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Mechanism Of Abnormal Cell Extracellular Matrix Interactions In Human Breast Cancer
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Book Synopsis Mechanism of Abnormal Cell-Extracellular Matrix Interactions in Human Breast Cancer by :
Download or read book Mechanism of Abnormal Cell-Extracellular Matrix Interactions in Human Breast Cancer written by and published by . This book was released on 1998 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: Message levels of premalignant (S2) and tumorigenic (T4-2) cells, two sublines of a human breast cancer series, were compared to identify molecules marking the final events in malignant transformation. A novel gene Az-i expressed at a>10-fold higher level in S2 than in T4-2 cells was isolated. While Az-i message was present in nonmalignant breast cell lines, primary luminal epithelial cells, and cells from reduction mammoplasty, it was drastically downregulated or absent in ten mammary carcinoma cell lines and four breast carcinomabiopsies. Ectopically-expressed Az- 1 in T4-2 cells reverted them to a normal-like phenotype in a three-dimensional basement membrane culture. interestingly, upregulation of Az-i message was also correlated with phenotypic normalization of breast tumor cells in a % 1 -integrin reversion system. Furthermore, Az-i stably- transfected T4-2 cells were 80% less invasive and clonogenic in matrigel invasion and colony-forming assays, respectively, than the vector transfectants. Second structure predictions indicated that C-terminus of Az-i is homologous to the rod domain of plakin family, the versatile organizers of cytoskeletal architecture. These data suggest that Az-i may participate in the cytoskeletal organization of breast epithelial cells and Az-i may provide a link to the understanding of the abnormal cell-cell and cell-extracellular matrix interactions in the breast tumor cells.
Book Synopsis Mechanisms of Abnormal Cell-Extracellular Matrix Interactions in Human Breast Cancer by :
Download or read book Mechanisms of Abnormal Cell-Extracellular Matrix Interactions in Human Breast Cancer written by and published by . This book was released on 1995 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: By a three-dimensional reconstituted basement membrane (EHS matrix) assay, we have previously shown that breast morphogenesis is regulated by cell-extracellular matrix (ECM) interactions and these contacts are impaired in malignancy. A series of studies were conducted to investigate the significance of cell/ECM interactions in tumorigenesis. ECM influences expression of lactoferrin, a differentiation marker, either by altering cell-cell interactions or by providing mechanochemical signals that regulate cell shape. Emphasis on the importance of intact beta-1-integrin signaling was indicated by function blocking studies. Phenotypically normal HMT-3522 cells failed to grow or differentiate and underwent apoptosis in the presence of beta-1 integrin blocking antibodies. In contrast a number of tumorigenic cell lines demonstrated refractoriness to these effects indicating they have circumvented this regulatory pathway. Finally the importance of cell/ECM interactions in the maintenance of the differentiated phenotype was underscored by examining the effects of overexpression of the putative tumor suppressor gene nm23-H1 in metastatic cell line MDA-MB- 435, where several aspects of normal breast morphogenesis was recapitulated. Further studies are presently underway to dissect other ECM components and their signaling pathways that are critical in breast cancer progression.
Book Synopsis Cell-Extracellular Matrix Interactions in Cancer by : Roy Zent
Download or read book Cell-Extracellular Matrix Interactions in Cancer written by Roy Zent and published by Springer Science & Business Media. This book was released on 2010-10-22 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.
Book Synopsis Adhesion-Dependent Regulation of Cell Growth and Apoptosis in Human Breast Cancer by :
Download or read book Adhesion-Dependent Regulation of Cell Growth and Apoptosis in Human Breast Cancer written by and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of a tumor cell to grow outside its local environment (metastasize) is a major problem in the development and therapeutic treatment of breast cancer. The loss of the requirement for cell-matrix interactions plays a critical role in the development of cancer. Normal epithelial cells require attachment to the extracellular matrix (ECM) not only for proliferation but also for survival, as disruption of cell-ECM interactions can result in reversible cell growth arrest and induction of apoptosis, a phenomenon termed 'anoikis'. Elucidating the mechanisms by which the interactions of cells with the ECM generate and regulate downstream signals that promote cell growth and survival is critical to understanding cancer. Activation of actomyosin contractility is an essential step during adhesion-dependent signaling. We are studying the role of specific components of the actin cytoskeleton whose expression has been implicated in the transformed phenotype. These studies will provide important new information concerning the role of these actin filament-associated proteins in adhesion-dependent cell signaling and the potential of inhibiting signal transduction pathways dependent on actomyosin contractility as a therapeutic target and adjuvant for the treatment of breast cancer, as well as other cancers.
Book Synopsis Extracellular Matrix in Tumor Biology by : Rolf A. Brekken
Download or read book Extracellular Matrix in Tumor Biology written by Rolf A. Brekken and published by Springer. This book was released on 2017-08-04 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.
Book Synopsis Epithelial—Mesenchymal Interactions in Cancer by : Itzhak D. Goldberg
Download or read book Epithelial—Mesenchymal Interactions in Cancer written by Itzhak D. Goldberg and published by Birkhäuser. This book was released on 2013-03-07 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contribution of epithelia-mesenchyme interaction to normal development (eg., tissue formation) and to neoplasia has become a subject of increasing interest to scientists because of recent progress in deciphering the molecular signals that mediate this interaction. Clearly, some of the same types of molecules (eg., growth factors and their receptors, proteolytic enzymes, cell adhesion molecules, and structural proteins of the extracellular matrix) mediate exchange of information between epithelia and mesenchyme during normal development and malignant growth. However, defects in the regulation of this exchange appear to contribute to malignancy by allowing growth promoting, invasogenic, and angiogenic factors to accumulate within the microenvironment of the tumor. For example, recent studies suggest that abnormal interactions between tumor epithelial cells and stromal mesenchymal cells contribute to the overproduction and accumulation of scatter factor (hepatocyte growth factor), an invasogenic and angiogenic cytokine, in certain types of tumor. The production and and activation of type IV collagenase, a matrix-degrading enzyme required for tumor cell invasion, appears to require intimate cooperation between tumor and stromal cells. The material contained in this volume highlights the state-of-the-art of knowledge of the molecular mechanisms by which epithelia and mesenchyme collaborate, and the abnormalities in these mechanisms that may lead to the development of cancer.
Book Synopsis Signal Transduction in Cancer by : David A. Frank
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Book Synopsis Extracellular Matrix Induced Integrin Signal Transduction and Breast Cancer Invasion by :
Download or read book Extracellular Matrix Induced Integrin Signal Transduction and Breast Cancer Invasion written by and published by . This book was released on 1997 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast epithelial cell function is greatly influenced by interactions with the underlying basal lamina. Matrilysin, a matrix metalloproteinase, has previously been shown to be expressed in both adenomas and carcinomas of the human breast. We have tested the hypothesis that cell-ECM interactions regulate the expression of matrilysin in human breast carcinoma cells in vitro. We have used northern analysis and in situ hybridization to determine levels and localization of several members of the MMP family in human tumors implanted into nude mouse mammary glands. Tumors from mammary glands injected with the human breast adenocarcinoma cell line MDA-MB-468 were shown to express matrilysin; a MMP that is primarily expressed in normal and neoplastic cells of epithelial origin. Stromelysin-1 was induced in the stroma of the host mammary gland in the region immediately surrounding the tumor. Northern analysis revealed that gelatinase A, which - was not produced by MDA-MB-468 in vitro. was expressed in the tumor. This combination of MMPs along with stromelysin-3, which has been extensively studied in breast cancer. may lead to the eventual metastasis of mammary tumors to the regional lymph nodes and distant sites. We also describe a new antibody against human matrilysin which indicates that matrilysin is expressed in epithelial cells as expected and appears to be apically secreted in endometrium, Breast and prostate. This lumenal secretion of an MMP that degrades extracellular matrix molecules may have important implications as to its function in normal and neoplastic tissues.
Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Influence of Extracellular Matrix on Hormonal Responsiveness of Human Breast Cancer Cells by : Martin Bryan Levy
Download or read book Influence of Extracellular Matrix on Hormonal Responsiveness of Human Breast Cancer Cells written by Martin Bryan Levy and published by . This book was released on 1982 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Extracellular Matrix in Development by : Douglas W. DeSimone
Download or read book Extracellular Matrix in Development written by Douglas W. DeSimone and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.
Book Synopsis Extracellular Matrix in Breast Cancer Invasion by :
Download or read book Extracellular Matrix in Breast Cancer Invasion written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of our project is to find novel treatments for breast cancer metastasis. We view metastasis as a breakdown of mechanisms that govern tissue organization. We postulated that metastasis is initiated by molecular cues that improperly stimulate cancer cell motility. Therefore, our approach is to block metastasis by understanding, and then interfering with, molecular and cellular mechanisms that regulate cell motility. We found that, in the mammary gland, several of these mechanisms revolve around the interaction of matrix metalloproteases (MMP) with laminin-5 (Ln-5), an extracellular matrix protein of the breast gland basement membrane. One major finding in this past year was the identification of the Ln-5 site onto which cells adhere and migrate. We also defined the position, relative to this site, of the docking site for antibodies that block cell motility. A second important finding is the location of Ln-5 sites that are cleaved by MMPs, and the compositon of the Ln-5 fragments resulting from this proteolytic activity. This information is critical to design in vivo animal experiments in which we will test the ability of antibodies to Ln-5, or Ln-5 fragments, to block tumor cell motility and hopefully metastasis.
Book Synopsis Second Harmonic Generation Imaging by : Francesco S. Pavone
Download or read book Second Harmonic Generation Imaging written by Francesco S. Pavone and published by Taylor & Francis. This book was released on 2016-04-19 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second-harmonic generation (SHG) microscopy has shown great promise for imaging live cells and tissues, with applications in basic science, medical research, and tissue engineering. Second Harmonic Generation Imaging offers a complete guide to this optical modality, from basic principles, instrumentation, methods, and image analysis to biomedical a
Book Synopsis Principles of Bone Biology by : John P. Bilezikian
Download or read book Principles of Bone Biology written by John P. Bilezikian and published by Academic Press. This book was released on 2008-09-29 with total page 2074 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition
Download or read book Tumor Organoids written by Shay Soker and published by Humana Press. This book was released on 2017-10-20 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
Book Synopsis Inflammation and Cancer by : Bharat B. Aggarwal
Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
