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Download or read book Farum Midtpunkt kabel TV written by and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
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Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.:/5 (675 download)
Download or read book 在宅インスリン自己注射患者・介護者用マニュアル written by and published by . This book was released on 1994 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)
Download or read book Mechanism of Regression of C-MYC-Induced Mammary Tumors in a Conditional Transgenic Model written by and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathways stimulated by the oncogenes HER2/Neu/ErbB2, Wnt-l, and H-ras are aberrantly activated in many human cancers, including breast cancer, and have been shown to play a role in carcinogenesis. In order to better investigate the role these genes play in breast cancer, we generated mouse models that inducibly express activated forms of these oncogenes in the mammary gland. This system allows us to activate these oncogenic pathways during specific windows of mammary gland development, as well as to remove the initiating oncogenic stimulus after the development of a tumor or during later stages of tumor progression. As such, we anticipate that the study of these models will provide valuable insights into the mechanisms by which activation of these pathways contributes to breast cancer development or progression, and will ultimately aid in the generation of therapeutic strategies that specifically target these pathways. We have found that expression of Neu in the mammary glands of transgenic mice results in the development of both invasive adenocarcinomas and pulmonary metastases that remain dependent upon Neu expression for maintenance of the transformed state. We have also determined that both Wnt-l and c-Myc synergize with Neu in mammary tumorigenesis.
Author : Matthew Jamerson
Publisher :
ISBN 13 :
Total Pages : 14 pages
Book Rating : 4.:/5 (452 download)
Download or read book Cooperation of Bc1-XL and C-Myc in Mammary Tumorigenesis written by Matthew Jamerson and published by . This book was released on 1998 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: C-Myc oncogene has been reported to be amplified in 25-30% and overexpressed in more than 70% of human breast cancers and has been demonstrated to be involved in signaling cell proliferation and apoptosis. The Bcl-xL protein, a member of the Bcl-2 apoptosis- modulatory family, is known to block apoptotic cell death under a wide variety of conditions and has been shown to be overexpressed in some human breast cancers and breast cancer cell lines. Evidence from a c-Myc/TGFalpha bitransgenic mouse model suggests that escape from c-Myc-induced apoptosis may be necessary for continued cell cycle progression and neoplastic development. The focus of this study is to determine if Bcl-xL expression cooperates with c-Myc overexpression in mammary tumorigenesis in vi and in vitro by blocking c-Myc-induced apoptosis but not c-Myc-mediated cell cycle progression and cell proliferation. Transgenic c-Myc mice will be mated with transgenic Bcl-xL mice to produce bitransgenic offspring which will be observed to determine whether Bcl-xL expression is sufficient to synergize with c-Myc and enhance mammary tumor incidence and accelerate tumor onset (latency). The utilization of this model system will aid in the dissection of the molecular mechanisms behind the development of breast cancer.
Author : Jeffrey Stuart Ross
Publisher : Jones & Bartlett Learning
ISBN 13 : 9780763748104
Total Pages : 642 pages
Book Rating : 4.7/5 (481 download)
Download or read book Molecular Oncology of Breast Cancer written by Jeffrey Stuart Ross and published by Jones & Bartlett Learning. This book was released on 2005 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive reference to focus on the molecular development and treatment of the disease, Molecular Oncology of Breast Cancer provides authoritative information across the spectrum of modern breast cancer research and clinical care. Edited by two world-class experts in cancer pathology, drug development, and patient management, with contributions from over 50 experts, this ground-breaking text describes the genes, proteins, and biologic pathways that are being evaluated today and will be tested in the future to derive the molecular signature of each newly diagnosed breast cancer. For the first time, readers can now obtain, in a single volume, up-to-date information on how molecular-based tests are being used to identify predisposition, provide earliest detection, decide classification based on genetic fingerprint and predict therapy-specific outcomes. MOBC includes unique chapters on functional imaging and the impact of targeted therapies on the FDA approval process. This book gives readers vital, up-to-date information on important molecular discoveries that affect the everyday management of the breast cancer patient.
Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mohammed S. Razzaque
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805575688
Total Pages : 222 pages
Book Rating : 4.8/5 (55 download)
Download or read book Renal Fibrosis written by Mohammed S. Razzaque and published by Karger Medical and Scientific Publishers. This book was released on 2003-01-01 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication provides a synopsis of the rapid progress made in the field of renal cell biology during the last decade, progress which has resulted in a better conceptual understanding of the cellular and molecular mechanisms of fibrotic renal disease. These developments have provided new therapeutic choices and led to the discovery of gene-based therapeutic options. The topics covered in this book have been carefully selected from the immense number of aspects of the disease to provide essential information on the molecular basis of renal fibrosis. Individual chapters discuss topics such as proteinuria and tubulointerstitial injury, the roles and regulation of TGF-beta, chemokines, oxidant stress, matrix remodeling, significance of renal expression of NF-kappa, and the potential impact of cell death in renal fibrosis.Written so as to present the complex information as simply as possible, this publication will be a very useful tool for general health professionals involved in the fields of immunology and cell biology, as well as for clinicians and researchers within the fields of nephrology, pathology and matrix biology.
Author : Marc E. Lippman
Publisher : Springer Science & Business Media
ISBN 13 : 1461539404
Total Pages : 455 pages
Book Rating : 4.4/5 (615 download)
Download or read book Regulatory Mechanisms in Breast Cancer written by Marc E. Lippman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.
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ISBN 13 :
Total Pages : 1588 pages
Book Rating : 4.:/5 (3 download)
Download or read book Research Awards Index written by and published by . This book was released on 1985 with total page 1588 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David A. Frank
Publisher : Springer Science & Business Media
ISBN 13 : 1402073402
Total Pages : 358 pages
Book Rating : 4.4/5 (2 download)
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Author : Bharat B. Aggarwal
Publisher : Springer
ISBN 13 : 3034808372
Total Pages : 489 pages
Book Rating : 4.0/5 (348 download)
Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
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Publisher : Elsevier
ISBN 13 : 0080542433
Total Pages : 349 pages
Book Rating : 4.0/5 (85 download)
Download or read book Protein Lipidation written by and published by Elsevier. This book was released on 2000-10-19 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented. The enzymatic mechanisms of protein lipidation Three-dimensional structures of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase
Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author : Laura Soucek
Publisher : Humana
ISBN 13 : 9781071614785
Total Pages : 349 pages
Book Rating : 4.6/5 (147 download)
Download or read book The Myc Gene written by Laura Soucek and published by Humana. This book was released on 2021-05-23 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides new and updated chapters detailing recent advances in MYC research and current techniques. Chapters guide readers through protocols on how to express and purify MYC protein, X-ray crystallography, NMR, techniques to study how MYC is modified, apoptosis, senescence, proliferation, metabolic changes, translation, tumorigenesis,reprogramming, and clinical application of MYC studies.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Myc Gene: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
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Publisher :
ISBN 13 :
Total Pages : 1808 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1808 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stuart K. Calderwood
Publisher : Springer Science & Business Media
ISBN 13 : 1402064012
Total Pages : 399 pages
Book Rating : 4.4/5 (2 download)
Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Author : Graham Carpenter
Publisher : Elsevier
ISBN 13 : 0080472583
Total Pages : 175 pages
Book Rating : 4.0/5 (84 download)
Download or read book The EGF Receptor Family written by Graham Carpenter and published by Elsevier. This book was released on 2004-02-06 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormity of the literature on growth factors, plus the breadth of the biological disciplines and technical expertise required prohibits a comprehensive review by even a multi-disciplinary panel of authors. To provide an alternative that is feasible for authors and digestible by readers, this review compendium consists of a collection of articles, each covering an aspect of teh ErbB/EGF field. This compilation features articles on growth factor ligands, neuregulins, and individual receptors. The second part of the book concentrates on the biological context of the ErbB receptors, particularly in mammary development and in cancer. It concludes with a discussion of the genetic systems that have enabled significant advances in research in this area.
