Mental Health Survival Kit and Withdrawal from Psychiatric Drugs

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Author :
Publisher : Institute for Scientific Freedom
ISBN 13 : 1615996192
Total Pages : 223 pages
Book Rating : 4.6/5 (159 download)

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Book Synopsis Mental Health Survival Kit and Withdrawal from Psychiatric Drugs by : Peter C. Gøtzsche

Download or read book Mental Health Survival Kit and Withdrawal from Psychiatric Drugs written by Peter C. Gøtzsche and published by Institute for Scientific Freedom. This book was released on 2021-12-06 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book can help people with mental health issues to survive and return to a normal life. Citizens believe, and the science shows, that medications for depression and psychosis and admission to a psychiatric ward are more often harmful than beneficial. Yet most patients take psychiatric drugs for years. Doctors have made hundreds of millions of patients dependent on psychiatric drugs without knowing how to help them taper off the drugs safely, which can be very difficult. The book explains in detail how harmful psychiatric drugs are and gives detailed advice about how to come off them. You will learn: • why you should not see a psychiatrist if you have a mental health issue • that psychiatric drugs are addictive • that the biggest lie in psychiatry is the one about a chemical imbalance being the cause of psychiatric disorders • that psychiatric diagnoses are unscientific and that doctors disagree widely when making diagnoses • that psychiatric drugs can lead to permanent brain damage • that psychiatric drugs should never be stopped abruptly because withdrawal reactions can be dangerous • why psychotherapy and other psychosocial interventions should be preferred over drugs • why you should generally not believe what doctors tell you about psychiatric disorders and their treatment • why volunteers have found the book so important that they have translated it into French, Portuguese and Spanish "Peter Gøtzsche has written a very personal account of his battle to get the institution of psychiatry to accept that its drugs are not the 'magic pills' they are made out to be. Every medical practitioner who prescribes them, and every person who takes them, should read this book and be warned." -- Niall McLaren, author of Anxiety: The Inside Story "Peter Gøtzsche's new book meets patients' need to get tools on how to deal with psychoactive drugs and, above all, not to start them. Gøtzsche is very clear about the role of GPs in medicalizing grief, misfortune, opposition, and bad luck. In this he finds the American emeritus professor of psychiatry and chairman of the DSM-III committee, Allen Frances, at his side. Both Gøtzsche and Frances have repeatedly stated that psychoactive drugs should not be prescribed by GPs because they lack experience in their use. And above all, unhappiness, grief, and bad luck are not signs of brain disorders, they belong to daily life." Additionally, Gøtzsche reveals that most psychoactive drugs do not work - 'they might only achieve statistically significant differences compared to placebo, but that's not what patients need.'" -- Dick Bijl, former GP, epidemiologist, and current president of the International Society of Drug Bulletins. "Peter C. Gøtzsche wrote this book to help people with mental health problems survive and return to a normal life. His book explains in detail how psychiatric drugs are harmful and people are told how they can safely withdraw from them. It also advises on how people with mental health problems can avoid making a 'career' as a psychiatric patient and losing 10 or 15 years of their life to psychiatry. You will find precious material to help plan and accompany this process of liberation from psychiatry." - Fernando Freitas, PhD, Psychologist, Full Professor and Researcher at the National School of Public Health (ENSP/FIOCRUZ). Co-editor of Mad in Brazil "In this work, addressed to people affected by the risk of being caught in the system of attention to mental health issues, Dr. Gøtzsche succinctly exposes, without beating about the bush, the damage caused by psychiatric medications, demonstrates that their widespread use is not based on evidence, which is mainly driven by commercial pressures that have nothing to do with the recovery of patients, and present safe ways to dispose of them, always gradually and under supervision of trustworthy people to minimize the syndrome of abstinence and successfully overcome all the difficulties that the process involves." -- Enric García Torrents, writing for Mad in Spain Learn more at www.scientificfreedom.dk From the Institute for Scientific Freedom

Psychiatric Drug Withdrawal

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Author :
Publisher : Springer Publishing Company
ISBN 13 : 0826108431
Total Pages : 335 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Psychiatric Drug Withdrawal by : Peter Roger Breggin

Download or read book Psychiatric Drug Withdrawal written by Peter Roger Breggin and published by Springer Publishing Company. This book was released on 2012-07-19 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Print+CourseSmart

Psychiatric Drug Withdrawal

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Publisher : Springer Publishing Company
ISBN 13 : 082610844X
Total Pages : 352 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Psychiatric Drug Withdrawal by : Peter R. Breggin, MD

Download or read book Psychiatric Drug Withdrawal written by Peter R. Breggin, MD and published by Springer Publishing Company. This book was released on 2012-07-19 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to establish guidelines and to assist prescribers and therapists in withdrawing their patients from psychiatric drugs, including those patients with long-term exposure to antipsychotic drugs, benzodiazepines, stimulants, antidepressants, and mood stabilizers. It describes a method developed by the author throughout years of clinical experience, consultations with experienced colleagues, and scientific research. Based on a person-centered collaborative approach, with patients as partners, this method builds on a cooperative and empathic team effort involving prescribers, therapists, patients, and their families or support network. The author, known for such books as Talking Back to Prozac, Toxic Psychiatry, and Medication Madness, is a lifelong reformer and scientist in mental health whose work has brought about significant change in psychiatric practice. This book provides critical information about when to consider psychiatric drug reduction or withdrawal, and how to accomplish it as safely, expeditiously, and comfortably as possible. It offers the theoretical framework underlying this approach along with extensive scientific information, practical advice, and illustrative case studies that will assist practitioners in multiple ways, including in how to: Recognize common and sometimes overlooked adverse drug effects that may require withdrawal Treat emergencies during drug therapy and during withdrawal Determine the first drugs to withdraw during multi-drug therapy Distinguish between withdrawal reactions, newly occurring emotional problems, and recurrence of premedication issues Estimate the length of withdrawal

Your Drug May Be Your Problem

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Author :
Publisher : Da Capo Lifelong Books
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Your Drug May Be Your Problem by : Peter Roger Breggin

Download or read book Your Drug May Be Your Problem written by Peter Roger Breggin and published by Da Capo Lifelong Books. This book was released on 1999-07-21 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides uncensored descriptions of the dangers involved in taking every kind of psychiatric medication, and tells how to safely stop taking each type. Complex material is explained in plain language. Discusses the role of pharmaceutical companies in the psychiatric drug explosion, and considers ethical and scientific questions surrounding these drugs. Breggin is international director of the Center for the Study of Psychiatry and Psychology, and is the author of Talking Back to Prozac and Toxic Psychiatry. Cohen is a professor of social work at the University of Montreal, and is associate editor of The Journal of Mind and Behavior. Annotation copyrighted by Book News, Inc., Portland, OR

Deadly Medicines and Organised Crime

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Author :
Publisher : CRC Press
ISBN 13 : 1908911123
Total Pages : 251 pages
Book Rating : 4.9/5 (89 download)

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Book Synopsis Deadly Medicines and Organised Crime by : Peter Gotzsche

Download or read book Deadly Medicines and Organised Crime written by Peter Gotzsche and published by CRC Press. This book was released on 2019-08-21 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: PRESCRIPTION DRUGS ARE THE THIRD LEADING CAUSE OF DEATH AFTER HEART DISEASE AND CANCER. In his latest ground-breaking book, Peter C Gotzsche exposes the pharmaceutical industries and their charade of fraudulent behaviour, both in research and marketing where the morally repugnant disregard for human lives is the norm. He convincingly draws close co

Coming Off Psychiatric Drugs

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Publisher :
ISBN 13 : 9780954542801
Total Pages : 350 pages
Book Rating : 4.5/5 (428 download)

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Book Synopsis Coming Off Psychiatric Drugs by : Karl Bach Jensen

Download or read book Coming Off Psychiatric Drugs written by Karl Bach Jensen and published by . This book was released on 2004 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an amazing text on the subject of coming off psychotropic drugs. This book is for anyone who has an interest in the preparation and process of what it takes to learn to come off these drugs and live life without them. Amazing stories of many who had been led to believe they were ill and now live life outside of the constricting paradigm of mental disease. A must read for therapists, doctors, users of these drugs and their family members.

Mammography Screening

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Publisher : CRC Press
ISBN 13 : 1000477096
Total Pages : 271 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Mammography Screening by : Peter Gotzsche

Download or read book Mammography Screening written by Peter Gotzsche and published by CRC Press. This book was released on 2021-06-29 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'This book gives plenty of examples of ad hominem attacks, intimidation, slander, threats of litigation, deception, dishonesty, lies and other violations of good scientific practice. For some years I kept a folder labeled Dishonesty in breast cancer screening on top of my filing cabinet, storing articles and letters to the editor that contained statements I knew were dishonest. Eventually I gave up on the idea of writing a paper about this collection, as the number of examples quickly exceeded what could be contained in a single article.' From the Introduction The most effective way to decrease women's risk of becoming a breast cancer patient is to avoid attending screening. Mammography screening is one of the greatest controversies in healthcare, and the extent to which some scientists have sacrificed sound scientific principles in order to arrive at politically acceptable results in their research is extraordinary. In contrast, neutral observers increasingly find that the benefit has been much oversold and that the harms are much greater than previously believed. This groundbreaking book takes an evidence-based, critical look at the scientific disputes and the information provided to women by governments and cancer charities. It also explains why mammography screening is unlikely to be effective today. All health professionals and members of the public will find these revelations disturbingly illuminating. It will radically transform the way healthcare policy makers view mammography screening in the future. 'If Peter Gotzsche did not exist, there would be a need to invent him ...It may still take time for the limitations and harms of screening to be properly acknowledged and for women to be enabled to make adequately informed decisions. When this happens, it will be almost entirely due to the intellectual rigour and determination of Peter Gotzsche.' From the Foreword by Iona Heath, President, RCGP 'If you care about breast cancer, and we all should, you must read this book. Breast cancer is complex and we cannot afford to rely on the popular media, or on information from marketing campaigns from those who are invested in screening. We need to question and to understand. The story that Peter tells matters very much.' From the Foreword by Fran Visco, President, National Breast Cancer Coalition

Toxic Psychiatry

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Publisher : St. Martin's Griffin
ISBN 13 : 1250108721
Total Pages : 480 pages
Book Rating : 4.2/5 (51 download)

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Book Synopsis Toxic Psychiatry by : Peter R. Breggin, M.D.

Download or read book Toxic Psychiatry written by Peter R. Breggin, M.D. and published by St. Martin's Griffin. This book was released on 2015-12-22 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prozac, Xanax, Halcion, Haldol, Lithium. These psychiatric drugs--and dozens of other short-term "solutions"--are being prescribed by doctors across the country as a quick antidote to depression, panic disorder, obsessive-compulsive disorder, and other psychiatric problems. But at what cost? In this searing, myth-shattering exposé, psychiatrist Peter R. Breggin, M.D., breaks through the hype and false promises surrounding the "New Psychiatry" and shows how dangerous, even potentially brain-damaging, many of its drugs and treatments are. He asserts that: psychiatric drugs are spreading an epidemic of long-term brain damage; mental "illnesses" like schizophrenia, depression, and anxiety disorder have never been proven to be genetic or even physical in origin, but are under the jurisdiction of medical doctors; millions of schoolchildren, housewives, elderly people, and others are labeled with medical diagnoses and treated with authoritarian interventions, rather than being patiently listened to, understood, and helped. Toxic Psychiatry sounds a passionate, much-needed wake-up call for everyone who plays a part, active or passive, in America's ever-increasing dependence on harmful psychiatric drugs.

The Medical Model in Mental Health

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Publisher : Oxford University Press
ISBN 13 : 0192534092
Total Pages : 384 pages
Book Rating : 4.1/5 (925 download)

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Book Synopsis The Medical Model in Mental Health by : Ahmed Samei Huda

Download or read book The Medical Model in Mental Health written by Ahmed Samei Huda and published by Oxford University Press. This book was released on 2019-05-16 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many published books that comment on the medical model have been written by doctors, who assume that readers have the same knowledge of medicine, or by those who have attempted to discredit and attack the medical practice. Both types of book have tended to present diagnostic categories in medicine as universally scientifically valid examples of clear-cut diseases easily distinguished from each other and from health; with a fixed prognosis; and with a well-understood aetiology leading to disease-reversing treatments. These are contrasted with psychiatric diagnoses and treatments, which are described as unclear and inadequate in comparison. The Medical Model in Mental Health: An Explanation and Evaluation explores the overlap between the usefulness of diagnostic constructs (which enable prognosis and treatment decisions) and the therapeutic effectiveness of psychiatry compared with general medicine. The book explains the medical model and how it applies in mental health, assuming little knowledge or experience of medicine, and defends psychiatry as a medical practice.

Essential Psychiatry

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Publisher : Cambridge University Press
ISBN 13 : 1139473654
Total Pages : 1385 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Essential Psychiatry by : Robin M. Murray

Download or read book Essential Psychiatry written by Robin M. Murray and published by Cambridge University Press. This book was released on 2008-09-18 with total page 1385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a major international textbook for psychiatrists and other professionals working in the field of mental healthcare. With contributions from opinion-leaders from around the globe, this book will appeal to those in training as well as to those further along the career path seeking a comprehensive and up-to-date overview of effective clinical practice backed by research evidence. The book is divided into cohesive sections moving from coverage of the tools and skills of the trade, through descriptions of the major psychiatric disorders and on to consider special topics and issues surrounding service organization. The final important section provides a comprehensive review of treatments covering all of the major modalities. Previously established as the Essentials of Postgraduate Psychiatry, this new and completely revised edition is the only book to provide this depth and breadth of coverage in an accessible, yet authoritative manner.

Vaccines

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Publisher : Skyhorse
ISBN 13 : 9781510762190
Total Pages : 264 pages
Book Rating : 4.7/5 (621 download)

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Book Synopsis Vaccines by : Peter C. Gøtzsche

Download or read book Vaccines written by Peter C. Gøtzsche and published by Skyhorse. This book was released on 2021-07-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will help you navigate the bewildering and often contradictory flood of information about vaccines. There is substantial misinformation about vaccines on the Internet, particularly from those who reject all vaccines, but also from official sources, which are expected to be neutral and objective. Vaccines: Truth, Lies, and Controversy is based on the best available evidence, and Professor Peter S. Gøtzsche explains when and why we should not have confidence in the science and official recommendations. Some vaccines are so beneficial—and have saved millions of lives—that we should all get them; some are so poor that many healthcare professionals do not use them for themselves or their families; and some are in-between. We must evaluate carefully each vaccine, one by one, assessing the balance between its benefits and harms, just as we do for other drugs, and then form an opinion about whether we think the vaccine is worth getting or recommending to other people. Vaccines focuses on measles, influenza, COVID-19, and HPV, but discusses also childhood vaccination programs and whether mandatory vaccination can be justified. Raising critical questions to vaccines is essential because there are still many unresolved issues. For example, we know virtually nothing about what happens when we use many vaccines and what the long-term effects are on the immune system. Vaccines demystifies the controversial topic and helps the reader formulate their own opinion.

Rational Diagnosis and Treatment

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Publisher : John Wiley & Sons
ISBN 13 : 9780470723685
Total Pages : 244 pages
Book Rating : 4.7/5 (236 download)

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Book Synopsis Rational Diagnosis and Treatment by : Peter Gøtzsche

Download or read book Rational Diagnosis and Treatment written by Peter Gøtzsche and published by John Wiley & Sons. This book was released on 2008-03-11 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its fourth edition, Rational Diagnosis and Treatment: Evidence-Based Clinical Decision-Making is a unique book to look at evidence-based medicine and the difficulty of applying evidence from group studies to individual patients. The book analyses the successive stages of the decision process and deals with topics such as the examination of the patient, the reliability of clinical data, the logic of diagnosis, the fallacies of uncontrolled therapeutic experience and the need for randomised clinical trials and meta-analyses. It is the main theme of the book that, whenever possible, clinical decisions must be based on the evidence from clinical research, but the authors also explain the pitfalls of such research and the problems involved in applying evidence from groups of patients to the individual patient. For this new edition, the sections on placebo and meta-analysis and on alternative medicine have been thoroughly updated, and there is more focus on insufficient reporting of harms of interventions. The sections on different research designs describe advantages and limitations, and the increased medicalisation and the effects of cancer screening on health people are noted. A section on academic freedom when clinicians collaborate with industry and ghost authors is added. This essential reference work integrates the science and statistical approach of evidence-based medicine with the art and humanism of medical practice; distinguishing between data, sets of data, knowledge and wisdom, and their application. Such an intellectually challenging book is ideal for both medical students and doctors who require theoretical and practical clinical skills to help ensure that they apply theory in practice.

Evidence-biased Antidepressant Prescription

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Author :
Publisher : Springer Nature
ISBN 13 : 3030825876
Total Pages : 355 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Evidence-biased Antidepressant Prescription by : Michael P. Hengartner

Download or read book Evidence-biased Antidepressant Prescription written by Michael P. Hengartner and published by Springer Nature. This book was released on 2021-12-09 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the over-prescribing of antidepressants in people with mostly mild and subthreshold depression. It outlines the steep increase in antidepressant prescription and critically examines the current scientific evidence on the efficacy and safety of antidepressants in depression. The book is not only concerned with the conflicting views as to whether antidepressants are useful or ineffective in various forms of depression, but also aims at detailing how flaws in the conduct and reporting of antidepressant trials have led to an overestimation of benefits and underestimation of harms. The transformation of the diagnostic concept of depression from a rare but serious disorder to an over-inclusive, highly prevalent but predominantly mild and self-limiting disorder is central to the books argument. It maintains that biological reductionism in psychiatry and pharmaceutical marketing reframed depression as a brain disorder, corroborating the overemphasis on drug treatment in both research and practice. Finally, the author goes on to explore how pharmaceutical companies have distorted the scientific literature on the efficacy and safety of antidepressants and how patient advocacy groups, leading academics, and medical organisations with pervasive financial ties to the industry helped to promote systematically biased benefit-harm evaluations, affecting public attitudes towards antidepressants as well as medical education, training, and practice.

Big Pharma

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Author :
Publisher : Robinson
ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.3/5 (555 download)

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Book Synopsis Big Pharma by : Jacky Law

Download or read book Big Pharma written by Jacky Law and published by Robinson. This book was released on 2006 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical medicine is very, very big business. The top ten players earned more than $200 billion in 2003. One drug, Pfizer's cholesterol pill Lipitor, had sales of more than $9 billion. This kind of money buys an awful lot of friends among doctors and politicians. Most of those involved in the formulation of public health policy seems happy with the present system. The trouble is that the public is starting to have doubts. There is a growing sense that the vast profits of drug companies and their control of the research agenda might not be that good for our health. Jacky Law takes the reader on a journey through the pharmaceutical business and shows how the public is quite right to be concerned about conventional medicine, as it has developed since the late 1970s. She tells a story of spectacular regulatory failure, phenomenally high prices, betrayal of the public interest and a growing awareness among ordinary people that things could be very different. Sophisticated marketing and public relations, not scientific excellence, have helped corporations to preside unchallenged over matters of life and death. It is time, Law argues, for us to take responsibility for our health, not as passive consumers of pharmaceutical medicine, but as informed citizens.

TIP 35: Enhancing Motivation for Change in Substance Use Disorder Treatment (Updated 2019)

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Author :
Publisher : Lulu.com
ISBN 13 : 1794755136
Total Pages : 208 pages
Book Rating : 4.7/5 (947 download)

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Book Synopsis TIP 35: Enhancing Motivation for Change in Substance Use Disorder Treatment (Updated 2019) by : U.S. Department of Health and Human Services

Download or read book TIP 35: Enhancing Motivation for Change in Substance Use Disorder Treatment (Updated 2019) written by U.S. Department of Health and Human Services and published by Lulu.com. This book was released on 2019-11-19 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motivation is key to substance use behavior change. Counselors can support clients' movement toward positive changes in their substance use by identifying and enhancing motivation that already exists. Motivational approaches are based on the principles of person-centered counseling. Counselors' use of empathy, not authority and power, is key to enhancing clients' motivation to change. Clients are experts in their own recovery from SUDs. Counselors should engage them in collaborative partnerships. Ambivalence about change is normal. Resistance to change is an expression of ambivalence about change, not a client trait or characteristic. Confrontational approaches increase client resistance and discord in the counseling relationship. Motivational approaches explore ambivalence in a nonjudgmental and compassionate way.

The Antidepressant Solution

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Publisher : Simon and Schuster
ISBN 13 : 074328898X
Total Pages : 272 pages
Book Rating : 4.7/5 (432 download)

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Book Synopsis The Antidepressant Solution by : Joseph Glenmullen

Download or read book The Antidepressant Solution written by Joseph Glenmullen and published by Simon and Schuster. This book was released on 2006-01-20 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the FDA's warning that antidepressants may cause agitation, anxiety, hostility, and even violent or suicidal tendencies, these medications are at the forefront of national legal news. Harvard physician Joseph Glenmullen has led the charge to warn the public that antidepressants are overprescribed, underregulated, and, especially, misunderstood in their side and withdrawal effects. Now he offers a solution! More than twenty million Americans -- including over one million teens and children -- take one of today's popular antidepressants, such as Paxil, Zoloft, or Effexor. Dr. Glenmullen recognizes the many benefits of antidepressants and prescribes them to his patients, but he is also committed to warning the public of the dangers associated with overprescription. Dr. Glenmullen's last book, Prozac Backlash, sounded the alarm about possible dangers. The Antidepressant Solution provides the remedy. It is the first book to call attention to the drugs' catch-22: Although many people are ready to go off these drugs, they continue to take them because either the patient or the doctor mistakes antidepressant withdrawal for depressive relapse. The Antidepressant Solution offers an easy, step-by-step guide for patients and their doctors. Written by the premier authority in the field, The Antidepressant Solution is an invaluable book for all those concerned with going through the process -- from friends and family members to doctors and patients themselves.

Pain Management and the Opioid Epidemic

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Author :
Publisher : National Academies Press
ISBN 13 : 0309459575
Total Pages : 483 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine

Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.