Methods In Cancer Stem Cell Biology

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Methods in Cancer Stem Cell Biology

Author : Said M. Afify
Publisher : Springer Nature
ISBN 13 : 9819913314
Total Pages : 251 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Methods in Cancer Stem Cell Biology by : Said M. Afify

Download or read book Methods in Cancer Stem Cell Biology written by Said M. Afify and published by Springer Nature. This book was released on 2023-07-02 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the use of stem cells and cancer stem cell generation in the inflammatory microenvironment (cancer-inducing niche) using induced pluripotent stem cells. It provides step-by-step techniques and manuals for studying stem cell and cancer stem cell generation with different applications in cancer research. The development of induced pluripotent stem cells has provided a new approach to studying cancer initiation by producing cancer stem cells without introducing mutations or foreign genes. The book features the research of the authors’ group, which was the first to generate cancer stem cells from stem cells in the presence of inflammatory conditions. The 20 chapters of this book cover topics such as generating pluripotent stem cells, converting normal stem cells to cancer stem cells, enriching, isolating and evaluating cancer stem cells. Methods for evaluating the characteristics of cancer stem cells and possible therapies against them are also discussed. The book provides easy-to-follow protocols that help researchers in the study of cancer stem cells. Illustrations help readers understand how the method of cancer stem cell generation can be applied as an essential method for assessing the carcinogenic potential of various non-mutagenic compounds. It will be a useful resource for graduate students, researchers, technicians, and physicians working in academic, hospital, and pharmaceutical settings.

Methods in Stem Cell Biology - Part B

Author :
Publisher : Academic Press
ISBN 13 : 0323900194
Total Pages : 262 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Methods in Stem Cell Biology - Part B by :

Download or read book Methods in Stem Cell Biology - Part B written by and published by Academic Press. This book was released on 2022-08-09 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Cancer Stem Cell Biology: Part B, Volume 171 in the Methods in Cell Biology series highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Orthotopic brain tumor models derived from glioblastoma stem-like cells, RNA sequencing in hematopoietic stem cells, Generation of inducible pluripotent stem cells from human dermal fibroblasts, In vitro preparation of dental pulp stem cell grafts combined with biocompatible scaffolds for tissue engineering, Gene expression knockdown in chronic myeloid leukemia stem cells, Identification and isolation of slow-cycling GSCs, Assessment of CD133, EpCAM, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Cell Biology series Includes the latest information on the topic of Methods in Cancer Stem Cell Biology

Cancer Stem Cells

Author : Federica Papaccio
Publisher : Springer Nature
ISBN 13 : 1071637304
Total Pages : 263 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Cancer Stem Cells by : Federica Papaccio

Download or read book Cancer Stem Cells written by Federica Papaccio and published by Springer Nature. This book was released on with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Stem Cells

Author : Sharmila A. Bapat
Publisher : John Wiley & Sons
ISBN 13 : 0470391561
Total Pages : 274 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Cancer Stem Cells by : Sharmila A. Bapat

Download or read book Cancer Stem Cells written by Sharmila A. Bapat and published by John Wiley & Sons. This book was released on 2008-10-03 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because the concept and discoveries of cancer stem cells are relatively new, scientists and researchers need an introduction to this dynamic area. Cancer Stem Cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells. Such a presentation facilitates a better understanding of and draws attention to stem cell and cancer biology - two fields that enhance, move, and evolve into each other continuously. It provides an informative study in designing approaches to apply stem cell principles to cancer biology while offering an overview of the challenges in developing combination stem and cancer biology targets for therapeutics. This book serves as a primer for new researchers in the field of cancer biology.

Methods in Stem Cell Biology - Part A

Author :
Publisher : Academic Press
ISBN 13 : 0323900216
Total Pages : 228 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Methods in Stem Cell Biology - Part A by :

Download or read book Methods in Stem Cell Biology - Part A written by and published by Academic Press. This book was released on 2022-07-08 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Cancer Stem Cell Biology: Part A, Volume 170 in the Methods in Cell Biology series highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Orthotopic brain tumor models derived from glioblastoma stem-like cells, RNA sequencing in hematopoietic stem cells, Generation of inducible pluripotent stem cells from human dermal fibroblasts, In vitro preparation of dental pulp stem cell grafts combined with biocompatible scaffolds for tissue engineering, Gene expression knockdown in chronic myeloid leukemia stem cells, Identification and isolation of slow-cycling GSCs, Assessment of CD133, EpCAM, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Cell Biology series Includes the latest information on the topic of Methods in Cancer Stem Cell Biology

Methods in Stem Cell Biology - Part B

Author :
Publisher : Academic Press
ISBN 13 : 9780323900188
Total Pages : 0 pages
Book Rating : 4.9/5 (1 download)

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Book Synopsis Methods in Stem Cell Biology - Part B by :

Download or read book Methods in Stem Cell Biology - Part B written by and published by Academic Press. This book was released on 2022-08-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Cancer Stem Cell Biology: Part B, Volume 171 in the Methods in Cell Biology series highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Orthotopic brain tumor models derived from glioblastoma stem-like cells, RNA sequencing in hematopoietic stem cells, Generation of inducible pluripotent stem cells from human dermal fibroblasts, In vitro preparation of dental pulp stem cell grafts combined with biocompatible scaffolds for tissue engineering, Gene expression knockdown in chronic myeloid leukemia stem cells, Identification and isolation of slow-cycling GSCs, Assessment of CD133, EpCAM, and much more.

Role of Cancer Stem Cells in Cancer Biology and Therapy

Author : Thomas Dittmar
Publisher : CRC Press
ISBN 13 : 1466577355
Total Pages : 334 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Role of Cancer Stem Cells in Cancer Biology and Therapy by : Thomas Dittmar

Download or read book Role of Cancer Stem Cells in Cancer Biology and Therapy written by Thomas Dittmar and published by CRC Press. This book was released on 2013-03-01 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark side of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence CSCs. Finally, it supplies a brief overview of current concepts that may allow for a selective eradication of CSCs.

Principles of Stem Cell Biology and Cancer

Author : Tarik Regad
Publisher : John Wiley & Sons
ISBN 13 : 1118670604
Total Pages : 376 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Principles of Stem Cell Biology and Cancer by : Tarik Regad

Download or read book Principles of Stem Cell Biology and Cancer written by Tarik Regad and published by John Wiley & Sons. This book was released on 2015-04-01 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.

Advances in Cancer Stem Cell Biology

Author : Roberto Scatena
Publisher : Springer Science & Business Media
ISBN 13 : 1461408091
Total Pages : 349 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Advances in Cancer Stem Cell Biology by : Roberto Scatena

Download or read book Advances in Cancer Stem Cell Biology written by Roberto Scatena and published by Springer Science & Business Media. This book was released on 2011-10-06 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.

Advances in Cancer Stem Cell Biology

Author : Hans-Juergen Schulten
Publisher : Frontiers Media SA
ISBN 13 : 2889667987
Total Pages : 117 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Advances in Cancer Stem Cell Biology by : Hans-Juergen Schulten

Download or read book Advances in Cancer Stem Cell Biology written by Hans-Juergen Schulten and published by Frontiers Media SA. This book was released on 2021-05-24 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Stem Cells in Solid Tumors

Author : Alison L. Allan
Publisher : Springer Science & Business Media
ISBN 13 : 1617792462
Total Pages : 479 pages
Book Rating : 4.6/5 (177 download)

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Book Synopsis Cancer Stem Cells in Solid Tumors by : Alison L. Allan

Download or read book Cancer Stem Cells in Solid Tumors written by Alison L. Allan and published by Springer Science & Business Media. This book was released on 2011-08-12 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.

Cancer Stem Cells: Basic Concept and Therapeutic Implications

Author : Farhadul Islam
Publisher : Springer Nature
ISBN 13 : 9819931851
Total Pages : 375 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Cancer Stem Cells: Basic Concept and Therapeutic Implications by : Farhadul Islam

Download or read book Cancer Stem Cells: Basic Concept and Therapeutic Implications written by Farhadul Islam and published by Springer Nature. This book was released on 2023-07-26 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.

Stem Cell Assays

Author : Mohan C. Vemuri
Publisher : Springer Science & Business Media
ISBN 13 : 1588297446
Total Pages : 815 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Stem Cell Assays by : Mohan C. Vemuri

Download or read book Stem Cell Assays written by Mohan C. Vemuri and published by Springer Science & Business Media. This book was released on 2007-08-10 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope for improving health care using stem cell therapies is thrilling, but has considerable technical challenges and methodological constraints that need to be addressed. Keeping with the tradition of Humana Press to bring these developments to the forefront in a timely manner, this book presents scientific advances in stem cell methods for a wider use by novice and expert scientists, through the series of Methods in Molecular Biology.

Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

Author : Sadegh Babashah
Publisher : Springer
ISBN 13 : 3319210300
Total Pages : 576 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology by : Sadegh Babashah

Download or read book Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology written by Sadegh Babashah and published by Springer. This book was released on 2015-11-12 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.

Stem Cells

Author : Suchandra Chowdhury
Publisher : Springer Nature
ISBN 13 : 9811616388
Total Pages : 271 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Stem Cells by : Suchandra Chowdhury

Download or read book Stem Cells written by Suchandra Chowdhury and published by Springer Nature. This book was released on 2021-07-24 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells hold great promise for cell therapy, tissue engineering, regenerative medicine and pharmaceutical and biotechnological applications. This book highlights the potency of stem cells, their property of self-renewal and their ability to differentiate into different cell lineages. It further describes the different markers to identify stem cells, sources, methods of isolation, culture including 2D, 3D and beyond and their cryopreservation. This is among the first books to discuss glycosylation and sialylation in stem cells. Chapters describe application of stem cells in regenerative medicine and therapy, and highlight their application in cancer therapy and spinal cord injury. The book talks about the important patents on stem cells. The book also highlights the plant stem cells, discussing their pluoripotent nature, role in organ regeneration after injury, specific stem cell niches, that signals to block differentiation studied in plants shoot, root, and vascular meristems, differentiation of plant stem cell, transcriptional regulation and epigenetic modification of plant stem cells. This book is exciting and cutting edge. It will be of great interest to doctors, students and researchers in the field of regenerative medicine, cancer , biotechnology and plant sciences.

Stem Cells and Cancer Stem Cells, Volume 5

Author : M.A. Hayat
Publisher : Springer Science & Business Media
ISBN 13 : 9400729006
Total Pages : 309 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Stem Cells and Cancer Stem Cells, Volume 5 by : M.A. Hayat

Download or read book Stem Cells and Cancer Stem Cells, Volume 5 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2012-02-21 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is pointed out that a cancer stem cell is a type within a tumor that possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells, which comprise the tumor. It is emphasized that a unique feature of cancer stem cells is that, although conventional chemotherapy kills most cells in a tumor, cancer stem cells remain intact. Vast applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, human mesenchymal stem cells, cancer stem cells, arterial stem cells, neural stem cells, cardiac stem cells, dental stem cells, limbal stem cells, and hematopoietic stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. These cells are used in tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. It is pointed out that the formation of embryoid bodies, which are three-dimensional aggregates of embryonic cells, is the initial step in the differentiation of these cells. Therapeutic implications of signalling pathways in cancer stem cells are pointed out. Targeting self-renewal pathways in cancer stem cells are also included. Application of mesenchymal stem cells for treating ischemic brain injury is explained. Neural stem cells proliferation into the surrounding area of the traumatic brain injury is explained.

Adult Stem Cells

Author : Donald G. Phinney
Publisher : Springer Science & Business Media
ISBN 13 : 1617790028
Total Pages : 282 pages
Book Rating : 4.6/5 (177 download)

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Book Synopsis Adult Stem Cells by : Donald G. Phinney

Download or read book Adult Stem Cells written by Donald G. Phinney and published by Springer Science & Business Media. This book was released on 2011-02-11 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is comprehensive overview of a vital area of scientific enquiry, which covers a broad spectrum of issues. With contributions from some of the key researchers in the field, Adult Stem Cells: Biology and Methods of Analysis offers readers a historical perspective as well as unique insights into cutting-edge thoughts. The volume contextualizes the recent discovery of stem/progenitor cell populations resident in many adult tissues and organs. It confronts the complexities scientists face in trying to validate these cells, while it also describes and critically evaluates the methods currently used to assess stem cell self-renewal. The chapters also seek to distinguish this process from other aspects of cell survival, such as the regulation of life span, senescence, and immortalization at a molecular level. The monograph begins with a section that examine the basic biology of adult stem cells, including chapters on the emerging role of microRNAs in regulating their fate and the molecular mechanisms that govern their self-renewal, the book moves on to analyze the varying methodologies employed in characterizing these elusive elements of our genetic make-up. The second section details in-vivo lineage tracing of tissue-specific stem cells, explores the neural stem cell paradigm, and considers the function of ABC transporters and aldehyde dehydrogenase in adult stem-cell biology. The final section shifts the focus to the life-span regulation and immortalization and features a chapter on the cancer stem cell paradigm. This is an authoritative volume on one of the frontiers of genetic research, and will serve as a valuable resource, not just for established scientists but also for those now entering the field of stem cell biology.