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Author : Yehuda Arav
Publisher :
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.:/5 (457 download)
Download or read book Mathematical Modeling of Intestinal Drug Absorption written by Yehuda Arav and published by . This book was released on 2008 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stephen James Firmer
Publisher :
ISBN 13 :
Total Pages : 716 pages
Book Rating : 4.:/5 (22 download)
Download or read book Mathematical Modelling of Drug Absorption from the Gastrointestinal Tract written by Stephen James Firmer and published by . This book was released on 1989 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : CRC Press
ISBN 13 : 9780849330872
Total Pages : 627 pages
Book Rating : 4.3/5 (38 download)
Download or read book Understanding Drug Release and Absorption Mechanisms written by and published by CRC Press. This book was released on 2007 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Understanding Drug Release and Absorption Mechanisms builds a firm understanding ofall elements needed to conceive, build, and implement successful models of drug release. Written by experts with broad industrial and academic experience, this book discusses the underlying physical principles, shows how to build mathematical models based on these principles, and finally compares the resulting models with experimental results. The authors begin by introducing the basics of modeling, physiological details of gastrointestinal and dermal absorption pathways, rheology, mass transport and thermodynamics, dissolution and partitioning, as well as size effects on the dissolution of crystallites. From this baseline, the authors explore applications in drug release from various delivery systems, specifically matrix systems, microemulsions, and permeability through membranes. Working systematically from theory to working models, Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach demonstrates the steps involved in designing, building, and implementing realistic and reliable models of drug release without unrealistically simplifying the theoretical parameters.
Author : Jean-Maurice Vergnaud
Publisher : CRC Press
ISBN 13 : 1420037854
Total Pages : 245 pages
Book Rating : 4.4/5 (2 download)
Download or read book Assessing Bioavailablility of Drug Delivery Systems written by Jean-Maurice Vergnaud and published by CRC Press. This book was released on 2005-05-26 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring how to apply in vitro/in vivo correlations for controlled release dosage forms, Bioavailability of Drug Delivery Systems: Mathematical Modeling clearly elucidates this complex phenomena and provides a guide for the respective mathematical modeling. The book introduces mathematical modeling methods for calculating the profiles of plasma le
Author : Panos Macheras
Publisher : Springer Science & Business Media
ISBN 13 : 0387319107
Total Pages : 446 pages
Book Rating : 4.3/5 (873 download)
Download or read book Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics written by Panos Macheras and published by Springer Science & Business Media. This book was released on 2006-04-26 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.
Author : Mario Grassi
Publisher : CRC Press
ISBN 13 : 1420004654
Total Pages : 648 pages
Book Rating : 4.4/5 (2 download)
Download or read book Understanding Drug Release and Absorption Mechanisms written by Mario Grassi and published by CRC Press. This book was released on 2006-12-26 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Under
Author : Maria Prapopoulou
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book The Development of a Computation/mathematical Model to Predict Drug Absorption Across the Skin written by Maria Prapopoulou and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bret Berner
Publisher : John Wiley & Sons
ISBN 13 : 1119772737
Total Pages : 466 pages
Book Rating : 4.1/5 (197 download)
Download or read book Drug Delivery Approaches written by Bret Berner and published by John Wiley & Sons. This book was released on 2021-08-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
Author : William Henry Barr
Publisher :
ISBN 13 :
Total Pages : 412 pages
Book Rating : 4.:/5 (44 download)
Download or read book Some Physico-chemical and Physiological Factors in Intestinal Drug Absorption and Metabolism written by William Henry Barr and published by . This book was released on 1966 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Clive Washington
Publisher : Taylor & Francis Group
ISBN 13 :
Total Pages : 128 pages
Book Rating : 4.3/5 (91 download)
Download or read book Pharmacokinetic Modelling Using Stella on the Apple Macintosh written by Clive Washington and published by Taylor & Francis Group. This book was released on 1990 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to STELLA, a computer program which allows time-dependent processes to be modelled and their behaviour investigated. Aimed at pharmacologists involved in modelling physiological reactions, it provides a way of constructing a model of a system and calculating its behaviour.
Author : Jennifer B. Dressman
Publisher : CRC Press
ISBN 13 : 1420077341
Total Pages : 432 pages
Book Rating : 4.4/5 (2 download)
Download or read book Oral Drug Absorption written by Jennifer B. Dressman and published by CRC Press. This book was released on 2016-04-19 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an
Author : Bret Berner
Publisher : John Wiley & Sons
ISBN 13 : 1119772753
Total Pages : 466 pages
Book Rating : 4.1/5 (197 download)
Download or read book Drug Delivery Approaches written by Bret Berner and published by John Wiley & Sons. This book was released on 2021-08-04 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : Naga Lakshmi Ramana Susarla
Publisher :
ISBN 13 :
Total Pages : 111 pages
Book Rating : 4.:/5 (934 download)
Download or read book Theoretical Prediction of Drug Release in GI Tract from Spherical Matrix Systems written by Naga Lakshmi Ramana Susarla and published by . This book was released on 2011 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: The significance of controlled release drug delivery systems (CRDDS) lies in their ability to deliver the drug at a steady rate thus reducing the dosage interval and providing a prolonged pharmacodynamic effect. But despite the steadily increasing practical importance of these devices, little is known regarding their underlying drug release mechanisms. Mathematical modeling of these drug delivery systems could help us understand the underlying mass transport mechanisms involved in the control of drug release. Mathematical modeling also plays an important role in providing us with valuable information such as the amount of drug released during a certain period of time and when the next dosage needs to be administered. Thus, potentially reducing the number of in-vitro and in-vivo experiments which in some cases are infeasible. There is a large spectrum of published mathematical models for predicting drug release from CRDDS in vitro following conventional approaches. These models describe drug release from various types of controlled delivery devices for perfect sink conditions. However in a real system (human body) a sink condition may not be applicable. For a CRDDS along with the physiochemical properties (solubility, diffusion, particle size, crystal form etc.) the physiological factors such as gastrointestinal tract (GI) pH, stomach emptying, (GI) motility, presence of food, elimination kinetics etc., also affect the rate of drug release. As the drug delivery system is expected to stay in the human body for a longer period of time when compared to a immediate release dosage form the process of drug release occurs in conjunction with the absorption (for oral delivery systems) and elimination kinetics. Earlier work by Ouruemchi et.al.[71] include prediction of the plasma drug concentration for an oral diffusion controlled drug delivery system. Amidon et.al.[68] developed several models for predicting the amount of drug absorbed within through the intestine walls for immediate release dosage forms. However none of these models study the effect of absorption rate on the rate of drug release for an oral controlled drug delivery system. In this work mathematical models are developed for prediction of drug release from both diffusion controlled and dissolution controlled drug delivery systems taking into account the affect of absorption rate. Spherical geometry of the particles is considered. The model is developed by assuming that the drug is release into a finite volume and is thereby absorbed through the intestine wall following first order kinetics. A closed form solution is obtained for the prediction of fraction of drug released for a diffusion controlled drug delivery system. The results are compared with both experimental data (taken from literature) as well as existing models in the literature. Whereas for a dissolution-diffusion controlled drug delivery system non linear dissolution kinetics are taken into consideration and the problem is solved by both numerical and analytical techniques. In addition two simple models are also presented for dissolution controlled drug delivery devices.
Author : Xuanqiang Yu
Publisher :
ISBN 13 :
Total Pages : 364 pages
Book Rating : 4.3/5 (91 download)
Download or read book A Biopharmaceutics Design Model for Oral Delivery written by Xuanqiang Yu and published by . This book was released on 1996 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Erik Matteo Prochet Widmark
Publisher :
ISBN 13 : 9780931890079
Total Pages : 163 pages
Book Rating : 4.8/5 (9 download)
Download or read book Principles and Applications of Medicolegal Alcohol Determination written by Erik Matteo Prochet Widmark and published by . This book was released on 1981-01-01 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Carsten Ehrhardt
Publisher : Springer Science & Business Media
ISBN 13 : 0387749012
Total Pages : 711 pages
Book Rating : 4.3/5 (877 download)
Download or read book Drug Absorption Studies written by Carsten Ehrhardt and published by Springer Science & Business Media. This book was released on 2007-12-22 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a well thought-out, highly practical text covering contemporary ‘in vitro’ techniques for drug absorption studies. Starting at the molecular level of investigation, it continues with cell monolayer models (both primary and cell lines) and culminates with in situ techniques as a final testing format. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix consisting of a number of practical protocols is available online, updated as needed, and should prove very helpful to apply the techniques directly to the benchside.
