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Microarrays For The Neurosciences
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Book Synopsis Microarrays for the Neurosciences by : Daniel H. Geschwind
Download or read book Microarrays for the Neurosciences written by Daniel H. Geschwind and published by MIT Press. This book was released on 2002 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effort to sequence the human genome has generated a new discipline, functional genomics, or the study of the relationship between the genetic code and its biologic potential. Gene expression studies are made possible not only by the decoding of the human genome, but by the development of new technologies. The preeminent technology in this area, DNA microarrays, is helping to revolutionize the field of neuroscience.
Download or read book DNA Arrays in Neurobiology written by and published by Elsevier. This book was released on 2004-12-10 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA array technology is a technique for studying gene expression by comparing samples of different genes. The result is an enormous amount of data that must be carefully analyzed in order for it to be useful and meaningful. This book examines both data analysis and techniques for ensuring optimal experimental conditions. The array approach has applications in a number of model systems, including development, learning and drug abuse. In addition, the technique has applications in a number of neurological disorders such as Alzheimer's disease, schizophrenia, multiple sclerosis, and neurological cancers.
Download or read book DNA Arrays written by Elena V. Grigorenko and published by CRC Press. This book was released on 2001-12-21 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: A quantum leap in technology took place a few years ago with the introduction of cDNA arrays that have been developed in response to the need for simultaneous analysis of the patterns of expression of thousands of genes. DNA Arrays: Technologies and Experimental Strategies offers a view of different aspects of this rapidly developing technology, in
Book Synopsis Methods in Genomic Neuroscience by : Hemin R. Chin
Download or read book Methods in Genomic Neuroscience written by Hemin R. Chin and published by CRC Press. This book was released on 2001-09-26 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable sco
Book Synopsis Microarray Innovations by : Gary Hardiman
Download or read book Microarray Innovations written by Gary Hardiman and published by CRC Press. This book was released on 2019-08-30 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarray Innovations: Technology and Experimentation examines the incredibly powerful nature of array technology and the ways in which it can be applied to understanding the genomic basis of disease. Explores a myriad of applications in use today This volume explores recent innovations in the microarray field and tracks the evolution of the major platforms currently used. The international panel of contributors presents a survey of the past five years' research and advancements in microarray methods and applications and their usage in drug discovery and biomedical research. The contributions discuss improvements in automation (array fabrication and hybridization), new substrates for printing arrays, platform comparisons and contrasts, experimental design, and data normalization and mining schemes. They also review epigenomic array studies, electronic microarrays, comparative genomic hybridization, microRNA arrays, and mutational analyzes. In addition, the book provides coverage of important clinical diagnostic arrays, protein arrays, and neuroscience applications. Examines improved methodologies As microarrays have evolved steadily over time from archetypical in-house complementary DNA (cDNA) arrays to robust commercial oligonucleotide platforms, there has been a migration to higher density biochips with increasing content and better analytical methodologies. This compendium summarizes the vast advances that have been made in this technology, highlighting the supreme advantages of microarray-based appro
Download or read book DNA Microarrays written by Mark Schena and published by Scion Publishing Ltd. This book was released on 2007-10-01 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Microarrays: Methods Express covers the very latest in DNA microarray technology, with a clear focus on how these techniques can be used in the lab to gain the very best results. The authors are from some of the leading laboratories in the field and write with real authority on the latest methodology. Every chapter provides detailed step-by-step protocols with valuable hints and tips for success, as well as giving typical experimental results and selected literature citations. This book is a 'must have' manual for researchers in all fields of biology, medicine and agriculture.
Book Synopsis A Beginner’s Guide to Microarrays by : Eric M. Blalock
Download or read book A Beginner’s Guide to Microarrays written by Eric M. Blalock and published by Springer Science & Business Media. This book was released on 2011-06-27 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Beginner's Guide to Microarrays addresses two audiences - the core facility manager who produces, hybridizes, and scans arrays, and the basic research scientist who will be performing the analysis and interpreting the results. User friendly coverage and detailed protocols are provided for the technical steps and procedures involved in many facets of microarray technology, including: -Cleaning and coating glass slides, -Designing oligonucleotide probes, -Constructing arrays for the detection and quantification of different bacterial species, -Preparing spotting solutions, -Troubleshooting spotting problems, -Setting up and running a core facility, -Normalizing background signal and controlling for systematic variance, -Designing experiments for maximum effect, -Analyzing data with statistical procedures, -Clustering data with machine-learning protocols.
Book Synopsis Neurosciences at the Postgenomic Era by : Jacques Mallet
Download or read book Neurosciences at the Postgenomic Era written by Jacques Mallet and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this new volume in the series Research and Perspectives in Neurosciences the authors have presented and discussed their findings in the fields of speech and language disorders, X-linked mental retardation, gene therapy in the CNS, memory and learning disorders and other fields.
Book Synopsis Microarrays by : Hans-Joachim Müller
Download or read book Microarrays written by Hans-Joachim Müller and published by Academic Press. This book was released on 2006 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microarray technology allows us to answer many questions about gene expression and drug-target screening by employing high-throughput screening. This book dedicates itself to microarrays with clear and understandable explanations and an overview of the presently available hardware, biochips and software. Separate chapters cover the different requirements for DNA and protein chips as well as spotters and scanners.
Book Synopsis Functional Genomics and Proteomics in the Clinical Neurosciences by : Scott E. Hemby
Download or read book Functional Genomics and Proteomics in the Clinical Neurosciences written by Scott E. Hemby and published by Elsevier. This book was released on 2006-10-09 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would revolutionize biology and medicine. While important strides are being made towards achieving the goal of global mRNA analysis, mRNA is not the functional endpoint of gene expression and mRNA expression may not directly equate with protein expression. There are many potential applications for proteomics in neuroscience: determination of the neuro-proteome, comparative protein expression profiling, post-translational protein modification profiling and mapping protein-protein interactions, to name but a few. Functional Genomics and Proteomics in Clinical Neuroscience will comment on all of these applications, but with an emphasis on protein expression profiling. This book combines the basic methodology of genomics and proteomics with the current applications of such technologies in understanding psychiatric illnesses. * Introduction of basic methodologies in genomics and proteomics and their integration in psychiatry* Development of the text in sections related to methods, application and future directions of these rapidly advancing technologies* Use of actual data to illustrate many principles of functional genomics and proteomics. * Introduction to bioinformatics and database management techniques
Download or read book The OMICs written by Giovanni Coppola and published by Oxford University Press. This book was released on 2013-12-11 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: The OMICs: Applications in Neuroscience summarizes the state of the art in high-throughput approaches (collectively known as 'OMICs') in neurology and neuroscience, and is of interest to both neurologists tracking the progress of these methods towards clinical applications, and neuroscientists curious about the most recent advances in this ever-changing field. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience, and medicine in general. The book includes a rich survey of the most relevant OMICs applications and how they relate to neurology and neuroscience. The reader is given an overview of the method, a perspective on the current and future applications, and published examples illustrating practical uses.
Book Synopsis Neuroscience for Neurologists by : Patrick F. Chinnery
Download or read book Neuroscience for Neurologists written by Patrick F. Chinnery and published by World Scientific. This book was released on 2006 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in the field, this timely book presents the scientific principles behind neurology. It aims to take the reader from the human genome, through gene expression, to molecular and cellular pathology, and subsequently to contemporary clinical investigations and clinical trials. Each contribution includes a discussion about the future of the field and highlights areas of potential growth and their relevance to routine clinical practice over the next decade. The succinctly written chapters will be easily accessible to both neurologists and trainees who have no expertise in the area.
Book Synopsis Encyclopedia of Neuroscience, Volume 1 by : Larry R. Squire
Download or read book Encyclopedia of Neuroscience, Volume 1 written by Larry R. Squire and published by Academic Press. This book was released on 2009-06-12 with total page 12505 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields.
Book Synopsis Neuroscience of Clinical Psychiatry by : Edmund S. Higgins
Download or read book Neuroscience of Clinical Psychiatry written by Edmund S. Higgins and published by Lippincott Williams & Wilkins. This book was released on 2013-05-07 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Little information from this complex and evolving field of neuroscience has been readily accessible to the clinical psychiatrist on the front lines of patient care, let alone to the resident preparing for the Boards. There thus has existed a need for a concise and accessible text that builds a bridge between the two disciplines. To meet this need, the fully updated Second Edition of this straightforward and reader-friendly reference provides readers with a basic link between the science of the brain and the treatment of common mental health disorders. Both comprehensive and easy to follow, this textbook is being used in psychology graduate programs, nurse practitioner training and psychiatry residencies. It is useful for board exam review as well as for the practicing clinician looking to keep pace with the latest advances in neuroscience. The book’s clear and direct language will enhance your understanding of basic neuroscientific concepts underlying commonly encountered disorders, and the effects of brain chemistry on common behaviors. Practical applications, insightful illustrations, and review questions following each chapter help solidify your grasp of neuropathology and its link to mental health disorders and their treatment.
Book Synopsis Springer Handbook of Bio-/Neuro-Informatics by : Nikola Kasabov
Download or read book Springer Handbook of Bio-/Neuro-Informatics written by Nikola Kasabov and published by Springer Science & Business Media. This book was released on 2013-11-30 with total page 1239 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Springer Handbook of Bio-/Neuro-Informatics is the first published book in one volume that explains together the basics and the state-of-the-art of two major science disciplines in their interaction and mutual relationship, namely: information sciences, bioinformatics and neuroinformatics. Bioinformatics is the area of science which is concerned with the information processes in biology and the development and applications of methods, tools and systems for storing and processing of biological information thus facilitating new knowledge discovery. Neuroinformatics is the area of science which is concerned with the information processes in biology and the development and applications of methods, tools and systems for storing and processing of biological information thus facilitating new knowledge discovery. The text contains 62 chapters organized in 12 parts, 6 of them covering topics from information science and bioinformatics, and 6 cover topics from information science and neuroinformatics. Each chapter consists of three main sections: introduction to the subject area, presentation of methods and advanced and future developments. The Springer Handbook of Bio-/Neuroinformatics can be used as both a textbook and as a reference for postgraduate study and advanced research in these areas. The target audience includes students, scientists, and practitioners from the areas of information, biological and neurosciences. With Forewords by Shun-ichi Amari of the Brain Science Institute, RIKEN, Saitama and Karlheinz Meier of the University of Heidelberg, Kirchhoff-Institute of Physics and Co-Director of the Human Brain Project.
Book Synopsis International Review of Neurobiology by : Ronald J. Bradley
Download or read book International Review of Neurobiology written by Ronald J. Bradley and published by Elsevier. This book was released on 2005-04-04 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
Book Synopsis Neuroscience in the 21st Century by : Donald W. Pfaff
Download or read book Neuroscience in the 21st Century written by Donald W. Pfaff and published by Springer Nature. This book was released on 2022-10-17 with total page 4592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its third edition serves as a comprehensive resource to students and researchers alike.
