Metabotropic Glutamate Receptor Mglur4 As A Novel Target For Parkinsons Disease

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Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders

Author : Enza Palazzo
Publisher : Frontiers Media SA
ISBN 13 : 2889458628
Total Pages : 139 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders by : Enza Palazzo

Download or read book Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders written by Enza Palazzo and published by Frontiers Media SA. This book was released on 2019-06-19 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considering that neurological and psychiatric illnesses do not still have efficient therapies and are becoming increasingly widespread, the search for novel targets appears fundamental. Neuroinflammation, alterations in adult neurogenesis and excitotoxicity, all associated with glutamate transmission dysfunction, are key components of the pathogenetic mechanisms underlying neuropsychiatric illnesses. Counteracting the neurotoxic actions of glutamate through the modulatory actions of metabotropic glutamate receptors (mGluRs), represents a rational intervention that offers tolerability compatible with clinical therapy. Their suitability as targets for developing novel therapies is also based on the fact that mGluRs are found abundantly expressed in synapses of the central nervous system (CNS) that are considered critical in certain neurological and psychiatric disorders. Moreover, recently there has been an exponential development of selective ligands, especially positive and negative allosteric modulators, which by binding to less conserved transmembrane domain sequences ensure, besides a good permeability in the CNS, an adequate selectivity for each mGluR subtype. The eBook “Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders”, collects contributes (original and review articles) on the beneficial effects of positive and negative allosteric modulators of mGluRs in animal models of neurological and psychiatric diseases from renown experts in the field. The hope is that the effort of both Editors and Contributors of this eBook confirms the unlimited potential of mGluRs in CNS diseases and generate a collaborative discussion on the state of art, overall trends, novel strategies, and future direction of this attractive field of research.

Primer on Cerebrovascular Diseases

Author : Louis R. Caplan
Publisher : Academic Press
ISBN 13 : 0080539513
Total Pages : 855 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Primer on Cerebrovascular Diseases by : Louis R. Caplan

Download or read book Primer on Cerebrovascular Diseases written by Louis R. Caplan and published by Academic Press. This book was released on 1997-05-12 with total page 855 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primer on Cerebrovascular Diseases is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, and presents the information in a comprehensive and easily accessible manner. The book also contains valuable information on practical applications of basic research. - Presents topics in a comprehensive and accessible format - Written by international authorities on cerebral vasculature - Provides practical applications for researchers

Glial ⇔ Neuronal Signaling

Author : Glenn I. Hatton
Publisher : Springer Science & Business Media
ISBN 13 : 9781402079368
Total Pages : 460 pages
Book Rating : 4.0/5 (793 download)

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Book Synopsis Glial ⇔ Neuronal Signaling by : Glenn I. Hatton

Download or read book Glial ⇔ Neuronal Signaling written by Glenn I. Hatton and published by Springer Science & Business Media. This book was released on 2004-05-31 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glial Neuronal Signaling fills a need for a monograph/textbook to be used in advanced courses or graduate seminars aimed at exploring glial-neuronal interactions. Even experts in the field will find useful the authoritative summaries of evidence on ion channels and transporters in glia, genes involved in signaling during development, metabolic cross talk and cooperation between astrocytes and neurons, to mention but a few of the timely summaries of a wide range of glial-neuronal interactions. The chapters are written by the top researchers in the field of glial-neuronal signaling, and cover the most current advances in this field. The book will also be of value to the workers in the field of cell biology in general. When we think about the brain we usually think about neurons. Although there are 100 billion neurons in mammalian brain, these cells do not constitute a majority. Quite the contrary, glial cells and other non-neuronal cells are 10-50 times more numerous than neurons. This book is meant to integrate the emerging body of information that has been accumulating, revealing the interactive nature of the brain's two major neural cell types, neurons and glia, in brain function.

Human Drug Targets

Author : Edward D. Zanders
Publisher : John Wiley & Sons
ISBN 13 : 111884985X
Total Pages : 454 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Human Drug Targets by : Edward D. Zanders

Download or read book Human Drug Targets written by Edward D. Zanders and published by John Wiley & Sons. This book was released on 2015-11-09 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation of drug development candidates. The first part of the book consists of introductory chapters that provide the background to drug target discovery and highlight the way in which these targets have been organised into online databases. It also includes a user’s guide to the list of entries that forms the bulk of the book. Since this is not designed to be a compendium of drugs, the emphasis will be on the known (or speculated) biological role of the targets and not on the issues associated with pharmaceutical development. The objective is to provide just enough information to be informative and prompt further searches, while keeping the amount of text for each of the many entries to a minimum. Human Drug Targets will prove invaluable to those drug discovery professionals, in both industry and academia, who need to make some sense of the bewildering array of online information sources on current and potential human drug targets. As well as creating order out of a complex target landscape, the book will act as an ideas generator for potentially novel targets that might form the basis of future discovery projects.

Nerve-Driven Immunity

Author : Mia Levite
Publisher : Springer Science & Business Media
ISBN 13 : 3709108888
Total Pages : 374 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Nerve-Driven Immunity by : Mia Levite

Download or read book Nerve-Driven Immunity written by Mia Levite and published by Springer Science & Business Media. This book was released on 2012-02-14 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Nerve-Driven Immunity: Neurotransmitters and Neuropeptides in the Immune System” summarizes, analyzes and sheds new light on an unrecognized, yet very important role of key neurotransmitters and neuropeptides in the immune system. Each chapter of the book deals with a different neurotransmitter/neuropeptide from the following list: Dopamine, Adrenaline, Noradrenaline, Acetylcholine, Glutamate, GABA, Somatostatin, Neuropeptide Y (NPY), Vasoactive intestinal polypeptide (VIP), Calcitonin gene related peptide (CGRP), Opioids and Cannabinoids. For each of these neurotransmitters/neuropeptides, the following four topics are discussed: The specific receptors for the neurotransmitter/neuropeptide expressed in various types of immune cells The direct effects induced by the neurotransmitter/neuropeptide in various types of immune cells (either resting or activated), and the specific immune functions and features it activates/elevates or rather inhibits in specific concentrations The production of the neurotransmitter/neuropeptide in, and its release by, various types of immune cells The involvement of the neurotransmitter/neuropeptide in various diseases of the immune system (among them autoimmune diseases, immunodeficiency diseases and hematological cancers) The book includes many original figures, overview tables, and proposed models of events which are instrumental, enriching and stimulating for the reader. In light of the above-mentioned aspects, “Nerve-Driven Immunity: Neurotransmitters and Neuropeptides in the Immune System” is ideally suited as a textbook for new courses in Immunology, Neurology, Neuro-immunology or Pharmacology. The book chapters were written by highly skilled authors from 10 countries: the USA, the United Kingdom, Italy, Israel, Sweden, France, Germany, Spain, Serbia and Romania. “Nerve-Driven Immunity” is a term first coined by Dr. Mia Levite (the editor of the book).

Practical Psychopharmacology

Author : Joseph F. Goldberg
Publisher : Cambridge University Press
ISBN 13 : 1108450741
Total Pages : 611 pages
Book Rating : 4.1/5 (84 download)

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Book Synopsis Practical Psychopharmacology by : Joseph F. Goldberg

Download or read book Practical Psychopharmacology written by Joseph F. Goldberg and published by Cambridge University Press. This book was released on 2021-04-29 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide translating clinical trials findings, across major psychiatric disorders, to devise tailored, evidence-based treatments.

The Glutamate/GABA-Glutamine Cycle

Author : Arne Schousboe
Publisher : Springer
ISBN 13 : 3319450964
Total Pages : 420 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis The Glutamate/GABA-Glutamine Cycle by : Arne Schousboe

Download or read book The Glutamate/GABA-Glutamine Cycle written by Arne Schousboe and published by Springer. This book was released on 2016-11-25 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.

Neural Mechanisms of Addiction

Author : Mary Torregrossa
Publisher : Academic Press
ISBN 13 : 0128123311
Total Pages : 308 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Neural Mechanisms of Addiction by : Mary Torregrossa

Download or read book Neural Mechanisms of Addiction written by Mary Torregrossa and published by Academic Press. This book was released on 2018-08-24 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field. Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research. - Transcends multiple neural, neurochemical and behavioral domains - Summarizes advances in the field of addiction research since the advent of optogenetics - Discusses the most current, leading theories of addiction, including molecular mechanisms and dopamine mechanisms

Inflammation-Associated Depression: Evidence, Mechanisms and Implications

Author : Robert Dantzer
Publisher : Springer
ISBN 13 : 3319511521
Total Pages : 357 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Inflammation-Associated Depression: Evidence, Mechanisms and Implications by : Robert Dantzer

Download or read book Inflammation-Associated Depression: Evidence, Mechanisms and Implications written by Robert Dantzer and published by Springer. This book was released on 2016-12-28 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.

The Glutamate Receptors

Author : Robert W. Gereau
Publisher : Springer Science & Business Media
ISBN 13 : 1597450553
Total Pages : 585 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis The Glutamate Receptors by : Robert W. Gereau

Download or read book The Glutamate Receptors written by Robert W. Gereau and published by Springer Science & Business Media. This book was released on 2008-02-23 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This insightful and comprehensive book covers nearly every aspect of glutamate receptor structure and function for the working researcher and student. It condenses two previous landmark volumes into one easily accessible volume, and covers the extraordinary research and significant developments in the decade since the previous books were published. This includes the central role glutamate receptors play in neurotransmission.

Introduction to Neuropsychopharmacology

Author : Leslie Iversen
Publisher : Oxford University Press
ISBN 13 : 0195380533
Total Pages : 568 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Introduction to Neuropsychopharmacology by : Leslie Iversen

Download or read book Introduction to Neuropsychopharmacology written by Leslie Iversen and published by Oxford University Press. This book was released on 2009 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The text ranges from drugs that affect the mood and behavior to hypnotics, narcotics, anticonvulsants, and analgesics, as well as a variety of drugs that affect the autonomic nervous system and psychoactive drugs used for non-medical reasons - nicotine, alcohol, opiates, psychostimulants and cannabis."--BOOK JACKET.

Pathology, Prevention and Therapeutics of Neurodegenerative Disease

Author : Sarika Singh
Publisher : Springer
ISBN 13 : 9811309442
Total Pages : 302 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Pathology, Prevention and Therapeutics of Neurodegenerative Disease by : Sarika Singh

Download or read book Pathology, Prevention and Therapeutics of Neurodegenerative Disease written by Sarika Singh and published by Springer. This book was released on 2018-09-24 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by a leading panel of experts in the field of neurosciences, provides a comprehensive overview of the pathology of neurodegenerative diseases as well as the preventive measures. Prevention is important due to the lack of early diagnostic markers and the limitations/ problems of treating neurodegenerative diseases

Basal Ganglia and Thalamus in Health and Movement Disorders

Author : Kristy Kultas-Ilinsky
Publisher : Springer Science & Business Media
ISBN 13 : 1461512352
Total Pages : 370 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Basal Ganglia and Thalamus in Health and Movement Disorders by : Kristy Kultas-Ilinsky

Download or read book Basal Ganglia and Thalamus in Health and Movement Disorders written by Kristy Kultas-Ilinsky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is comprised of the majority of lecture presentations and a few select posters presented at the International Workshop, "Basal Ganglia and Thalamus in Health and Movement Disorders," held in Moscow, Russia, on May 29-31, 2000. The International Committee responsible for organizing this workshop included Alexander Konovalov, Director, Burdenko Institute of Neurosurgery of the Russian Academy of Medical Sciences, Mahlon DeLong, Chair, Department of Neurology, Emory University, Atlanta, USA, Alim Louis Benabid, Chief, Neurosurgery Service, University of Joseph Fourrier, Grenoble, France, and the two undersigned. The workshop was conceived out of a desire to provide a forum for discussions of both basal ganglia-and motor thalamus-related issues by bringing together basic scientists and clinicians representing different disciplines, research directions, and philosophies. The primary goals were to encourage an exchange of information and ideas in an informal environment, to stimulate integration of the data from different disciplines, and to identifY controversial issues and the most essential questions to be addressed in future research.

Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481654551
Total Pages : 340 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition by :

Download or read book Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Fundamental Neuroscience

Author : Larry Squire
Publisher : Academic Press
ISBN 13 : 0080561020
Total Pages : 1277 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Fundamental Neuroscience by : Larry Squire

Download or read book Fundamental Neuroscience written by Larry Squire and published by Academic Press. This book was released on 2008-04-02 with total page 1277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental Neuroscience, Third Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts.Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness Additional text boxes describing key experiments, disorders, methods, and concepts Multiple model system coverage beyond rats, mice, and monkeys Extensively expanded index for easier referencing

Introduction to Basics of Pharmacology and Toxicology

Author : Abialbon Paul
Publisher : Springer Nature
ISBN 13 : 9813360097
Total Pages : 1156 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Introduction to Basics of Pharmacology and Toxicology by : Abialbon Paul

Download or read book Introduction to Basics of Pharmacology and Toxicology written by Abialbon Paul and published by Springer Nature. This book was released on 2021-03-13 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Central Nervous System Diseases: New Insights for the Healthcare Professional: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481651315
Total Pages : 736 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Central Nervous System Diseases: New Insights for the Healthcare Professional: 2013 Edition by :

Download or read book Central Nervous System Diseases: New Insights for the Healthcare Professional: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: Central Nervous System Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Central Nervous System Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Central Nervous System Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.