Discovery and Development of Antidiabetic Agents from Natural Products

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Author :
Publisher : Elsevier
ISBN 13 : 0128096926
Total Pages : 334 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Discovery and Development of Antidiabetic Agents from Natural Products by : Goutam Brahmachari

Download or read book Discovery and Development of Antidiabetic Agents from Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2016-10-11 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. - Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery - Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues - Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Inflammation and Natural Products

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Publisher : Academic Press
ISBN 13 : 0128192194
Total Pages : 420 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Inflammation and Natural Products by : Sreeraj Gopi

Download or read book Inflammation and Natural Products written by Sreeraj Gopi and published by Academic Press. This book was released on 2021-01-19 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approx.446 pagesApprox.446 pages

Marine Anti-inflammatory Agents

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Publisher : MDPI
ISBN 13 : 3039215728
Total Pages : 248 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Marine Anti-inflammatory Agents by : Javier Avila-Román

Download or read book Marine Anti-inflammatory Agents written by Javier Avila-Román and published by MDPI. This book was released on 2019-10-25 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute inflammation is a highly regulated process, and its dysregulation can lead to the development of a chronic inflammatory state which is believed to play a main role in the pathogenesis of many diseases, including cancer. In recent years, the need to find new anti-inflammatory molecules has raised the scientific community´s interest for marine natural products. In this regard, the marine environment represents a source for isolating a wealth of bioactive compounds. In this Special Issue, the reported products have been obtained from microalgae, sea cucumber, octopus, squid, red alga-derived fungus, cnidarians, hard-shelled mussel, and sponges. This Special Issue of Marine Drugs covers both the in vitro and in vivo studies of marine agents with anti-inflammatory activities, in addition to clinical trials conducted in humans. Among the bioactive molecules reported in the papers are lipid compounds, such as glycolipids, which, for the first time, demonstrated their preventive effects in an inflammatory model of skin hyperplasia. In addition, beneficial effects of the carotenoid fucoxanthin were shown in the same model of skin hyperplasia, in UVB-induced damage and in a model of inflammatory pain. Moreover, frondanol, a lipid extract from Cucumaria frondosa, attenuated inflammation in an acute colitis model. Another paper evaluated the fatty acid compositions of lipid extracts from some common seafood organisms, reporting the highest level of omega 3 polyunsaturated fatty acids and the highest anti-inflammatory activity in the extracts from octopus and squid byproducts. Additionally, the anti-inflammatory effects of other marine compounds have been reported, including hirsutanol A, a sesquiterpene from the red alga-derived marine fungus Chondrostereum sp. NTOU4196, two zoanthamine alkaloids from the zoantharian Zoanthus cf. pulchellus, an α-D-glucan from the hard-shelled mussel (Mytilus coruscus), and the polyphenol pyrogallol-phloroglucinol-6,6-bieckol from an edible marine brown alga.Finally, this Special Issue is supplemented by three reviews focused on the occurrence of prostaglandins in the marine environment and their anti-inflammatory role; fish lipid emulsions used to improve patient outcomes in an inflammatory environment, such as postoperative; and the chemically induced production of compounds with anti-inflammatory activity from microalgae.

Non-Steroidal Anti-Inflammatory Drugs in Water

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Author :
Publisher : Springer Nature
ISBN 13 : 3030562948
Total Pages : 338 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Non-Steroidal Anti-Inflammatory Drugs in Water by : Leobardo Manuel Gómez-Oliván

Download or read book Non-Steroidal Anti-Inflammatory Drugs in Water written by Leobardo Manuel Gómez-Oliván and published by Springer Nature. This book was released on 2020-10-14 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers the main international research findings on non-steroidal anti-inflammatory drugs (NSAIDs) as emerging contaminants in water. It focuses on the major routes of exposure, and the destinations and life cycles of NSAIDs in water, as well as the manifestations of toxicity in different organisms. It also reviews the methods used in the detection, analysis and quantification of NSAIDs in water as well as the biological and chemical methods of removing them. Lastly, the book offers an overview of the legal frameworks in place and provides conclusions and recommendations for the future. Given its scope, the book is an indispensable resource for scientists in academia and industry, as well as for decision-makers involved in contamination assessment and environmental analysis and NGOs interested in the problem of water contamination by NSAIDs.

Inflammation, 4 Volume Set

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Publisher : John Wiley & Sons
ISBN 13 : 3527338993
Total Pages : 1818 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Inflammation, 4 Volume Set by : Jean-Marc Cavaillon

Download or read book Inflammation, 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.

Pharmaceuticals in Marine and Coastal Environments

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Publisher : Elsevier
ISBN 13 : 0081029721
Total Pages : 704 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Pharmaceuticals in Marine and Coastal Environments by : Juan Carlos Duran-Alvarez

Download or read book Pharmaceuticals in Marine and Coastal Environments written by Juan Carlos Duran-Alvarez and published by Elsevier. This book was released on 2021-06-23 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceuticals in Marine and Coastal Environments: Occurrence, Effects, and Challenges in a Changing World is divided into three sections that address a) coastal areas as the main entrance of pharmaceuticals into the ocean, b) the occurrence and distribution of pharmaceuticals in the environmental compartments of the ocean media, and c) the effects that such pollutants may cause to the exposed marine organisms. With its comprehensive discussions, the book provides a wide depiction of the current state-of-the-art on these topics in an effort to open new sources of investigation and find suitable solutions. - Includes maps edited by the Water Information Network System of the International Hydrological Program (IHP-WINS) - Provides a compilation of information regarding the occurrence and distribution of pharmaceuticals in the marine environment which will help establish new and more efficient monitoring programs and new research lines - Depicts the most important results of environmental risk assessments that can be used as a first step for further toxicological studies

Pathobiology of Alzheimer's Disease

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Publisher : Elsevier
ISBN 13 : 0080538495
Total Pages : 273 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Pathobiology of Alzheimer's Disease by :

Download or read book Pathobiology of Alzheimer's Disease written by and published by Elsevier. This book was released on 1995-10-17 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field.With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease.Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research.* * Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective* A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease.* Up-to-date research data* Clear illustrations complement the text

Marine Pharmacognosy

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Publisher : CRC Press
ISBN 13 : 1439892296
Total Pages : 457 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Marine Pharmacognosy by : Se-Kwon Kim

Download or read book Marine Pharmacognosy written by Se-Kwon Kim and published by CRC Press. This book was released on 2012-12-06 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diverse and abundant, marine-derived bioactive compounds offer a plethora of pharmacologically active agents with the potential to produce valuable therapeutic entities. Marine-derived organisms, including some macroalgae, microalgae, blue-green algae, invertebrates, and vertebrates—valued in traditional Chinese medicine since ancient times—are now recognized as rich sources of pharmaceutically active compounds. These factors, coupled with the growing need for novel bioactives for the treatment of severe human diseases such as cancer, diabetes, microbial infections, and inflammatory processes, has brought marine pharmaceuticals to the forefront of pharmacology. Marine Pharmacognosy: Trends and Applications provides a comprehensive account of marine-derived bioactive pharmaceuticals and their potential health benefits, including antioxidant, anticancer, antiviral, anticoagulant, antidiabetic, antiallergy, anti-inflammatory, antihypertensive, antibacterial, and radioprotective activities. Moreover, it discusses the sources, isolation and purification, chemistry, functionality interactions, applications, and industrial features of a variety of marine-derived pharmaceuticals. Marine pharmacognosy is a dynamic field that has been systematically investigated over the last 50 years, and the number of publications and patents are increasing every year. Bringing together a global team of experts, Marine Pharmacognosy: Trends and Applications reviews current research on marine-derived bioactive compounds and provides insight into future research on their potential as pharmacologically active agents.

Marine Compounds and Cancer

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Publisher : MDPI
ISBN 13 : 3038427659
Total Pages : 119 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Marine Compounds and Cancer by : Friedemann Honecker

Download or read book Marine Compounds and Cancer written by Friedemann Honecker and published by MDPI. This book was released on 2018-06-26 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Marine Compounds and Cancer" that was published in Marine Drugs

Bioactive Marine Natural Products

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Publisher : Springer Science & Business Media
ISBN 13 : 1402034849
Total Pages : 397 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Bioactive Marine Natural Products by : Dewan S. Bhakuni

Download or read book Bioactive Marine Natural Products written by Dewan S. Bhakuni and published by Springer Science & Business Media. This book was released on 2006-06-30 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Marine Natural Products is the first book available that covers all aspects of bioactive marine natural products. It fills the void in the literature for bioactive marine natural products. The book covers various aspects of marine natural products and it is hoped that all the major classes of bioactive compounds are included. Different classes of marine organisms and the separation and isolation techniques are discussed. The chemistry and biology of marine toxins, peptides, alkaloids, nucleosides and prostanoids are discussed in detail. Biological, toxicological and clinical evaluations are also dealt with to ensure that the book may be adopted at any stage by any practicing organic chemist or biologist, working in academia or in R and D divisions of pharmaceutical companies. Each chapter in the book includes an abstract to highlight the major points discussed in the text and concluding remarks are given. References to books, monographs, review articles and original papers are provided at the end of each chapter.

Marine Anti-inflammatory Agents 2020

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Author :
Publisher : MDPI
ISBN 13 : 3036507884
Total Pages : 112 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Marine Anti-inflammatory Agents 2020 by : Donatella Degl’Innocenti

Download or read book Marine Anti-inflammatory Agents 2020 written by Donatella Degl’Innocenti and published by MDPI. This book was released on 2021-05-18 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue covers original and innovative basic research regarding the anti-inflammatory potential of several classes of secondary metabolites (i.e., polyphenols, phytosterols, proteoglycans, and polysaccharides) in manifestations of acute and chronic inflammation in both in vitro and in vivo experimental models.

Marine Nutraceuticals

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Publisher : CRC Press
ISBN 13 : 1466513519
Total Pages : 467 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Marine Nutraceuticals by : Se-Kwon Kim

Download or read book Marine Nutraceuticals written by Se-Kwon Kim and published by CRC Press. This book was released on 2013-03-25 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a great deal of consumer interest in natural bioactive substances due to their health benefits. Offering the potential to provide valuable nutraceuticals and functional food ingredients, marine-derived compounds are an abundant source of nutritionally and pharmacologically active agents, with both chemical diversity and complexity. Functional ingredients derived from marine algae, invertebrates, vertebrates, and microorganisms can help fill the need for novel bioactives to treat chronic conditions such as cancer, microbial infections, and inflammatory processes. With contributions from an international group of experts, Marine Nutraceuticals: Prospects and Perspectives provides a comprehensive account of marine-derived nutraceuticals and their potential health benefits. These include antioxidant, anticancer, antiviral, anticoagulant, antidiabetic, antiallergic, anti-inflammatory, antihypertensive, antibacterial, and radioprotective properties. The book focuses on various types of marine-derived compounds—such as secondary metabolites like phlorotannins and fucoxanthin, carotenoid pigments, chito-oligosaccharide derivatives from chitin and chitosan, bioactive peptides, and polysaccharides—presenting an overview of their nutraceutical activities. Chapters address neuroprotecive properties of seaweeds, bioactive compounds in abalone, marine products and autoimmune disease, chitosan for weight management, anticancer actions of omega-3 fatty acids, chitosan in dentistry, and much more. The book discusses the sources, isolation and purification, chemistry, functional interactions, applications, and industrial perspectives of marine-derived nutraceuticals. The inaugural book in the new CRC Press series, Nutraceuticals: Basic Research/Clinical Applications, it provides a state-of-the-art reference for all readers interested in this growing field—a rich source for new compounds with promising uses in the nutraceutical, medicinal, and functional food industries.

Acute Pain Management

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Publisher : Cambridge University Press
ISBN 13 : 0521874912
Total Pages : 729 pages
Book Rating : 4.5/5 (218 download)

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Book Synopsis Acute Pain Management by : Raymond S. Sinatra

Download or read book Acute Pain Management written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2009-04-27 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.

Cosmetic Dermatology

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Publisher : John Wiley & Sons
ISBN 13 : 111865546X
Total Pages : 34 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Cosmetic Dermatology by : Zoe Diana Draelos

Download or read book Cosmetic Dermatology written by Zoe Diana Draelos and published by John Wiley & Sons. This book was released on 2015-10-14 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: Back for a new edition, Zoe Draelos' outstanding resource to cosmetic dermatology again provides a highly-illustrated, clinical guide to the full range of cosmetic skin treatments. Bringing together experts from research, industry, surgery and practice, it is structured in four distinct parts for easy navigation by the busy clinician: Basic Concepts - giving an overview of the physiology pertinent to cosmetic dermatology and the delivery systems by which treatments can take effect; Hygiene Products - evaluating cleansing and moisturising products; Adornment - looking at aesthetic techniques such as cosmetics, nail protheses and hair treatment; Antiaging - ie, injectables, resurfacing and skin contouring techniques, and the rapidly growing area of Cosmeceuticals. With over 300 high-quality images and key summary boxes throughout, this new edition incorporates the newest procedural innovations in this rapidly developing field. Perfect for all dermatologists, especially those specialising in cosmetic dermatology and whether hospital-based or in private practice, it provides the complete cosmetic regimen for your patients and will be an indispensable tool to consult over and over again.

Marine Natural Products as Anticancer Agents

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Author :
Publisher :
ISBN 13 : 9783036518190
Total Pages : 150 pages
Book Rating : 4.5/5 (181 download)

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Book Synopsis Marine Natural Products as Anticancer Agents by : Celso Alves

Download or read book Marine Natural Products as Anticancer Agents written by Celso Alves and published by . This book was released on 2021 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment.

Antifouling Compounds

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Publisher : Springer Science & Business Media
ISBN 13 : 3540300163
Total Pages : 236 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Antifouling Compounds by : Nobuhiro Fusetani

Download or read book Antifouling Compounds written by Nobuhiro Fusetani and published by Springer Science & Business Media. This book was released on 2006-10-11 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Awareness of the dangers of toxic components in antifouling coatings has raised interest in the potential for nontoxic alternatives. Marine organisms from bacteria to invertebrates and plants use chemicals to communicate and defend themselves. This book explores natural based antifoulants, their ecological functions, methods of characterisation and possible uses in antifouling. The text takes on the challenge of identifying such compounds, designing sustainable production and incorporating them into antifouling coatings.

Emerging Nanotechnologies in Immunology

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Author :
Publisher : William Andrew
ISBN 13 : 0323401139
Total Pages : 291 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Emerging Nanotechnologies in Immunology by : Ranjita Shegokar

Download or read book Emerging Nanotechnologies in Immunology written by Ranjita Shegokar and published by William Andrew. This book was released on 2018-05-17 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Nanotechnologies in Immunology aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanophamaceuticals currently in the pipeline of S&T development for skin, ocular, and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure.The scientific development of manufactured nanomaterials for drug delivery is increasing rapidly. One of the most prominent applications is topical drug delivery, where cutaneous, ocular, and nasal exposure becomes even more relevant. These targets are the first barrier that nanoparticles encounter when in contact with the human body.The contributors addresses a representative set of the broad spectrum of nanopharmaceuticals currently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue engineered skin substitutes. Regulation and risk is also covered, since the safety of these nanophamaceuticals still represents a barrier to their wide innovative use. - Provides the reader with a thorough knowledge of the safety aspects of nanopharmaceuticals which are currently under research - Focuses on the characterization and quantification of the nanopharmaceuticals - Allows readers to understand the correlation between the nature of the materials and their potential nanotoxicological effects - Includes an overview of regulatory aspects related to the R&D of nanopharmaceuticals