Links between Fibrogenesis and Cancer

Download Links between Fibrogenesis and Cancer PDF Online Free

Author :
Publisher : MDPI
ISBN 13 : 3039217062
Total Pages : 348 pages
Book Rating : 4.0/5 (392 download)

DOWNLOAD NOW!


Book Synopsis Links between Fibrogenesis and Cancer by : Esteban C. Gabazza

Download or read book Links between Fibrogenesis and Cancer written by Esteban C. Gabazza and published by MDPI. This book was released on 2019-11-18 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, and now accumulating evidence suggests that fibrotic lesions enhance the risk of cancer in several organs such as liver, lungs, and breast. Disruption of an organ parenchymal cells and of its normal structural scaffold during tissue fibrogenesis appears to induce loss of cell polarity, promoting uncontrolled cell proliferation that may eventually lead to cancer development. Many cellular and molecular abnormalities including aberrant expression of microRNAs, genetic and epigenetic alterations, evasion or delayed apoptosis, unregulated intracellular signal pathways, and dysregulation or defective intercellular communications have been proposed to explain this link between fibrogenesis and carcinogenesis. However, the precise mechanisms of this fibrosis-to-cancer transition remain unclear. This book presents a collection of reviews and original articles summarizing recent advances in understanding the molecular mechanisms of cancer development in fibrotic organs.

Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges

Download Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges PDF Online Free

Author :
Publisher :
ISBN 13 : 9783039217076
Total Pages : 348 pages
Book Rating : 4.2/5 (17 download)

DOWNLOAD NOW!


Book Synopsis Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges by : Esteban C. Gabazza

Download or read book Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges written by Esteban C. Gabazza and published by . This book was released on 2019 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, and now accumulating evidence suggests that fibrotic lesions enhance the risk of cancer in several organs such as liver, lungs, and breast. Disruption of an organ parenchymal cells and of its normal structural scaffold during tissue fibrogenesis appears to induce loss of cell polarity, promoting uncontrolled cell proliferation that may eventually lead to cancer development. Many cellular and molecular abnormalities including aberrant expression of microRNAs, genetic and epigenetic alterations, evasion or delayed apoptosis, unregulated intracellular signal pathways, and dysregulation or defective intercellular communications have been proposed to explain this link between fibrogenesis and carcinogenesis. However, the precise mechanisms of this fibrosis-to-cancer transition remain unclear. This book presents a collection of reviews and original articles summarizing recent advances in understanding the molecular mechanisms of cancer development in fibrotic organs.

Tumor Organoids

Download Tumor Organoids PDF Online Free

Author :
Publisher : Humana Press
ISBN 13 : 3319605119
Total Pages : 225 pages
Book Rating : 4.3/5 (196 download)

DOWNLOAD NOW!


Book Synopsis Tumor Organoids by : Shay Soker

Download or read book Tumor Organoids written by Shay Soker and published by Humana Press. This book was released on 2017-10-20 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

The Renin Angiotensin System in Cancer, Lung, Liver and Infectious Diseases

Download The Renin Angiotensin System in Cancer, Lung, Liver and Infectious Diseases PDF Online Free

Author :
Publisher : Springer Nature
ISBN 13 : 3031236211
Total Pages : 499 pages
Book Rating : 4.0/5 (312 download)

DOWNLOAD NOW!


Book Synopsis The Renin Angiotensin System in Cancer, Lung, Liver and Infectious Diseases by : Sukhwinder K. Bhullar

Download or read book The Renin Angiotensin System in Cancer, Lung, Liver and Infectious Diseases written by Sukhwinder K. Bhullar and published by Springer Nature. This book was released on 2023-03-14 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.

Pathogenesis of Fibrosis

Download Pathogenesis of Fibrosis PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (788 download)

DOWNLOAD NOW!


Book Synopsis Pathogenesis of Fibrosis by :

Download or read book Pathogenesis of Fibrosis written by and published by . This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

How Tobacco Smoke Causes Disease

Download How Tobacco Smoke Causes Disease PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

DOWNLOAD NOW!


Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Inflammation and Cancer

Download Inflammation and Cancer PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 3034808372
Total Pages : 489 pages
Book Rating : 4.0/5 (348 download)

DOWNLOAD NOW!


Book Synopsis Inflammation and Cancer by : Bharat B. Aggarwal

Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

Download Stem Cell Aging: Mechanisms, Consequences, Rejuvenation PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 370911232X
Total Pages : 357 pages
Book Rating : 4.7/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Stem Cell Aging: Mechanisms, Consequences, Rejuvenation by : Hartmut Geiger

Download or read book Stem Cell Aging: Mechanisms, Consequences, Rejuvenation written by Hartmut Geiger and published by Springer. This book was released on 2015-07-06 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.

Machine Learning in Radiation Oncology

Download Machine Learning in Radiation Oncology PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 3319183052
Total Pages : 336 pages
Book Rating : 4.3/5 (191 download)

DOWNLOAD NOW!


Book Synopsis Machine Learning in Radiation Oncology by : Issam El Naqa

Download or read book Machine Learning in Radiation Oncology written by Issam El Naqa and published by Springer. This book was released on 2015-06-19 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​This book provides a complete overview of the role of machine learning in radiation oncology and medical physics, covering basic theory, methods, and a variety of applications in medical physics and radiotherapy. An introductory section explains machine learning, reviews supervised and unsupervised learning methods, discusses performance evaluation, and summarizes potential applications in radiation oncology. Detailed individual sections are then devoted to the use of machine learning in quality assurance; computer-aided detection, including treatment planning and contouring; image-guided radiotherapy; respiratory motion management; and treatment response modeling and outcome prediction. The book will be invaluable for students and residents in medical physics and radiation oncology and will also appeal to more experienced practitioners and researchers and members of applied machine learning communities.

Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor

Download Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor PDF Online Free

Author :
Publisher :
ISBN 13 : 9783039367856
Total Pages : 276 pages
Book Rating : 4.3/5 (678 download)

DOWNLOAD NOW!


Book Synopsis Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor by : Klaus Holzmann

Download or read book Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor written by Klaus Holzmann and published by . This book was released on 2020 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fibroblast growth factor (FGF) signal transmission has an essential function in embryonic development and tissue repair, and is dysregulated in the vast majority of malignancies studied. The FGF signaling in the tumor cells is usually increased by autocrine and paracrine mechanisms and gives them a high growth potential, resistance to apoptosis, neoangiogenesis and metastasis, all essential parameters relevant for tumor progression. This makes FGFs, and their tyrosine kinase receptors FGFRs, valuable targets for therapeutic interventions. This book is a collection of 15 recent articles--both original work and reviews--that summarize the current research state effectively. The content covers FGF signaling aspects in gastric, skin, liver, esophageal cancer, melanoma, mesothelioma and glioblastoma, including one article that addresses the role of FGF in the tumor-microenvironment cross-talk. Several reports describe the development of compounds targeting FGFRs, their structure and interaction with the receptor molecules, and their effectivity in preclinical and clinical testing. In summary, the papers demonstrate the complexity of the topic, with various FGF ligands and receptors involved and the need for further research. They also present results that fuel hope that targeting cancer with dysfunctional FGF signaling can become a realistic treatment option.

The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity

Download The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity PDF Online Free

Author :
Publisher : Office of the Surgeon General
ISBN 13 :
Total Pages : 80 pages
Book Rating : 4.:/5 ( download)

DOWNLOAD NOW!


Book Synopsis The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity by :

Download or read book The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity written by and published by Office of the Surgeon General. This book was released on 2001 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: Promotes the recognition, treatment, and prevention of conditions of overweight and obesity in the United States.

Treatment of Soft Tissue Sarcomas

Download Treatment of Soft Tissue Sarcomas PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461317576
Total Pages : 143 pages
Book Rating : 4.4/5 (613 download)

DOWNLOAD NOW!


Book Synopsis Treatment of Soft Tissue Sarcomas by : H.M. Pinedo

Download or read book Treatment of Soft Tissue Sarcomas written by H.M. Pinedo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major advances of the last decade concerning the treatment of patients with soft tissue sarcomas is that an increased number of patients are being discussed in multidisciplinary teams prior to the initial treatment. The present volume on soft tissue sarcomas in the series Cancer Treatment and Research reflects the multidisciplinary approach with a focus on recent developments. The availability of new histopathologic techniques has reduced the number of unclassified sarcomas and has furhter increased the importance of the histo pathologist in providing estimates of the prognosis of the patient as well as data for the planning of treatment strategy. Further data for this strategy will be provided by diagnostic imaging. In this field, the role of magnetic reson ance imaging has been further defined. Of utmost importance is the recent trend toward consensus in staging. The modification of the staging system of the American Joint Commission for Cancer Staging and End Results Report ing brings the possibility of a single staging system within reach in the next decade. As surgery still provides the only chance for cure, the importance of being the most sparing as possible is obvious. For this reason, radiotherapy has been applied with success. The introduction of relatively new radiation tech niques is therefore being observed with interest.

Multiple Myeloma

Download Multiple Myeloma PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3540857729
Total Pages : 349 pages
Book Rating : 4.5/5 (48 download)

DOWNLOAD NOW!


Book Synopsis Multiple Myeloma by : Thomas Moehler

Download or read book Multiple Myeloma written by Thomas Moehler and published by Springer Science & Business Media. This book was released on 2011-04-21 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy, including in particular the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.

Colon Cancer Cells

Download Colon Cancer Cells PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 586 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Colon Cancer Cells by : Mary Pat Moyer

Download or read book Colon Cancer Cells written by Mary Pat Moyer and published by . This book was released on 1990 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bugs as Drugs

Download Bugs as Drugs PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 1555819702
Total Pages : 514 pages
Book Rating : 4.5/5 (558 download)

DOWNLOAD NOW!


Book Synopsis Bugs as Drugs by : Robert A. Britton

Download or read book Bugs as Drugs written by Robert A. Britton and published by John Wiley & Sons. This book was released on 2020-07-02 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease. In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include: How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response. The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage. The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis. Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes. Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted.

Anti-inflammatory Nutraceuticals and Chronic Diseases

Download Anti-inflammatory Nutraceuticals and Chronic Diseases PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 3319413341
Total Pages : 479 pages
Book Rating : 4.3/5 (194 download)

DOWNLOAD NOW!


Book Synopsis Anti-inflammatory Nutraceuticals and Chronic Diseases by : Subash Chandra Gupta

Download or read book Anti-inflammatory Nutraceuticals and Chronic Diseases written by Subash Chandra Gupta and published by Springer. This book was released on 2016-09-26 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in various chronic diseases. Food and Drug Administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. This means that there is enormous potential for dietary agents that can modulate inflammatory pathways in humans. Leading experts describe the latest research on the role of anti-inflammatory nutraceuticals in preventing and treating chronic diseases.

Immunological Surveillance

Download Immunological Surveillance PDF Online Free

Author :
Publisher : Elsevier
ISBN 13 : 1483159221
Total Pages : 289 pages
Book Rating : 4.4/5 (831 download)

DOWNLOAD NOW!


Book Synopsis Immunological Surveillance by : Macfarlane Burnet

Download or read book Immunological Surveillance written by Macfarlane Burnet and published by Elsevier. This book was released on 2014-05-17 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Surveillance