Mammalian Amino Acid Transport

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Mammalian Amino Acid Transport

Author : D. Häussinger
Publisher : Springer Science & Business Media
ISBN 13 : 1489911618
Total Pages : 316 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Mammalian Amino Acid Transport by : D. Häussinger

Download or read book Mammalian Amino Acid Transport written by D. Häussinger and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amino acid transport is a part of each of two larger subjects, amino acid metabolism and the biomembrane transport of various . small molecules and ions. Nevertheless in this volume we treat amino acid transport as more than a fragment of either of these two larger subjects. A more comprehensive approach is justified when we remember two historic and ongoing aspects of the title subject. First, amino acid transport had its beginning and acquired a distinct momentum (even if somewhat interrupted from 1913 until about 1945) as amino acid metabolism with the central and pioneer work of Van Slyke and Meyer in 1913. The reviews in this volume will show that it steadily becomes a larger aspect of amino acid metabolism, broadly perceived. These chapters will show for how many organelles, cells, tissues, organs and organ systems, the transmembrane compartmentations and flows of amino acids play very large parts in their fundamental biological relations. The authors here are tending collectively to evaluate an understanding of amino acid flows across biomernbranes, and the regulation of these flows, as necessary to an ultimate understanding of the full range of development and metabolism. Such an understanding goes far beyond the purely substrate-destabilizing contributions by enzymes, which have often been arbitrarily limited to that conceptual entity, "the cell", and which for so long a splendid time had most of biochemical research attention.

Amino Acid Transport in Mammalian Tissues

Author : Armando Roberto Tovar
Publisher :
ISBN 13 :
Total Pages : 514 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Amino Acid Transport in Mammalian Tissues by : Armando Roberto Tovar

Download or read book Amino Acid Transport in Mammalian Tissues written by Armando Roberto Tovar and published by . This book was released on 1990 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Amino Acid Transport in Cultured Mammalian Cells

Author : Douglas Mackenzie Scott
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Amino Acid Transport in Cultured Mammalian Cells by : Douglas Mackenzie Scott

Download or read book Amino Acid Transport in Cultured Mammalian Cells written by Douglas Mackenzie Scott and published by . This book was released on 1975 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mechanism of Amino Acid Transport in Mammalian Cells

Author : Alma Domjan Melbourne
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.:/5 (244 download)

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Book Synopsis Mechanism of Amino Acid Transport in Mammalian Cells by : Alma Domjan Melbourne

Download or read book Mechanism of Amino Acid Transport in Mammalian Cells written by Alma Domjan Melbourne and published by . This book was released on 1973 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Red Cell Membrane Transport in Health and Disease

Author : Ingolf Bernhardt
Publisher : Springer Science & Business Media
ISBN 13 : 3662051818
Total Pages : 761 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Red Cell Membrane Transport in Health and Disease by : Ingolf Bernhardt

Download or read book Red Cell Membrane Transport in Health and Disease written by Ingolf Bernhardt and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 761 pages. Available in PDF, EPUB and Kindle. Book excerpt: 51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.

The Placenta and Human Developmental Programming

Author : Graham J. Burton
Publisher : Cambridge University Press
ISBN 13 : 1139494228
Total Pages : 267 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis The Placenta and Human Developmental Programming by : Graham J. Burton

Download or read book The Placenta and Human Developmental Programming written by Graham J. Burton and published by Cambridge University Press. This book was released on 2010-12-16 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.

Human Biochemistry

Author : Gerald Litwack
Publisher : Academic Press
ISBN 13 : 032391053X
Total Pages : 883 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Human Biochemistry by : Gerald Litwack

Download or read book Human Biochemistry written by Gerald Litwack and published by Academic Press. This book was released on 2021-11-28 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers. Presents an update on a past edition winner of the 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association and the PROSE Award of the Association of American Publishers Provides a fully updated resource on current research in human and medical biochemistry Includes clinical case studies, applications, chapter summaries and review-based questions Adopts a practice-based approach, reflecting the needs of both researchers and clinically oriented readers

The Transporter Factsbook

Author : Jeffrey Griffith
Publisher : Elsevier
ISBN 13 : 0080542654
Total Pages : 511 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Transporter Factsbook by : Jeffrey Griffith

Download or read book The Transporter Factsbook written by Jeffrey Griffith and published by Elsevier. This book was released on 1997-12-22 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, and structure? Are you tired of scanning review articles, primary papers, and databases to locate that elusive fact? The Academic Press FactsBook Series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as "a growing series of excellent manuals" by Molecular Medicine Today and "essential works of reference" by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. Using an easy-to-follow format, the FactsBooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity. Meticulously researched and compiled by experts in the field, keeping abreast of developments has never been so easy!The Transporter FactsBook contains entries covering almost 800 transporters. Organized into 55 families of structurally related transporters, this volume includes ATPases, ABC transporters, H+-dependent antiporters and symporters, Na+-dependent antiporters and symporters, and other transporters such as mitochondrial transporters. Nomenclature, biological sources and substrates Phylogenetic relationships Predicted structures Physical and genetic characteristics Multiple amino acid sequence alignments Database accession numbers Key references

Facilitative Glucose Transporters

Author : Gwyn W. Gould
Publisher : Springer Science & Business Media
ISBN 13 : 9780412132919
Total Pages : 270 pages
Book Rating : 4.1/5 (329 download)

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Book Synopsis Facilitative Glucose Transporters by : Gwyn W. Gould

Download or read book Facilitative Glucose Transporters written by Gwyn W. Gould and published by Springer Science & Business Media. This book was released on 1997-03-15 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive text covering the major aspects of the cell and molecular biology of the facilitative glucose transporter family. The text reviews the biology and function of each family member, covers structure-function studies, the regulation of glucose transport by insulin and the consequence of diabetes and insulin resistance, discusses aspects of cellular signalling which control glucose transport, reviews the control of expression and function of GLUT2 in liver and pancreatic beta-cells, and reviews the effects of nutrients on the control of sugar transporter expression.

Neurotoxicity of Nanomaterials and Nanomedicine

Author : Xinguo Jiang
Publisher : Academic Press
ISBN 13 : 0128046201
Total Pages : 368 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Neurotoxicity of Nanomaterials and Nanomedicine by : Xinguo Jiang

Download or read book Neurotoxicity of Nanomaterials and Nanomedicine written by Xinguo Jiang and published by Academic Press. This book was released on 2016-10-03 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotoxicity of Nanomaterials and Nanomedicine presents an overview of the exciting research in neurotoxicity and nanomaterials. Nanomaterials have been extensively used in medicine, including diagnosis probes, drug carriers, and embedded materials. While some have been approved for clinical use, most nanomaterials are waiting to be transferred from lab to clinic. However, the toxicity is a main barrier that restricts the translation. This comprehensive book includes chapters on the most commonly used individual nanoparticles, with information on the applications, neurotoxicity, and related mechanisms of each, providing the most in-depth and current information available. The book examines the pathways that nanomaterials enter into, and eliminate, from the brain, along with the strategies that could reduce the neurotoxicity of nanomaterials. Providing a background to the subject, detailed information, and ideas for future directions in research, the book is essential for students and researchers in toxicology, and for those in medicine, neurology, pharmacology, pharmaceutical science, and materials science who are researching nanomaterials. Presents a thorough discussion of the most common nanoparticles in the brain and their neurotoxicology Includes the most common nanoparticles, their applications, and mechanisms Provides one of the first books to focus on nanomedicine and neurotoxicity

Astrocytes and Epilepsy

Author : Jacqueline A. Hubbard
Publisher : Academic Press
ISBN 13 : 0128026243
Total Pages : 395 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Astrocytes and Epilepsy by : Jacqueline A. Hubbard

Download or read book Astrocytes and Epilepsy written by Jacqueline A. Hubbard and published by Academic Press. This book was released on 2016-07-05 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Biomembrane Transport

Author : Lon J. Van Winkle
Publisher : Elsevier
ISBN 13 : 0080528104
Total Pages : 412 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Biomembrane Transport by : Lon J. Van Winkle

Download or read book Biomembrane Transport written by Lon J. Van Winkle and published by Elsevier. This book was released on 1999-05-20 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomembrane Transport covers the fundamental principles of biomembrane transport proteins, including thermodynamics and kinetics, structure and catalytic mechanism, and regulation and integration classification. The book considers recent advances in transport protein structure and function, along with established concepts. The importance of biomembrane transport to regulation and interorgan nutrient flows and metabolism is covered, as well as classical and modern techniques for characterizing transport. The book also contains a classification scheme for all known transport proteins according to their functions and amino acid residue sequence similarities. Considers recent advances in transport protein structure and function, along with established concepts Distinguishes the similarities and differences in the mechanisms of action of transport proteins Provides an up-to-date discussion of the thermodynamics and kinetics of biomembrane transport Discusses regulation of biomembrane transport Details the importance of biomembrane transport to regulation and interorgan nutrient flows and metabolism Contains a classification scheme for all known transport proteins according to their functions and amino acid residue sequence similarities Presents classical and modern techniques for characterizing transport

The Glutamate/GABA-Glutamine Cycle

Author : Arne Schousboe
Publisher : Springer
ISBN 13 : 3319450964
Total Pages : 420 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis The Glutamate/GABA-Glutamine Cycle by : Arne Schousboe

Download or read book The Glutamate/GABA-Glutamine Cycle written by Arne Schousboe and published by Springer. This book was released on 2016-11-25 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.

Amino acid transport in mammalian tissues

Author : Bryan Mackenzie
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (111 download)

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Book Synopsis Amino acid transport in mammalian tissues by : Bryan Mackenzie

Download or read book Amino acid transport in mammalian tissues written by Bryan Mackenzie and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Culture Media, Solutions, and Systems in Human ART

Author : Patrick Quinn
Publisher : Cambridge University Press
ISBN 13 : 1139917358
Total Pages : 307 pages
Book Rating : 4.1/5 (399 download)

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Book Synopsis Culture Media, Solutions, and Systems in Human ART by : Patrick Quinn

Download or read book Culture Media, Solutions, and Systems in Human ART written by Patrick Quinn and published by Cambridge University Press. This book was released on 2014-03-27 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes culture media and solutions used in human ART; how they have been developed for in vitro human pre-implantation embryo development, the function and importance of the various components in media and solutions and how they interact, and how the systems in which these are used can influence outcomes. Chapters discuss inorganic solutes, energy substrates, amino acids, macromolecules, cytokines, growth factors, buffers, pH, osmolality, and the interaction of these parameters. The role of incubators and other physical factors are reviewed, along with the relevance and prospects of emerging technologies: morphokinetic analysis using time-lapse imaging and dynamic fluid incubation systems. Results of prospective randomized trials are emphasized to ascertain the added value of these techniques for selecting viable embryos. This comprehensive guide will be invaluable for embryologists, physicians and all personnel involved in the fluid products used in human ART seeking to optimize their successful use of these components.

Molecular and Functional Characterisation of a New Mammalian Family of Proton-coupled Amino Acid Transporters

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (696 download)

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Book Synopsis Molecular and Functional Characterisation of a New Mammalian Family of Proton-coupled Amino Acid Transporters by :

Download or read book Molecular and Functional Characterisation of a New Mammalian Family of Proton-coupled Amino Acid Transporters written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Proton-coupled amino acid transport (PAT) systems in the apical membrane of epithelial cells of the small intestine and the renal tubule have been demonstrated by use of the human intestinal cell line Caco-2 and renal brush border membrane vesicles. The present thesis summarises the revelation of the molecular entity of the PAT system and provides deeper insights into this new mammalian family of proton/amino acid cotransporters. The identified family comprises four structural similar murine and human transport proteins (proton/amino acid transporter, PAT1 - 4), all consisting of around 500 amino acid residues with 11 predicted transmembrane spanning domains. Orthologous proteins of this family are found in lower and higher eukaryotes. The murine PATs exhibit a distinct mRNA expression pattern, with PAT1 found inter alia in epithelial cells of small intestine and kidney. Moreover, the PAT1 protein is localised in the brush border membrane of murine and human small intestine. After expression in Xenopus laevi oocytes PAT1 mediates proton-coupled, electrogenic transport of small and neutral amino acids such as Gly, Ala, and Pro, the corresponding D-isomers and of a variety of amino acid derivatives, e.g. GABA, betaine, and taurine. The apparent affinities for these substrates are in the range of 1 - 10 mM. Beside these physiological substrates PAT1 transports efficiently selected pharmacological compounds. As shown recently, PAT1 resembles in all features the functionally described PAT system in intestinal and renal epithelial cells. The transporter PAT2, expressed in the central nervous system, lung, heart, and brain exhibits similar transport characteristics as PAT1. However, PAT2 is in comparison to PAT1 a high affinity transporter, with 10 to 30- times higher affinities for the identical substrates (app. Km-values of 100 - 1000 æM) but has in general a narrower substrate spectrum. So far, PAT3 and PAT4 remain orphan transporters with no assigned function. Critical.