Metastasis

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Introduction to Cancer Metastasis

Author : Aamir Ahmad
Publisher : Academic Press
ISBN 13 : 0128040335
Total Pages : 416 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Introduction to Cancer Metastasis by : Aamir Ahmad

Download or read book Introduction to Cancer Metastasis written by Aamir Ahmad and published by Academic Press. This book was released on 2016-11-14 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. Includes basic biology and translational approaches to organ-specific cancer sites Provides readers with information on emerging therapeutic targets for cancer metastasis Contains contributions from leading researchers around the globe

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2008 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Cancer Metastasis

Author : David Lyden
Publisher : Cambridge University Press
ISBN 13 : 1139498754
Total Pages : 661 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Cancer Metastasis by : David Lyden

Download or read book Cancer Metastasis written by David Lyden and published by Cambridge University Press. This book was released on 2011-04-25 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.

TxNxM1

Author : J.M. Debois
Publisher : Springer Science & Business Media
ISBN 13 : 0306476789
Total Pages : 757 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis TxNxM1 by : J.M. Debois

Download or read book TxNxM1 written by J.M. Debois and published by Springer Science & Business Media. This book was released on 2006-05-08 with total page 757 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although distant metastases are the most dreaded situation in the evolution of cancer of every organ, the medical literature has surprisingly given little attention to the anatomical relationship between the primary tumor and metastasic sites. Only risk factors, treatment possibilities, and survival results are extensively examined. Stimulated by the occurrence in his practice of some puzzling and unexpected metastases, the author reviewed more than 12,000 references. He looked for anatomical relationships highlighting the relation between the location of the primary tumors and the particular patterns of metastasis observed. It would seem that the `pathways and flows' are apparently a more decisive factor in the implantation of the metastases than the `seed and soil' properties of the cancer cells and the metastatic site. Aided by his colleague Dr. T. Geukens, M.D., the author includes original anatomical drawings, illustrating the sometimes unexpected pathways the cancer cells follow in order to reach the organs where they will become lodged and give rise to metastatic tumors. The subject has apparently not been exhausted in the literature and several ideas are given for further research.

Stereotactic Body Radiation Therapy

Author : Simon S. Lo
Publisher : Springer Science & Business Media
ISBN 13 : 364225604X
Total Pages : 433 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Stereotactic Body Radiation Therapy by : Simon S. Lo

Download or read book Stereotactic Body Radiation Therapy written by Simon S. Lo and published by Springer Science & Business Media. This book was released on 2012-08-28 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Metastasis of Colorectal Cancer

Author : Nicole Beauchemin
Publisher : Springer Science & Business Media
ISBN 13 : 9048188334
Total Pages : 422 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Metastasis of Colorectal Cancer by : Nicole Beauchemin

Download or read book Metastasis of Colorectal Cancer written by Nicole Beauchemin and published by Springer Science & Business Media. This book was released on 2010-07-23 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer is the third most common cancer worldwide, and in many parts of the western world, it is the second leading cause of cancer-related deaths. This book covers colon cancer metastasis from the most fundamental aspects to clinical practice. Major topics include physiopathology, genetic and epigenetic controls, cancer initiating cells, epithelial-mesenchymal transition, growth factors and signalling, cell adhesion, natures of liver metastasis, angiogenesis and lymphangiogenesis, inflammatory response, prognostic markers, sentinel node and staging, and finally diagnosis and treatment. Each chapter has been contributed by leaders in the field. A key feature is that it connects with a large readership including students, fundamentalists and clinicians. Another specific feature of the book is that the chapters are written in a didactic and illustrative fashion. These characteristics coupled with the choice of the topics and authors, makes this book a reference in the field. It represents an essential acquisition for medical libraries, clinicians as well as medical and graduate students.

Brain Metastases from Primary Tumors Volume 1

Author : M. A. Hayat
Publisher : Academic Press
ISBN 13 : 0128010959
Total Pages : 274 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Brain Metastases from Primary Tumors Volume 1 by : M. A. Hayat

Download or read book Brain Metastases from Primary Tumors Volume 1 written by M. A. Hayat and published by Academic Press. This book was released on 2014-04-03 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an annual rate of more than 12 million global diagnoses and 7.6 million deaths, the societal and economic burden of cancer cannot be overstated. Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. Brain Metastases from Primary Tumors Volume 1 fills that gap, serving as the first reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types – lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age and gender related trends are also discussed, as is the use of biomarkers for early detection. The only comprehensive reference detailing the link between primary cancers and brain metastases Aids the target audience in determining the incidence of brain metastases in patients with a primary cancer Provided education about the potential use of biomarkers for early detection, diagnosis and prevention of the spread of primary cancer to the brain Documents temporal and gender-related trends in brain metastases from other cancers Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Breast Cancer Metastasis and Drug Resistance

Author : Aamir Ahmad
Publisher : Springer Nature
ISBN 13 : 3030203018
Total Pages : 427 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Breast Cancer Metastasis and Drug Resistance by : Aamir Ahmad

Download or read book Breast Cancer Metastasis and Drug Resistance written by Aamir Ahmad and published by Springer Nature. This book was released on 2019-08-27 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.

Metastatic Cancer: Clinical and Biological Perspectives

Author : Rahul Jandial
Publisher : CRC Press
ISBN 13 : 9781587066597
Total Pages : 312 pages
Book Rating : 4.0/5 (665 download)

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Book Synopsis Metastatic Cancer: Clinical and Biological Perspectives by : Rahul Jandial

Download or read book Metastatic Cancer: Clinical and Biological Perspectives written by Rahul Jandial and published by CRC Press. This book was released on 2013-08-08 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.

Tight Junctions in Cancer Metastasis

Author : Tracey A. Martin
Publisher : Springer Science & Business Media
ISBN 13 : 9400760280
Total Pages : 313 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Tight Junctions in Cancer Metastasis by : Tracey A. Martin

Download or read book Tight Junctions in Cancer Metastasis written by Tracey A. Martin and published by Springer Science & Business Media. This book was released on 2013-02-26 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.

Brain Metastases from Primary Tumors, Volume 3

Author : M. A. Hayat
Publisher : Academic Press
ISBN 13 : 0128035595
Total Pages : 384 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Brain Metastases from Primary Tumors, Volume 3 by : M. A. Hayat

Download or read book Brain Metastases from Primary Tumors, Volume 3 written by M. A. Hayat and published by Academic Press. This book was released on 2016-04-07 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Metastases from Primary Tumors Volume Three: Epidemiology, Biology, and Therapy of Melanoma and Other Cancers provides a comprehensive overview of the metastasis of cancer, the main cause of approximately 90% of cancer associated deaths, yet the mechanisms governing this clinically important process remain poorly understood. Melanoma is the third most common diagnosis among patients with brain metastases, after lung and breast cancer. Approximately 75% of patients with metastatic melanoma develop brain metastases during the course of their disease. Although tumorigenesis of melanoma remains poorly understood, recent advances in gene expression profiling have revealed molecular mechanisms of this deadly disease. In addition, high-throughput gene expression has many advantages over techniques in cancer transcriptomic studies and has led to the discovery of numerous diagnostic, prognostic, and therapeutic targets, which are also detailed in this book. The book discusses the link between primary tumors and brain metastasis of melanoma, including molecular mechanisms, treatment options, prognosis, and general applications. Comprehensive chapters discuss systemic therapy, integrin inhibitors, stereotaxic radiosurgery, and more, making this book a great resource for neurooncologists, neurosurgeons, neurologists, and cancer researchers. Presents the only comprehensive reference detailing the link between primary cancers and brain metastases in melanoma Aids the target audience in discussing various treatment options for patients with brain metastases from melanoma Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Pulmonary Metastasis

Author : Leonard Weiss
Publisher : Macmillan Reference USA
ISBN 13 :
Total Pages : 362 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Pulmonary Metastasis by : Leonard Weiss

Download or read book Pulmonary Metastasis written by Leonard Weiss and published by Macmillan Reference USA. This book was released on 1978 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Central Nervous System Metastases

Author : Manmeet Ahluwalia
Publisher : Springer Nature
ISBN 13 : 3030234177
Total Pages : 421 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Central Nervous System Metastases by : Manmeet Ahluwalia

Download or read book Central Nervous System Metastases written by Manmeet Ahluwalia and published by Springer Nature. This book was released on 2019-11-05 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

Central Nervous System Metastases

Author : Rohan Ramakrishna
Publisher : Springer Nature
ISBN 13 : 303042958X
Total Pages : 725 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Central Nervous System Metastases by : Rohan Ramakrishna

Download or read book Central Nervous System Metastases written by Rohan Ramakrishna and published by Springer Nature. This book was released on 2020-05-27 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a multi-specialty book on the diagnosis, evaluation, and treatment of CNS metastases of the brain and spine. Written by renowned experts in their fields, the book covers essential contemporary topics in CNS metastases care. The book is divided into seven parts that begin with chapters that cover the fundamental biology of disease so that subsequent chapters on imaging, diagnosis, treatment, and palliation can be properly contextualized. This text also provides a framework for understanding the biology of radiation therapy so that radiation treatment options of the brain and spine can be more fully understood. New medications and technologies are reviewed from the perspective of maximizing efficacy and minimizing toxicity, independently and as combinatorial therapy. Central Nervous System Metastases: Diagnosis and Treatment serves as a practical reference for health care providers and trainees. It provides the comprehensive, detailed perspective required to provide holistic care to patients with metastatic disease to the brain and spine.

Adrenal Imaging

Author : Michael A. Blake
Publisher : Springer Science & Business Media
ISBN 13 : 1597455601
Total Pages : 229 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Adrenal Imaging by : Michael A. Blake

Download or read book Adrenal Imaging written by Michael A. Blake and published by Springer Science & Business Media. This book was released on 2009-02-28 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging of the adrenal gland has made tremendous progress in the last decade as new technologies continue to evolve. Adrenal Imaging highlights the pertinent clinical and pathological information that underpins the accurate interpretation and use of adrenal imaging. Written by a prestigious group of international contributors, individual chapters in Adrenal Imaging serve as a relevant and up-to-date reference of adrenal imaging findings, algorithms and techniques in CT, MR nuclear medicine, intervention and trauma. Summary sections at the end of each chapter illuminate key teaching points to enhance retention.

AJCC Cancer Staging Manual

Author : Frederick L, Greene
Publisher : Springer Science & Business Media
ISBN 13 : 1475736568
Total Pages : 386 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis AJCC Cancer Staging Manual by : Frederick L, Greene

Download or read book AJCC Cancer Staging Manual written by Frederick L, Greene and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Joint Committee on Cancer's Cancer Staging Manual is used by physicians throughout the world to diagnose cancer and determine the extent to which cancer has progressed. All of the TNM staging information included in this Sixth Edition is uniform between the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer). In addition to the information found in the Handbook, the Manual provides standardized data forms for each anatomic site, which can be utilized as permanent patient records, enabling clinicians and cancer research scientists to maintain consistency in evaluating the efficacy of diagnosis and treatment. The CD-ROM packaged with each Manual contains printable copies of each of the book’s 45 Staging Forms.

Colorectal Cancer Liver Metastases

Author : Mauro Monteiro Correia
Publisher : Springer Nature
ISBN 13 : 3030254860
Total Pages : 597 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Colorectal Cancer Liver Metastases by : Mauro Monteiro Correia

Download or read book Colorectal Cancer Liver Metastases written by Mauro Monteiro Correia and published by Springer Nature. This book was released on 2019-12-28 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology. The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients. This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.). Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations. This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases.