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Metabolic Control Of Brain Homeostasis
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Book Synopsis Metabolic Control of Brain Homeostasis by : Detlev Boison
Download or read book Metabolic Control of Brain Homeostasis written by Detlev Boison and published by Frontiers Media SA. This book was released on 2017-10-03 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain function is under metabolic control, which in turn determines the equilibrium of homeostatic systems that affect neuronal and glial networks on the molecular, cellular, and systems levels. The collection of articles ranges from molecules and mechanisms involved in regulating homeostasis and neuronal excitability to therapeutic mechanisms tailored to restore homeostatic function. It also features neurological diseases and novel treatment approaches that are based on metabolic and homeostatic interventions. Together, the collection of articles outlines novel strategies to restore brain function in neurology and highlights limitations of conventional pharmacological approaches. We suggest that restoration of molecular and biochemical networks could lead to a new era of therapeutic opportunities.
Book Synopsis Fuel Homeostasis and the Nervous System by : Mladen Vranic
Download or read book Fuel Homeostasis and the Nervous System written by Mladen Vranic and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has a dual purpose, to review in depth the control of fuel homeostasis in the brain and the role of the nervous system in the control of fuel deposition in the body. From the methodological point of view the emphasis is on the application of advanced technologies to assess fuel transport and brain metabolism, the role of peptides in the neuroendocrine system and the response of the brain to hypoglycemia. These technologies include positron emmission tomography, nuclear magnetic resonance, immunocytochemistry, molecular biology, autoradiography. To study fuel homeostasis in the body advanced tracer methods that include modelling are set out. From the pathophysiological point of view the emphasis is on abnormalities in stress, brain metabolism in diabetes, eating and degenerative disorders. This book contains contributions from endocrinologists, physiologists, neurologists, psychoneuroendocrinOlogists, biophysicists, biochemists and experts in nutrition. This authorship represents a unique diversity of researchers who, for the first time, cover comprehensively the interaction between the nervous system and fuel homeostasis, both in health and disease. We hope this book will be an important source of information for both researchers and practicing clinicians. Mladen Vranic Suad Efendic Charles Hollenberg v ACKNOWLEDGEMENTS The Symposium from which this volume arose (University of Toronto, June 27-28, 1990) was the first Toronto-Stockholm symposium on Perspectives in Diabetes Research. These Symposia are organized triennially by the Banting and Best Diabetes Centre, University of Toronto and the Department of Endocrinology, Karolinska Institute, Stockholm.
Book Synopsis Integration/Interaction of Oncologic Growth by : Gary G. Meadows
Download or read book Integration/Interaction of Oncologic Growth written by Gary G. Meadows and published by Springer Science & Business Media. This book was released on 2005-05-25 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique book on the interactions and interrelationships between tumor and host that modulate progression and metastasis. Several authors emphasize targeting the host rather than the tumor itself for therapeutic intervention to control cancer.
Book Synopsis Neural and Metabolic Control of Macronutrient Intake by : Hans-Rudolf Berthoud
Download or read book Neural and Metabolic Control of Macronutrient Intake written by Hans-Rudolf Berthoud and published by CRC Press. This book was released on 1999-10-25 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: When an excessive proportion of the human energy requirement is derived from fat, the likelihood of obesity increases. Any such individual is at risk for diabetes and cardiovascular disease- grave and costly health hazards. The selective control of fat ingestion is a promising solution to these concerns. Existing data suggests that macronutrient intake can be manipulated. Further research is working to create pharmacological tools that will suppress fat consumption. It will also be possible to fight obesity, heart disease and diabetes. Neural and Metabolic Control of Macronutrient Intake systematically discusses the known physiological mechanisms involved in macronutrientselection, including their molecular, genetic and neurochemical aspects. The book is also a critical review of the hypothesis that ingestion of the three nutrients is regulated by separate neural control mechanisms, leaving open the possibility that strategies could be devised to intervene in bodily control systems and alter the proportion of fat in the diet. This reference provides three types of information: First, the basic background of the biochemical and physiological systems as they relate to macronutrient selection. Second, opinions and data concerning to what degree animals and humans show evidence of macronutrient selection. And, third, evidence about how the central nervous system might be involved in the choices animals make among macronutrients.
Book Synopsis Sensory and Metabolic Control of Energy Balance by : Wolfgang Meyerhof
Download or read book Sensory and Metabolic Control of Energy Balance written by Wolfgang Meyerhof and published by Springer Science & Business Media. This book was released on 2010-09-24 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last two decades, the prevalence of obesity has dramatically increased in western and westernized societies. Its devastating health consequences include hypertension, cardiovascular diseases, or diabetes and make obesity the second leading cause of unnecessary deaths in the USA. As a consequence, obesity has a strong negative impact on the public health care systems. Recently emerging scienti?c insight has helped understanding obesity as a complex chronic disease with multiple causes. A multileveled gene–environment interaction appears to involve a substantial number of susceptibility genes, as well as associations with low physical activity levels and intake of high-calorie, low-cost, foods. Unfor- nately, therapeutic options to prevent or cure this disease are extremely limited, posing an extraordinary challenge for today’s biomedical research community. Obesity results from imbalanced energy metabolism leading to lipid storage. Only detailed understanding of the multiple molecular underpinnings of energy metabolism can provide the basis for future therapeutic options. Numerous aspects of obesity are currently studied, including the essential role of neural and endocrine control circuits, adaptive responses of catabolic and anabolic pathways, metabolic fuel sensors, regulation of appetite and satiation, sensory information processing, transcriptional control of metabolic processes, and the endocrine role of adipose tissue. These studies are predominantly fuelled by basic research on mammalian models or clinical studies, but these ?ndings were paralleled by important insights, which have emerged from studying invertebrate models.
Book Synopsis Encyclopedia of Basic Epilepsy Research by :
Download or read book Encyclopedia of Basic Epilepsy Research written by and published by Academic Press. This book was released on 2009-05-27 with total page 1853 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research
Book Synopsis Metabolic Regulation in Mammals by : David Gibson
Download or read book Metabolic Regulation in Mammals written by David Gibson and published by CRC Press. This book was released on 2003-09-02 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Regulation in Mammals presents the basic principles of metabolic control, based on investigations conducted during the past twenty years. It explains the impact of recent advances in cell biology, molecular biology and genetics on the field. Beginning with the basic concepts, this text covers all angles of metabolic regulation, including blood caloric homeostasis, cardiac and skeletal muscle, adipose tissue, and liver metabolism. Review questions, summary sections and worked examples help break down the complexity of the subject and allow the reader to review the principles and concepts presented. Details of metabolic pathways are provided for each body system, with accompanying charts to provide the reader with an overall perspective. This text is ideal for undergraduates across a range of biological and health science disciplines, particularly those taking one or two semester courses in metabolic regulation.
Book Synopsis Biomedical Index to PHS-supported Research by :
Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1990 with total page 1060 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis From precocious puberty to infertility: metabolic control of the reproductive function by : Meenakshi Alreja
Download or read book From precocious puberty to infertility: metabolic control of the reproductive function written by Meenakshi Alreja and published by Frontiers E-books. This book was released on 2013-06-03 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: The existence of a fundamental link between nutrition and reproduction is well established. It is known for decades that a critical amount of stored energy is required for sexual maturation and maintenance of fertility. This concept is based on the idea that when survival is threatened by scarcity of food or increased energy demands, male and female of most species divert energy away from reproduction. This includes sexual maturation, the production of reproductive hormones and gametes, and the maintenance of pregnancy and lactation. If excessive leanness occurs in young women, puberty is often delayed. On the other hand, excess stored energy also negatively impacts fertility. Elevated adiposity aggravates polycystic ovarian syndrome, ovulatory dysfunctions and may induce hypothalamic hypogonadism in women. In obese men, fertility is usually decreased likely due to altered activity of the hypothalamus-pituitary axis and defective steroidogenesis in testis. Recently, studies have documented the link between the advance of obesity and the increasing rates of “precocious puberty”. In 1997, an epidemiologic study reported that 6.7% of American girls had clinical evidence of puberty at age 7 years, and 14.7% at age 8 years. That study described the youngest ever reported population age at puberty onset of 9.96 ± 1.82 years. In September of 2010, an alarming study showed that this phenomenon has been aggravated in the last decade. The authors found an increment of 5-8% in the number of girls with clinical evidence of puberty at age 7 and 8 years, compared to the 1997 study. They also reported a high correlation of early puberty onset and childhood obesity. These observations suggest the existence of a previously unrecognized deleterious effect of the increasing rates of childhood obesity: “the precocious puberty”, which will bring profound social and health implications for the next generations. Earlier menarche in girls is associated with increased risk of adult obesity, type 2 Diabetes and breast cancer. Thus, changing levels of key metabolic cues is an essential signal for the onset of puberty and maintenance of the tone of the reproductive system. As the activity of gonadotropin releasing hormone (GnRH) neurons is essential for the development and maturity of the reproductive axis, efforts have been made to identify the factors that directly regulate the activity of GnRH neurons. For example, sensory signals and metabolic cues (e.g. glucose) may reach the reproductive control sites of the central nervous system via sensory inputs conveyed by the vagus nerve or by direct action in the caudal brainstem. In addition, circulating metabolic factors such as leptin, insulin and ghrelin also inform the brain about the individual nutritional state. The goal of this Research Topic is to assemble multidisciplinary specialists to provide up-to-date reviews on the recent advances and achievements in the field.
Book Synopsis Metabolic Control by : Stephan Herzig
Download or read book Metabolic Control written by Stephan Herzig and published by Springer. This book was released on 2016-03-17 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The HEP issue on Metabolic Control provides a state-of the art overview over both classical concepts and emerging areas in metabolism and associated disorders. In this context, metabolic control is highlighted at various levels of complexity ranging from transcriptional mechanisms in metabolic pathway control over metabolic communication routes in physiology and pathophysiology to current treatment modalities and options in metabolic disorders, including type 2 diabetes and obesity. Dedicated chapters by leading experts in their fields provide a concise overview over important areas in metabolic research at a molecular level, including the role of the central nervous system in metabolism, inflammation and metabolism, pancreatic hormone signaling, brown adipose tissue, and therapeutic concepts.
Download or read book Research Awards Index written by and published by . This book was released on 1989 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neuron Signaling in Metabolic Regulation by : Qingchun Tong
Download or read book Neuron Signaling in Metabolic Regulation written by Qingchun Tong and published by CRC Press. This book was released on 2021-06-07 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on neuron signaling in the regulation of metabolism and body weight, and especially on methods used in these studies. Obesity and related metabolic syndromes have reached epidemic status, but still are no effective strategies for prevention and treatment. Body weight homeostasis is maintained by balanced food intake and energy expenditure, both of which are under the control of brain neurons. In the recent years, significant progress has been made in identifying specific neurons, neural pathways, and non-neuron cells in feeding regulation, as well as in delineating autonomic nervous systems targeting peripheral metabolic tissues in the regulation of energy expenditure and metabolism. This book reviews recent progress on important neuron signaling for body weight and metabolic regulation and the state-of-the-art methods that has been applied in this field, ranging from animal models with neuron-specific manipulations, pharmacology, optogenetics, in vivo Ca2+ imaging, and viral tracing. Readers will be exposed to latest research frontiers on neuron regulation of metabolism. Key Features Explores the role signaling between neurons plays with respect to metabolism Documents how neurotransmitters affect the regulation of feeding Describes various methods and technologies used to study the neuronal control of metabolism Includes contributions from an international team of leading researchers. Related Titles Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Feltz, A. Physiology of Neurons (ISBN 978-0-8153-4600-5) Zempleni, J. & K. Dakshinamurti, eds. Nutrients and Cell Signaling (ISBN 978-0367-39307-6)
Book Synopsis Cardiovascular Physiology: Microcirculation and Capillary Exchange by : A. G. B. Kovàch
Download or read book Cardiovascular Physiology: Microcirculation and Capillary Exchange written by A. G. B. Kovàch and published by Elsevier. This book was released on 2013-10-22 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Physiological Sciences, Volume 7: Cardiovascular Physiology: Microcirculation and Capillary Exchange is a collection of papers that tackles the advances in the understanding of microcirculation and capillary exchange. The text first details the coordination of microcirculatory function with oxygen demand in skeletal muscle, and then proceeds to discussing the role of intravascular pressure in the regulation of the microcirculation. Next, the selection covers the circulatory actions of prostacyclin and thromboxane, along with the routes of transcapillary transport. The last two parts of the text deal with the lymphatic system and blood-brain barrier. The book will be of great interest to health professionals, particularly cardiologists and cardiovascular surgeons.
Author :National Institutes of Health (U.S.). Division of Research Grants Publisher : ISBN 13 : Total Pages :1116 pages Book Rating :4.3/5 (91 download)
Book Synopsis Research Grants Index by : National Institutes of Health (U.S.). Division of Research Grants
Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1973 with total page 1116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 1850 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Oesophagogastric Surgery - E-Book by : Peter J. Lamb
Download or read book Oesophagogastric Surgery - E-Book written by Peter J. Lamb and published by Elsevier Health Sciences. This book was released on 2023-07-10 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oesophagogastric Surgery provides a short, up-to-date and practical reference guide for surgical trainees and established consultants needing an update in their subspecialty practice The seventh edition has been edited and fully revised by respected international experts in their fields, and provides a full list of current references and relevant resources. It includes a focus on early cancer and covers new developments in hiatal surgery and bariatric surgery. This volume is part of the Companion to Specialist Surgical Practice series, the pre-eminent reference for trainees in general surgery and those preparing for the FRCS examinations. Each volume summarises key issues within each surgical sub-specialty and provides evidence-based recommendations to support practice. Written by leading experts from the UK, Europe and around the world Covers all key areas of upper Gastrointestinal surgery Concise and easy to follow – ideal for exam revision or as a refresher aid Fully updated with latest evidence on recent developments, management issues and operative procedures Details of relevant investigations and evidence-based recommendations to support practice Key references to support content, plus a comprehensive list of references in the accompanying eBook Links to recommended online videos for further learning New chapters on the detection and the treatment of early oesophageal and gastric cancer Focus on new developments in hiatal surgery and the rapidly moving world of bariatric surgery New authors and extensive revisions
Book Synopsis Neuroendocrine Control of Feeding Behavior by : Serge H. Luquet
Download or read book Neuroendocrine Control of Feeding Behavior written by Serge H. Luquet and published by Frontiers Media SA. This book was released on 2019-11-20 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hypothalamus plays a crucial role in the regulation of food intake and energy homeostasis. Hypothalamic neuronal circuits thus represent a privileged target for the treatment of eating disorders and metabolic diseases. The present eBook constitutes a unique collection of research articles and reviews that highlight new concepts and recent findings about the neuroendocrine control of feeding behavior.
