Mechanisms Of Organ Dysfunction In Critical Illness

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Mechanisms of Organ Dysfunction in Critical Illness

Author : Timothy W. Evans
Publisher : Springer Science & Business Media
ISBN 13 : 3642561071
Total Pages : 410 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Mechanisms of Organ Dysfunction in Critical Illness by : Timothy W. Evans

Download or read book Mechanisms of Organ Dysfunction in Critical Illness written by Timothy W. Evans and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathophysiology of sepsis can be regarded as a series of steps, beginning with the invasion of normally sterile tissue by microbes and the elaboration of various pro-inflammatory mediators. The final common pathway is often the development of the multiple organ dysfunction syndrome (MODS). Whereas a great deal has been learned during the past quarter century about the inflammatory processes associated with sepsis (and other related conditions, such as ischemia/reperfusion injury), our understanding is far less developed with respect to the pathophysiological events that lead to organ dysfunction under these conditions. Nevertheless, efforts by both clinical and laboratory scientists are leading to new knowledge in this area. The chapters in this volume provide a state-of-the-art overview of many aspects of the pathophysiology of organ dysfunction in critical illness.

Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery

Author : E. Abraham
Publisher : Springer Science & Business Media
ISBN 13 : 9783540301585
Total Pages : 476 pages
Book Rating : 4.3/5 (15 download)

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Book Synopsis Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery by : E. Abraham

Download or read book Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery written by E. Abraham and published by Springer Science & Business Media. This book was released on 2007-08-27 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.

Multiple Organ Failure

Author : Arthur E. Baue
Publisher : Springer Science & Business Media
ISBN 13 : 1461212227
Total Pages : 712 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Multiple Organ Failure by : Arthur E. Baue

Download or read book Multiple Organ Failure written by Arthur E. Baue and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation in itself is not to be considered as a disease . . . and in disease, where it can alter the diseased mode of action, it likewise leads to a cure; but where it cannot accomplish that solitary purpose . . . it does mischief - John Hunter, A Treatise on the Blood, ITfIlammation, and Gunshot Woundr (London, 1794)1 As we reached the millennium, we recognized the gap between our scientific knowledge of biologic processes and our more limited clinical capabilities in the care of patients. Our science is strong. Molecular biology is powerful, but our therapy to help patients is weaker and more limited. For this reason, this book focuses on the problems of multiple organ failure (MOF), multiple organ dysfunction syndrome (MODS), and systemic inflammatory response syndrome is, patients who have severe injuries; require major, (SIRS) in high-risk patients, that overwhelming operations; or have serious illnesses requiring intensive care; patients who have diseases elsewhere, in other organs or systems, that limit their capabilities to survive a new insult; and patients who are elderly or at high risk for sepsis or other complications. These are the patients who need our help. They need the advances in science, in molecular biology, immunology, pathophysiology, biochemistry, genetics, high technology, and other areas of maximum support at the bedside. These advances could potentially have the greatest impact on improving patient care.

Sepsis, Kidney and Multiple Organ Dysfunction

Author : Claudio Ronco
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805577559
Total Pages : 417 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Sepsis, Kidney and Multiple Organ Dysfunction by : Claudio Ronco

Download or read book Sepsis, Kidney and Multiple Organ Dysfunction written by Claudio Ronco and published by Karger Medical and Scientific Publishers. This book was released on 2004-01-01 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe sepsis is among the most common causes of death in the United States and the most common cause of death in the Intensive Care Units worldwide, and its recognition and treatment remain the most important challenges of critical care medicine. Severe sepsis and septic shock have a profound effect on kidney function and the function of other organs through complex mechanisms, which involve the immune response, multiple pro and anti-inflammatory pathways, intracellular dysfunction and hemodynamic instability. Their optimal management requires complex knowledge of general medicine, immunology, nephrology, extra-corporeal technology, fluid resuscitation and critical care endocrinology. In order to deliver optimal patient care, nephrologists and intensive care medicine specialists need to understand and be highly knowledgeable in the epidemiology of sepsis, the mechanisms of injury which determine outcome and the fundamental aspects of new insights into fluid resuscitation, acid-base physiology and glucose control. They also need to have a clear appreciation of new technical developments in the monitoring of critically ill patients and in the delivery of advanced extra-corporeal blood purification therapies.Experts from the fields of intensive care medicine, nephrology, endocrinology, acid-base physiology, extra-corporeal blood purification technology and immunology have contributed to the present book, providing a cutting edge view of developments in each field which contribute to the care of patients with severe sepsis, acute renal failure and multiple organ failure. The resulting mix of fundamental knowledge and recent developments from clinical trials and laboratory research constitute a valuable tool for all professionals involved in the care of the critically ill patient.

Sepsis and Organ Dysfunction

Author : A.E. Baue
Publisher : Springer Science & Business Media
ISBN 13 : 8847022711
Total Pages : 180 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Sepsis and Organ Dysfunction by : A.E. Baue

Download or read book Sepsis and Organ Dysfunction written by A.E. Baue and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sepsis is a syndrome or sometimes it is a clinical condition evoked by uncontrolled endotoxin-reactions. These pathophysiological alterations can disturb the organism's homeostasis leading ultimately to a condition of severe organ dysfunction which in itself means a bad prognosis for patient survival. In the last decades researchers and clinicians have been involved in process directed to a better understanding of the basic mechanisms of sepsis and MODS. The best goal will be the achievement of preventive measures and optimization of management in patients suffering severe infections and critical conditions. This objective represents a true challenge at the dawn of the XXI century.

Sepsis, An Issue of Critical Care Clinics, E-Book

Author : Mervyn Singer
Publisher : Elsevier Health Sciences
ISBN 13 : 0323566340
Total Pages : pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Sepsis, An Issue of Critical Care Clinics, E-Book by : Mervyn Singer

Download or read book Sepsis, An Issue of Critical Care Clinics, E-Book written by Mervyn Singer and published by Elsevier Health Sciences. This book was released on 2017-11-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Critical Care Clinics, edited by Mervyn singer and Manu Shankar-Hari, includes: Sepsis 3.0 Definitions; Epidemiology and Outcomes; Pathophysiology of sepsis; Pathophysiology of Septic shock; Mechanism of organ dysfunction in sepsis; Endocrine and metabolic alterations in sepsis: challenges and treatments; The immune system in sepsis; Nutrition and Sepsis; Common sense approach to managing sepsis; Biomarkers for sepsis and their use; Personalizing sepsis care; Novel interventions - What’s new and the future; and Long term outcomes following Sepsis.

Sepsis and Organ Dysfunction

Author : A.E. Baue
Publisher : Springer Science & Business Media
ISBN 13 : 8847022843
Total Pages : 168 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Sepsis and Organ Dysfunction by : A.E. Baue

Download or read book Sepsis and Organ Dysfunction written by A.E. Baue and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: An experienced physician knows how to recognize a patient suffering from sepsis, but cannot accurately determine whether the patient will survive. Cardinal elements of the treatment for sepsis include specific antibiotic and vasoactive drugs, enteral and parenteral nutrition, artificial respiration, and optimization of the oxygen transport to tissues. Nonetheless, with a certain frequency, these techniques are insufficient to ensure the recovery of a critically ill patient, especially when it is necessary to overcome functional alterations subsequent to organ and vital-system overload. The key elements in the progression of the sepsis-MODS syndrome are tied to numerous factors. These include: the severity and location of the lesion; the patient's age; the remaining functional reserve; the presence of mediatory which may be stimulatory, inhibitory or both.

Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery

Author : E. Abraham
Publisher : Springer
ISBN 13 : 9783540301578
Total Pages : 453 pages
Book Rating : 4.3/5 (15 download)

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Book Synopsis Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery by : E. Abraham

Download or read book Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery written by E. Abraham and published by Springer. This book was released on 2006-09-25 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.

Core Topics in Critical Care Medicine

Author : Fang Gao Smith
Publisher : Cambridge University Press
ISBN 13 : 1139489682
Total Pages : 409 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Core Topics in Critical Care Medicine by : Fang Gao Smith

Download or read book Core Topics in Critical Care Medicine written by Fang Gao Smith and published by Cambridge University Press. This book was released on 2010-04-22 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critical care unit manages patients with a vast range of disease and injuries affecting every organ system. The unit can initially be a daunting environment, with complex monitoring equipment producing large volumes of clinical data. Core Topics in Critical Care Medicine is a practical, comprehensive, introductory-level text for any clinician in their first few months in the critical care unit. It guides clinicians in both the initial assessment and the clinical management of all CCU patients, demystifying the critical care unit and providing key knowledge in a concise and accessible manner. The full spectrum of disorders likely to be encountered in critical care are discussed, with additional chapters on transfer and admission, imaging in the CCU, structure and organisation of the unit, and ethical and legal issues. Written by Critical Care experts, Core Topics in Critical Care Medicine provides comprehensive, concise and easily accessible information for all trainees.

Brain Disorders in Critical Illness

Author : Robert D. Stevens
Publisher : Cambridge University Press
ISBN 13 : 1107434424
Total Pages : 457 pages
Book Rating : 4.1/5 (74 download)

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Book Synopsis Brain Disorders in Critical Illness by : Robert D. Stevens

Download or read book Brain Disorders in Critical Illness written by Robert D. Stevens and published by Cambridge University Press. This book was released on 2013-09-19 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This comprehensive clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.

Mechanisms of Vascular Disease

Author : Robert Fitridge
Publisher : University of Adelaide Press
ISBN 13 : 1922064009
Total Pages : 589 pages
Book Rating : 4.9/5 (22 download)

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Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge

Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Essentials of Shock Management

Author : Gil Joon Suh
Publisher : Springer
ISBN 13 : 9811054061
Total Pages : 147 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Essentials of Shock Management by : Gil Joon Suh

Download or read book Essentials of Shock Management written by Gil Joon Suh and published by Springer. This book was released on 2018-11-30 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to offer the reader first-rate guidance on shock management in the real world. Comprehensive, evidence-based, and up-to-date instruction is provided on optimal care of patients with different types of shock – septic, hemorrhagic, cardiogenic, anaphylactic, and obstructive – at all stages from initial response through to ICU admission. As well as management, the coverage encompasses pathophysiology, clinical presentation, diagnosis, and emerging trends. A further key feature is the use of a scenario-based approach to present a series of cases based on real-life experiences. Here, a narrative style and Q&A form are employed to vividly convey scenarios that may be encountered in clinical practice and to elucidate decision making in complex circumstances. When readers experience difficulty in answering the questions, the earlier sections can be consulted to identify the correct response. This book will be of great value for all health care professionals. In particular, it will be very helpful for novice or inexperienced practitioners in emergency medicine, critical care medicine, and traumatology.

Sepsis and Organ Dysfunction

Author : A.E. Baue
Publisher : Springer Science & Business Media
ISBN 13 : 8847022487
Total Pages : 194 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Sepsis and Organ Dysfunction by : A.E. Baue

Download or read book Sepsis and Organ Dysfunction written by A.E. Baue and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sepsis represents a life threatening condition to ICU patients. The evolution of sepsis to severe sepsis or septic shock may occur in an unpredictable way. In the coming millennium the prevention and management of sepsis and organ dysfunction will present a real challenge for researchers and clinicians.

Multiple Organ Dysfunction & Failure

Author : Virginia Huddleston Secor
Publisher :
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Multiple Organ Dysfunction & Failure by : Virginia Huddleston Secor

Download or read book Multiple Organ Dysfunction & Failure written by Virginia Huddleston Secor and published by . This book was released on 1996 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revision of this text provides up-to-date information on the science of multiple organ dysfunction syndrome (MODS). This edition brings not only new science but new nomenclature based on the recommendations of the American College of Chest Physicians and the Society of Critical Care Medicine Consensus Conference. The text gives the experienced critical care practitioner the pathophysiologic background and understanding of MODS necessary to develop an effective plan of care and anticipate events associated with this yndrome. The focus is on integration of clinical assessment with pathophysiological knowledge so the decision-making process is based on a scientific and research foundation.

Textbook of Post-ICU Medicine

Author : Robert D. Stevens
Publisher : Academic
ISBN 13 : 0199653461
Total Pages : 649 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Textbook of Post-ICU Medicine by : Robert D. Stevens

Download or read book Textbook of Post-ICU Medicine written by Robert D. Stevens and published by Academic. This book was released on 2014 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surviving critical illness is not always the happy ending that we imagine for patients. Intensive care unit (ICU) teams have traditionally focused on short term goals such as stabilizing or reversing organ system dysfunction, with little understanding of what became of patients once they left the ICU. However, research conducted in recent years has demonstrated that many ICU survivors can suffer from ill health and mental health issues for months or years to follow. The Textbook of Post-ICU Medicine: The Legacy of Critical Care identifies the long term outcomes of ICU and the steps that can be taken to improve patients' health and wellbeing. Describing the major clinical syndromes affecting ICU survivors, the book delineates established or postulated biological mechanisms of the post-acute recovery process, and discusses strategies for treatment and rehabilitation to promote recovery in the ICU and in the long term. The book serves as a unique reference for general practitioners, internists and nurses caring for long term ICU survivors as well as specialists in intensive care medicine, neurology, psychiatry, and rehabilitation medicine.

Infectious Diseases in Critical Care

Author : Jordi Rello
Publisher : Springer Science & Business Media
ISBN 13 : 9783540344056
Total Pages : 646 pages
Book Rating : 4.3/5 (44 download)

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Book Synopsis Infectious Diseases in Critical Care by : Jordi Rello

Download or read book Infectious Diseases in Critical Care written by Jordi Rello and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Critical care practitioners are often the initial providers of care to seriously ill patients with infections. This book provides clinicians practicing in the intensive care unit with a reference to help guide their care of infected patients. It brings together a group of international authors to address important topics related to infectious diseases for the critical care practitioner.

ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes

Author : J.A. Kellum
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318024074
Total Pages : 218 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes by : J.A. Kellum

Download or read book ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes written by J.A. Kellum and published by Karger Medical and Scientific Publishers. This book was released on 2013-05-14 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Associated with both acute kidney injury (AKI) and cardio-renal syndromes (CRS), new biomarkers represent both a popular area of investigation and a new opportunity for advancement of therapy. This book contains the resolutions of the most recent ADQI conferences on biomarkers in AKI (Dublin) and on cardio-renal syndromes (Venice). The first part answers specific questions about new biomarkers and their use and utility in AKI: What are the most suitable candidate molecules and physiologic measures, how solid and evidence based is the discovery phase? How can we incorporate the new biomarkers in the AKI conceptual model describing the evolution from susceptibility to insult, decreased GFR and organ death? Even if we have a positive biomarker pattern and we can identify patients at risk or patients with early or even subclinical AKI, how is this information affecting our clinical behavior and practice? The second part is dedicated to the appraisal of the current knowledge about the pathophysiological mechanisms involved in different forms of CRS: it contains contributions on the state-of-the-art knowledge and practice of CRS, particularly focusing on the pathophysiology of the five subtypes. Acute and chronic mechanisms of damage are explored in depth, with particular attention to the primacy of organ involvement and the subsequent pathways of organ crosstalk.Presenting the most recent research in the field of biomarkers, AKI and CRS, this publication is an important educational tool for advanced investigators and clinical experts, but also for students and fellows.