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Metallothioneins In Normal And Cancer Cells
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Book Synopsis Metallothioneins in Normal and Cancer Cells by : Piotr Dziegiel
Download or read book Metallothioneins in Normal and Cancer Cells written by Piotr Dziegiel and published by Springer. This book was released on 2016-02-04 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system.
Book Synopsis Metallothionein III by : Kazuo T. Suzuki
Download or read book Metallothionein III written by Kazuo T. Suzuki and published by Birkhauser. This book was released on 1993 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Zinc and Prostate Cancer by : Hua Wei (Ph.D.)
Download or read book Zinc and Prostate Cancer written by Hua Wei (Ph.D.) and published by . This book was released on 2009 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normal human prostate epithelial cells accumulate high levels of zinc. In contrast, a dramatically decrease in zinc levels is considered a hallmark of prostate cancer. Restoring zinc in prostate cancer cells results in cells apoptosis. The objectives of this study are: 1) to study the effect of zinc on gene expression profile in normal and malignant prostate cells; 2) to determine the expression of metallothioneins (MTs) in response to zinc in normal and malignant prostate cells and tissues; 3) to investigate and characterize the synergistic inhibotory effect of zinc and a chemotherapeutic reagent sulforaphane (SFN) on prostate cancer cell growth...
Book Synopsis Metallothioneins in Biochemistry and Pathology by : Paolo Zatta
Download or read book Metallothioneins in Biochemistry and Pathology written by Paolo Zatta and published by World Scientific. This book was released on 2008 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.
Book Synopsis Cancer Drug Resistance by : Beverly A. Teicher
Download or read book Cancer Drug Resistance written by Beverly A. Teicher and published by Springer Science & Business Media. This book was released on 2007-11-09 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
Book Synopsis Dietary Phytochemicals by : Chukwuebuka Egbuna
Download or read book Dietary Phytochemicals written by Chukwuebuka Egbuna and published by Springer Nature. This book was released on 2021-08-20 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents comprehensive coverage on the importance of good nutrition in the treatment and management of obesity, cancer and diabetes. Naturally occurring bioactive compounds are ubiquitous in most dietary plants available to humans and provide opportunities for the management of diseases. The text provides information about the major causes of these diseases and their association with nutrition. The text also covers the role of dietary phytochemicals in drug development and their pathways. Later chapters emphasize novel bioactive compounds as anti-diabetic, anti-cancer and anti-obesity agents and describe their mechanisms to regulate cell metabolism. Written by global team of experts, Dietary Phytochemicals: A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes describes the potentials of novel phytochemicals, their sources, and underlying mechanism of action. The chapters were drawn systematically and incorporated sequentially to facilitate proper understanding. This book is intended for nutritionists, physicians, medicinal chemists, drug developers in research and development, postgraduate students and scientists in area of nutrition and life sciences.
Download or read book Vitamin D written by Adrian F. Gombart and published by CRC Press. This book was released on 2012-11-21 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. F
Download or read book Metallothionein II written by J.H. Kägi and published by Birkhäuser. This book was released on 2014-03-27 with total page 723 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
Book Synopsis Zinc Signaling by : Toshiyuki Fukada
Download or read book Zinc Signaling written by Toshiyuki Fukada and published by Springer Nature. This book was released on 2019-12-13 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.
Book Synopsis Essential and Non-essential Metals by : Anuradha Mudipalli
Download or read book Essential and Non-essential Metals written by Anuradha Mudipalli and published by Springer. This book was released on 2017-07-14 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.
Book Synopsis Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy by : Stephen B. Howell
Download or read book Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy written by Stephen B. Howell and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations.
Book Synopsis Chromosomal Instability in Cancer Cells by : B. Michael Ghadimi
Download or read book Chromosomal Instability in Cancer Cells written by B. Michael Ghadimi and published by Springer. This book was released on 2015-09-16 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
Book Synopsis Plant Metal Interaction by : Parvaiz Ahmad
Download or read book Plant Metal Interaction written by Parvaiz Ahmad and published by Elsevier. This book was released on 2016-02-02 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Metal Interaction: Emerging Remediation Techniques covers different heavy metals and their effect on soils and plants, along with the remediation techniques currently available. As cultivable land is declining day-by-day as a result of increased metals in our soil and water, there is an urgent need to remediate these effects. This multi-contributed book is divided into four sections covering the whole of plant metal interactions, including heavy metals, approaches to alleviate heavy metal stress, microbial approaches to remove heavy metals, and phytoremediation. Provides an overview of the effect of different heavy metals on growth, biochemical reactions, and physiology of various plants Serves as a reference guide for available techniques, challenges, and possible solutions in heavy metal remediation Covers sustainable technologies in uptake and removal of heavy metals
Book Synopsis Gene Expression and Regulation in Mammalian Cells by : Fumiaki Uchiumi
Download or read book Gene Expression and Regulation in Mammalian Cells written by Fumiaki Uchiumi and published by BoD – Books on Demand. This book was released on 2018-02-28 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.
Book Synopsis Journal of the National Cancer Institute by :
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2000 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Metallothioneins and Related Chelators by : Astrid Sigel
Download or read book Metallothioneins and Related Chelators written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2015-07-24 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: These sulfur-rich chelators, being important in metal ion homeostasis, find increasing attention. MILS-5, written by 30 internationally recognized experts, focuses on this hot topic. The reader is supported by about 20 tables, more than 80 illustrations and nearly 2000 references. This book is an essential resource for scientists working in a wide range of disciplines from environmental toxicology and inorganic biochemistry all the way through to physiology and medicine.
