Membrane Proteins As Drug Targets

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Membrane Proteins as Drug Targets

Author :
Publisher : Academic Press
ISBN 13 : 0123812895
Total Pages : 260 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Membrane Proteins as Drug Targets by :

Download or read book Membrane Proteins as Drug Targets written by and published by Academic Press. This book was released on 2010-09-24 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane proteins continue to be prime drug targets because they perform essential processes in the cell including controlling the flow of information and materials between cells and mediating activities like hormone action and nerve impulses. The study of membrane proteins could lead to new and improved pharmaceutical treatments for a wide range of illnesses such as heart disease, cystic fibrosis and depression. Membrane Proteins as Drug Targets reviews the latest developments in the field. Discusses new discoveries, approaches, and ideas in the field of membrane proteins and reviews how they are being used to develop new drugs Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

Membrane Transporters and Channels as Targets for Drugs

Author : Graça Soveral
Publisher : Frontiers Media SA
ISBN 13 : 2889633578
Total Pages : 333 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Membrane Transporters and Channels as Targets for Drugs by : Graça Soveral

Download or read book Membrane Transporters and Channels as Targets for Drugs written by Graça Soveral and published by Frontiers Media SA. This book was released on 2020-01-03 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transporters and channels are membrane proteins that mediate the traffic of metabolites, water and ions across biological membranes. Membrane transport proteins are crucial to maintain homeostasis and assure cell survival upon intracellular or environmental stress. A failure of any of these transport systems may have dramatic consequences for cell function. There is increasing evidence that membrane transport proteins play important functions in healthy conditions and that their absence or dysfunction may cause diseases. In recent years much attention has been paid to diseases resulting from defective transporters (“carrier diseases”) and ion channels (“channelopathies”). Very interestingly, altered expression of transporters has been described in several human pathologies. On this basis, many transport proteins are well acknowledged targets for drugs. Many others are involved in drug delivery and disposition and/or are considered potential targets. Others are off-targets for drugs and then, are responsible for side effects. Thus, membrane protein drug discovery is now an emerging field where the search for physiological mechanisms of regulation and for chemical compounds as modulators of transport activity, present new opportunities for drug development and for new therapies. This Research Topic addresses the latest research advances in membrane transport proteins, stimulating future research on these important protein families.

Advances in Membrane Proteins

Author : Yu Cao
Publisher : Springer Nature
ISBN 13 : 9811390770
Total Pages : 130 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Advances in Membrane Proteins by : Yu Cao

Download or read book Advances in Membrane Proteins written by Yu Cao and published by Springer Nature. This book was released on 2019-09-30 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent advances regarding the biochemical and biophysical properties of membrane proteins and their applications in biomedicine. Divided into two thematic parts, this second volume addresses proteins’ formation, signaling and malfunctions. It covers a number of important membrane proteins including receptors, cell adhesion molecules, single-transmembrane proteins and viral membrane proteins, and discusses their structures, functions, related diseases, and roles in drug discovery in detail. In turn, the book elucidates the lifecycle of membrane proteins, including their synthesis and facilitated folding process, as well as QC procedures for their production. Additional topics include fundamental concepts, the latest findings, and critical puzzles yet to be solved. Given its scope, the book will appeal to a broad readership in the field of membrane structural and functional biology. Junior scientists can use it as an introduction to the field, while advanced scientists will find a broader view of the field beyond their area of specialization.

Membrane Transporters as Drug Targets

Author : Gordon L. Amidon
Publisher : Springer Science & Business Media
ISBN 13 : 0306468123
Total Pages : 547 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Membrane Transporters as Drug Targets by : Gordon L. Amidon

Download or read book Membrane Transporters as Drug Targets written by Gordon L. Amidon and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1367 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Viral Membrane Proteins: Structure, Function, and Drug Design

Author : Wolfgang B. Fischer
Publisher : Springer Science & Business Media
ISBN 13 : 0387281460
Total Pages : 294 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Viral Membrane Proteins: Structure, Function, and Drug Design by : Wolfgang B. Fischer

Download or read book Viral Membrane Proteins: Structure, Function, and Drug Design written by Wolfgang B. Fischer and published by Springer Science & Business Media. This book was released on 2007-08-02 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Viral Membrane Proteins: Structure, Function, and Drug Design, Wolfgang Fischer summarizes the current structural and functional knowledge of membrane proteins encoded by viruses. In addition, contributors to the book address questions about proteins as potential drug targets. The range of information covered includes signal proteins, ion channels, and fusion proteins. This book has a place in the libraries of researchers and scientists in a wide array of fields, including protein chemistry, molecular biophysics, pharmaceutical science and research, bioanotechnology, molecular biology, and biochemistry.

Bile Acids in Gastroenterology: Basic and Clinical Advances

Author : A.F. Hofmann
Publisher : Springer Science & Business Media
ISBN 13 : 9780792388807
Total Pages : 428 pages
Book Rating : 4.3/5 (888 download)

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Book Synopsis Bile Acids in Gastroenterology: Basic and Clinical Advances by : A.F. Hofmann

Download or read book Bile Acids in Gastroenterology: Basic and Clinical Advances written by A.F. Hofmann and published by Springer Science & Business Media. This book was released on 1995-06-30 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the proceedings of the XIIIth International Bile Acid Meeting (Falk Symposium 80), an official satellite meeting of the World Congress of Gastroenterology, held in San Diego, California, U.S.A., September 30--October 2, 1994. It begins with presentations of major advances in bile acid chemistry, biology and pharmacology. The new structure proposed for the mixed micelles present in bile is reviewed, as are the properties of new synthetic analogues of bile acids. The mechanisms by which bile acids interact with cell membranes are discussed in order to provide insight into the hepatotoxic effects of bile acids in cholestatic liver disease. The book further shows the exciting progress in the molecular biology of bile acid transport by the hepatocyte and enterocyte, and concludes with a consensus on the use of ursodeoxycholic acid in cholestatic liver disease and as an adjunct to immunosuppressive therapy after liver transplantation, and to interferon therapy in chronic viral hepatitis.

Characterization and Modulation of Transmembrane Domain Interactions in Membrane Protein Drug-targets

Author : Megan Lynn Plotkowski
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis Characterization and Modulation of Transmembrane Domain Interactions in Membrane Protein Drug-targets by : Megan Lynn Plotkowski

Download or read book Characterization and Modulation of Transmembrane Domain Interactions in Membrane Protein Drug-targets written by Megan Lynn Plotkowski and published by . This book was released on 2008 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein-Protein Interactions as New Drug Targets

Author : Enno Klussmann
Publisher : Springer Science & Business Media
ISBN 13 : 3540728430
Total Pages : 511 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Protein-Protein Interactions as New Drug Targets by : Enno Klussmann

Download or read book Protein-Protein Interactions as New Drug Targets written by Enno Klussmann and published by Springer Science & Business Media. This book was released on 2008-05-20 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Multifaceted Roles of Crystallography in Modern Drug Discovery

Author : Giovanna Scapin
Publisher : Springer
ISBN 13 : 9401797196
Total Pages : 245 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Multifaceted Roles of Crystallography in Modern Drug Discovery by : Giovanna Scapin

Download or read book Multifaceted Roles of Crystallography in Modern Drug Discovery written by Giovanna Scapin and published by Springer. This book was released on 2015-02-27 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. This work will be of interest to researchers and policy makers interested in the latest developments in drug design.

Use of Membrane Proteins as Antifungal Drug Targets

Author : Alexis Lodé
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Use of Membrane Proteins as Antifungal Drug Targets by : Alexis Lodé

Download or read book Use of Membrane Proteins as Antifungal Drug Targets written by Alexis Lodé and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This note is part of Quality testing.

Unbiased Identification of Extracellular Protein,ÄìProtein Interactions for Drug Target and Biologic Drug Discovery

Author : Nadia Martinez-Martin
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Unbiased Identification of Extracellular Protein,ÄìProtein Interactions for Drug Target and Biologic Drug Discovery by : Nadia Martinez-Martin

Download or read book Unbiased Identification of Extracellular Protein,ÄìProtein Interactions for Drug Target and Biologic Drug Discovery written by Nadia Martinez-Martin and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological improvements in unbiased screening have accelerated drug target discovery. In particular, membrane-embedded and secreted proteins have gained attention because of their ability to orchestrate intercellular communication. Dysregulation of their extracellular protein,Äìprotein interactions (ePPIs) underlies the initiation and progression of many human diseases. Practically, ePPIs are also accessible for modulation by therapeutics since they operate outside of the plasma membrane. Therefore, it is unsurprising that while these proteins make up about 30% of human genes, they encompass the majority of drug targets approved by the FDA. Even so, most secreted and membrane proteins remain uncharacterized in terms of binding partners and cellular functions. To address this, a number of approaches have been developed to overcome challenges associated with membrane protein biology and ePPI discovery. This chapter will cover recent advances that use high-throughput methods to move towards the generation of a comprehensive network of ePPIs in humans for future targeted drug discovery.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Transporters as Drug Targets

Author : Gerhard F. Ecker
Publisher : John Wiley & Sons
ISBN 13 : 3527333843
Total Pages : 354 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Transporters as Drug Targets by : Gerhard F. Ecker

Download or read book Transporters as Drug Targets written by Gerhard F. Ecker and published by John Wiley & Sons. This book was released on 2017-04-10 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

G Protein-Coupled Receptors in Drug Discovery

Author : Kenneth H. Lundstrom
Publisher : CRC Press
ISBN 13 : 1420028219
Total Pages : 376 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis G Protein-Coupled Receptors in Drug Discovery by : Kenneth H. Lundstrom

Download or read book G Protein-Coupled Receptors in Drug Discovery written by Kenneth H. Lundstrom and published by CRC Press. This book was released on 2005-07-11 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development. Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Discovery describes the physiological roles of GPCRs

Enzymes as Targets for Drug Design

Author : Michael Palfreyman
Publisher : Elsevier
ISBN 13 : 0323140483
Total Pages : 282 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Enzymes as Targets for Drug Design by : Michael Palfreyman

Download or read book Enzymes as Targets for Drug Design written by Michael Palfreyman and published by Elsevier. This book was released on 2012-12-02 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymes as Targets for Drug Design is a collection of scientific discussions related to enzyme inhibitors that show the many facets of the drug discovery process from the basic sciences through clinical applications. Topics include the biogenesis of phosphatidylinositol glycosyl membrane proteins, structure and catalytic function of ADP-ribose polymerase (ADPRT), and modulation of the dopaminergic system in cardiovascular therapeutics. The therapeutic utility of selected enzyme-activated irreversible inhibitors, the role of proteinases in the fibrosis of systemic sclerosis, and therapeutic opportunities in eicosanoid biosynthesis are also discussed. This book consists of 18 chapters and begins with examples of enzymes whose activities have recently been elucidated, or for which newer insights have been gleaned, but which do not yet have selective or potent inhibitors. The second part provides examples of enzymes where inhibitors have been identified but it is still not clear whether or not such an enzymatic blockade will be therapeutically beneficial. The final section describes clinical studies of newer, and not so new, enzyme inhibitors that are clearly of therapeutic importance. The therapeutic activity of monoamine oxidase inhibitors and the associated clinical issues are considered. This book is intended for clinicians as well as basic scientists in biochemistry, chemistry, pharmacology, and cell biology.

Aquaporins in Health and Disease

Author : Graca Soveral
Publisher : CRC Press
ISBN 13 : 149870784X
Total Pages : 356 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Aquaporins in Health and Disease by : Graca Soveral

Download or read book Aquaporins in Health and Disease written by Graca Soveral and published by CRC Press. This book was released on 2018-10-30 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology. The studies have also shown aquaporins as potential drug targets and targets for improving crop properties. Written by an international group of contributors at the forefront of the field, Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery presents the latest research advances in aquaporins and other major intrinsic protein (MIP) channels. The first section of the book describes the general concepts of aquaporin channel function, genomic research, structure-function analysis of aquaporins and glycerol facilitators, and regulation by gating and trafficking, including yeast aquaporin regulation and function. The second section discusses the physiological and pathophysiological roles of aquaporins in humans and microbes. The final section covers the development of inhibitors of aquaporin function. The book’s epilogue offers future perspectives and directions, mainly in the area of aquaporin-based diagnostics and therapeutics. Stimulating future research on this important protein family, this book facilitates a paradigm shift in the understanding and roles of aquaporin membrane proteins in all biological settings. It encourages scientists to develop novel approaches for the treatment of human diseases based on aquaporin function or dysfunction.