Topic have highlighted the evolution and phylogenetic distribution of AQPs in several plant species. Numerous aspects of regulation that seek to explain AQP-mediated transport system have been addressed. These contributions will help to improve our understanding of AQPs and their role in important physiological aspects and will bring AQP research closer to practical applications.

Arsenic in Plants

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Publisher : John Wiley & Sons
ISBN 13 : 1119791421
Total Pages : 452 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Arsenic in Plants by : Prabhat Kumar Srivastava

Download or read book Arsenic in Plants written by Prabhat Kumar Srivastava and published by John Wiley & Sons. This book was released on 2022-09-26 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arsenic in Plants Comprehensive resource detailing the chemistry, toxicity and impact of arsenic in plants, and solutions to the problem Arsenic in Plants: Uptake, Consequences and Remediation Techniques provides comprehensive coverage of the subject, detailing arsenic in our environment, the usage of arsenicals in crop fields, phytotoxicity of arsenic and arsenic’s impact on the morphology, anatomy and quantitative and qualitative traits of different plant groups, including their physiology and biochemistry. The work emphasizes the occurrence of arsenic, its speciation and transportation in plants, and differences in mechanisms of tolerance in hyper-accumulator and non-accumulator plants. Throughout the text, the highly qualified authors delve into every facet of the interaction of arsenic with plants, including the ionomics, genomics, transcriptomics and proteomics in relation to arsenic toxicity, impact of exogenous phytohormones and growth-regulating substances, management of arsenic contamination in the soil-plant continuum, phytoremediation of arsenic toxicity and physical removal of arsenic from water. General discussion has also been included on subjects such as the ways through which this metalloid affects plant and human systems. Topics covered include: Introduction and historical background of arsenic and the mechanism of arsenic transport and metabolism in plants Arsenic-induced responses in plants, including impact on biochemical processes and different plant groups, from cyanobacteria to higher plants The role of phytohormones, mineral nutrients, metabolites and signaling molecules in regulating arsenic-induced toxicity in plants Genomic, proteomic, metabolomic, ionomic and transcriptional regulation during arsenic stress Strategies to reduce the arsenic contamination in soil-plant systems and arsenic removal by phytoremediation techniques Researchers, academics, and students of plant physiology, biotechnology, and agriculture will find valuable information in Arsenic in Plants to understand this pressing subject in full, along with its implications and how we can adapt our strategies and behaviors to promote reduced contamination through practical applications.

Environmental Toxicants

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Publisher : John Wiley & Sons
ISBN 13 : 1119438802
Total Pages : 1029 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Environmental Toxicants by : Morton Lippmann

Download or read book Environmental Toxicants written by Morton Lippmann and published by John Wiley & Sons. This book was released on 2020-04-07 with total page 1029 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Updated Reference on Human Exposure to Environmental Toxicants and A Study of Their Impact on Public Health With the 4th edition of Environmental Toxicants: Human Exposures and Their Health Effects, readers have access to up-to-date information on the study and science of environmental toxicology and public health worldwide. Practitioners and professionals can use this resource to understand newly discovered information on the adverse health effects of toxins and pollutants in air, water, and occupational and environmental environments on large human populations. The 4th edition of this book is updated to reflect new knowledge and research on: ● Performing risk assessments on exposed individuals ● Assessing the effects of toxicants and substances on large populations for health and medical professionals ● Patterns of human exposure to select chemical toxicants ● World Trade Center dust, agents for chemical terrorism, and nanoparticles For health professionals, including health authorities, public health officials, physicians, and industrial managers, who are seeking new research and techniques for managing environmental substances, this invaluable reference will guide you through in a thorough, easy- to-read manner.

Microbe Mediated Remediation of Environmental Contaminants

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Publisher : Woodhead Publishing
ISBN 13 : 0128232072
Total Pages : 474 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Microbe Mediated Remediation of Environmental Contaminants by : Ajay Kumar

Download or read book Microbe Mediated Remediation of Environmental Contaminants written by Ajay Kumar and published by Woodhead Publishing. This book was released on 2020-10-14 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbe Mediated Remediation of Environmental Contaminants presents recent scientific progress in applying microbes for environmental management. The book explores the current existing practical applications and provides information to help readers develop new practices and applications. Edited by recognized leaders in the field, this penetrating assessment of our progress to date in deploying microorganisms to the advantage of environmental management and biotechnology will be widely welcomed by those working in soil contamination management, agriculture, environment management, soil microbiology, and waste management. The polluting effects on the world around us of soil erosion, the unwanted migration of sediments, chemical fertilizers and pesticides, and the improper treatment of human and animal wastes have resulted in serious environmental and social problems around the world, problems which require us to look for solutions elsewhere than established physical and chemical technologies. Often the answer lies in hybrid applications in which microbial methods are combined with physical and chemical ones. When we remember that these highly effective microorganisms, cultured for a variety of applications, are but a tiny fraction of those to be found in the world around us, we realize the vastness of the untapped and beneficial potential of microorganisms. Explores microbial application redressing for soil and water contamination challenges Includes information on microbial synthesized nanomaterials for remediation of contaminated soils Presents a uniquely hybrid approach, combining microbial interactions with other chemical and physical methods

Protective Chemical Agents in the Amelioration of Plant Abiotic Stress

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Publisher : John Wiley & Sons
ISBN 13 : 111955165X
Total Pages : 704 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Protective Chemical Agents in the Amelioration of Plant Abiotic Stress by : Aryadeep Roychoudhury

Download or read book Protective Chemical Agents in the Amelioration of Plant Abiotic Stress written by Aryadeep Roychoudhury and published by John Wiley & Sons. This book was released on 2020-05-20 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the chemical agents that protect plants from various environmental stressors Protective Chemical Agents in the Amelioration of Plant Abiotic Stress offers a guide to the diverse chemical agents that have the potential to mitigate different forms of abiotic stresses in plants. Edited by two experts on the topic, the book explores the role of novel chemicals and shows how using such unique chemical agents can tackle the oxidative damages caused by environmental stresses. Exogenous application of different chemical agents or chemical priming of seeds presents opportunities for crop stress management. The use of chemical compounds as protective agents has been found to improve plant tolerance significantly in various crop and non-crop species against a range of different individually applied abiotic stresses by regulating the endogenous levels of the protective agents within plants. This important book: Explores the efficacy of various chemical agents to eliminate abiotic stress Offers a groundbreaking look at the topic and reviews the most recent advances in the field Includes information from noted authorities on the subject Promises to benefit agriculture under stress conditions at the ground level Written for researchers, academicians, and scientists, Protective Chemical Agents in the Amelioration of Plant Abiotic Stress details the wide range of protective chemical agents, their applications, and their intricate biochemical and molecular mechanism of action within the plant systems during adverse situations.

The Praeger Handbook of Environmental Health

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Publisher : Bloomsbury Publishing USA
ISBN 13 : 0313386013
Total Pages : 2395 pages
Book Rating : 4.3/5 (133 download)

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Book Synopsis The Praeger Handbook of Environmental Health by : Robert H. Friis

Download or read book The Praeger Handbook of Environmental Health written by Robert H. Friis and published by Bloomsbury Publishing USA. This book was released on 2012-04-23 with total page 2395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally acclaimed experts in the United States and abroad, this comprehensive set of environmental health articles serves to clarify our impending challenges as well as opportunities for health and wellness. Written in an accessible style that is appropriate for general readers as well as professionals in the environmental health field, this work provides a comprehensive yet coherent review of the principal environmental challenges that confront our society. This four-volume work taps a multidisciplinary team of experts from across the nation to present emerging information about how our world is being impacted, the effects on health and life, and the steps we are taking—and should take—to correct or avoid the problems. The Praeger Handbook of Environmental Health comprises four volumes: Foundations of the Field; Agents of Disease; Water, Air, and Solid Waste; and Current Issues and Emerging Debates. Within each volume, chapters cover the latest scientific research findings in an objective manner and present practical applications of the information. Topics addressed include air and water contaminants, PCBs, hazardous waste, household cleaning products, dioxin, plastics, radiation, radon, electromagnetic fields, and noise and light pollution, just to name a few. This title stands alone in its comprehensive coverage of environmental health topics.

Benefits of Silicon in the Nutrition of Plants

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Publisher : Springer Nature
ISBN 13 : 3031266730
Total Pages : 381 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Benefits of Silicon in the Nutrition of Plants by : Renato de Mello Prado

Download or read book Benefits of Silicon in the Nutrition of Plants written by Renato de Mello Prado and published by Springer Nature. This book was released on 2023-06-22 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to describe the role of silicon in the environment from the biogeochemical cycle of terrestrial ecosystems, uptake to cellular and tissue bioaccumulation and its effects in mitigating abiotic and biotic stresses. From an agronomic point of view, this knowledge is essential to boost agricultural production and improve its quality and the sustainability of crops in the face of the growing pressure of different stresses on crop systems of different natures. Si is the only multi-stress mitigator in plant nutrition. It plays an important role in mitigating nutritional deficiency by increasing nutrient use efficiency, something that will be very important in the future: producing more with less nutrient accumulated in the plant. The book focuses on the effects of Si on plant mineral nutrition, exploring nutritional deficiencies and toxicity of Al and potentially toxic heavy metals such as Cd, as well as important stresses such as salinity, water deficit and high temperature. The book will also discuss the Si extractors in the soil and criteria for recommending Si in crops and the sources of the element for its application in soil and leaves, as well as the role of Si in the activity of microorganisms and in plant diseases and pests. São Paulo Research Foundation (FAPESP)(2022/10092-9).

Transporters and Pumps in Plant Signaling

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Publisher : Springer Science & Business Media
ISBN 13 : 3642143695
Total Pages : 385 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Transporters and Pumps in Plant Signaling by : Markus Geisler

Download or read book Transporters and Pumps in Plant Signaling written by Markus Geisler and published by Springer Science & Business Media. This book was released on 2010-10-17 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to their sessile lifestyle, plants need to efficiently adapt to changing environmental conditions during their life cycle. Nutrient acquisition from the soil has to be able to adapt to considerable fluctuations in concentrations to ensure adequate distribution between tissues, cells and organelles. The storage and retrieval of nutrients, metabolites or toxic substances in vacuoles plays an important part in cellular homeostasis in plants. The long-range transport and maintenance of turgor is critically dependent on the availability of water and rate of evaporation, while at the same time photosynthetic products have to be transported to all plant parts. As a result plants contain a large number of ATP-dependent pumps and secondary transporters that, in order to adapt to the changing environment, need to be regulated by a complex network of sensing and signaling mechanisms. Plants share many basic elements of signal transduction with animals, but also contain plant-specific signaling molecules and mechanisms. In this volume, the role of transporters and pumps in the regulation of movement, long-range transport and compartmentalization of water, solutes, nutrients and classical signaling molecules is highlighted, and the function, regulation and membrane-transporter interaction and their roles in plant signaling controlling plant physiology and development are discussed.

Beneficial Chemical Elements of Plants

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Publisher : John Wiley & Sons
ISBN 13 : 1119688809
Total Pages : 405 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Beneficial Chemical Elements of Plants by : Sangeeta Pandey

Download or read book Beneficial Chemical Elements of Plants written by Sangeeta Pandey and published by John Wiley & Sons. This book was released on 2023-09-12 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: BENEFICIAL CHEMICAL ELEMENTS OF PLANTS Understand beneficial elements and their role in the future of botany and agriculture Beneficial elements are those which, while not essential to plant life, can provide stimulation and enhance plant growth. Properly harnessed, these elements can bolster plant growth in the face of environmental conditions—including drought, nutrient deficiency, and excessive soil salinity—and biotic stresses like pathogens and animal activity. As climate change and population growth pose increasingly serious challenges to agriculture and essential plant production, it has never been more important to unleash the potential of beneficial elements. Beneficial Chemical Elements of Plants is an essential resource for researchers and industry specialists looking to enhance their understanding of these elements and the range and variety of their enhancements to plant growth. Written by leading scholars in the field of plant stress tolerance and nutrient enrichment, it discusses not only the rich possibilities of beneficial elements but their mechanisms of action at both biochemical and molecular levels. It details the precise potential roles played by each major beneficial element and surveys a range of elemental responses to specific environmental conditions and plant stresses. Beneficial Chemical Elements of Plants readers will also find: Chapters covering beneficial elements including aluminum, cobalt, sodium, selenium, and silicon Discussion of application methods and typical plant responses Treatment of beneficial elements in a wider environmental context Beneficial element applications to the field of sustainable agriculture Beneficial Chemical Elements of Plants is a fundamental starting point for researchers and students in the fields of plant physiology, crop science, agriculture, and botany, as well as for professionals in the biotechnology and agricultural industries.

A Tale of Seven Elements

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Author :
Publisher : Oxford University Press
ISBN 13 : 0199875030
Total Pages : 304 pages
Book Rating : 4.1/5 (998 download)

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Book Synopsis A Tale of Seven Elements by : Eric Scerri

Download or read book A Tale of Seven Elements written by Eric Scerri and published by Oxford University Press. This book was released on 2013-05-20 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1913, English physicist Henry Moseley established an elegant method for "counting" the elements based on atomic number, ranging them from hydrogen (#1) to uranium (#92). It soon became clear, however, that seven elements were mysteriously missing from the lineup--seven elements unknown to science. In his well researched and engaging narrative, Eric Scerri presents the intriguing stories of these seven elements--protactinium, hafnium, rhenium, technetium, francium, astatine and promethium. The book follows the historical order of discovery, roughly spanning the two world wars, beginning with the isolation of protactinium in 1917 and ending with that of promethium in 1945. For each element, Scerri traces the research that preceded the discovery, the pivotal experiments, the personalities of the chemists involved, the chemical nature of the new element, and its applications in science and technology. We learn for instance that alloys of hafnium--whose name derives from the Latin name for Copenhagen (hafnia)--have some of the highest boiling points on record and are used for the nozzles in rocket thrusters such as the Apollo Lunar Modules. Scerri also tells the personal tales of researchers overcoming great obstacles. We see how Lise Meitner and Otto Hahn--the pair who later proposed the theory of atomic fission--were struggling to isolate element 91 when World War I intervened, Hahn was drafted into the German army's poison gas unit, and Meitner was forced to press on alone against daunting odds. The book concludes by examining how and where the twenty-five new elements have taken their places in the periodic table in the last half century. A Tale of Seven Elements paints a fascinating picture of chemical research--the wrong turns, missed opportunities, bitterly disputed claims, serendipitous findings, accusations of dishonesty--all leading finally to the thrill of discovery.

Melanocortins

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Publisher : Springer Science & Business Media
ISBN 13 : 1441963545
Total Pages : 171 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Melanocortins by : Anna Catania

Download or read book Melanocortins written by Anna Catania and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is clear that the melanocortins are of immense academic interest. Further, these molecules have remarkable potential as pharmaceutical agents for treatment of multiple human and veterinary disorders and diseases. The evidence to support academic interest and clinical applications lies in significant part within the chapters of this book, chapters written by noted experts in the field who have worked diligently to understand the molecules and to move them toward clinical applications. I personally believe that the - MSH molecule and its derivatives will be used as routine therapeutics in the very near future. My belief is so strong that I left academia to form a company based on -MSH analogs and have caused millions of dollars to be spent on melanocortin research. Now why would a sane professor pick up such a challenge and enter business, an essential step toward any clinical application? It is the - MSH story that drove me. Consider that - MSH occurs in exactly the same amino acid sequence in humans and in the sea lamprey, an organism unchanged since its appearance during the Pennsylvanian period of the Paleozoic era (about 300 million years ago—way before dinosaurs were to be considered). There is unpublished evidence that the stability of the molecule can be traced back a half billion years. Frankly, I believe that the molecule existed even when single cells began to live together.

BCL‐2 Protein Family

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Publisher : Springer Science & Business Media
ISBN 13 : 1441967060
Total Pages : 156 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis BCL‐2 Protein Family by : Claudio Hetz

Download or read book BCL‐2 Protein Family written by Claudio Hetz and published by Springer Science & Business Media. This book was released on 2011-01-12 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL‐2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles stress and the consequences of dysregulation of this process for human disease will find this book very valuable. It attempts to describe a fascinating area of research where physiology and biomedicine converge at different levels, revealing a trip from the molecular regulation of apoptosis to the impact of this process to the physiology of a whole organism.