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Minimax Optimal Designs
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Book Synopsis An Introduction to Optimal Designs for Social and Biomedical Research by : Martijn P.F. Berger
Download or read book An Introduction to Optimal Designs for Social and Biomedical Research written by Martijn P.F. Berger and published by John Wiley & Sons. This book was released on 2009-05-27 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increasing cost of research means that scientists are in more urgent need of optimal design theory to increase the efficiency of parameter estimators and the statistical power of their tests. The objectives of a good design are to provide interpretable and accurate inference at minimal costs. Optimal design theory can help to identify a design with maximum power and maximum information for a statistical model and, at the same time, enable researchers to check on the model assumptions. This Book: Introduces optimal experimental design in an accessible format. Provides guidelines for practitioners to increase the efficiency of their designs, and demonstrates how optimal designs can reduce a study’s costs. Discusses the merits of optimal designs and compares them with commonly used designs. Takes the reader from simple linear regression models to advanced designs for multiple linear regression and nonlinear models in a systematic manner. Illustrates design techniques with practical examples from social and biomedical research to enhance the reader’s understanding. Researchers and students studying social, behavioural and biomedical sciences will find this book useful for understanding design issues and in putting optimal design ideas to practice.
Book Synopsis H∞-Optimal Control and Related Minimax Design Problems by : Tamer Başar
Download or read book H∞-Optimal Control and Related Minimax Design Problems written by Tamer Başar and published by Springer Science & Business Media. This book was released on 2009-05-21 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to one of the fastest developing fields in modern control theory - the so-called H-infinity optimal control theory. The book can be used for a second or third year graduate level course in the subject, and researchers working in the area will find the book useful as a standard reference. Based mostly on recent work of the authors, the book is written on a good mathematical level. Many results in it are original, interesting, and inspirational. The topic is central to modern control and hence this definitive book is highly recommended to anyone who wishes to catch up with important theoretical developments in applied mathematics and control.
Book Synopsis Interpolation and Extrapolation Optimal Designs V1 by : Giorgio Celant
Download or read book Interpolation and Extrapolation Optimal Designs V1 written by Giorgio Celant and published by John Wiley & Sons. This book was released on 2016-06-07 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of a series which focuses on the interpolation and extrapolation of optimal designs, an area with significant applications in engineering, physics, chemistry and most experimental fields. In this volume, the authors emphasize the importance of problems associated with the construction of design. After a brief introduction on how the theory of optimal designs meets the theory of the uniform approximation of functions, the authors introduce the basic elements to design planning and link the statistical theory of optimal design and the theory of the uniform approximation of functions. The appendices provide the reader with material to accompany the proofs discussed throughout the book.
Book Synopsis Optimal Design for Nonlinear Response Models by : Valerii V. Fedorov
Download or read book Optimal Design for Nonlinear Response Models written by Valerii V. Fedorov and published by CRC Press. This book was released on 2013-07-15 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors’ many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian designs. The authors also discuss adaptive designs, focusing on procedures with non-informative stopping. The common goals of experimental design—such as reducing costs, supporting efficient decision making, and gaining maximum information under various constraints—are often the same across diverse applied areas. Ethical and regulatory aspects play a much more prominent role in biological, medical, and pharmaceutical research. The authors address all of these issues through many examples in the book.
Book Synopsis Optimal Design for Nonlinear Response Models by : Valerii V. Fedorov
Download or read book Optimal Design for Nonlinear Response Models written by Valerii V. Fedorov and published by CRC Press. This book was released on 2013-07-15 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors' many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of
Book Synopsis Handbook of Design and Analysis of Experiments by : Angela Dean
Download or read book Handbook of Design and Analysis of Experiments written by Angela Dean and published by CRC Press. This book was released on 2015-06-26 with total page 946 pages. Available in PDF, EPUB and Kindle. Book excerpt: This carefully edited collection synthesizes the state of the art in the theory and applications of designed experiments and their analyses. It provides a detailed overview of the tools required for the optimal design of experiments and their analyses. The handbook covers many recent advances in the field, including designs for nonlinear models and algorithms applicable to a wide variety of design problems. It also explores the extensive use of experimental designs in marketing, the pharmaceutical industry, engineering and other areas.
Book Synopsis Randomized Phase II Cancer Clinical Trials by : Sin-Ho Jung
Download or read book Randomized Phase II Cancer Clinical Trials written by Sin-Ho Jung and published by CRC Press. This book was released on 2013-05-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: In cancer research, a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues, including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems, oncologists and biosta
Book Synopsis mODa 10 – Advances in Model-Oriented Design and Analysis by : Dariusz Ucinski
Download or read book mODa 10 – Advances in Model-Oriented Design and Analysis written by Dariusz Ucinski and published by Springer Science & Business Media. This book was released on 2013-03-21 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collects the proceedings of the 10th Workshop on Model-Oriented Design and Analysis (mODa). A model-oriented view on the design of experiments, which is the unifying theme of all mODa meetings, assumes some knowledge of the form of the data-generating process and naturally leads to the so-called optimum experimental design. Its theory and practice have since become important in many scientific and technological fields, ranging from optimal designs for dynamic models in pharmacological research, to designs for industrial experimentation, to designs for simulation experiments in environmental risk management, to name but a few. The methodology has become even more important in recent years because of the increased speed of scientific developments, the complexity of the systems currently under investigation and the mounting pressure on businesses, industries and scientific researchers to reduce product and process development times. This increased competition requires ever increasing efficiency in experimentation, thus necessitating new statistical designs. This book presents a rich collection of carefully selected contributions ranging from statistical methodology to emerging applications. It primarily aims to provide an overview of recent advances and challenges in the field, especially in the context of new formulations, methods and state-of-the-art algorithms. The topics included in this volume will be of interest to all scientists and engineers and statisticians who conduct experiments.
Book Synopsis Statistics in Industry by : Ravindra Khattree
Download or read book Statistics in Industry written by Ravindra Khattree and published by Gulf Professional Publishing. This book was released on 2003-07-18 with total page 1222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents an exposition of topics in industrial statistics. It serves as a reference for researchers in industrial statistics/industrial engineering and a source of information for practicing statisticians/industrial engineers. A variety of topics in the areas of industrial process monitoring, industrial experimentation, industrial modelling and data analysis are covered and are authored by leading researchers or practitioners in the particular specialized topic. Targeting the audiences of researchers in academia as well as practitioners and consultants in industry, the book provides comprehensive accounts of the relevant topics. In addition, whenever applicable ample data analytic illustrations are provided with the help of real world data.
Book Synopsis Developments in Statistical Evaluation of Clinical Trials by : Kees van Montfort
Download or read book Developments in Statistical Evaluation of Clinical Trials written by Kees van Montfort and published by Springer. This book was released on 2014-10-07 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes various ways of approaching and interpreting the data produced by clinical trial studies, with a special emphasis on the essential role that biostatistics plays in clinical trials. Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial improvement. The book includes 18 carefully reviewed chapters on recent developments in clinical trials and their statistical evaluation, with each chapter providing one or more examples involving typical data sets, enabling readers to apply the proposed procedures. The chapters employ a uniform style to enhance comparability between the approaches.
Book Synopsis Optimum Experimental Designs, With SAS by : Anthony Atkinson
Download or read book Optimum Experimental Designs, With SAS written by Anthony Atkinson and published by Oxford University Press, USA. This book was released on 2007-05-24 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experiments in the field and in the laboratory cannot avoid random error and statistical methods are essential for their efficient design and analysis. Authored by leading experts in key fields, this text provides many examples of SAS code, results, plots and tables, along with a fully supported website.
Book Synopsis Textbook of Clinical Trials in Oncology by : Susan Halabi
Download or read book Textbook of Clinical Trials in Oncology written by Susan Halabi and published by CRC Press. This book was released on 2019-04-24 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area. The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology. Key Features: Cutting-edge topics with appropriate technical background Built around case studies which give the work a "hands-on" approach Real examples of flaws in previously reported clinical trials and how to avoid them Access to statistical code on the book’s website Chapters written by internationally recognized statisticians from academia and pharmaceutical companies Carefully edited to ensure consistency in style, level, and approach Topics covered include innovating phase I and II designs, trials in immune-oncology and rare diseases, among many others
Book Synopsis Encyclopedia of Biopharmaceutical Statistics - Four Volume Set by : Shein-Chung Chow
Download or read book Encyclopedia of Biopharmaceutical Statistics - Four Volume Set written by Shein-Chung Chow and published by CRC Press. This book was released on 2018-09-03 with total page 2434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition in 2000, there has been an explosive growth of literature in biopharmaceutical research and development of new medicines. This encyclopedia (1) provides a comprehensive and unified presentation of designs and analyses used at different stages of the drug development process, (2) gives a well-balanced summary of current regulatory requirements, and (3) describes recently developed statistical methods in the pharmaceutical sciences. Features of the Fourth Edition: 1. 78 new and revised entries have been added for a total of 308 chapters and a fourth volume has been added to encompass the increased number of chapters. 2. Revised and updated entries reflect changes and recent developments in regulatory requirements for the drug review/approval process and statistical designs and methodologies. 3. Additional topics include multiple-stage adaptive trial design in clinical research, translational medicine, design and analysis of biosimilar drug development, big data analytics, and real world evidence for clinical research and development. 4. A table of contents organized by stages of biopharmaceutical development provides easy access to relevant topics. About the Editor: Shein-Chung Chow, Ph.D. is currently an Associate Director, Office of Biostatistics, U.S. Food and Drug Administration (FDA). Dr. Chow is an Adjunct Professor at Duke University School of Medicine, as well as Adjunct Professor at Duke-NUS, Singapore and North Carolina State University. Dr. Chow is the Editor-in-Chief of the Journal of Biopharmaceutical Statistics and the Chapman & Hall/CRC Biostatistics Book Series and the author of 28 books and over 300 methodology papers. He was elected Fellow of the American Statistical Association in 1995.
Book Synopsis Inverse Problems, Design and Optimization - vol. 2 by :
Download or read book Inverse Problems, Design and Optimization - vol. 2 written by and published by Editora E-papers. This book was released on with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Stochastic Simulation Methods by : N. Balakrishnan
Download or read book Advances in Stochastic Simulation Methods written by N. Balakrishnan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a volume consisting of selected papers that were presented at the 3rd St. Petersburg Workshop on Simulation held at St. Petersburg, Russia, during June 28-July 3, 1998. The Workshop is a regular international event devoted to mathematical problems of simulation and applied statistics organized by the Department of Stochastic Simulation at St. Petersburg State University in cooperation with INFORMS College on Simulation (USA). Its main purpose is to exchange ideas between researchers from Russia and from the West as well as from other coun tries throughout the World. The 1st Workshop was held during May 24-28, 1994, and the 2nd workshop was held during June 18-21, 1996. The selected proceedings of the 2nd Workshop was published as a special issue of the Journal of Statistical Planning and Inference. Russian mathematical tradition has been formed by such genius as Tchebysh eff, Markov and Kolmogorov whose ideas have formed the basis for contempo rary probabilistic models. However, for many decades now, Russian scholars have been isolated from their colleagues in the West and as a result their mathe matical contributions have not been widely known. One of the primary reasons for these workshops is to bring the contributions of Russian scholars into lime light and we sincerely hope that this volume helps in this specific purpose.
Book Synopsis 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering by :
Download or read book 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering written by and published by Elsevier. This book was released on 2015-07-14 with total page 2667 pages. Available in PDF, EPUB and Kindle. Book excerpt: 25th European Symposium on Computer-Aided Process Engineering contains the papers presented at the 12th Process Systems Engineering (PSE) and 25th European Society of Computer Aided Process Engineering (ESCAPE) Joint Event held in Copenhagen, Denmark, 31 May - 4 June 2015. The purpose of these series is to bring together the international community of researchers and engineers who are interested in computing-based methods in process engineering. This conference highlights the contributions of the PSE/CAPE community towards the sustainability of modern society. Contributors from academia and industry establish the core products of PSE/CAPE, define the new and changing scope of our results, and future challenges. Plenary and keynote lectures discuss real-world challenges (globalization, energy, environment, and health) and contribute to discussions on the widening scope of PSE/CAPE versus the consolidation of the core topics of PSE/CAPE. - Highlights how the Process Systems Engineering/Computer-Aided Process Engineering community contributes to the sustainability of modern society - Presents findings and discussions from both the 12th Process Systems Engineering (PSE) and 25th European Society of Computer-Aided Process Engineering (ESCAPE) Events - Establishes the core products of Process Systems Engineering/Computer Aided Process Engineering - Defines the future challenges of the Process Systems Engineering/Computer Aided Process Engineering community
Author :Christodoulos A. Floudas Publisher :Springer Science & Business Media ISBN 13 :0387747583 Total Pages :4646 pages Book Rating :4.3/5 (877 download)
Book Synopsis Encyclopedia of Optimization by : Christodoulos A. Floudas
Download or read book Encyclopedia of Optimization written by Christodoulos A. Floudas and published by Springer Science & Business Media. This book was released on 2008-09-04 with total page 4646 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of the Encyclopedia of Optimization is to introduce the reader to a complete set of topics that show the spectrum of research, the richness of ideas, and the breadth of applications that has come from this field. The second edition builds on the success of the former edition with more than 150 completely new entries, designed to ensure that the reference addresses recent areas where optimization theories and techniques have advanced. Particularly heavy attention resulted in health science and transportation, with entries such as "Algorithms for Genomics", "Optimization and Radiotherapy Treatment Design", and "Crew Scheduling".
