Lipoxygenases And Their Metabolites

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Lipoxygenases and their Metabolites

Author : Santosh Nigam
Publisher : Springer Science & Business Media
ISBN 13 : 1461548616
Total Pages : 226 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Lipoxygenases and their Metabolites by : Santosh Nigam

Download or read book Lipoxygenases and their Metabolites written by Santosh Nigam and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a result of the First Conference on Lipoxygenases, held at Malta, May 17th-2l st, 1997. The goal was very ambitious: having lipoxygenases as a focus for distant and diverse experimental approaches, we brought together scientists to discuss and build a consensus on the biological role of lipoxygenases. Although still fuzzy in many details, the Malta conference has shown that a unifying view on lipoxygenases is finally taking shape, and that the experimental evidence of links and conjugations among events OCCUf ing from cell membranes to intracellular compartments and the nucleus is becoming in creasingly convincing. The editors are deeply grateful to Hospital for Sick Children, Toronto, Free Univer sity Berlin, NOAA Sea Grant College Program (U. S. A. ), Schering, Berlin (F. R. G. ), and Cayman Chemicals, Ann Arbor, Michigan (U. S. A. ), for their generous financial support, which was crucial in making the conference a scientific success. The conference received financial support from a number of additional sponsors, and we express our gratitude to Abbott Labs (U. S. A. ), Air Malta (Malta), Ass. Int. Cancer Res. (U. K. ), Biometra (F. R. G. ), Bayer AG (F. R. G. ), IBL Co. (F. R. G. ), Merck Frosst (Canada), Perkin Elmer (F. R. G. ), Scotia Pharmaceuticals (Canada), Searle (U. S. A. ), SPI Chemicals (France), and TOPCRO (Austria).

Lipoxygenases and Their Products

Author : Stanley Crooke
Publisher : Academic Press
ISBN 13 : 0323156533
Total Pages : 313 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Lipoxygenases and Their Products by : Stanley Crooke

Download or read book Lipoxygenases and Their Products written by Stanley Crooke and published by Academic Press. This book was released on 2012-12-02 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipoxygenases and Their Products provides a cogent summary of the advances in understanding lipoxygenases and their products, emphasizing their pharmacology and pathophysiology; regulation and structure; physiological role; and receptors and receptor antagonists. This text also reviews the literature where specific receptor antagonists (as opposed to enzymatic inhibitors) have been used to characterize the pharmacologic action and the pathophysiologic roles of some of lipoxygenase products of arachidonic acid metabolism. This book is organized into 11 chapters and begins with an overview of the biochemical, pharmacological, and pathophysiological aspects of 5-lipoxygenase products of arachidonic acid metabolism in the respiratory, cardiovascular, renal, gastrointestinal, and central nervous systems. The discussion then shifts to human 5-lipoxygenase, emphasizing this enzyme purification, stimulatory factors, and membrane translocation. The reader is methodically introduced to 5-lipoxygenase activity in rats and pigs; the potential and therapeutic value of 5-lipoxygenase inhibitors; the distribution of 15-lipoxygenase in cells or tissues; and products formed through the 15-lipoxygenase pathway. This book also considers lipoxins and third-generation peptidoleukotriene receptor antagonists, and then concludes with a summary of the physiological and pathophysiological effects of leukotrienes and lipoxins in a variety of organs. This book is of interest to scientists interested in arachidonic acid and its metabolites, to scientists engaged in drug discovery-and-development activities in academia and the pharmaceutical industry, and to clinicians interested in diseases associated with leukotrienes and related products.

Lipid Oxidation

Author : Edwin N. Frankel
Publisher : Elsevier
ISBN 13 : 085709792X
Total Pages : 487 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Lipid Oxidation by : Edwin N. Frankel

Download or read book Lipid Oxidation written by Edwin N. Frankel and published by Elsevier. This book was released on 2014-01-23 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second edition, Edwin Frankel has updated and extended his now well-known book Lipid oxidation which has come to be regarded as the standard work on the subject since the publication of the first edition seven years previously. His main objective is to develop the background necessary for a better understanding of what factors should be considered, and what methods and lipid systems should be employed, to achieve suitable evaluation and control of lipid oxidation in complex foods and biological systems. The oxidation of unsaturated fatty acids is one of the most fundamental reactions in lipid chemistry. When unsaturated lipids are exposed to air, the complex, volatile oxidation compounds that are formed cause rancidity. This decreases the quality of foods that contain natural lipid components as well as foods in which oils are used as ingredients. Furthermore, products of lipid oxidation have been implicated in many vital biological reactions, and evidence has accumulated to show that free radicals and reactive oxygen species participate in tissue injuries and in degenerative disease. Although there have been many significant advances in this challenging field, many important problems remain unsolved. This second edition of Lipid oxidation follows the example of the first edition in offering a summary of the many unsolved problems that need further research. The need to understand lipid oxidation is greater than ever with the increased interest in long-chain polyunsaturated fatty acids, the reformulation of oils to avoid hydrogenation and trans fatty acids, and the enormous attention given to natural phenolic antioxidants, including flavonoids and other phytochemicals.

Lipoxygenases in Inflammation

Author : Dieter Steinhilber
Publisher : Springer
ISBN 13 : 3319277669
Total Pages : 252 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Lipoxygenases in Inflammation by : Dieter Steinhilber

Download or read book Lipoxygenases in Inflammation written by Dieter Steinhilber and published by Springer. This book was released on 2016-04-27 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume summarizes the physiological and pathophysiological functions of lipoxygenases.

ARACHIDONATE CYCLOOXYGENASE AND LIPOXYGENASE METABOLITES (their Involvement in Immunological Responses and General Physiology)

Author : Daren K. Bair
Publisher :
ISBN 13 :
Total Pages : 16 pages
Book Rating : 4.:/5 (172 download)

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Book Synopsis ARACHIDONATE CYCLOOXYGENASE AND LIPOXYGENASE METABOLITES (their Involvement in Immunological Responses and General Physiology) by : Daren K. Bair

Download or read book ARACHIDONATE CYCLOOXYGENASE AND LIPOXYGENASE METABOLITES (their Involvement in Immunological Responses and General Physiology) written by Daren K. Bair and published by . This book was released on 1986 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Amphioxus Immunity

Author : An-Long Xu
Publisher : Elsevier
ISBN 13 : 0128096470
Total Pages : 306 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Amphioxus Immunity by : An-Long Xu

Download or read book Amphioxus Immunity written by An-Long Xu and published by Elsevier. This book was released on 2015-12-31 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: Amphioxus as a model for understanding the evolution of vertebrates basic knowledge of immunology immune organs and cells of amphioxus a genomic and transcriptomic view of the Amphioxus immunity pattern recognition system in Amphioxus transcription factors in Amphioxus the complement system of Amphioxus the oxidative burst system in Amphioxus immune effectors in Amphioxus lipid signaling of immune response in Amphioxus apoptosis in amphioxus; primitive adaptive immune system of Amphioxus and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity. Provides new evidence on the origin of the adaptive immune system, the evolution of innate immunity, and evolution-stage specific immune defense mechanisms Not only presents the cells and molecules involved in the adaptive immune response in Amphioxus, but also characterizes the origination and evolution of the gene families and pathways involved in innate immunity Includes much pioneering work, from the molecular, genomic, and cellular to the individual level

The Resolution of Inflammation

Author : Adriano Rossi
Publisher : Springer Science & Business Media
ISBN 13 : 376437506X
Total Pages : 246 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis The Resolution of Inflammation by : Adriano Rossi

Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Antioxidant and Redox Regulation of Genes

Author : Chandan K. Sen
Publisher : Academic Press
ISBN 13 : 0080527299
Total Pages : 591 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Antioxidant and Redox Regulation of Genes by : Chandan K. Sen

Download or read book Antioxidant and Redox Regulation of Genes written by Chandan K. Sen and published by Academic Press. This book was released on 1999-11-08 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses oxidant-reduction or redox and antioxidant sensitive molecular mechanisms and how they are implicated in different disease processes. Possible strategies to pharmacologically and/or nutritionally manipulate such redox-sensitive molecular responses are emphasized. - Reactive species as intracellular messengers - Redox regulation of cellular responses - Clinical implications of redox signaling and antioxidant therapy

Polyunsaturated fatty acids and their association with 5-lipoxygenase pathway metabolites and myocardial infarction

Author : Michael René Skjelbo Nielsen
Publisher :
ISBN 13 : 9788792010636
Total Pages : pages
Book Rating : 4.0/5 (16 download)

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Book Synopsis Polyunsaturated fatty acids and their association with 5-lipoxygenase pathway metabolites and myocardial infarction by : Michael René Skjelbo Nielsen

Download or read book Polyunsaturated fatty acids and their association with 5-lipoxygenase pathway metabolites and myocardial infarction written by Michael René Skjelbo Nielsen and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Epigenetics: Development and Disease

Author : Tapas Kumar Kundu
Publisher : Springer Science & Business Media
ISBN 13 : 9400745257
Total Pages : 698 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Epigenetics: Development and Disease by : Tapas Kumar Kundu

Download or read book Epigenetics: Development and Disease written by Tapas Kumar Kundu and published by Springer Science & Business Media. This book was released on 2012-11-13 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.

The Endothelium

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041230
Total Pages : 309 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Endothelium by : Michel Félétou

Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids

Author :
Publisher : Academic Press
ISBN 13 : 9780128022153
Total Pages : 0 pages
Book Rating : 4.0/5 (221 download)

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Book Synopsis Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids by :

Download or read book Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids written by and published by Academic Press. This book was released on 2014-12-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural compounds from a variety of natural resources including plants have emerged as important source of anticancer drug development. This special issue will highlight the significant advance in elucidating mechanisms of action of these natural compounds, focusing especially on isoprenoids and polyphenols/flavonoids.

Textbook of Veterinary Physiological Chemistry

Author : Larry Engelking
Publisher : Academic Press
ISBN 13 : 012391910X
Total Pages : 789 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Textbook of Veterinary Physiological Chemistry by : Larry Engelking

Download or read book Textbook of Veterinary Physiological Chemistry written by Larry Engelking and published by Academic Press. This book was released on 2014-08-12 with total page 789 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic and clinical science concepts, the Textbook of Veterinary Physiological Chemistry, Third Edition offers broad coverage of biochemical principles for students and practitioners of veterinary medicine. The only recent biochemistry book written specifically for the veterinary field, this text covers cellular-level concepts related to whole-body physiologic processes in a reader-friendly, approachable manner. Each chapter is written in a succinct and concise style that includes an overview summary section, numerous illustrations for best comprehension of the subject matter, targeted learning objectives, and end of the chapter study questions to assess understanding. With new illustrations and an instructor website with updated PowerPoint images, the Textbook of Veterinary Physiological Chemistry, Third Edition, proves useful to students and lecturers from diverse educational backgrounds. Sectional exams and case studies, new to this edition, extend the breadth and depth of learning resources. - Provides newly developed case studies that demonstrate practical application of concepts - Presents comprehensive sectional exams for self-assessment - Delivers instructor website with updated PowerPoint images and lecture slides to enhance teaching and learning - Employs a succinct communication style in support of quick comprehension

Novel Enzyme Technology for Food Applications

Author : R Rastall
Publisher : Elsevier
ISBN 13 : 184569371X
Total Pages : 337 pages
Book Rating : 4.8/5 (456 download)

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Book Synopsis Novel Enzyme Technology for Food Applications by : R Rastall

Download or read book Novel Enzyme Technology for Food Applications written by R Rastall and published by Elsevier. This book was released on 2007-09-21 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: The food industry is constantly seeking advanced technologies to meet consumer demand for nutritionally balanced food products. Enzymes are a useful biotechnological processing tool whose action can be controlled in the food matrix to produce higher quality products. Written by an international team of contributors, Novel enzyme technology for food applications reviews the latest advanced methods to develop specific enzymes and their applications.Part one discusses fundamental aspects of industrial enzyme technology. Chapters cover the discovery, improvement and production of enzymes as well as consumer attitudes towards the technology. Chapters in Part two discuss enzyme technology for specific food applications such as textural improvement, protein-based fat replacers, flavour enhancers, and health-functional carbohydrates.Novel enzyme technology for food applications is a standard reference for all those in industry and academia concerned with improving food products with this advanced technology. - Reviews the latest advanced methods to develop specific enzymes - Discusses ways of producing higher quality food products - Explores the improvement and production of enzymes

The Eicosanoids

Author : Peter Curtis-Prior
Publisher : John Wiley & Sons
ISBN 13 : 047002061X
Total Pages : 654 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis The Eicosanoids by : Peter Curtis-Prior

Download or read book The Eicosanoids written by Peter Curtis-Prior and published by John Wiley & Sons. This book was released on 2004-07-16 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).

Lipid Biochemistry

Author : Michael I. Gurr
Publisher : John Wiley & Sons
ISBN 13 : 1405172703
Total Pages : 339 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Lipid Biochemistry by : Michael I. Gurr

Download or read book Lipid Biochemistry written by Michael I. Gurr and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition of this successful and popular book in 1970, the subject of lipid biochemistry has evolved greatly and this fifth up-to-date and comprehensive edition includes much new and exciting information. Lipid Biochemistry, fifth edition has been largely re-written in a user-friendly way, with chapters containing special interest topic boxes, summary points and lists of suggested reading, further enhancing the accessibility and readability of this excellent text. Contents include abbreviations and definitions used in the study of lipids, routine analytical methods, fatty acid structure and metabolism, dietary lipids and lipids as energy stores, lipid transport, lipids in cellular structures and the metabolism of structural lipids. The book provides a most comprehensive treatment of the subject, making it essential reading for all those working with or studying lipids. Upper level students of biochemistry, biology, clinical subjects, nutrition and food science will find the contents of this book invaluable as a study aid, as will postgraduates specializing in the topics covered in the book. Professionals working in research in academia and industry, including personnel involved in food and nutrition research, new product formulation, special diet formulation (including nutraceuticals and functional foods) and other clinical aspects will find a vast wealth of information within the book's pages. Michael Gurr was a Visiting Professor in Human Nutrition at the University of Reading, UK and at Oxford Brookes University, UK. John Harwood is a Professor of Biochemistry at the School of Biosciences, Cardiff University, UK. Keith Frayn is a Professor of Human Metabolism at the Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK.

Gastrointestinal Tissue

Author : Jordi Gracia-Sancho
Publisher : Academic Press
ISBN 13 : 0128093005
Total Pages : 396 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Gastrointestinal Tissue by : Jordi Gracia-Sancho

Download or read book Gastrointestinal Tissue written by Jordi Gracia-Sancho and published by Academic Press. This book was released on 2017-05-10 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastrointestinal Tissue: Oxidative Stress and Dietary Antioxidants brings together leading experts from world renowned institutions, combining the basic mechanisms of gastrointestinal diseases with information regarding new and alternative treatments. The processes within the science of oxidative stress are described in concert with other processes, including apoptosis, cell signaling and receptor mediated responses, further recognizing that diseases are often multifactorial with oxidative stress as a component. By combining the critical molecular processes underlying free radical mediated pathologies and the role of dietary antioxidant molecules, a connection is made that helps advance therapies and the prevention of gastrointestinal pathological processes. This important reference is well designed with two complementary sections. Section One, Oxidative Stress and Gastroenterology, covers the basic processes of oxidative stress from molecular biology to whole organs, the gastrointestinal anatomy and sources of oxidative stress and free radicals and their products in gastrointestinal diseases. Section Two, Antioxidants and Gastroenterology covers antioxidants in foods, including plants and components. - Covers the science of oxidative stress in gastrointestinal tissue and associated conditions and scenarios - Provides information on optimal levels for human consumption of antioxidants, suggested requirements per day, recommended dietary allowances and curative/preventive effects of dietary antioxidants - Presents an easy to reference guide with two complementary sections that discuss the pathophysiology of gastrointestinal diseases in relation to oxidative stress and antioxidant therapies