Manual Of Biological Markers Of Disease

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Manual of Biological Markers of Disease

Author : W.J. van Venrooij
Publisher : Springer Science & Business Media
ISBN 13 : 9401154449
Total Pages : 532 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Manual of Biological Markers of Disease by : W.J. van Venrooij

Download or read book Manual of Biological Markers of Disease written by W.J. van Venrooij and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Section A: Methods of Autoantibody Detection This Section provides well structured protocols for autoantibody detection. Step-by-step procedures are accompanied by explanatory notes and comments, clear diagrams, line illustrations and excellent photo illustrations. Extensive literature references lead the way to further background information. The methods presented were validated by more than 40 leading laboratories active in sera analysis, which indicates that these methods have been found to be practically useful and lead to consistent inter-laboratory results: consensus in autoantibody detection. Section B: Autoantigens This Section contains the first compilation of full, detailed information on autoantigens related to important autoimmune diseases. The chapters are all structured according to an easy-reference fixed template structure: specific detection methods, cellular localization, biochemical characteristics, function, cDNA and derived amino acid sequence, gene structure, B- and T-cell epitopes and lists of published monoclonal antibodies. The text is greatly enhanced by many beautiful schematic figures and photo illustrations. As in Section A, extensive literature references are provided. The information for this section was brought together by leading experts in their fields. This Manual is an ideal text and reference book for bench scientists working in the field of autoimmunity, but also for rheumatologists, general (internal medicine) physicians or clinical immunologists caring for patients with autoimmune disorders.

Manual of Biological Markers of Disease Including Sections A, B and C

Author : W. J. Van Venrooij
Publisher : Kluwer Academic Pub
ISBN 13 : 9780792338086
Total Pages : 193 pages
Book Rating : 4.3/5 (38 download)

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Book Synopsis Manual of Biological Markers of Disease Including Sections A, B and C by : W. J. Van Venrooij

Download or read book Manual of Biological Markers of Disease Including Sections A, B and C written by W. J. Van Venrooij and published by Kluwer Academic Pub. This book was released on 1996-01-01 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference work: This looseleaf work is an authoritative compilation of methods for the detection of autoantibodies (Section A: Methods of Autoantibody Detection); the structure, function, and molecular and biochemical concepts of autoantigens (Section B: Autoantigens); and the clinical significance of measuring autoantibodies in patients with rheumatic, connective tissue and autoimmune diseases (Section C: Clinical Significance of Autoantibodies). This unique work brings together all the molecular and medical information - very difficult to retrieve otherwise - in ONE publication. The Editors and contributors are leading experts in the immunological, molecular biological, and clinical fields. The format of this looseleaf publication allows regular updating of data as well as inclusion of new advances in research on autoimmunity. Until now, the work (Basic work including Supplement 1) included Section A, and the larger part of Section B, both in an attractive and robust ringbinder. Audience: By nature and design of this exciting reference work, it is especially aimed at scientists, including immunologists, pathologists and molecular biologists, and clinical chemists, as well as clinicians specializing in rheumatic diseases and autoimmune disorders, inflammation or clinical immunology. Supplement 2: This supplement primarily contains Section C (Clinical Significance of Autoantibodies). As in the other sections, the contents are presented in a consistently structured manner, beautifully illustrated with photos and schematic figures. Extensive literature references are provided. Also, this supplement includes an addition to Section B (Autoantigens), being chapter B.1.5: The Antigens Defined by Antikeratin Antibodies (AKA).

Neuroscience Biomarkers and Biosignatures

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309178282
Total Pages : 128 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Neuroscience Biomarkers and Biosignatures by : Institute of Medicine

Download or read book Neuroscience Biomarkers and Biosignatures written by Institute of Medicine and published by National Academies Press. This book was released on 2008-01-08 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers, or biological markers, are quantitative measurements that offer researchers and clinicians valuable insight into diagnosis, treatment and prognosis for many disorders and diseases. A major goal in neuroscience medical research is establishing biomarkers for disorders of the nervous system. Given the promising potential and necessity for neuroscience biomarkers, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened a public workshop and released the workshop summary entitled Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships. The workshop brought together experts from multiple areas to discuss the most promising and practical arenas in neuroscience in which biomarkers will have the greatest impact. The main objective of the workshop was to identify and discuss biomarker targets that are not currently being aggressively pursued but that could have the greatest near-term impact on the rate at which new treatments are brought forward for psychiatric and neurological disorders.

Leong's Manual of Diagnostic Biomarkers for Immunohistology

Author : Runjan Chetty
Publisher : Cambridge University Press
ISBN 13 : 1108870864
Total Pages : pages
Book Rating : 4.1/5 (88 download)

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Book Synopsis Leong's Manual of Diagnostic Biomarkers for Immunohistology by : Runjan Chetty

Download or read book Leong's Manual of Diagnostic Biomarkers for Immunohistology written by Runjan Chetty and published by Cambridge University Press. This book was released on 2022-06-30 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: With the interest in biomarkers available for diagnostic, therapeutic, prognostic and research applications growing rapidly, it is now expected that every pathologist should be aware of the correct application of immunohistochemistry in daily practice. This fully updated fourth edition provides practical guidance about preparation, key uses and pitfalls of antibodies for immunohistology in a unique A-Z format. Seventeen full colour infographics present detail about specific biomarkers, including FOXL2, GATA3 and SOX10, pulling out information about expression in tissues and prognosis. Expanded with new biomarkers and the removal of biomarkers that are no longer in common use, each entry in this concise new edition follows a standard structure for quick and easy access by busy readers.

The Handbook of Biomarkers

Author : Kewal K. Jain
Publisher : Springer Science & Business Media
ISBN 13 : 1607616858
Total Pages : 492 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis The Handbook of Biomarkers by : Kewal K. Jain

Download or read book The Handbook of Biomarkers written by Kewal K. Jain and published by Springer Science & Business Media. This book was released on 2010-02-06 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various "-omics" technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today.

Molecular Epidemiology

Author : Paul A. Schulte
Publisher : Academic Press
ISBN 13 : 0323138578
Total Pages : 588 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Molecular Epidemiology by : Paul A. Schulte

Download or read book Molecular Epidemiology written by Paul A. Schulte and published by Academic Press. This book was released on 2012-12-02 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.

Examining the Use of Biomarkers in Establishing the Presence and Severity of Impairments

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309682630
Total Pages : 85 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Examining the Use of Biomarkers in Establishing the Presence and Severity of Impairments by : National Academies of Sciences, Engineering, and Medicine

Download or read book Examining the Use of Biomarkers in Establishing the Presence and Severity of Impairments written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2021-01-15 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: As part of the overall disability determination process, the Social Security Administration uses a step-by-step approach to understand how severe an individual's condition is and whether it meets program criteria for disability. The use of various types of biomarkers has been suggested as a way to strengthen the amount and quality of objective evidence available to the review process. At the request of the Social Security Administration, the National Academies of Sciences, Engineering, and Medicine's Board on Health Care Services organized a virtual workshop on July 21, 2020, titled The State of the Science of the Use of Biomarkers to Establish the Presence and Severity of Impairments. Workshop discussions focused on the current and potential uses for biomarkers; explored legal and ethical implications associated with biomarker use in clinical decision making; and considered the possible uses of nongenetic biomarkers as tools for the diagnosis or prognosis of the severity of specific physical and mental impairments. This publication summarizes the presentations and discussion of the workshop.

The Skin in Systemic Autoimmune Diseases

Author : Piercarlo Sarzi-Puttini
Publisher : Elsevier
ISBN 13 : 9780080461922
Total Pages : 358 pages
Book Rating : 4.4/5 (619 download)

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Book Synopsis The Skin in Systemic Autoimmune Diseases by : Piercarlo Sarzi-Puttini

Download or read book The Skin in Systemic Autoimmune Diseases written by Piercarlo Sarzi-Puttini and published by Elsevier. This book was released on 2006-01-26 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the state-of-the-art in the field of skin and autoimmune rheumatic diseases. It covers systematically a growing and multifaceted topic which is of great importance in the clinical practice. It also serves as a sharp educational tool as each chapter provides summaries and specific highlights to key references cited into the text. The pathophysiological link between skin involvement and autoimmunity has been explained in detail, as well as diagnostic and therapeutic aspects. This book yields an impressive body of well ordered information which summarizes the experience of a selected panel of distinguished physicians and scientists actively involved in the field of skin immunology and systemic autoimmunity. * Written by a respected panel of distinguished physician-scientists actively involved in the field of skin immunology and systemic autoimmunity * Box summaries at the end of each chapter highlight important topics * Up-to-date basic knowledge as well as modern approach to diagnosis and therapy

Epigenetic Biomarkers and Diagnostics

Author : José Luis García-Giménez
Publisher : Academic Press
ISBN 13 : 0128019212
Total Pages : 696 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Epigenetic Biomarkers and Diagnostics by : José Luis García-Giménez

Download or read book Epigenetic Biomarkers and Diagnostics written by José Luis García-Giménez and published by Academic Press. This book was released on 2015-12-07 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

Biomarkers in Breast Cancer

Author : Giampietro Gasparini
Publisher : Springer Science & Business Media
ISBN 13 : 159259915X
Total Pages : 342 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Biomarkers in Breast Cancer by : Giampietro Gasparini

Download or read book Biomarkers in Breast Cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2008-01-17 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

Monitoring Metabolic Status

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309091594
Total Pages : 469 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Monitoring Metabolic Status by : Institute of Medicine

Download or read book Monitoring Metabolic Status written by Institute of Medicine and published by National Academies Press. This book was released on 2004-08-29 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. military's concerns about the individual combat service member's ability to avoid performance degradation, in conjunction with the need to maintain both mental and physical capabilities in highly stressful situations, have led to and interest in developing methods by which commanders can monitor the status of the combat service members in the field. This report examines appropriate biological markers, monitoring technologies currently available and in need of development, and appropriate algorithms to interpret the data obtained in order to provide information for command decisions relative to the physiological "readiness" of each combat service member. More specifically, this report also provides responses to questions posed by the military relative to monitoring the metabolic regulation during prolonged, exhaustive efforts, where nutrition/hydration and repair mechanisms may be mismatched to intakes and rest, or where specific metabolic derangements are present.

Late Onset Schizophrenia

Author : Robert Howard
Publisher : Routledge
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Late Onset Schizophrenia by : Robert Howard

Download or read book Late Onset Schizophrenia written by Robert Howard and published by Routledge. This book was released on 1999 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia, which starts in middle age or late life, has been described as 'the darkest area of psychiatry.' It is certainly controversial, with much disagreement about cut-off ages, diagnostic criteria and nomenclature. The contributors to this unique and very important book represent views from Europe and North America as well as Australia, Japan, and Nepal; they come from backgrounds of clinical practice and research. The contributors and editors were motivated by common aims: to review current international knowledge about late onset schizophrenia, to debate issues of heterogenity, gender, brain maturation and aging, putative structural and functional cerebral substrates for psychosis, to reach consensus on diagnosis and terminology, and to future research directions. The resulting book is an unqualified success which as well as being invaluable in old age psychiatry, sheds light on all aspects of schizophrenia treatment and research.

Field Manual of Wildlife Diseases

Author :
Publisher : Geological Survey (USGS)
ISBN 13 :
Total Pages : 444 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Field Manual of Wildlife Diseases by :

Download or read book Field Manual of Wildlife Diseases written by and published by Geological Survey (USGS). This book was released on 1999 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:

ASPC Manual of Preventive Cardiology

Author : Ezra A. Amsterdam, MD
Publisher : Demos Medical Publishing
ISBN 13 : 1617051411
Total Pages : 296 pages
Book Rating : 4.6/5 (17 download)

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Book Synopsis ASPC Manual of Preventive Cardiology by : Ezra A. Amsterdam, MD

Download or read book ASPC Manual of Preventive Cardiology written by Ezra A. Amsterdam, MD and published by Demos Medical Publishing. This book was released on 2014-10-23 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endorsed by the American Society for Preventive Cardiology, this highly practical resource focuses on the application of current guidelines and practice standards in the clinical management of cardiovascular risk factors. The Manual presents concise descriptions of each major cardiovascular risk factor, and practical, to-the-point discussions of current best practices in clinical management. In addition, the Manual includes chapters on peripheral arterial disease, stroke, smoking, contemporary cardiovascular imaging, heart failure, metabolic syndrome, thrombosis, nutrition, special populations, novel risk factors, and psychosocial stress. Throughout the Manual, recommendations are based on the most recent prevention guidelines of the American College of Cardiology and American Heart Association, including those on Risk Assessment, Lifestyle Recommendations, Blood Cholesterol, and Obesity, as well as the new guidelines on Hypertension. Chapter authors are recognized leaders in each area of practice, and special efforts have been made by the authors and editors to ensure that the content of all chapters is as up-to-date as possible. Key Features: ■ Presents a highly practical focus on the application of current guidelines and practice standards regarding cardiovascular risk factors ■ Recommendations based on the most recent prevention guidelines ■ Authored by recognized leaders in the field ■ Covers all major cardiovascular risk factors, key methodologies in risk assessment, and special issues regarding specific patient populations

Immunofluorescence in Clinical Immunology

Author : Wulf B. Storch
Publisher : Birkhäuser
ISBN 13 : 3034883765
Total Pages : 239 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Immunofluorescence in Clinical Immunology by : Wulf B. Storch

Download or read book Immunofluorescence in Clinical Immunology written by Wulf B. Storch and published by Birkhäuser. This book was released on 2012-12-06 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunofluorescence, a suitable laboratory method for the microscopic demonstration of antigens and antibodies in biological materials, useable, for example, to provide evidence for the pathogenesis of disease in histological or cytological preparations and for tumour cell differentiation. For this reason immunofluorescence has a decisive role as the method of choice for the diagnosis of auto-immune diseases. This primer on immunofluorescence techniques, which first appeared in 1979, is a richly illustrated handbook suitable for everyday practical work in the laboratory, useable as both an introduction to the subject as well as an atlas. In hardly any other area of medicine are there so many new findings to report. The second edition of this book is concerned not only with the detection methods which now form an essential and established part of diagnostic techniques, but also with the most recent research results such as the discovery of antibodies against Auerbach's plexus and against podocytes...

Autoantibodies

Author : J.B. Peter
Publisher : Elsevier
ISBN 13 : 9780080527727
Total Pages : 880 pages
Book Rating : 4.5/5 (277 download)

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Book Synopsis Autoantibodies by : J.B. Peter

Download or read book Autoantibodies written by J.B. Peter and published by Elsevier. This book was released on 1996-07-17 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is THE definitive, completely up-to-date, reference work for ALL researchers and clinicians working in autoimmunity. Up-to-Date: This is a timely critical review of more than 100 autoantibodies by leading experts in their respective fields, and includes many recent references. International Experts: The 120 Chapters have been written by the top international cadre of authors who have provided structured, expert contributions. Comprehensive: A total comprehensive perspective on the processes which induce, inhibit or otherwise affect autoantibodies in humans. Useful to Researchers and Clinicians: Chapters generally include methods of detection, pathogenic role, factors in pathogenicity and genetics as well as clinical utility with disease associations and frequencies.

Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309157277
Total Pages : 335 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease by : Institute of Medicine

Download or read book Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease written by Institute of Medicine and published by National Academies Press. This book was released on 2010-06-25 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.