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Author : B. Jankovic
Publisher : Springer Science & Business Media
ISBN 13 : 1461590175
Total Pages : 710 pages
Book Rating : 4.4/5 (615 download)
Download or read book Microenvironmental Aspects of Immunity written by B. Jankovic and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Marie-Caroline Dieu-Nosjean
Publisher : Humana Press
ISBN 13 : 9781493987085
Total Pages : 289 pages
Book Rating : 4.9/5 (87 download)
Download or read book Tertiary Lymphoid Structures written by Marie-Caroline Dieu-Nosjean and published by Humana Press. This book was released on 2018-09-05 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the various methods used to study tertiary lymphoid structures (TLS) in pathological situations. Pre-clinical models are also discussed in detail to show how TLS structure, development, and maintenance can be targeted and studied in vivo. The chapters in this book cover topics such as humans and mice; strategies to quantify TLS in order to use it in stained tissue sections; classifying a gene signature form fixed and paraffin-embedded tissues; and development of murine inflammatory models to help look at TLS in the context of infection or malignancy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Tertiary Lymphoid Structures: Methods and Protocols is a valuable resource that increases the reader’s knowledge on immune functions and how they will pave the way to future therapeutic applications.
Author : Valérie Dutoit
Publisher : Frontiers Media SA
ISBN 13 : 2889741915
Total Pages : 212 pages
Book Rating : 4.8/5 (897 download)
Download or read book Impact of the Glioma Microenvironment on Antitumor Immunity written by Valérie Dutoit and published by Frontiers Media SA. This book was released on 2022-01-31 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Petranel T. Ferrao
Publisher : Frontiers Media SA
ISBN 13 : 288963115X
Total Pages : 186 pages
Book Rating : 4.8/5 (896 download)
Download or read book Cancer Plasticity and the Microenvironment: Implications for Immunity and Therapy Response written by Petranel T. Ferrao and published by Frontiers Media SA. This book was released on 2019-11-01 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cells can change and adapt, especially within the host environment; a phenomenon known as cancer plasticity. Several factors, including the immune system can influence, and be influenced by, cancer plasticity which in turn can impact upon patient responses to treatment. As such, we currently face several challenges for implementing combination therapies as effective cancer treatment strategies. We have compiled a topic with a number of articles that emphasize the various aspects of cancer plasticity, describing in particular the important role of the tumor microenvironment. As we embark on a new era of precision medicine with multi-modal therapies for improving patient outcomes, this topic highlights some relevant points for consideration that are pertinent to the incorporation and effective use of new treatments as part of cancer treatment regimens, including immune-modulating drugs.
Author : Selvarangan Ponnazhagan
Publisher : Frontiers Media SA
ISBN 13 : 2832555152
Total Pages : 190 pages
Book Rating : 4.8/5 (325 download)
Download or read book Implications of Immune Landscape in Tumor Microenvironment written by Selvarangan Ponnazhagan and published by Frontiers Media SA. This book was released on 2024-10-01 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor microenvironment (TME) plays an important role in immunosuppressive mechanisms that result in immune editing and treatment resistance. Elucidating the diversity of stromal and immune cell distribution, polarization, and changes in their gene expression signatures will enable a better understanding of key events to improve treatment and prognosis. With the onset of immune checkpoint inhibitors (ICIs) in clinics for patients with solid tumors and hematologic malignancies, immunotherapy has taken a new direction in cancer management, especially as combination therapies. However, limitations encountered with the use of ICIs, including toxicity and immune-related adverse events (irAE) indicate the need to understand multiple regulatory mechanisms at both cellular and molecular levels that alter the immune landscape of the TME. Since predominant changes in the immune landscape occur at the TME, focussed deliberation on these events will provide a comprehensive understanding on this topic for scientists in the fields of basic, translational, and clinical cancer immunology. The heterogeneity of TME and complex immune landscape pose major challenges in the treatment of solid tumors. Thus, integrative approaches, which relate immune mechanisms in the TME to that of peripheral and systemic immune signatures are essential to improve our understanding of the disease complexity and possibly improve immunotherapy outcomes. Such multiparametric studies should combine advances in current understanding of cancer immunobiology with powerful technologies, such as single-cell and spatial transcriptomics, and high dimensional flow cytometry that rapidly expand our ability to explore these interactions. Notably, tumor heterogeneity and inflammatory mediators in the TME vary significantly in neoplasms based on mutational load, lymphocyte infiltration, expression of checkpoint molecules, soluble inhibitors, and tumor cell metabolism. Overall, connecting key events to immune signatures that conform to a consensus will provide a benchmark to delve further into this important topic. Other parameters such as myeloid and lymphoid cell polarization to alter the immune homeostasis at the TME, favoring a tumor-supportive milieu would provide a macroscopic picture that may help guide treatment choices for more refined personalized tumor immunotherapy.
Author : Yewei Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2832547699
Total Pages : 246 pages
Book Rating : 4.8/5 (325 download)
Download or read book Metabolic and Senescence Characteristics Associated with the Immune Microenvironment in Tumor Cells written by Yewei Zhang and published by Frontiers Media SA. This book was released on 2024-04-11 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A common feature of cancer metabolism is the ability to obtain essential nutrients from a nutrient-poor environment and use them to maintain viability as well as generate new biomass. Alterations in intracellular and extracellular metabolites can be accompanied by tumor-associated metabolic reprogramming with profound effects on gene expression, cell differentiation, and tumor microenvironment. In these cases, the metabolic microenvironment of the tumor itself can present an immunosuppressive environment that needs to be overcome. Specifically, it will help maximize the efficacy of cancer therapies by identifying targets that suppress or alter cancer metabolism to improve the tumor microenvironment nutrient availability or that modulate immune metabolism to bolster inflammation.
Author : Eitan Yefenof
Publisher : Springer Science & Business Media
ISBN 13 : 140206750X
Total Pages : 215 pages
Book Rating : 4.4/5 (2 download)
Download or read book Innate and Adaptive Immunity in the Tumor Microenvironment written by Eitan Yefenof and published by Springer Science & Business Media. This book was released on 2007-12-20 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, the interplay between cancer cells and host immunity has been studied systemically. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. This volume compiles reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease.
Author : Pawel Kalinski
Publisher : Springer
ISBN 13 : 331967577X
Total Pages : 271 pages
Book Rating : 4.3/5 (196 download)
Download or read book Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy written by Pawel Kalinski and published by Springer. This book was released on 2017-12-22 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
Author : Roi Gazit
Publisher : Frontiers Media SA
ISBN 13 : 2832530362
Total Pages : 190 pages
Book Rating : 4.8/5 (325 download)
Download or read book Immunity, Cancer and the Microenvironment: Resolving a 3-Way Standoff written by Roi Gazit and published by Frontiers Media SA. This book was released on 2023-07-24 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Min Xue
Publisher : Frontiers Media SA
ISBN 13 : 2832509045
Total Pages : 175 pages
Book Rating : 4.8/5 (325 download)
Download or read book Emerging technologies and biology for tumor microenvironment and tumor-immune interplay written by Min Xue and published by Frontiers Media SA. This book was released on 2022-12-08 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yanyan Tang
Publisher : Frontiers Media SA
ISBN 13 : 2889769577
Total Pages : 446 pages
Book Rating : 4.8/5 (897 download)
Download or read book The Role of ncRNAs (non-coding RNAs) in Regulating Tumor Immune Microenvironment written by Yanyan Tang and published by Frontiers Media SA. This book was released on 2022-09-14 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Erika Adriana Eksioglu
Publisher : Frontiers Media SA
ISBN 13 : 2832541496
Total Pages : 131 pages
Book Rating : 4.8/5 (325 download)
Download or read book Therapeutic targeting Of MDSC in the tumor and immune microenvironment written by Erika Adriana Eksioglu and published by Frontiers Media SA. This book was released on 2023-12-18 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Laurence Zitvogel
Publisher : Springer
ISBN 13 : 3319624318
Total Pages : 700 pages
Book Rating : 4.3/5 (196 download)
Download or read book Oncoimmunology written by Laurence Zitvogel and published by Springer. This book was released on 2017-12-13 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Author : Angus G. Dalgleish
Publisher : Springer Science & Business Media
ISBN 13 : 0387262830
Total Pages : 260 pages
Book Rating : 4.3/5 (872 download)
Download or read book The Link Between Inflammation and Cancer written by Angus G. Dalgleish and published by Springer Science & Business Media. This book was released on 2006-03-05 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: A link between inflammation and cancer has been established many years ago, yet it is only recently that the potential significance of this connection has become apparent. Although several examples of chronic inflammatory conditions, often induced by persistent irritation and/or infection, developing into cancer have been known for some time, there has been a notable resistance to contemplate the possibility that this association may apply in a causative way to other cancers. Examples for such progression from chronic inflammation to cancer are colon carcinoma developing with increased frequency in patients with ulcerative colitis, and the increased incidence of bladder cancer in patients suffering from chronic Schistosoma infection. Inflammation and cancer have been recognized to be linked in another context for many years, i.e., with regards to pathologies resembling chronic lacerations or 'wounds that do not heal.' More recently, the immunology of wound healing has given us clues as to the mechanistic link between inflammation and cancer, in as much as wounds and chronic inflammation turn off local cell-mediated immune responses and switch on growth factor release as well the growth of new blood vessels - angiogenesis. Both of these are features of most types of tumours, which suggest that tumours may require an immunologically shielded milieu and a growth factor-rich environment.
Author : Giulia Pasello
Publisher : Frontiers Media SA
ISBN 13 : 2889748189
Total Pages : 163 pages
Book Rating : 4.8/5 (897 download)
Download or read book Understanding the Interplay Between the Tumor Immune Microenvironment and Genetic Alterations in Thoracic Malignancies written by Giulia Pasello and published by Frontiers Media SA. This book was released on 2022-03-28 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xu Wang
Publisher : Frontiers Media SA
ISBN 13 : 2889747549
Total Pages : 448 pages
Book Rating : 4.8/5 (897 download)
Download or read book Inflammatory Tumor Immune Microenvironment: Molecular Mechanisms and Signaling Pathways in Cancer Progression and Metastasis written by Xu Wang and published by Frontiers Media SA. This book was released on 2022-03-25 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fei Yu
Publisher : Frontiers Media SA
ISBN 13 : 2832534112
Total Pages : 170 pages
Book Rating : 4.8/5 (325 download)
Download or read book Ionizing radiation reprograms tumor immune microenvironment by inducing immunogenic cell death written by Fei Yu and published by Frontiers Media SA. This book was released on 2023-09-25 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
