Label Free And Multi Parametric Monitoring Of Cell Based Assays With Substrate Embedded Sensors

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Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors

Author : Maximilian Oberleitner
Publisher : Springer
ISBN 13 : 331945384X
Total Pages : 391 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors by : Maximilian Oberleitner

Download or read book Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors written by Maximilian Oberleitner and published by Springer. This book was released on 2017-09-26 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes novel substrate embedded physical sensors that can be used to monitor different types of cell-based assays non-invasively and label-free. The sensors described provide integrative information of the cells under study with an adaptable time resolution (ranging from milliseconds to days). This information about the dynamic cell response to chemical, physical or biological stimuli defines a new paradigm in fundamental biomedical research. The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design principles and elucidates the boundary conditions of the new sensors.

Biological Transformation

Author : Reimund Neugebauer
Publisher : Springer Nature
ISBN 13 : 3662596598
Total Pages : 404 pages
Book Rating : 4.6/5 (625 download)

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Book Synopsis Biological Transformation by : Reimund Neugebauer

Download or read book Biological Transformation written by Reimund Neugebauer and published by Springer Nature. This book was released on 2020-09-11 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The global population is expected to rise to 9.8 billion by the year 2050 - with everyone ultimately striving for prosperity. New methods must therefore be found to achieve more efficient production. Research to date shows that the biological inventory that has evolved: its products, processes, principles and tools, can spur modern technology. The development of technological innovations based on biological concepts, with the goal of particularly innovative and sustainable value creation, today is collectively known as "biological transformation". It results in highly functional products with striking properties that can be both manufactured and utilized in a resource-saving way. In terms of taking responsibility of the good of all people, biological transformation is therefore a path that applied research will have to take. The Fraunhofer-Gesellschaft has recognized the developmental technology potential of biological transformation and sees it as its task not only to drive the relevant research forward, but also to promote public awareness of the topic.

Label-Free Monitoring of Cells in vitro

Author : Joachim Wegener
Publisher : Springer Nature
ISBN 13 : 3030324338
Total Pages : 286 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Label-Free Monitoring of Cells in vitro by : Joachim Wegener

Download or read book Label-Free Monitoring of Cells in vitro written by Joachim Wegener and published by Springer Nature. This book was released on 2019-11-18 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is dedicated to label-free, non-invasive monitoring of cell-based assays and it comprises the most widely applied techniques. Each approach is described and critically evaluated by an expert in the field such that researchers get an overview on what is possible and where the limitations are. The book provides the theoretical basis for each technique as well as the most successful and exciting applications. Label-free bioanalytical techniques have been known for a long time as valuable tools to monitor adsorption processes at the solid-liquid interface in general – and biomolecular interaction analysis (BIA) in particular. The underlying concepts have been progressively transferred to the analysis of cell-based assays. The strength of these approaches is implicitly given with the name 'label-free': the readout is independent of any label, reagent or additive that contaminates the system under study and potentially affects its properties. Thus, label-free techniques provide an unbiased analytical perspective in the sense that the sample is not manipulated by additives but pure. They are commonly based on physical principles and read changes in integral physical properties of the sample like refractive index, conductivity, capacitance or elastic modulus to mention just a few. Even though it is not implied in the name, label-free approaches usually monitor the cells under study non-invasively meaning that the amplitude of the signal (e.g. electric field strength, mechanical elongation) that is used for the measurement is too low to interfere or affect. In contrast to label-based analytical techniques that are commonly restricted to a single reading at a predefined time point, label-free approaches allow for a continuous observation so that the dynamics of the biological system or reaction become accessible.

Cell-based Biosensors

Author : Qingjun Liu
Publisher : Artech House
ISBN 13 : 1596934409
Total Pages : 291 pages
Book Rating : 4.5/5 (969 download)

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Book Synopsis Cell-based Biosensors by : Qingjun Liu

Download or read book Cell-based Biosensors written by Qingjun Liu and published by Artech House. This book was released on 2009-10 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.

Imaging Flow Cytometry

Author : Natasha S. Barteneva
Publisher : Humana
ISBN 13 : 9781493933006
Total Pages : 0 pages
Book Rating : 4.9/5 (33 download)

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Book Synopsis Imaging Flow Cytometry by : Natasha S. Barteneva

Download or read book Imaging Flow Cytometry written by Natasha S. Barteneva and published by Humana. This book was released on 2015-11-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume for the first time explores techniques and protocols involving quantitative imaging flow cytometry (IFC), which has revolutionized our ability to analyze cells, cellular clusters, and populations in a remarkable fashion. Beginning with an introduction to technology, the book continues with sections addressing protocols for studies on the cell nucleus, nucleic acids, and FISH techniques using an IFC instrument, immune response analysis and drug screening, IFC protocols for apoptosis and cell death analysis, as well as morphological analysis and the identification of rare cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Imaging Flow Cytometry: Methods and Protocols will be a critical source for all laboratories seeking to implement IFC in their research studies.

Electrochemical Biosensors

Author : Serge Cosnier
Publisher : CRC Press
ISBN 13 : 9814411477
Total Pages : 405 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Electrochemical Biosensors by : Serge Cosnier

Download or read book Electrochemical Biosensors written by Serge Cosnier and published by CRC Press. This book was released on 2015-01-26 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analy

Angiogenesis Assays

Author : Carolyn A. Staton
Publisher : John Wiley & Sons
ISBN 13 : 047002934X
Total Pages : 410 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Angiogenesis Assays by : Carolyn A. Staton

Download or read book Angiogenesis Assays written by Carolyn A. Staton and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

Mammalian Toxicology

Author : Mohamed Abou-Donia
Publisher : John Wiley & Sons
ISBN 13 : 1119940419
Total Pages : 716 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Mammalian Toxicology by : Mohamed Abou-Donia

Download or read book Mammalian Toxicology written by Mohamed Abou-Donia and published by John Wiley & Sons. This book was released on 2015-05-04 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.

Advances in Cell Culture

Author :
Publisher :
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Advances in Cell Culture by :

Download or read book Advances in Cell Culture written by and published by . This book was released on 1989 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Electric Cell-Substrate Impedance Sensing and Cancer Metastasis

Author : Wen G. Jiang
Publisher : Springer Science & Business Media
ISBN 13 : 9400749279
Total Pages : 261 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Electric Cell-Substrate Impedance Sensing and Cancer Metastasis by : Wen G. Jiang

Download or read book Electric Cell-Substrate Impedance Sensing and Cancer Metastasis written by Wen G. Jiang and published by Springer Science & Business Media. This book was released on 2012-09-14 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell based impedance sensing is becoming a new biophysical and cellular technology in cell based analyses. The technology has been used in investigation of cellular growth and death, cell adhesion and migration, cell invasion and cell-cell interactions, cell toxicity, angiogenesis, cell permeability, signal transduction and cellular behaviour under flow conditions. It is a probe free, highly sensitive, and versatile technology platform. Recent development in the technology has also allowed high throughput, automated analyses. It has been widely explored in chemistry, toxicity, cell biology, cancer biology, and other areas of chemistry, medicinal chemistry, life and medical science. Written by experts in the area of cell impedance sensing, including the Nobel Laureate Dr Ivar Giaever, this books covers the background of electric cell-substrate impedance sensing, their applications in cell based investigations, particularly in the area of cancer biology. This book is the first on this technology platform and will be a highly useful reference for molecular and cell biologists, cancer biologists, chemists and biochemists, clinical researchers who work in the areas of cell biology, molecular biology, toxicology, pharmaceutical industry, life science and medical research.

Handbook of Surface Plasmon Resonance

Author : Richard B. M. Schasfoort
Publisher : Royal Society of Chemistry
ISBN 13 : 1782627308
Total Pages : 555 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Handbook of Surface Plasmon Resonance by : Richard B. M. Schasfoort

Download or read book Handbook of Surface Plasmon Resonance written by Richard B. M. Schasfoort and published by Royal Society of Chemistry. This book was released on 2017-05-30 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface plasmon resonance (SPR) plays a dominant role in real-time interaction sensing of biomolecular binding events, this book provides a total system description including optics, fluidics and sensor surfaces for a wide researcher audience.

The Microflow Cytometer

Author : Frances S. Ligler
Publisher : Pan Stanford Publishing
ISBN 13 : 9814267414
Total Pages : 394 pages
Book Rating : 4.8/5 (142 download)

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Book Synopsis The Microflow Cytometer by : Frances S. Ligler

Download or read book The Microflow Cytometer written by Frances S. Ligler and published by Pan Stanford Publishing. This book was released on 2010-05-31 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Great book! Excellent compilation. From history of the very early days of flow cytometers to the latest unique unconventional microflow cytometers. From commercialization philosophy to cutting edge engineering designs. From fluid mechanics to optics to electronic circuit considerations. Well balanced and comprehensive."--Shuichi Takayama University of Michigan, USA.

3D Printed Microfluidic Devices

Author : Savas Tasoglu
Publisher : MDPI
ISBN 13 : 3038974676
Total Pages : 213 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis 3D Printed Microfluidic Devices by : Savas Tasoglu

Download or read book 3D Printed Microfluidic Devices written by Savas Tasoglu and published by MDPI. This book was released on 2019-01-10 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "3D Printed Microfluidic Devices" that was published in Micromachines

Handbook of Cell Biosensors

Author : Gérald Thouand
Publisher : Springer
ISBN 13 : 9783030232160
Total Pages : 992 pages
Book Rating : 4.2/5 (321 download)

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Book Synopsis Handbook of Cell Biosensors by : Gérald Thouand

Download or read book Handbook of Cell Biosensors written by Gérald Thouand and published by Springer. This book was released on 2021-10-01 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is an interdisciplinary and comprehensive reference covering all aspects of cell biosensors. It is divided into four main sections which are led and organized by numerous international experts. The scope of coverage includes: Fundamentals and genetics for biosensor applications Transducers, Materials and Systems Markets, innovation and education Application of biosensors in business Biosensor research is an exciting hybrid world where biologists, chemists, physicists, engineers and computer engineers come together. This handbook will serve as an invaluable living resource for all researchers in academia and industry working with cell biosensors.

Fitting Models to Biological Data Using Linear and Nonlinear Regression

Author : Harvey Motulsky
Publisher : Oxford University Press
ISBN 13 : 9780198038344
Total Pages : 352 pages
Book Rating : 4.0/5 (383 download)

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Book Synopsis Fitting Models to Biological Data Using Linear and Nonlinear Regression by : Harvey Motulsky

Download or read book Fitting Models to Biological Data Using Linear and Nonlinear Regression written by Harvey Motulsky and published by Oxford University Press. This book was released on 2004-05-27 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most biologists use nonlinear regression more than any other statistical technique, but there are very few places to learn about curve-fitting. This book, by the author of the very successful Intuitive Biostatistics, addresses this relatively focused need of an extraordinarily broad range of scientists.

Semiconducting Polymers

Author : Georges Hadziioannou
Publisher : John Wiley & Sons
ISBN 13 : 3527312714
Total Pages : 786 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Semiconducting Polymers by : Georges Hadziioannou

Download or read book Semiconducting Polymers written by Georges Hadziioannou and published by John Wiley & Sons. This book was released on 2006-12-15 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of semiconducting polymers has attracted many researchers from a diversity of disciplines. Printed circuitry, flexible electronics and displays are already migrating from laboratory successes to commercial applications, but even now fundamental knowledge is deficient concerning some of the basic phenomena that so markedly influence a device's usefulness and competitiveness. This two-volume handbook describes the various approaches to doped and undoped semiconducting polymers taken with the aim to provide vital understanding of how to control the properties of these fascinating organic materials. Prominent researchers from the fields of synthetic chemistry, physical chemistry, engineering, computational chemistry, theoretical physics, and applied physics cover all aspects from compounds to devices. Since the first edition was published in 2000, significant findings and successes have been achieved in the field, and especially handheld electronic gadgets have become billion-dollar markets that promise a fertile application ground for flexible, lighter and disposable alternatives to classic silicon circuitry. The second edition brings readers up-to-date on cutting edge research in this field.

Biomedical Sensors

Author : Deric P. Jones
Publisher : Momentum Press
ISBN 13 : 1606500562
Total Pages : 482 pages
Book Rating : 4.6/5 (65 download)

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Book Synopsis Biomedical Sensors by : Deric P. Jones

Download or read book Biomedical Sensors written by Deric P. Jones and published by Momentum Press. This book was released on 2010 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sensors are the eyes, ears, and more, of the modern engineered product or system- including the living human organism. This authoritative reference work, part of Momentum Press's new Sensors Technology series, edited by noted sensors expert, Dr. Joe Watson, will offer a complete review of all sensors and their associated instrumentation systems now commonly used in modern medicine. Readers will find invaluable data and guidance on a wide variety of sensors used in biomedical applications, from fluid flow sensors, to pressure sensors, to chemical analysis sensors. New developments in biomaterials- based sensors that mimic natural bio-systems will be covered as well. Also featured will be ample references throughout, along with a useful Glossary and symbols list, as well as convenient conversion tables.