Lipoxygenases And Their Products

Download Lipoxygenases And Their Products full books in PDF, epub, and Kindle. Read online Lipoxygenases And Their Products ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Lipoxygenases and Their Products

Author : Stanley Crooke
Publisher : Academic Press
ISBN 13 : 0323156533
Total Pages : 313 pages
Book Rating : 4.3/5 (231 download)

DOWNLOAD NOW!

Book Synopsis Lipoxygenases and Their Products by : Stanley Crooke

Download or read book Lipoxygenases and Their Products written by Stanley Crooke and published by Academic Press. This book was released on 2012-12-02 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipoxygenases and Their Products provides a cogent summary of the advances in understanding lipoxygenases and their products, emphasizing their pharmacology and pathophysiology; regulation and structure; physiological role; and receptors and receptor antagonists. This text also reviews the literature where specific receptor antagonists (as opposed to enzymatic inhibitors) have been used to characterize the pharmacologic action and the pathophysiologic roles of some of lipoxygenase products of arachidonic acid metabolism. This book is organized into 11 chapters and begins with an overview of the biochemical, pharmacological, and pathophysiological aspects of 5-lipoxygenase products of arachidonic acid metabolism in the respiratory, cardiovascular, renal, gastrointestinal, and central nervous systems. The discussion then shifts to human 5-lipoxygenase, emphasizing this enzyme purification, stimulatory factors, and membrane translocation. The reader is methodically introduced to 5-lipoxygenase activity in rats and pigs; the potential and therapeutic value of 5-lipoxygenase inhibitors; the distribution of 15-lipoxygenase in cells or tissues; and products formed through the 15-lipoxygenase pathway. This book also considers lipoxins and third-generation peptidoleukotriene receptor antagonists, and then concludes with a summary of the physiological and pathophysiological effects of leukotrienes and lipoxins in a variety of organs. This book is of interest to scientists interested in arachidonic acid and its metabolites, to scientists engaged in drug discovery-and-development activities in academia and the pharmaceutical industry, and to clinicians interested in diseases associated with leukotrienes and related products.

Lipoxygenases and their Metabolites

Author : Santosh Nigam
Publisher : Springer Science & Business Media
ISBN 13 : 1461548616
Total Pages : 226 pages
Book Rating : 4.4/5 (615 download)

DOWNLOAD NOW!

Book Synopsis Lipoxygenases and their Metabolites by : Santosh Nigam

Download or read book Lipoxygenases and their Metabolites written by Santosh Nigam and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a result of the First Conference on Lipoxygenases, held at Malta, May 17th-2l st, 1997. The goal was very ambitious: having lipoxygenases as a focus for distant and diverse experimental approaches, we brought together scientists to discuss and build a consensus on the biological role of lipoxygenases. Although still fuzzy in many details, the Malta conference has shown that a unifying view on lipoxygenases is finally taking shape, and that the experimental evidence of links and conjugations among events OCCUf ing from cell membranes to intracellular compartments and the nucleus is becoming in creasingly convincing. The editors are deeply grateful to Hospital for Sick Children, Toronto, Free Univer sity Berlin, NOAA Sea Grant College Program (U. S. A. ), Schering, Berlin (F. R. G. ), and Cayman Chemicals, Ann Arbor, Michigan (U. S. A. ), for their generous financial support, which was crucial in making the conference a scientific success. The conference received financial support from a number of additional sponsors, and we express our gratitude to Abbott Labs (U. S. A. ), Air Malta (Malta), Ass. Int. Cancer Res. (U. K. ), Biometra (F. R. G. ), Bayer AG (F. R. G. ), IBL Co. (F. R. G. ), Merck Frosst (Canada), Perkin Elmer (F. R. G. ), Scotia Pharmaceuticals (Canada), Searle (U. S. A. ), SPI Chemicals (France), and TOPCRO (Austria).

Lipid Oxidation

Author : Edwin N. Frankel
Publisher : Elsevier
ISBN 13 : 085709792X
Total Pages : 487 pages
Book Rating : 4.8/5 (57 download)

DOWNLOAD NOW!

Book Synopsis Lipid Oxidation by : Edwin N. Frankel

Download or read book Lipid Oxidation written by Edwin N. Frankel and published by Elsevier. This book was released on 2014-01-23 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second edition, Edwin Frankel has updated and extended his now well-known book Lipid oxidation which has come to be regarded as the standard work on the subject since the publication of the first edition seven years previously. His main objective is to develop the background necessary for a better understanding of what factors should be considered, and what methods and lipid systems should be employed, to achieve suitable evaluation and control of lipid oxidation in complex foods and biological systems. The oxidation of unsaturated fatty acids is one of the most fundamental reactions in lipid chemistry. When unsaturated lipids are exposed to air, the complex, volatile oxidation compounds that are formed cause rancidity. This decreases the quality of foods that contain natural lipid components as well as foods in which oils are used as ingredients. Furthermore, products of lipid oxidation have been implicated in many vital biological reactions, and evidence has accumulated to show that free radicals and reactive oxygen species participate in tissue injuries and in degenerative disease. Although there have been many significant advances in this challenging field, many important problems remain unsolved. This second edition of Lipid oxidation follows the example of the first edition in offering a summary of the many unsolved problems that need further research. The need to understand lipid oxidation is greater than ever with the increased interest in long-chain polyunsaturated fatty acids, the reformulation of oils to avoid hydrogenation and trans fatty acids, and the enormous attention given to natural phenolic antioxidants, including flavonoids and other phytochemicals.

12-lipoxygenases

Author : Johanna Rapp
Publisher :
ISBN 13 :
Total Pages : 186 pages
Book Rating : 4.:/5 (182 download)

DOWNLOAD NOW!

Book Synopsis 12-lipoxygenases by : Johanna Rapp

Download or read book 12-lipoxygenases written by Johanna Rapp and published by . This book was released on 2006 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lipoxygenase enzymes are non-heme, non-sulfur iron dioxygenases that are widely distributed throughout plants, animals, fungi and some bacteria. This family of enzymes plays a major role in polyunsaturated fatty acid metabolism because they catalyze the incorporation of molecular oxygen into fatty acids containing a 1,4-pentadiene moiety producing hydroperoxide products. In mammals, the products of the dioxygenation catalyzed by lipoxygenases, hydroperoxyeicosatetraenoic acid (HPETEs), are intermediates in the formation of bioregulators including leukotrienes, hepoxilins and HETEs, that are implicated in a variety of human conditions such as inflammation, fever, arthritis and cancer. 12-Lipoxygenases are mammalian lipoxygenases that catalyze the conversion of arachidonic acid into 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE). Actually, 12-HPETE is a precursor to the formation of the hydroxy fatty acid 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) and also epoxy fatty acids called hepoxylins. There are three isoforms of 12-lipoxygenase named after the cells where they are found: leukocyte, platelet and epidermis type-enzymes. Even if the leukocyte and the platelet 12-lipoxygenase catalyze the same reaction, they differ by their tissue distribution, their substrate specificity, their primary structure and size. They are also involved in different kinds of diseases as inflammation, hypertension and diabetes. The goal of this research was to investigate the human platelet and porcine leukocyte 12-lipoxygenases. In order to study both 12-lipoxygenases, they need to be expressed, purified and in the best case crystallized to get the 3D structure. This thesis presents the expression and purification protocols that lead to the preparation of large amounts of pure porcine leukocyte 12-lipoxygenase. Several biophysical analyses were performed to characterize the protein in solution such as dynamic light scattering (DLS), differential scanning calorimetry (DSC), EPR spectroscopy and mass spectrometry. Many crystallization experiments were also tried in order to obtain diffraction-quality crystals of porcine leukocyte 12-lipoxygenase. As for the human platelet 12-lipoxygenase, the expression step turned out to be less successful, and leads to low yields and unsatisfactory purity.

Seed Proteins

Author : Peter R. Shewry
Publisher : Springer Science & Business Media
ISBN 13 : 9401144311
Total Pages : 892 pages
Book Rating : 4.4/5 (11 download)

DOWNLOAD NOW!

Book Synopsis Seed Proteins by : Peter R. Shewry

Download or read book Seed Proteins written by Peter R. Shewry and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seeds provide more than half of the world's intake of dietary protein and energy and thus are of immense economic, cultural and nutritional importance. Proteins can account for up to 40% of the dry weight of various types of seeds, thereby making a large contribution to the nutritional quality and processing properties of seeds. It is, therefore, not surprising that seed proteins were among the first plant components to be systematically studied, some 250 years ago, and have been a major focus of research over the past 100 years. The properties and behaviour of seed proteins pervade modem life in numerous ways. For example, legume and cereal proteins are used'in the production of a wide range of meat-free foods; the process of bread-making is dep~ndent on the physical chemical properties of wheat seed proteins; and in developed, as well as developing, countries, nutritional deficiencies among vegetarian diets are avoided through balancing legume and cereal seeds as sources of dietary proteins. Understanding seed proteins, in order to improve their composition and properties and to increase their concentrations, will thus continue to be an important research objective for the future. The present volume represents the culmination of a long-discussed plan of the editors, to bring together the best international authorities in order to compile a definitive monograph on biological, biochemical, molecular and genetic aspects of seed proteins.

Autoxidation in Food and Biological Systems

Author : M.G. Simic
Publisher : Springer Science & Business Media
ISBN 13 : 1475793510
Total Pages : 652 pages
Book Rating : 4.4/5 (757 download)

DOWNLOAD NOW!

Book Synopsis Autoxidation in Food and Biological Systems by : M.G. Simic

Download or read book Autoxidation in Food and Biological Systems written by M.G. Simic and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: The material presented in this book deals with basic mechanisms of free radical reactions in autoxidation processes and anitoxidant suppression of autoxidation of foods, biochemical models and biologi cal systems. Autoxidation in foods and corresponding biological effects are usually approached separately although recent mechanistic developments in the biochemistry and free radical chemistry of per oxides and their precursors tend to bring these two fields closer. Apparent ability of antioxidants in diets to reduce the inci dence of cancer has resulted in scrutiny of autoxidized products and their precursors as possibly toxic, mutagenic and carcinogenic agents. Mechanisms of any of these effects have been barely ad dressed. Yet we know now that free radicals, as esoteric as they were only a few decades ago, are being discovered in foods, biochem ical and biological systems and do play a role in the above-mentioned causalities. The purpose of the Workshop and the resulting book was to give a unifying approach towards study of beneficial and deleterious effects of autoxidation, based on rigorous scientific considerations. It is our hope that the material presented in this book will not only provide a review of the "state of the art" of autoxidation and anti oxidants, but also reflect the interaction which occurred during the Workshop between workers using model sytems, and food and biological systems.

The Resolution of Inflammation

Author : Adriano Rossi
Publisher : Springer Science & Business Media
ISBN 13 : 376437506X
Total Pages : 246 pages
Book Rating : 4.7/5 (643 download)

DOWNLOAD NOW!

Book Synopsis The Resolution of Inflammation by : Adriano Rossi

Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Epidermal Lipoxygenase Products

Author : Craig Cameron Miller
Publisher :
ISBN 13 :
Total Pages : 390 pages
Book Rating : 4.:/5 (42 download)

DOWNLOAD NOW!

Book Synopsis Epidermal Lipoxygenase Products by : Craig Cameron Miller

Download or read book Epidermal Lipoxygenase Products written by Craig Cameron Miller and published by . This book was released on 1990 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:

I. Determination of the Stereochemistry of Lipoxygenase Products

Author : Jon C. Andre
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (156 download)

DOWNLOAD NOW!

Book Synopsis I. Determination of the Stereochemistry of Lipoxygenase Products by : Jon C. Andre

Download or read book I. Determination of the Stereochemistry of Lipoxygenase Products written by Jon C. Andre and published by . This book was released on 1986 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Amphioxus Immunity

Author : An-Long Xu
Publisher : Elsevier
ISBN 13 : 0128096470
Total Pages : 306 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Amphioxus Immunity by : An-Long Xu

Download or read book Amphioxus Immunity written by An-Long Xu and published by Elsevier. This book was released on 2015-12-31 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: Amphioxus as a model for understanding the evolution of vertebrates basic knowledge of immunology immune organs and cells of amphioxus a genomic and transcriptomic view of the Amphioxus immunity pattern recognition system in Amphioxus transcription factors in Amphioxus the complement system of Amphioxus the oxidative burst system in Amphioxus immune effectors in Amphioxus lipid signaling of immune response in Amphioxus apoptosis in amphioxus; primitive adaptive immune system of Amphioxus and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity. Provides new evidence on the origin of the adaptive immune system, the evolution of innate immunity, and evolution-stage specific immune defense mechanisms Not only presents the cells and molecules involved in the adaptive immune response in Amphioxus, but also characterizes the origination and evolution of the gene families and pathways involved in innate immunity Includes much pioneering work, from the molecular, genomic, and cellular to the individual level

Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4

Author : Kenneth V. Honn
Publisher : Springer Science & Business Media
ISBN 13 : 1461547938
Total Pages : 660 pages
Book Rating : 4.4/5 (615 download)

DOWNLOAD NOW!

Book Synopsis Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4 by : Kenneth V. Honn

Download or read book Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4 written by Kenneth V. Honn and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains conference presentations regarding the regulation of eicosanoid enzymes and, in particular, cyclooxygenases, lipoxygenases, and phospholipases. The new field of isoprostanes is also represented.

A Comprehensive Survey of International Soybean Research

Author : James Board
Publisher : IntechOpen
ISBN 13 : 9789535108764
Total Pages : 0 pages
Book Rating : 4.1/5 (87 download)

DOWNLOAD NOW!

Book Synopsis A Comprehensive Survey of International Soybean Research by : James Board

Download or read book A Comprehensive Survey of International Soybean Research written by James Board and published by IntechOpen. This book was released on 2013-01-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Soybean is the most important oilseed and livestock feed crop in the world. These dual uses are attributed to the crop's high protein content (nearly 40% of seed weight) and oil content (approximately 20%); characteristics that are not rivaled by any other agronomic crop. Across the 10-year period from 2001 to 2010, world soybean production increased from 168 to 258 million metric tons (54% increase). Against the backdrop of soybean's striking ascendancy is increased research interest in the crop throughout the world. Information in this book presents a comprehensive view of research efforts in genetics, plant physiology, agronomy, agricultural economics, and nitrogen relationships that will benefit soybean stakeholders and scientists throughout the world. We hope you enjoy the book.

Five-Lipoxygenase Products in Asthma

Author : Jeffrey Drazen
Publisher : CRC Press
ISBN 13 : 0824746368
Total Pages : 520 pages
Book Rating : 4.8/5 (247 download)

DOWNLOAD NOW!

Book Synopsis Five-Lipoxygenase Products in Asthma by : Jeffrey Drazen

Download or read book Five-Lipoxygenase Products in Asthma written by Jeffrey Drazen and published by CRC Press. This book was released on 2016-04-19 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma. A critical reference for every asthma researcher and clinician, Five-Lipoxygenase Products in Asthma highlights agents and products

Leukotrienes and Lipoxygenases

Author : Joshua Rokach
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 560 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Leukotrienes and Lipoxygenases by : Joshua Rokach

Download or read book Leukotrienes and Lipoxygenases written by Joshua Rokach and published by Elsevier Publishing Company. This book was released on 1989 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Important advances have been made in the chemistry and biochemistry of the leukotrienes mainly as a result of the development of new biophysical and biochemical methodologies. The extraordinary effort of many scientists and the interactions of many scientific disciplines has created a vast amount of data and information and, with it, the need for a book addressing all aspects of this multidisciplinary field. This book has been written to respond to that need. It comprises six chapters which together provide a cohesive interdisciplinary coverage of the field, from the organic, analytical aspect to the biological sciences. Among the many subjects covered are many aspects of the leukotriene field which have not been covered in detail before, i.e. the numerous methodologies employed in the detection, localization and quantitation of lipoxygenase products; the role of leukotrienes in human disease states; leukotriene antagonists and lipoxygenase inhibitors, and potential therapeutic agents. The book brings together a wide variety of material to give a valuable overview of this important subject.

Antioxidant and Redox Regulation of Genes

Author : Chandan K. Sen
Publisher : Academic Press
ISBN 13 : 0080527299
Total Pages : 591 pages
Book Rating : 4.0/5 (85 download)

DOWNLOAD NOW!

Book Synopsis Antioxidant and Redox Regulation of Genes by : Chandan K. Sen

Download or read book Antioxidant and Redox Regulation of Genes written by Chandan K. Sen and published by Academic Press. This book was released on 1999-11-08 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses oxidant-reduction or redox and antioxidant sensitive molecular mechanisms and how they are implicated in different disease processes. Possible strategies to pharmacologically and/or nutritionally manipulate such redox-sensitive molecular responses are emphasized. Reactive species as intracellular messengers Redox regulation of cellular responses Clinical implications of redox signaling and antioxidant therapy

Arachidonic Acid in Cell Signaling

Author : Daniele Piomelli
Publisher : Springer Science & Business Media
ISBN 13 : 3662058073
Total Pages : 243 pages
Book Rating : 4.6/5 (62 download)

DOWNLOAD NOW!

Book Synopsis Arachidonic Acid in Cell Signaling by : Daniele Piomelli

Download or read book Arachidonic Acid in Cell Signaling written by Daniele Piomelli and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the arachidonic acid cascade, its biochemistry, its pharmacology, and its roles in signal transduction. Arachidonic acid may serve as an intracellular second messenger in many cell types, as well as precursor for biologically active molecules such as the eicosanoids (a family of oxygenated metabolites that may act as second messengers or as local mediators), and anandamide (an endogenous cannabinoid substance). Dysfunctions in the arachidonic acid cascade underlie a number of serious pathological conditions, making these biochemical pathways the target for drugs of clinical value.

Oxidation in Foods and Beverages and Antioxidant Applications

Author : E Decker
Publisher : Woodhead Publishing
ISBN 13 : 9780081014578
Total Pages : 0 pages
Book Rating : 4.0/5 (145 download)

DOWNLOAD NOW!

Book Synopsis Oxidation in Foods and Beverages and Antioxidant Applications by : E Decker

Download or read book Oxidation in Foods and Beverages and Antioxidant Applications written by E Decker and published by Woodhead Publishing. This book was released on 2016-08-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative rancidity is a major cause of food quality deterioration, leading to the formation of undesirable off-flavours as well as unhealthy compounds. Antioxidants are widely employed to inhibit oxidation, and with current consumer concerns about synthetic additives and natural antioxidants are of much interest. The two volumes of Oxidation in foods and beverages and antioxidant applications review food quality deterioration due to oxidation and methods for its control. The second volume reviews problems associated with oxidation and its management in different industry sectors. Part one focuses on animal products, with chapters on the oxidation and protection of red meat, poultry, fish and dairy products. The oxidation of fish oils and foods enriched with omega-3 polyunsaturated fatty acids is also covered. Part two reviews oxidation in plant-based foods and beverages, including edible oils, fruit and vegetables, beer and wine. Oxidation of fried products and emulsion-based foods is also discussed. Final chapters examine encapsulation to inhibit lipid oxidation and antioxidant active packaging and edible films. With its distinguished international team of editors and contributors, the two volumes of Oxidation in foods and beverages and antioxidant applications is standard references for R&D and QA professionals in the food industry, as well as academic researchers interested in food quality.