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Large Scale Multiple Hypothesis Testing With Complex Data Structure
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Book Synopsis Large-scale Multiple Hypothesis Testing with Complex Data Structure by : Xiaoyu Dai
Download or read book Large-scale Multiple Hypothesis Testing with Complex Data Structure written by Xiaoyu Dai and published by . This book was released on 2018 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade, motivated by a variety of applications in medicine, bioinformatics, genomics, brain imaging, etc., a growing amount of statistical research has been devoted to large-scale multiple testing, where thousands or even greater numbers of tests are conducted simultaneously. However, due to the complexity of real data sets, the assumptions of many existing multiple testing procedures, e.g. that tests are independent and have continuous null distributions of p-values, may not hold. This poses limitations in their performances such as low detection power and inflated false discovery rate (FDR). In this dissertation, we study how to better proceed the multiple testing problems under complex data structures. In Chapter 2, we study the multiple testing with discrete test statistics. In Chapter 3, we study the discrete multiple testing with prior ordering information incorporated. In Chapter 4, we study the multiple testing under complex dependency structure. We propose novel procedures under each scenario, based on the marginal critical functions (MCFs) of randomized tests, the conditional random field (CRF) or the deep neural network (DNN). The theoretical properties of our procedures are carefully studied, and their performances are evaluated through various simulations and real applications with the analysis of genetic data from next-generation sequencing (NGS) experiments.
Book Synopsis Analysis of Error Control in Large Scale Two-stage Multiple Hypothesis Testing by : Wenge Guo
Download or read book Analysis of Error Control in Large Scale Two-stage Multiple Hypothesis Testing written by Wenge Guo and published by . This book was released on 2017 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transactions on Large-Scale Data- and Knowledge-Centered Systems XLVII by : Abdelkader Hameurlain
Download or read book Transactions on Large-Scale Data- and Knowledge-Centered Systems XLVII written by Abdelkader Hameurlain and published by Springer Nature. This book was released on 2021-01-16 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. This, the 47th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, constitutes a special issue focusing on Digital Ecosystems and Social Networks. The 9 revised selected papers cover topics that include Social Big Data, Data Analysis, Cloud-Based Feedback, Experience Ecosystems, Pervasive Environments, and Smart Systems.
Book Synopsis Methods in Multiple Testing and Meta-analysis with Applications to the Analysis of Genomic Data by : Yihan Li
Download or read book Methods in Multiple Testing and Meta-analysis with Applications to the Analysis of Genomic Data written by Yihan Li and published by . This book was released on 2014 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Model-Based Hypothesis Testing in Biomedicine by : Rikard Johansson
Download or read book Model-Based Hypothesis Testing in Biomedicine written by Rikard Johansson and published by Linköping University Electronic Press. This book was released on 2017-10-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: The utilization of mathematical tools within biology and medicine has traditionally been less widespread compared to other hard sciences, such as physics and chemistry. However, an increased need for tools such as data processing, bioinformatics, statistics, and mathematical modeling, have emerged due to advancements during the last decades. These advancements are partly due to the development of high-throughput experimental procedures and techniques, which produce ever increasing amounts of data. For all aspects of biology and medicine, these data reveal a high level of inter-connectivity between components, which operate on many levels of control, and with multiple feedbacks both between and within each level of control. However, the availability of these large-scale data is not synonymous to a detailed mechanistic understanding of the underlying system. Rather, a mechanistic understanding is gained first when we construct a hypothesis, and test its predictions experimentally. Identifying interesting predictions that are quantitative in nature, generally requires mathematical modeling. This, in turn, requires that the studied system can be formulated into a mathematical model, such as a series of ordinary differential equations, where different hypotheses can be expressed as precise mathematical expressions that influence the output of the model. Within specific sub-domains of biology, the utilization of mathematical models have had a long tradition, such as the modeling done on electrophysiology by Hodgkin and Huxley in the 1950s. However, it is only in recent years, with the arrival of the field known as systems biology that mathematical modeling has become more commonplace. The somewhat slow adaptation of mathematical modeling in biology is partly due to historical differences in training and terminology, as well as in a lack of awareness of showcases illustrating how modeling can make a difference, or even be required, for a correct analysis of the experimental data. In this work, I provide such showcases by demonstrating the universality and applicability of mathematical modeling and hypothesis testing in three disparate biological systems. In Paper II, we demonstrate how mathematical modeling is necessary for the correct interpretation and analysis of dominant negative inhibition data in insulin signaling in primary human adipocytes. In Paper III, we use modeling to determine transport rates across the nuclear membrane in yeast cells, and we show how this technique is superior to traditional curve-fitting methods. We also demonstrate the issue of population heterogeneity and the need to account for individual differences between cells and the population at large. In Paper IV, we use mathematical modeling to reject three hypotheses concerning the phenomenon of facilitation in pyramidal nerve cells in rats and mice. We also show how one surviving hypothesis can explain all data and adequately describe independent validation data. Finally, in Paper I, we develop a method for model selection and discrimination using parametric bootstrapping and the combination of several different empirical distributions of traditional statistical tests. We show how the empirical log-likelihood ratio test is the best combination of two tests and how this can be used, not only for model selection, but also for model discrimination. In conclusion, mathematical modeling is a valuable tool for analyzing data and testing biological hypotheses, regardless of the underlying biological system. Further development of modeling methods and applications are therefore important since these will in all likelihood play a crucial role in all future aspects of biology and medicine, especially in dealing with the burden of increasing amounts of data that is made available with new experimental techniques. Användandet av matematiska verktyg har inom biologi och medicin traditionellt sett varit mindre utbredd jämfört med andra ämnen inom naturvetenskapen, såsom fysik och kemi. Ett ökat behov av verktyg som databehandling, bioinformatik, statistik och matematisk modellering har trätt fram tack vare framsteg under de senaste decennierna. Dessa framsteg är delvis ett resultat av utvecklingen av storskaliga datainsamlingstekniker. Inom alla områden av biologi och medicin så har dessa data avslöjat en hög nivå av interkonnektivitet mellan komponenter, verksamma på många kontrollnivåer och med flera återkopplingar både mellan och inom varje nivå av kontroll. Tillgång till storskaliga data är emellertid inte synonymt med en detaljerad mekanistisk förståelse för det underliggande systemet. Snarare uppnås en mekanisk förståelse först när vi bygger en hypotes vars prediktioner vi kan testa experimentellt. Att identifiera intressanta prediktioner som är av kvantitativ natur, kräver generellt sett matematisk modellering. Detta kräver i sin tur att det studerade systemet kan formuleras till en matematisk modell, såsom en serie ordinära differentialekvationer, där olika hypoteser kan uttryckas som precisa matematiska uttryck som påverkar modellens output. Inom vissa delområden av biologin har utnyttjandet av matematiska modeller haft en lång tradition, såsom den modellering gjord inom elektrofysiologi av Hodgkin och Huxley på 1950?talet. Det är emellertid just på senare år, med ankomsten av fältet systembiologi, som matematisk modellering har blivit ett vanligt inslag. Den något långsamma adapteringen av matematisk modellering inom biologi är bl.a. grundad i historiska skillnader i träning och terminologi, samt brist på medvetenhet om exempel som illustrerar hur modellering kan göra skillnad och faktiskt ofta är ett krav för en korrekt analys av experimentella data. I detta arbete tillhandahåller jag sådana exempel och demonstrerar den matematiska modelleringens och hypotestestningens allmängiltighet och tillämpbarhet i tre olika biologiska system. I Arbete II visar vi hur matematisk modellering är nödvändig för en korrekt tolkning och analys av dominant-negativ-inhiberingsdata vid insulinsignalering i primära humana adipocyter. I Arbete III använder vi modellering för att bestämma transporthastigheter över cellkärnmembranet i jästceller, och vi visar hur denna teknik är överlägsen traditionella kurvpassningsmetoder. Vi demonstrerar också frågan om populationsheterogenitet och behovet av att ta hänsyn till individuella skillnader mellan celler och befolkningen som helhet. I Arbete IV använder vi matematisk modellering för att förkasta tre hypoteser om hur fenomenet facilitering uppstår i pyramidala nervceller hos råttor och möss. Vi visar också hur en överlevande hypotes kan beskriva all data, inklusive oberoende valideringsdata. Slutligen utvecklar vi i Arbete I en metod för modellselektion och modelldiskriminering med hjälp av parametrisk ”bootstrapping” samt kombinationen av olika empiriska fördelningar av traditionella statistiska tester. Vi visar hur det empiriska ”log-likelihood-ratio-testet” är den bästa kombinationen av två tester och hur testet är applicerbart, inte bara för modellselektion, utan också för modelldiskriminering. Sammanfattningsvis är matematisk modellering ett värdefullt verktyg för att analysera data och testa biologiska hypoteser, oavsett underliggande biologiskt system. Vidare utveckling av modelleringsmetoder och tillämpningar är därför viktigt eftersom dessa sannolikt kommer att spela en avgörande roll i framtiden för biologi och medicin, särskilt när det gäller att hantera belastningen från ökande datamängder som blir tillgänglig med nya experimentella tekniker.
Book Synopsis LIST DATA STRUCTURE: THEORY AND APPLICATIONS WITH PYTHON AND TKINTER by : Vivian Siahaan
Download or read book LIST DATA STRUCTURE: THEORY AND APPLICATIONS WITH PYTHON AND TKINTER written by Vivian Siahaan and published by BALIGE PUBLISHING. This book was released on 2024-05-04 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the rapidly evolving world of technology, understanding foundational concepts like data structures, specifically lists, and their manipulation is essential. This book aims to delve deep into the practicalities of using lists in Python, a versatile and widely-used programming language known for its ease of use and powerful libraries. Coupled with this, the book explores the graphical user interface library, Tkinter, providing a comprehensive guide on how to make Python's capabilities more interactive and user-friendly. The significance of lists in programming cannot be overstated. They are among the most basic and crucial data structures in computer science, essential for storing sequences of data that are dynamically modifiable. In Python, lists are used extensively across simple applications to high-end data processing tasks. This book will start by exploring the anatomy of lists in Python, covering their creation, manipulation, and application in various real-world scenarios. Following the understanding of lists, the discussion will transition to operations on lists. Operations like appending, slicing, sorting, and more are pivotal in handling data efficiently. Through practical examples and detailed explanation, readers will learn how these operations are implemented in Python and how they can be used to solve common programming problems. Moreover, the power of list comprehensions, a distinctive feature of Python that allows for concise and efficient manipulation of lists, will be thoroughly discussed. This feature not only simplifies code but also enhances its readability and efficiency, making Python an appealing choice for developers. However, theoretical knowledge of these operations and their syntax only scratches the surface of their potential. To bridge the gap between theory and practical application, this book incorporates interactive examples using Tkinter, Python’s standard GUI library. Tkinter allows programmers to create graphical interfaces, making software applications accessible to a broader audience, including those who might not be comfortable with command-line interfaces. Integrating list operations into a GUI can significantly enhance the functionality and user-friendliness of applications. For instance, users can interact with the data more intuitively, perform operations in real-time, and see the results immediately, which is crucial for learning and debugging. The chapters dedicated to Tkinter will guide readers through setting up their first GUI applications. Starting from basic windows and widgets, the discussion will evolve to include how list operations can be integrated into these interfaces. Whether it's displaying a list, updating it based on user input, or sorting and filtering data based on user commands, the book will cover a wide range of use cases. One of the core strengths of combining list operations with Tkinter is in educational software, where interactive tools can significantly enhance the learning experience. By allowing students to manipulate data structures in real-time, they can see the immediate impact of their actions, thereby deepening their understanding of the subject matter. Furthermore, this approach has applications in professional software development, where developers need to build applications that are not only functional but also intuitive and responsive. The book will explore several project ideas and real-world applications, showing how the concepts discussed can be used to build meaningful and efficient software. Beyond educational and professional environments, this integration finds relevance in data analysis and visualization tasks. Analysts often need to manipulate large datasets and visualize their results effectively. Here, Python’s list operations and Tkinter’s graphical capabilities come together to offer powerful tools for data manipulation and display. In addition to practical applications, the book also addresses best practices and common pitfalls in both list manipulation and GUI development. Understanding these will help readers avoid common errors and improve the performance of their code. As technology continues to advance, the importance of understanding foundational programming skills and integrating them into user-friendly applications cannot be overstated. This book is designed not just to teach but also to inspire its readers to explore the possibilities of Python and Tkinter, encouraging them to develop applications that are powerful, efficient, and user-centric. In conclusion, this book serves as a comprehensive guide for anyone looking to deepen their understanding of Python’s list operations and GUI development using Tkinter. By the end of this book, readers will not only be proficient in these areas but will also be equipped to apply these skills in practical, innovative, and effective ways..
Book Synopsis Multiple Testing Procedures with Applications to Genomics by : Sandrine Dudoit
Download or read book Multiple Testing Procedures with Applications to Genomics written by Sandrine Dudoit and published by Springer Science & Business Media. This book was released on 2007-12-18 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.
Book Synopsis Modelling of Pollutants in Complex Environmental Systems by : Grady Hanrahan
Download or read book Modelling of Pollutants in Complex Environmental Systems written by Grady Hanrahan and published by ILM Publications. This book was released on 2009 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title showcases modern environmental modelling methods, the basic theory behind them and their incorporation into complex environmental investigations.
Book Synopsis Assessing Rare Variation in Complex Traits by : Eleftheria Zeggini
Download or read book Assessing Rare Variation in Complex Traits written by Eleftheria Zeggini and published by Springer. This book was released on 2015-08-13 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is unique in covering a wide range of design and analysis issues in genetic studies of rare variants, taking advantage of collaboration of the editors with many experts in the field through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES. Chapters provide details of state-of-the-art methodology for rare variant detection and calling, imputation and analysis in samples of unrelated individuals and families. The book also covers analytical issues associated with the study of rare variants, such as the impact of fine-scale population structure, and with combining information on rare variants across studies in a meta-analysis framework. Genetic association studies have in the last few years substantially enhanced our understanding of factors underlying traits of high medical importance, such as body mass index, lipid levels, blood pressure and many others. There is growing empirical evidence that low-frequency and rare variants play an important role in complex human phenotypes. This book covers multiple aspects of study design, analysis and interpretation for complex trait studies focusing on rare sequence variation. In many areas of genomic research, including complex trait association studies, technology is in danger of outstripping our capacity to analyse and interpret the vast amounts of data generated. The field of statistical genetics in the whole-genome sequencing era is still in its infancy, but powerful methods to analyse the aggregation of low-frequency and rare variants are now starting to emerge. The chapter Functional Annotation of Rare Genetic Variants is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis Statistical Bioinformatics with R by : Sunil K. Mathur
Download or read book Statistical Bioinformatics with R written by Sunil K. Mathur and published by Academic Press. This book was released on 2009-12-21 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Bioinformatics provides a balanced treatment of statistical theory in the context of bioinformatics applications. Designed for a one or two semester senior undergraduate or graduate bioinformatics course, the text takes a broad view of the subject – not just gene expression and sequence analysis, but a careful balance of statistical theory in the context of bioinformatics applications. The inclusion of R & SAS code as well as the development of advanced methodology such as Bayesian and Markov models provides students with the important foundation needed to conduct bioinformatics. Integrates biological, statistical and computational concepts Inclusion of R & SAS code Provides coverage of complex statistical methods in context with applications in bioinformatics Exercises and examples aid teaching and learning presented at the right level Bayesian methods and the modern multiple testing principles in one convenient book
Book Synopsis Models and Estimation of Genetic Effects by : José M Álvarez-Castro
Download or read book Models and Estimation of Genetic Effects written by José M Álvarez-Castro and published by Frontiers Media SA. This book was released on 2015-04-17 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ronald Fisher needed to develop elaborate models of genetic effects in order to set the foundations of Quantitative Genetics in his 1918 paper “The correlation between relatives on the supposition of Mendelian inheritance”. Since then, many significant implementations have been made to model genetic effects. However, at the verge of one century after Fisher’s kick-off, models of genetic effects keep on being discussed and implemented. Indeed, the relatively recent advent of QTL analyses challenged the state of the art of this field by providing researchers the opportunity to obtain and analyze estimates of genetic effects from real data. In this context, the development of this field was not exempt of some polemics, like the debate about the convenience of the functional and the statistical epistasis approaches. This research topic is meant to provide recent developments in models and estimation of genetic effects and to enrich the discussion about how and why models of genetic effects must be further developed and applied. The articles in this Research Topic shall thus extend, refine and/or provide a refresh look at Fisher’s original models of genetic effects and their application to genetic effects estimation and to improve our understanding of evolutionary processes and breeding programs.
Book Synopsis Basics of Bioinformatics by : Rui Jiang
Download or read book Basics of Bioinformatics written by Rui Jiang and published by Springer Science & Business Media. This book was released on 2013-11-26 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book outlines 11 courses and 15 research topics in bioinformatics, based on curriculums and talks in a graduate summer school on bioinformatics that was held in Tsinghua University. The courses include: Basics for Bioinformatics, Basic Statistics for Bioinformatics, Topics in Computational Genomics, Statistical Methods in Bioinformatics, Algorithms in Computational Biology, Multivariate Statistical Methods in Bioinformatics Research, Association Analysis for Human Diseases: Methods and Examples, Data Mining and Knowledge Discovery Methods with Case Examples, Applied Bioinformatics Tools, Foundations for the Study of Structure and Function of Proteins, Computational Systems Biology Approaches for Deciphering Traditional Chinese Medicine, and Advanced Topics in Bioinformatics and Computational Biology. This book can serve as not only a primer for beginners in bioinformatics, but also a highly summarized yet systematic reference book for researchers in this field. Rui Jiang and Xuegong Zhang are both professors at the Department of Automation, Tsinghua University, China. Professor Michael Q. Zhang works at the Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Book Synopsis Improved Tools for Large-scale Hypothesis Testing by : Zihao Zheng
Download or read book Improved Tools for Large-scale Hypothesis Testing written by Zihao Zheng and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Large-scale hypothesis testing, as one of the key statistical tools, has been widely studied and applied to high throughput bioinformatics experiments, such as high-density peptide array studies and brain image data sets. The high dimensionality and small sample size of many experiments challenge conventional statistical approaches, including those aiming to control the false discovery rate (FDR). Motivated by this, in this dissertation, I develop several improved statistical and computational tools for large-scale hypothesis testing. The first method, MixTwice, advances an empirical-Bayesian tool that computes local false discovery rate statistics when provided with data on estimated effects and estimated standard errors. I also extend this method from two group comparison problems to multiple group comparison settings and develop a generalized method called MixTwice-ANOVA. The second method GraphicalT calculates local FDRs semiparametrically using available graph-associated information. The first method, MixTwice, introduces an empirical-Bayes approach that involves the estimation of two mixing distributions, one on underlying effects and one on underlying variance parameters. Provided with the estimated effect sizes and estimated errors, MixTwice estimates the mixing distribution and calculates the local false discovery rates via nonparametric MLE and constrained optimization with unimodal shape constraint of the effect distribution. Numerical experiments show that MixTwice can accurately estimate generative parameters and have good testing operating characteristics. Applied to a high-density peptide array, it powerfully identifies non-null peptides to recover meaningful peptide markers when the underlying signal is weak, and has strong reproducibility properties when the underlying signal is strong. The second contribution of this dissertation generalizes MixTwice from scenarios comparing two conditions to scenarios comparing multiple groups. Similar to MixTwice, MixTwice-ANOVA takes numerator and denominator statistics of F test to estimate two underlying mixing distributions. Compared with other large-scale testing tools for one-way ANOVA settings, MixTwice-ANOVA has better power properties and FDR control through numerical experiments. Applied to the peptide array study comparing multiple Sjogren-disease (SjD) populations, the proposed approach discovers meaningful epitope structure and novel scientific findings on Sjogren disease. Numerical experiments support evaluation among testing tools. Besides the methodology contribution of MixTwice in large-scale testing, I also discuss generalized evaluation and computational aspects. For the former part, I propose an evaluation metric, in additional to FDR control, power, etc., called reproducibility, to provide a practical guide for different testing tools. For the latter part, I borrow the idea from pool adjacent violator algorithm (PAVA) and advance a computational algorithm called EM-PAVA to solve nonparametric MLE with isotonic partial order constraint. This algorithm is discussed through theoretical guarantees and computational performances. The last contribution of this dissertation deals with large-scale testing problems with graph-associated data. Different from many studies that incorporate the graph-associated information through detailed modeling specifications, GraphicalT provides a semiparametric way to calculate the local false discovery rates using available auxiliary data graph. The method shows good performance in synthetic examples and in a brain-imaging problem from the study of Alzheimer's disease.
Book Synopsis Computational Medicine by : Zlatko Trajanoski
Download or read book Computational Medicine written by Zlatko Trajanoski and published by Springer Science & Business Media. This book was released on 2012-09-18 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational methodologies and modeling play a growing role for investigating mechanisms, and for the diagnosis and therapy of human diseases. This progress gave rise to computational medicine, an interdisciplinary field at the interface of computer science and medicine. The main focus of computational medicine lies in the development of data analysis methods and mathematical modeling as well as computational simulation techniques specifically addressing medical problems. In this book, we present a number of computational medicine topics at several scales: from molecules to cells, organs, and organisms. At the molecular level, tools for the analysis of genome variations as well as cloud computing resources for medical genetics are reviewed. Then, an analysis of gene expression data and the application to the characterization of microbial communities are highlighted. At the protein level, two types of analyses for mass spectrometry data are reviewed: labeled quantitative proteomics and lipidomics, followed by protein sequence analysis and a 3D structure and drug design chapter. Finally, three chapters on clinical applications focus on the integration of biomolecular and clinical data for cancer research, biomarker discovery, and network-based methods for computational diagnostics.
Book Synopsis Genetic Analysis of Complex Disease by : William K. Scott
Download or read book Genetic Analysis of Complex Disease written by William K. Scott and published by John Wiley & Sons. This book was released on 2021-11-11 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Analysis of Complex Diseases An up-to-date and complete treatment of the strategies, designs and analysis methods for studying complex genetic disease in human beings In the newly revised Third Edition of Genetic Analysis of Complex Diseases, a team of distinguished geneticists delivers a comprehensive introduction to the most relevant strategies, designs and methods of analysis for the study of complex genetic disease in humans. The book focuses on concepts and designs, thereby offering readers a broad understanding of common problems and solutions in the field based on successful applications in the design and execution of genetic studies. This edited volume contains contributions from some of the leading voices in the area and presents new chapters on high-throughput genomic sequencing, copy-number variant analysis and epigenetic studies. Providing clear and easily referenced overviews of the considerations involved in genetic analysis of complex human genetic disease, including sampling, design, data collection, linkage and association studies and social, legal and ethical issues. Genetic Analysis of Complex Diseases also provides: A thorough introduction to study design for the identification of genes in complex traits Comprehensive explorations of basic concepts in genetics, disease phenotype definition and the determination of the genetic components of disease Practical discussions of modern bioinformatics tools for analysis of genetic data Reflecting on responsible conduct of research in genetic studies, as well as linkage analysis and data management New expanded chapter on complex genetic interactions This latest edition of Genetic Analysis of Complex Diseases is a must-read resource for molecular biologists, human geneticists, genetic epidemiologists and pharmaceutical researchers. It is also invaluable for graduate students taking courses in statistical genetics or genetic epidemiology.
Book Synopsis Large Scale Multiple Testing for Data with Spatial Signals by : Yunda Zhong
Download or read book Large Scale Multiple Testing for Data with Spatial Signals written by Yunda Zhong and published by . This book was released on 2013 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis consists of three projects. The abstracts for each project are listed below.
Book Synopsis Applications of Synthetic High Dimensional Data by : Sobczak-Michalowska, Marzena
Download or read book Applications of Synthetic High Dimensional Data written by Sobczak-Michalowska, Marzena and published by IGI Global. This book was released on 2024-03-25 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need for tailored data for machine learning models is often unsatisfied, as it is considered too much of a risk in the real-world context. Synthetic data, an algorithmically birthed counterpart to operational data, is the linchpin for overcoming constraints associated with sensitive or regulated information. In high-dimensional data, where the dimensions of features and variables often surpass the number of available observations, the emergence of synthetic data heralds a transformation. Applications of Synthetic High Dimensional Data delves into the algorithms and applications underpinning the creation of synthetic data, which surpass the capabilities of authentic datasets in many cases. Beyond mere mimicry, synthetic data takes center stage in prioritizing the mathematical domain, becoming the crucible for training robust machine learning models. It serves not only as a simulation but also as a theoretical entity, permitting the consideration of unforeseen variables and facilitating fundamental problem-solving. This book navigates the multifaceted advantages of synthetic data, illuminating its role in protecting the privacy and confidentiality of authentic data. It also underscores the controlled generation of synthetic data as a mechanism to safeguard private information while maintaining a controlled resemblance to real-world datasets. This controlled generation ensures the preservation of privacy and facilitates learning across datasets, which is crucial when dealing with incomplete, scarce, or biased data. Ideal for researchers, professors, practitioners, faculty members, students, and online readers, this book transcends theoretical discourse.
