Liver Myofibroblasts

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Liver Myofibroblasts

Author : Jiri Kanta
Publisher : Frontiers Media SA
ISBN 13 : 2889199894
Total Pages : 101 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Liver Myofibroblasts by : Jiri Kanta

Download or read book Liver Myofibroblasts written by Jiri Kanta and published by Frontiers Media SA. This book was released on 2016-10-25 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myofibroblasts (MFB) are found in most tissues of the body. They have the matrix-producing functions of fibroblasts and contractile properties that are known from smooth muscle cells. Fundamental work of the last decades has shed remarkable light on their origin, biological functions and role in disease. During hepatic injury, they fulfill manifold functions in connective tissue remodeling and wound healing, but overshooting activity of MFB on the other side induces fibrosis and cirrhosis. The present e-book "Liver myofibroblasts" contains 9 articles providing comprehensive information on "hot topics" of MFB. In our opening editorial we provide a short overview of the origin of MFB and their relevance in extracellular matrix formation which is the hallmark of hepatic fibrosis. Thereafter, leading experts in the field share their current perspectives on special topics of (i) MFB in development and disease, ii) their role in hepatic fibrogenesis, and (iii) promising therapies and targets that are suitable to interfere with hepatic fibrosis.

Liver Myofibroblasts

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Liver Myofibroblasts by :

Download or read book Liver Myofibroblasts written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myofibroblasts (MFB) are found in most tissues of the body. They have the matrix-producing functions of fibroblasts and contractile properties that are known from smooth muscle cells. Fundamental work of the last decades has shed remarkable light on their origin, biological functions and role in disease. During hepatic injury, they fulfill manifold functions in connective tissue remodeling and wound healing, but overshooting activity of MFB on the other side induces fibrosis and cirrhosis. The present e-book "Liver myofibroblasts" contains 9 articles providing comprehensive information on "hot topics" of MFB. In our opening editorial we provide a short overview of the origin of MFB and their relevance in extracellular matrix formation which is the hallmark of hepatic fibrosis. Thereafter, leading experts in the field share their current perspectives on special topics of (i) MFB in development and disease, ii) their role in hepatic fibrogenesis, and (iii) promising therapies and targets that are suitable to interfere with hepatic fibrosis.

Stellate Cells in Health and Disease

Author : Chandrashekhar Gandhi
Publisher : Academic Press
ISBN 13 : 0128005440
Total Pages : 335 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Stellate Cells in Health and Disease by : Chandrashekhar Gandhi

Download or read book Stellate Cells in Health and Disease written by Chandrashekhar Gandhi and published by Academic Press. This book was released on 2015-04-10 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.

Tissue Repair and Fibrosis

Author : Alexis Desmouliere
Publisher : Springer Science & Business Media
ISBN 13 : 364258456X
Total Pages : 358 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Tissue Repair and Fibrosis by : Alexis Desmouliere

Download or read book Tissue Repair and Fibrosis written by Alexis Desmouliere and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts

Extracellular Matrix and The Liver

Author : Isao Okazaki
Publisher : Academic Press
ISBN 13 : 9780125252515
Total Pages : 508 pages
Book Rating : 4.2/5 (525 download)

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Book Synopsis Extracellular Matrix and The Liver by : Isao Okazaki

Download or read book Extracellular Matrix and The Liver written by Isao Okazaki and published by Academic Press. This book was released on 2003-02-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches. The chapters are divided into six sections as follows: * Basic Science of Extracellular Matrix * Cells Responsible for Extracellular Matrix Production * Activation Mechanism of Hepatic Cells and Signal Transduction * Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors * Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases * New Strategies for the treatment of Liver Cirrhosis Key Features * Discusses the possibility of gene therapy for liver cirrhosis * Includes information on new aspects of hepatic stellate cells * Written by top experts in basic science and clinical hepatology.

Tissue Repair, Contraction and the Myofibroblast

Author : Christine Chaponnier
Publisher : Springer Science & Business Media
ISBN 13 : 0387336508
Total Pages : 154 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Tissue Repair, Contraction and the Myofibroblast by : Christine Chaponnier

Download or read book Tissue Repair, Contraction and the Myofibroblast written by Christine Chaponnier and published by Springer Science & Business Media. This book was released on 2007-02-26 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue Repair, Contraction and the Myofibroblast summarizes the latest findings concerning the biology of the myofibroblast, a cell involved in the evolution and contraction of granulation tissue and of fibrotic changes. Coverage shows that the myofibroblast is responsible for the development of hypertrophic scars, pulmonary and renal fibrosis and bronchial asthma. Reviews the cell biology and pathology of the myofibroblast as well as mechanisms of fibrosis evolution in many organs and tissues.

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

Author : Arthur Zimmermann
Publisher : Springer
ISBN 13 : 9783319269542
Total Pages : 0 pages
Book Rating : 4.2/5 (695 download)

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Book Synopsis Tumors and Tumor-Like Lesions of the Hepatobiliary Tract by : Arthur Zimmermann

Download or read book Tumors and Tumor-Like Lesions of the Hepatobiliary Tract written by Arthur Zimmermann and published by Springer. This book was released on 2016-11-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all liver tumors and lesions that clinically and radiologically mimic liver tumors. It provides readers with a comprehensive overview of this complex and rapidly evolving field. All aspects of surgical pathology are addressed, supplemented by detailed presentations of the lesions’ cell-biologic and molecular features. In addition, the methods employed for diagnosis and diagnostic algorithms are discussed. It appeals to pathologists and hepatologists and serves as an invaluable aid to diagnosis.The field of liver tumors and tumor-like lesions in adults and children has experienced tremendous advances in recent years. Specifically, the recognition of novel entities, deepened insights into known tumors, and refinement of classifications have necessitated continual updates and reappraisals. In addition, previous understanding of hepatic carcinogenesis and tumor progression has been transformed by the very rapid evolution of our understanding of cell biology, genomics, signaling pathways, cell interactions, and mechanisms of invasion and spread of hepatic tumor cells. These general pathology issues must be combined with surgical pathology if a comprehensive understanding of liver tumor pathology is to be achieved.

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Hepatic Fibrosis

Author : Pablo Muriel
Publisher : Academic Press
ISBN 13 : 0323952895
Total Pages : 276 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Hepatic Fibrosis by : Pablo Muriel

Download or read book Hepatic Fibrosis written by Pablo Muriel and published by Academic Press. This book was released on 2022-04-23 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatic Fibrosis: Mechanisms and Targets is a complete volume of liver extracellular matrix biology, including molecular signaling pathways, cells and factors that modulate fibrogenesis and fibrosis. The book uses an integrated approach toward the molecular and cellular mechanisms involved in the synthesis and degradation of hepatic fibrotic tissue, emphasizing the possible molecular targets to fight fibrosis. This important reference describes, in detail and didactically, the cellular and molecular events that are conducive to fibrosis that leads to cirrhosis, hepatocellular carcinoma and death. The provided information allows readers to understand the molecular mechanisms of hepatic fibrogenesis to accelerate the development of new therapies. Presents progression from inflammation to fibrosis, with a special focus on the molecular mechanisms involved Didactically explains the participation of cells, cytokines and factors in profibrogenic pathways Illuminates the causative participation of free radicals in liver fibrogenesis Explains the role of gut dysbiosis in chronic liver diseases leading to fibrosis Provides experimental models to study liver fibrosis and describes available, noninvasive monitoring methods

Liver Disease in Children

Author : Frederick J. Suchy
Publisher : Cambridge University Press
ISBN 13 : 1108911374
Total Pages : 875 pages
Book Rating : 4.1/5 (89 download)

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Book Synopsis Liver Disease in Children by : Frederick J. Suchy

Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.

Liver Metastasis: Biology and Clinical Management

Author : Pnina Brodt
Publisher : Springer Science & Business Media
ISBN 13 : 9400702922
Total Pages : 447 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Liver Metastasis: Biology and Clinical Management by : Pnina Brodt

Download or read book Liver Metastasis: Biology and Clinical Management written by Pnina Brodt and published by Springer Science & Business Media. This book was released on 2011-03-01 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.

Scleroproteins: Advances in Research and Application: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464921873
Total Pages : 402 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Scleroproteins: Advances in Research and Application: 2011 Edition by :

Download or read book Scleroproteins: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scleroproteins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Scleroproteins. The editors have built Scleroproteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Scleroproteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Scleroproteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Chronic Liver Disease: New Targets and New Mechanisms

Author : Jinhang Gao
Publisher : Frontiers Media SA
ISBN 13 : 2889767760
Total Pages : 186 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Chronic Liver Disease: New Targets and New Mechanisms by : Jinhang Gao

Download or read book Chronic Liver Disease: New Targets and New Mechanisms written by Jinhang Gao and published by Frontiers Media SA. This book was released on 2022-08-16 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Role of Immune Cells in Hepatic Ischemia Reperfusion

Author : Tao Qiu
Publisher : Frontiers Media SA
ISBN 13 : 2832508170
Total Pages : 147 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis The Role of Immune Cells in Hepatic Ischemia Reperfusion by : Tao Qiu

Download or read book The Role of Immune Cells in Hepatic Ischemia Reperfusion written by Tao Qiu and published by Frontiers Media SA. This book was released on 2022-12-01 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cooperation of Liver Cells in Health and Disease

Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Cooperation of Liver Cells in Health and Disease by : Z. Kmiec

Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Autonomy in Education

Author : Walter Berka
Publisher : Springer Science & Business Media
ISBN 13 : 9789041113115
Total Pages : 684 pages
Book Rating : 4.1/5 (131 download)

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Book Synopsis Autonomy in Education by : Walter Berka

Download or read book Autonomy in Education written by Walter Berka and published by Springer Science & Business Media. This book was released on 2000-04-13 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: The push towards greater autonomy is one of the three main trends in every modern educational policy, alongside quality assurance and quality evaluation techniques and the need to devote attention to special — and often disadvantaged — target groups. It is, however, difficult to derive a unified concept of `autonomy’ from the comparative indicators which are published on a regular basis and it has emerged that there are significant differences depending on the specific area and the administrative organisation of education in the country in question. During the discussions of the annual Congress of the European Association for Education Law and Policy (ELA) in Salzburg (1998) it was apparent that autonomy has to be considered in its various applications. Autonomy for school boards is realised through management, administrative mechanisms, management of staff and pedagogical options. Autonomy of administration requires competence, the willingness to establish an autonomous administration and awareness of each party’s responsibility in the educational process. The contents of this Yearbook are an answer to the question of how legislatures are responding to the trend towards greater responsibility, decentralisation and autonomy. It is an overview of the efforts made by the Member States of the European Union to apply the principle of subsidiarity.

Medical Applications of iPS Cells

Author : Haruhisa Inoue
Publisher : Springer
ISBN 13 : 9811336725
Total Pages : 190 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Medical Applications of iPS Cells by : Haruhisa Inoue

Download or read book Medical Applications of iPS Cells written by Haruhisa Inoue and published by Springer. This book was released on 2019-04-01 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.