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Author : Anthony E. Boitano
Publisher :
ISBN 13 :
Total Pages : 846 pages
Book Rating : 4.3/5 (91 download)
Download or read book Mechanisms of a Pro-apoptotic Benzodiazepine written by Anthony E. Boitano and published by . This book was released on 2005 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Cory D. Emal
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.3/5 (91 download)
Download or read book Design and Synthesis of Mechanism-based Cysteine Protease Inhibitors and Pro-apoptotic 1,4-benzodiazepines written by Cory D. Emal and published by . This book was released on 2003 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kathryn Marie Johnson
Publisher :
ISBN 13 :
Total Pages : 770 pages
Book Rating : 4.3/5 (91 download)
Download or read book Elucidation of the Target and Molecular Mechanism of Action of the Immunomodulatory Benzodiazepine, Bz-423 written by Kathryn Marie Johnson and published by . This book was released on 2005 with total page 770 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Neal Benjamin Blatt
Publisher :
ISBN 13 :
Total Pages : 574 pages
Book Rating : 4.3/5 (91 download)
Download or read book Characterization of a Novel Pro-apoptotic Benzodiazepine written by Neal Benjamin Blatt and published by . This book was released on 2002 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 994 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 994 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lori M. Buhlman
Publisher : Springer
ISBN 13 : 3319421395
Total Pages : 279 pages
Book Rating : 4.3/5 (194 download)
Download or read book Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease written by Lori M. Buhlman and published by Springer. This book was released on 2016-09-13 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.
Author : Gyorgy Keri
Publisher : CRC Press
ISBN 13 : 020321997X
Total Pages : 662 pages
Book Rating : 4.2/5 (32 download)
Download or read book Molecular Pathomechanisms and New Trends in Drug Research written by Gyorgy Keri and published by CRC Press. This book was released on 2002-11-14 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the basic mechanisms of human disease is essential for any student or professional engaged in drug research and development. Functional gene analysis (genomics), protein analysis (proteomics), and other molecular biological techniques have made it possible to understand these cellular processes, opening up exciting opportunities for no
Author : James A. Radosevich
Publisher : John Wiley & Sons
ISBN 13 : 1119432359
Total Pages : 768 pages
Book Rating : 4.1/5 (194 download)
Download or read book Apoptosis and Beyond written by James A. Radosevich and published by John Wiley & Sons. This book was released on 2018-09-18 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.
Author : David A. Gewirtz
Publisher : Springer Science & Business Media
ISBN 13 : 1588295273
Total Pages : 596 pages
Book Rating : 4.5/5 (882 download)
Download or read book Apoptosis, Senescence and Cancer written by David A. Gewirtz and published by Springer Science & Business Media. This book was released on 2007-12-17 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides insight into established practices and research into apoptosis and senescence by examining techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. This book concludes with established cancer therapies.
Author :
Publisher :
ISBN 13 :
Total Pages : 2036 pages
Book Rating : 4.:/5 (319 download)
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2036 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author : Jane K. Setlow
Publisher : Springer Science & Business Media
ISBN 13 : 0306466457
Total Pages : 242 pages
Book Rating : 4.3/5 (64 download)
Download or read book Genetic Engineering written by Jane K. Setlow and published by Springer Science & Business Media. This book was released on 2001-08-31 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, our laboratory and others have been concerned with molecular archaeological studies aimed at revealing the origins and evolutionary histories of permeases (1). These studies have revealed that several different families, defined on the basis of sequence similarities, arose independently of each other, at different times in evolutionary history, following different routes. When complete microbial genomes first became available for analysis, we adapted p- existing software and designed new programs that allowed us quickly to identify probable transmembrane proteins, estimate their topologies and determine the likelihood that they function in transport (2). This work allowed us to expand previously-recognized families and to identify dozens of new families. All of this work then led us to attempt to design a rational but comprehensive classification system that would be applicable to the complete complement of transport systems found in all living organisms (3). The classification system that we have devised is based primarily on mode of transport and energy coupling mechanism, secondarily on molecular phylogeny, and lastly on the substrate specificities of the individual permeases (4).
Author : Ian Stolerman
Publisher : Springer Science & Business Media
ISBN 13 : 3540686983
Total Pages : 1433 pages
Book Rating : 4.5/5 (46 download)
Download or read book Encyclopedia of Psychopharmacology written by Ian Stolerman and published by Springer Science & Business Media. This book was released on 2010-07-31 with total page 1433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a broad overview of the central topics and issues in psychopharmacology, biological psychiatry and behavioral neurosciences, with information about developments in the field, including novel drugs and technologies. The more than 2000 entries are written by leading experts in pharmacology and psychiatry and comprise in-depth essays, illustrated with full-color figures, and are presented in a lucid style.
Author : James A. Radosevich
Publisher : John Wiley & Sons
ISBN 13 : 1119432421
Total Pages : 784 pages
Book Rating : 4.1/5 (194 download)
Download or read book Apoptosis and Beyond, 2 Volume Set written by James A. Radosevich and published by John Wiley & Sons. This book was released on 2018-12-27 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.
Author : Margaret Knowles
Publisher : Oxford University Press
ISBN 13 : 0198568533
Total Pages : 555 pages
Book Rating : 4.1/5 (985 download)
Download or read book Introduction to the Cellular and Molecular Biology of Cancer written by Margaret Knowles and published by Oxford University Press. This book was released on 2005-07-28 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title includes the following features: Great breadth of coverage inone volume: covers all aspects of cancer, in a concise and affordable format;Provides a comprehensive introduction to the initiation, development, andtreatment of cancer; Chapter are written by experts in each field, giving astate-of-the-art summary of each topic; Extensive references provide links toall the relevant literature, facilitating further study
Author : Covadonga Alonso
Publisher : Springer Science & Business Media
ISBN 13 : 3540742646
Total Pages : 346 pages
Book Rating : 4.5/5 (47 download)
Download or read book Viruses and Apoptosis written by Covadonga Alonso and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using different viral models, molecular pathways regulated by viral genes and their role in the pathogenesis of infection are analyzed. The book also offers an update of known signaling pathways in apoptosis and their role in normal and infected cells. Special emphasis is given to molecular pathways underlying viral transformation and oncogenesis and how research in this area is opening opportunities in cancer therapy.
Author : Charles O. Pickens
Publisher : Nova Publishers
ISBN 13 : 9781600215070
Total Pages : 238 pages
Book Rating : 4.2/5 (15 download)
Download or read book Cell Apoptotic Signalling Pathways written by Charles O. Pickens and published by Nova Publishers. This book was released on 2007 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer's disease and cancer. A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. This book focuses on cell apoptotic signalling pathways.
Author : Mercurio
Publisher : Jones & Bartlett Publishers
ISBN 13 : 0763771163
Total Pages : 973 pages
Book Rating : 4.7/5 (637 download)
Download or read book Understanding Toxicology written by Mercurio and published by Jones & Bartlett Publishers. This book was released on 2016-08-30 with total page 973 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding Toxicology is a comprehensive study of toxicants and their impact on all levels of biology--from cell, to complex organism, to ecosystem. Unlike other texts of its kind, this text is uniquely structured by biological system, making it easy for readers to understand the impact of toxins on each system. Common mechanisms are explored in the cellular and complex organ system chapters to approach a systems biology perspective that is more applicable to modern computational toxicology risk assessment. Understanding Toxicology begins with three research questions that challenge the reader to discover what information is needed to solve controversies at the level of the cell, the complex organism, and the ecosystem. The book continues with a cellular, complex organism, and ecosystem analysis of toxicology principles including risk assessment. The cellular section follows common mechanisms from the outside to the inside of cells and individual organelles. A forensic approach analyzes complex organisms from outside to inside. The ecosystem section starts with a dispersion approach to determine environmental concentration and addresses toxicants in divisions similar to how the EPA determines impacts. Key Features • Uses lively, engaging examples making the text fun and easy to read and understand • Allows the reader to approach the subject from a research perspective as well as a public policy perspective • Covers biological toxicants including venoms, poisons, as well as microbial and fungal toxins, and plant toxins • Thoroughly covers all organisms including fish, plants, and microbes • Includes outlines and review questions in each chapter
