Management of Chemical and Biological Samples for Screening Applications

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Publisher : John Wiley & Sons
ISBN 13 : 352732822X
Total Pages : 435 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Management of Chemical and Biological Samples for Screening Applications by : Mark Wigglesworth

Download or read book Management of Chemical and Biological Samples for Screening Applications written by Mark Wigglesworth and published by John Wiley & Sons. This book was released on 2012-04-30 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical and biotechnological field. It spans the entire fi eld of this emerging discipline, from compound acquisition to collection optimization for specific purposes, to technology and quality control. In so doing, it applies two decades of expertise gathered by several large pharmaceutical companies to current and future challenges in high-throughput screening. With its treatment of libraries of small molecules as well as biobanks containing biomolecules, microorganisms and tissue samples, this reference is universally applicable for any molecular scientist involved in a large screening program.

Chemical Biology

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Publisher : John Wiley & Sons
ISBN 13 : 1118434501
Total Pages : 657 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Chemical Biology by : Natanya Civjan

Download or read book Chemical Biology written by Natanya Civjan and published by John Wiley & Sons. This book was released on 2012-08-07 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.

Analytical Characterization of Biotherapeutics

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Publisher : John Wiley & Sons
ISBN 13 : 1119053102
Total Pages : 378 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Analytical Characterization of Biotherapeutics by : Jennie R. Lill

Download or read book Analytical Characterization of Biotherapeutics written by Jennie R. Lill and published by John Wiley & Sons. This book was released on 2017-08-14 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.

Small Molecule Medicinal Chemistry

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Publisher : John Wiley & Sons
ISBN 13 : 1118771605
Total Pages : 546 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Small Molecule Medicinal Chemistry by : Werngard Czechtizky

Download or read book Small Molecule Medicinal Chemistry written by Werngard Czechtizky and published by John Wiley & Sons. This book was released on 2015-11-02 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting

The Biological Resources of Model Organisms

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Publisher : CRC Press
ISBN 13 : 1351587765
Total Pages : 260 pages
Book Rating : 4.3/5 (515 download)

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Book Synopsis The Biological Resources of Model Organisms by : Robert L. Jarret

Download or read book The Biological Resources of Model Organisms written by Robert L. Jarret and published by CRC Press. This book was released on 2019-07-16 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses 14 model organisms and are used by thousands of researchers, teachers, and students each year in laboratories and classrooms, around the globe. Though acknowledged in innumerable scientific journal articles, little is generally known about the origin of these collections, how the organisms contained within them have been acquired, and how they are maintained and distributed. While some collections such as Drosophila have long histories others, such as the collection of Brachionus, are relatively new. They vary greatly in size. Yet, all have contributed and are continuing to contribute to global research efforts in many areas of scientific research as diverse as tissue regeneration, skin cancer, evolution, water purity, gene function, and hundreds of others. In addition to providing the raw materials for national and international research programs, these collections also provide educational tools used by colleges and high schools. The chapters in this book attempt to provide a brief look at the individual organisms, how they came to be accepted as model organisms, the history of the individual collections, examples of how the organisms have been and are being used in scientific research, and a description of the facilities and procedures used to maintain them. Features: • Provides an in-depth look at the collections of 14 model organisms that have enabled innumerable scientific breakthroughs over decades, and that continue to do so. • Includes detailed descriptions of the operating procedures used for the maintenance of each model organism collection. • Discusses the holdings of the collections of model organisms and its relevance to past, current and future scientific research. • Written by the leaders in the field of the management of model organisms.

Microbial Forensics

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Publisher : Academic Press
ISBN 13 : 0128153806
Total Pages : 526 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Microbial Forensics by : Bruce Budowle

Download or read book Microbial Forensics written by Bruce Budowle and published by Academic Press. This book was released on 2019-11-30 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial Forensics, Third Edition, serves as a complete reference on the discipline, describing the advances, challenges and opportunities that are integral in applying science to help solve future biocrimes. New chapters include: Microbial Source Tracking, Clinical Recognition, Bioinformatics, and Quality Assurance. This book is intended for a wide audience, but will be indispensable to forensic scientists and researchers interested in contributing to the growing field of microbial forensics. Biologists and microbiologists, the legal and judicial system, and the international community involved with Biological Weapons Treaties will also find this volume invaluable. Presents new and expanded content that includes a statistical analysis of forensic data, legal admissibility and standards of evidence Discusses actual cases of forensic bioterrorism Includes contributions from editors and authors who are leading experts in the field, with primary experience in the application of this fast-growing discipline

Comprehensive Biomarker Discovery and Validation for Clinical Application

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Publisher : Royal Society of Chemistry
ISBN 13 : 1849734364
Total Pages : 320 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Comprehensive Biomarker Discovery and Validation for Clinical Application by : Péter Horvatovich

Download or read book Comprehensive Biomarker Discovery and Validation for Clinical Application written by Péter Horvatovich and published by Royal Society of Chemistry. This book was released on 2013-06-17 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks.

Environmental Sampling and Analysis

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Publisher : Routledge
ISBN 13 : 1351450190
Total Pages : 160 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Environmental Sampling and Analysis by : LawrenceH. Keith

Download or read book Environmental Sampling and Analysis written by LawrenceH. Keith and published by Routledge. This book was released on 2017-12-01 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise book covers all the critical aspects of environmental sampling and analysis. Extensively peer-reviewed by scientists from the U.S. Environmental Protection Agency and other government agencies, industry and academia, it is packed with practical advice and tips from renowned experts. Planning, sampling, analysis, QA/QC, and reporting are discussed for air, water, solid liquid, and biological samples, with emphasis on the interdependence between sampling and analytical activities. Special requirements for sampling devices, containers, and preservatives are provided with convenient checklists for sampling plans and protocols. New and revised recommendations involving method detection levels, reliable detection levels, and levels of quantitation are discussed in conjunction with laboratory reports and user presentations of data near analytical detection limits. This is a valuable and comprehensive reference book for chemists, technicians, consultants, lawyers, regulators, engineers, quality control officers, news and information managers, teachers, and students.

Sensor Technologies

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Publisher : Apress
ISBN 13 : 1430260149
Total Pages : 321 pages
Book Rating : 4.4/5 (32 download)

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Book Synopsis Sensor Technologies by : Michael J. McGrath

Download or read book Sensor Technologies written by Michael J. McGrath and published by Apress. This book was released on 2014-01-23 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sensor Technologies: Healthcare, Wellness and Environmental Applications explores the key aspects of sensor technologies, covering wired, wireless, and discrete sensors for the specific application domains of healthcare, wellness and environmental sensing. It discusses the social, regulatory, and design considerations specific to these domains. The book provides an application-based approach using real-world examples to illustrate the application of sensor technologies in a practical and experiential manner. The book guides the reader from the formulation of the research question, through the design and validation process, to the deployment and management phase of sensor applications. The processes and examples used in the book are primarily based on research carried out by Intel or joint academic research programs. “Sensor Technologies: Healthcare, Wellness and Environmental Applications provides an extensive overview of sensing technologies and their applications in healthcare, wellness, and environmental monitoring. From sensor hardware to system applications and case studies, this book gives readers an in-depth understanding of the technologies and how they can be applied. I would highly recommend it to students or researchers who are interested in wireless sensing technologies and the associated applications.” Dr. Benny Lo Lecturer, The Hamlyn Centre, Imperial College of London “This timely addition to the literature on sensors covers the broad complexity of sensing, sensor types, and the vast range of existing and emerging applications in a very clearly written and accessible manner. It is particularly good at capturing the exciting possibilities that will occur as sensor networks merge with cloud-based ‘big data’ analytics to provide a host of new applications that will impact directly on the individual in ways we cannot fully predict at present. It really brings this home through the use of carefully chosen case studies that bring the overwhelming concept of 'big data' down to the personal level of individual life and health.” Dermot Diamond Director, National Centre for Sensor Research, Principal Investigator, CLARITY Centre for Sensor Web Technologies, Dublin City University "Sensor Technologies: Healthcare, Wellness and Environmental Applications takes the reader on an end-to-end journey of sensor technologies, covering the fundamentals from an engineering perspective, introducing how the data gleaned can be both processed and visualized, in addition to offering exemplar case studies in a number of application domains. It is a must-read for those studying any undergraduate course that involves sensor technologies. It also provides a thorough foundation for those involved in the research and development of applied sensor systems. I highly recommend it to any engineer who wishes to broaden their knowledge in this area!" Chris Nugent Professor of Biomedical Engineering, University of Ulster

Rapid Chemical and Biological Techniques for Water Monitoring

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Publisher : John Wiley & Sons
ISBN 13 : 9780470745434
Total Pages : 440 pages
Book Rating : 4.7/5 (454 download)

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Book Synopsis Rapid Chemical and Biological Techniques for Water Monitoring by : Catherine Gonzalez

Download or read book Rapid Chemical and Biological Techniques for Water Monitoring written by Catherine Gonzalez and published by John Wiley & Sons. This book was released on 2009-03-30 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid Chemical and Biological Techniques for Water Monitoring presents in one volume the broad spectrum of monitoring tools, both available and under development, and provides an assessment of their potential for underpinning environmental management and legislation. The book explores screening methods in the context of water policies; chemical methods; biological methods; potential use of screening methods; quality assurance and validation methods; integration of screening methods in water monitoring strategies. The text provides a timely source of information for post-graduates, researchers, and professionals involved in water management at all levels.

Selected Water Resources Abstracts

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Publisher :
ISBN 13 :
Total Pages : 504 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Selected Water Resources Abstracts by :

Download or read book Selected Water Resources Abstracts written by and published by . This book was released on 1990 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Official Gazette of the United States Patent and Trademark Office

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Publisher :
ISBN 13 :
Total Pages : 926 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Official Gazette of the United States Patent and Trademark Office by :

Download or read book Official Gazette of the United States Patent and Trademark Office written by and published by . This book was released on 2003 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Sensory Panel Management

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Publisher : Woodhead Publishing
ISBN 13 : 0081011156
Total Pages : 376 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Sensory Panel Management by : Lauren Rogers

Download or read book Sensory Panel Management written by Lauren Rogers and published by Woodhead Publishing. This book was released on 2017-10-26 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering all aspects of sensory panel management, this volume describes the different types of sensory panels (for example panels for quality control, descriptive analysis and discrimination tests), discusses the issues involved with sensory testing, and gives detailed information about sensory panel recruitment, training and on-going management. Sensory Panel Management gives both theoretical and practical information from deciding what type of panel to recruit and how to conduct panel training, to creating the best sensory team and how to deal with any issues. Downloads of several of the documents included in the book are available from http://www.laurenlrogers.com/sensory-panel-management.html The book is divided into three main sections. The first section looks at the recruitment of sensory panels, covering the process from both a scientific and a human resources angle. The second section deals with the training of a sensory panel. Initial training, as well as method and product specific training is covered. Example session plans for running panel sessions for quality control, discrimination tests, descriptive profiling, temporal methods and consumer tests are included within the specific chapters. Refresher and advanced training such as training panelists to take part in gas chromatography-olfactometry are also included. The third section examines the performance of sensory panels. Chapters within this section explore performance measures and ways of preventing (and dealing with) difficult situations relating to panellists. A final chapter looks at the future of sensory panels. Throughout the book there are short case study examples demonstrating the practical application of the methods being discussed. Sensory Panel Management is a key reference for academics, technical and sensory staff in food companies. Lauren Rogers is an independent sensory science consultant in the UK with more than twenty years of practical experience. She has worked on a wide variety of projects, including shelf life studies, product and flavor optimization, new flavor development and in-depth brand analyses. She is a member of the Society of Sensory Professionals, the Institute of Food Science and Technology’s Sensory Science Group, the Sensometric Society and is also a member of the ASTM Sensory Evaluation Committee (E18). Discusses sensory panels for testing food and non-food based products Covers best practices for recruitment, selection and training of panels Provides examples of training plans for sensory panels Encompasses experimental design and data analysis of panel results Organized in modular format for practical uses

Engineering Tools for Environmental Risk Management

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Publisher : CRC Press
ISBN 13 : 1317697448
Total Pages : 467 pages
Book Rating : 4.3/5 (176 download)

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Book Synopsis Engineering Tools for Environmental Risk Management by : Katalin Gruiz

Download or read book Engineering Tools for Environmental Risk Management written by Katalin Gruiz and published by CRC Press. This book was released on 2017-01-20 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the third volume of the five-volume book series “Engineering Tools for Environmental Risk Management”. The book series deals with the following topics: • Environmental deterioration and pollution, management of environmental problems • Environmental toxicology – a tool for managing chemical substances and contaminated environment • Assessment and monitoring tools, risk assessment • Risk reduction measures and technologies • Case studies for demonstration of the application of engineering tools The authors aim to describe interactions and options in risk management by providing a broad scientific overview of the environment, its human uses and the associated local, regional and global environmental problems; interpreting the holistic approach used in solving environmental protection issues; striking a balance between nature’s needs and engineering capabilities; understanding interactions between regulation, management and engineering; obtaining information about novel technologies and innovative engineering tools. This third volume provides an overview on the basic principles, concepts, practices and tools of environmental monitoring and contaminated site assessment. The volume focuses on those engineering tools that enable integrated site assessment and decision making and ensure an efficient control of the environment. Some topics supporting sustainable land use and efficient environmental management are listed below: • Efficient management and regulation of contaminated land and the environment; • Early warning and environmental monitoring; • Assessment of contaminated land: the best practices; • Environmental sampling; • Risk characterization and contaminated matrix assessment; • Integrated application of physical, chemical, biological, ecological and (eco) toxicological characterization methods; • Direct toxicity assessment (DTA) and decision making; • Online analyzers, electrodes and biosensors for assessment and monitoring of waters.; • In situ and real-time measurement tools for soil and contaminated sites; • Rapid on-site methods and contaminant and toxicity assessment kits; • Engineering tools from omics technologies, microsensors to heavy machinery; • Dynamic characterization of subsurface soil and groundwater using membrane interface probes, optical and X-ray fl uorescence and ELCAD wastewater characterization; • Geochemical modeling: methods and applications; • Environmental assessment using cyclodextrins. This book series focuses on the state of knowledge about the environment and its conscious and structured application in environmental engineering, management and decision making.

Inventory of Federal Energy-related Environment and Safety Research for ...

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Author :
Publisher :
ISBN 13 :
Total Pages : 732 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Inventory of Federal Energy-related Environment and Safety Research for ... by :

Download or read book Inventory of Federal Energy-related Environment and Safety Research for ... written by and published by . This book was released on 1979 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Inventory of Federal Energy-related Environment and Safety Research for FY 1978

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Author :
Publisher :
ISBN 13 :
Total Pages : 732 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Inventory of Federal Energy-related Environment and Safety Research for FY 1978 by :

Download or read book Inventory of Federal Energy-related Environment and Safety Research for FY 1978 written by and published by . This book was released on 1979 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Inventory of Federal Energy-related Environment and Safety Research for FY 1978: Project listings and indexes

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Author :
Publisher :
ISBN 13 :
Total Pages : 740 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Inventory of Federal Energy-related Environment and Safety Research for FY 1978: Project listings and indexes by :

Download or read book Inventory of Federal Energy-related Environment and Safety Research for FY 1978: Project listings and indexes written by and published by . This book was released on 1979 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: