La quantification ciblée de protéines et peptides par chromatographie liquide couplée à la spectrométrie de masse en tandem

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Total Pages : 0 pages
Book Rating : 4.:/5 (862 download)

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Book Synopsis La quantification ciblée de protéines et peptides par chromatographie liquide couplée à la spectrométrie de masse en tandem by : Romain Simon

Download or read book La quantification ciblée de protéines et peptides par chromatographie liquide couplée à la spectrométrie de masse en tandem written by Romain Simon and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: En recherche clinique ou environnementale, les biomarqueurs protéiques présentent un intérêt croissant. Bien que les immuno-dosages restent les méthodes de référence pour leur quantification, les récentes avancées en spectrométrie de masse (MS) font de cette technique une alternative crédible à l'ELISA. Ce travail apporte quelques éléments méthodologiques pour repousser certaines limitations de la MS. D'abord, deux dosages ont été proposés. Celui réalisé chez G. fossarum représente le premier exemple de dosage de la Vitellogénine chez un invertébré par LC-MS/MS. L'un des défis de la méthode présentée est de doser spécifiquement une protéine dans un organisme dont le génome est majoritairement inconnu. Le second dosage concerne les peptides contenant une méthionine. Nous avons développé un protocole d'oxydation des méthionines afin de s'affranchir du biais lié à leur oxydation partielle. Cette méthode a ensuite été appliquée à une protéine impliquée dans la maladie d'Alzheimer (l'Apolipoprotéine E4) dans une cohorte de 673 plasmas. Ce dosage est à ce jour l'une des plus grandes études réalisées par LC-MS/MS et montre toute la robustesse de cette approche. Enfin, l'influence de la phase mobile sur la sensibilité des dosages de peptides a été étudiée : d'abord en phase inverse, où le méthanol est une bonne alternative à l'acétonitrile ; ensuite en HILIC, où les difficultés liées à l'étude d'ions multichargés en milieu majoritairement organique ont été abordées. Les problèmes liés à la capacité de charge des colonnes ont également été soulevés. La chromatographie HILIC reste prometteuse pour la quantification de peptides puisqu'un facteur dix en sensibilité peut être apporté.

Mass Spectrometry of Proteins and Peptides

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Publisher : Springer Science & Business Media
ISBN 13 : 1592590454
Total Pages : 539 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Mass Spectrometry of Proteins and Peptides by : John R. Chapman

Download or read book Mass Spectrometry of Proteins and Peptides written by John R. Chapman and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Little more than three years down the line and I am already writing the Preface to a second volume to follow Protein and Peptide Analysis by Mass . What has happened in between these times to make this second venture worthwhile? New types of mass spectrometric instrumentation have appeared so that new techniques have become possible and existing techniques have become much more feasible. More particularly, however, the newer ionization te- niques, introduced for the analysis of high molecular weight materials, have now been thoroughly used and studied. As a result, there has been an en- mous improvement in the associated sample handling technology so that these methods are now routinely applied to much smaller sample amounts as well as to more intractable samples. Again, this particular community of mass spectrometry users has both increased in number and diversified. And, riding this wave of acceptance, leaders in the field have set their sights on more complex problems: molecular interaction, ion structures, quantitation, and kinetics are just a few of the newer areas reported in Mass Spectrometry of Proteins and Peptides. As with the first volume, one purpose of this collection, Mass Spectr- etry of Proteins and Peptides, is to show the reader what can be done by the application of mass spectrometry, and perhaps even to encourage the reader to venture down new paths.

Protein and Peptide Mass Spectrometry in Drug Discovery

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Publisher : John Wiley & Sons
ISBN 13 : 1118116542
Total Pages : 407 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Protein and Peptide Mass Spectrometry in Drug Discovery by : Michael L. Gross

Download or read book Protein and Peptide Mass Spectrometry in Drug Discovery written by Michael L. Gross and published by John Wiley & Sons. This book was released on 2011-09-26 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.

HPLC of Peptides and Proteins

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Publisher : Springer Science & Business Media
ISBN 13 : 1592597424
Total Pages : 411 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis HPLC of Peptides and Proteins by : Marie-Isabel Aguilar

Download or read book HPLC of Peptides and Proteins written by Marie-Isabel Aguilar and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: The introduction of high-performance liquid chromatography (HPLC) to the analysis of peptides and proteins some 25 years ago revolutionized the biological sciences by enabling the rapid and sensitive analysis of peptide and protein structure through the exquisite speed, sensitivity, and resolution that can be easily obtained. Today, HPLC in its various modes has become the pivotal technique in the characterization of peptides and proteins and currently plays a critical role in both our understanding of biological processes and in the development of peptide- and protein-based pharmaceuticals. The number of applications of HPLC in peptide and protein purification continues to expand at an extremely rapid rate. Solid-phase peptide synthesis and recombinant DNA techniques have allowed the production of large quantities of peptides and proteins that need to be highly purified. HPLC techniques are also used extensively in the isolation and characterization of novel proteins that will become increasingly important in the postgenomic age. The design of multidimensional purification schemes to achieve high levels of product purity further demonstrates the power of HPLC techniques not only in the characterization of cellular events, but also in the production of pepti- and protein-based therapeutics. HPLC continues to be at the heart of the analytical techniques with which scientists in both academia and in industry must arm themselves to be able to fully characterize the identity, purity, and potency of peptides and proteins.

Protein and Peptide Analysis by LC-MS

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Publisher : Royal Society of Chemistry
ISBN 13 : 1849733147
Total Pages : 195 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Protein and Peptide Analysis by LC-MS by : Thomas Letzel

Download or read book Protein and Peptide Analysis by LC-MS written by Thomas Letzel and published by Royal Society of Chemistry. This book was released on 2011-07-22 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first example in presenting LC-MS strategies for the analysis of peptides and proteins with detailed information and hints about the needs and problems described from experts on-the-job. The best advantage is -for sure- the practical insight of experienced analysts into their novel protein analysis techniques. Readers starting in 'Proteomics' should be able to repeat each experiment with own equipment and own protein samples, like clean-up, direct protein analysis, after (online) digest, with modifications and others. Furthermore, the reader will learn more about strategies in protein analysis, like quantitative analysis, industrial standards, functional analysis and more.

Quantitative Proteomics by Mass Spectrometry

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Publisher : Springer Science & Business Media
ISBN 13 : 1597452556
Total Pages : 223 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Quantitative Proteomics by Mass Spectrometry by : Salvatore Sechi

Download or read book Quantitative Proteomics by Mass Spectrometry written by Salvatore Sechi and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a compendium of cutting-edge protocols for quantitative proteomics, and presents the most significant methods used in the field today. The focus on mass spectrometry (MS) is integral. Attention is given to state-of-the-art techniques for the characterization of the phosphoproteome and tandem MS for detection of inborn errors of metabolism. This volume is an indispensable resource in the search for novel biomarkers.

Application du couplage chromatographie liquide-spectrométrie de masse à l'étude de la biodisponibilité de peptides issus de produits laitiers et à la protéomique

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ISBN 13 :
Total Pages : 252 pages
Book Rating : 4.:/5 (492 download)

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Book Synopsis Application du couplage chromatographie liquide-spectrométrie de masse à l'étude de la biodisponibilité de peptides issus de produits laitiers et à la protéomique by : François Delalande

Download or read book Application du couplage chromatographie liquide-spectrométrie de masse à l'étude de la biodisponibilité de peptides issus de produits laitiers et à la protéomique written by François Delalande and published by . This book was released on 2003 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Le couplage chromatographie liquide-spectrométrie de masse est devenu une méthode de choix pour la quantification de molécules dans une matrice, la détermination des séquences primaires de peptides et de protéines ainsi que la mise en évidence de modifications post-traductionnelles. Les progrès réalisés tant au niveau de la LC qu'au niveau de la spectrométrie de masse ont aussi révolutionné la biologie en permettant une identification sur des quantités femtomolaires de protéines séparées par électrophorèse bidimensionelle dans le cadre d'études protéomiques et la détection toujours plus sensible de molécules d'intérêt par exemple dans les fluides biologiques (plasma, urine, LCR).Mon travail de thèse a porté sur le choix et la mise au point de stratégies instrumentales et analytiques en optimisant de façon poussée tous les paramètres du couplage LC-MS et LC-MS-MS. La première partie concerne la mise au point expérimentale de techniques de microLC-MS et microLC-MS-MS pour la caractérisation de composés peptidiques et la mesure de leur biodisponibilité. La seconde partie porte sur le développement, l'optimisation et l'utilisation de la nano-LC-MS pour l'étude protéomique avec une première étude protéomique visant à caractériser les interactions entre le riz et le rice yellow mottle virus. Ce travail a permis par les techniques MALDI-MS et LC-MS-MS, de mettre en évidence les protéines du riz recrutées par les protéines de capside du virus et l'identification des protéines différentiellement exprimées selon la variété de riz (résistant/sensible). La seconde étude protéomique concerne la caractérisation de marqueurs d'expressions liés à l'anomalie "Mantled" chez le palmier à huile faisant appel au séquençage de novo. Pour conclure, nous avons utilisé les multiples potentiels du couplage microLC-MS et nanoLC-MS-MS pour répondre à différents problèmes biologiques. Ces réponses n'ont pu être obtenues que grâce à la mise au point de méthodologie particulière.

Computational and Statistical Methods for Protein Quantification by Mass Spectrometry

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Publisher : John Wiley & Sons
ISBN 13 : 111849377X
Total Pages : 290 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Computational and Statistical Methods for Protein Quantification by Mass Spectrometry by : Ingvar Eidhammer

Download or read book Computational and Statistical Methods for Protein Quantification by Mass Spectrometry written by Ingvar Eidhammer and published by John Wiley & Sons. This book was released on 2012-12-10 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive introduction to data analysis in quantitative proteomics This book provides all the necessary knowledge about mass spectrometry based proteomics methods and computational and statistical approaches to pursue the planning, design and analysis of quantitative proteomics experiments. The author’s carefully constructed approach allows readers to easily make the transition into the field of quantitative proteomics. Through detailed descriptions of wet-lab methods, computational approaches and statistical tools, this book covers the full scope of a quantitative experiment, allowing readers to acquire new knowledge as well as acting as a useful reference work for more advanced readers. Computational and Statistical Methods for Protein Quantification by Mass Spectrometry: Introduces the use of mass spectrometry in protein quantification and how the bioinformatics challenges in this field can be solved using statistical methods and various software programs. Is illustrated by a large number of figures and examples as well as numerous exercises. Provides both clear and rigorous descriptions of methods and approaches. Is thoroughly indexed and cross-referenced, combining the strengths of a text book with the utility of a reference work. Features detailed discussions of both wet-lab approaches and statistical and computational methods. With clear and thorough descriptions of the various methods and approaches, this book is accessible to biologists, informaticians, and statisticians alike and is aimed at readers across the academic spectrum, from advanced undergraduate students to post doctorates entering the field.

Protein and Peptide Analysis by Mass Spectrometry

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Publisher : Springer Science & Business Media
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Protein and Peptide Analysis by Mass Spectrometry by : J. R. Chapman

Download or read book Protein and Peptide Analysis by Mass Spectrometry written by J. R. Chapman and published by Springer Science & Business Media. This book was released on 1996-08-19 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading practitioners authoritatively describe the newest and most effective spectrometric techniques for the analysis of proteins and peptides. The areas covered range from the elucidation of primary and secondary protein structure and the rapid identification of proteins using database techniques to methods for sequencing, as well as methods for the quantitative determination of peptides. Other chapters provide detailed information on the analysis of glycoproteins and glycopeptides and on the use of mass spectrometry to probe the interactions of proteins, both covalent and noncovalent.

Mass Spectrometry of Proteins and Peptides

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Publisher : Humana Press
ISBN 13 : 9781607611042
Total Pages : 470 pages
Book Rating : 4.6/5 (11 download)

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Book Synopsis Mass Spectrometry of Proteins and Peptides by : Mary S. Lipton

Download or read book Mass Spectrometry of Proteins and Peptides written by Mary S. Lipton and published by Humana Press. This book was released on 2008-11-01 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: When the last edition of this book was published in 2000, the field of proteomics was in its infancy. At that time, multidimensional liquid chromatographic separations were being introduced as an alternative to traditional gel-based techniques for separating complex protein and peptide mixtures prior to mass spectrometric detection. Today, this approach – referred to as shotgun proteomics – is considered routine for lar- scale global analyses of protein mixtures. Now in its adolescence, proteomics is fundamentally transforming biological and medical research. Much of this transformation can be attributed to technological advancements, particularly in mass spectrometry. Much wider accessibility of hi- resolution and mass measurement accuracy instrumentation in recent years has ini- ated a new revolution in the field by providing more reliable data and shifting the focus from cataloging proteins to precisely quantifying changes in protein abundance over time and in response to stimuli. Advanced mass spectrometers and novel ion d- sociation schemes such as electron transfer/capture dissociation make it possible to venture boldly into the maze of protein posttranslational modifications, which are an integral component of understanding functional proteomics in the spatial and t- poral domains. Another area that has benefited from these advancements is top-down proteomics, an emerging method essential for characterizing various protein variants that has potentially high impact in biomedical research.

Mass Spectrometry of Peptides

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Publisher : CRC Press
ISBN 13 : 9780849362934
Total Pages : 438 pages
Book Rating : 4.3/5 (629 download)

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Book Synopsis Mass Spectrometry of Peptides by : Dominic M. Desiderio

Download or read book Mass Spectrometry of Peptides written by Dominic M. Desiderio and published by CRC Press. This book was released on 1990-11-14 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to collect into one volume the research done on the mass spectrometry of peptides. It balances a range of topics including theory, instrumentation, analytical techniques, and biological applications. The scope of the work contains three major sections: ionization methods, instrumental developments, and analysis of peptides. It describes 252Cf plasma desorption and laser-induced multiphoton ionization methodology. This exciting resource covers many new areas, including continuous flow FAB, quantification of human neuropeptides, and peptide mapping. It also discusses Q-FTMS, cross-links, and metal ions.

Analysis of Protein Post-Translational Modifications by Mass Spectrometry

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Publisher : John Wiley & Sons
ISBN 13 : 1119250897
Total Pages : 377 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Analysis of Protein Post-Translational Modifications by Mass Spectrometry by : John R. Griffiths

Download or read book Analysis of Protein Post-Translational Modifications by Mass Spectrometry written by John R. Griffiths and published by John Wiley & Sons. This book was released on 2016-10-18 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation Discussion of the chemistry behind each modification, along with key methods and references Contributions from some of the leading researchers in the field A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research

DEVELOPPEMENT DU COUPLAGE DE LA CHROMATOGRAPHIE LIQUIDE AVEC LA SPECTROMETRIE DE MASSE PAR L'INTERFACE FAB A FLUX CONTINU. CARACTERISATION DES PROTEINES H, T ET L DU COMPLEXE DE LA GLYCINE DECARBOXYLASE DES FEUILLES DE POIS

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Publisher :
ISBN 13 :
Total Pages : 178 pages
Book Rating : 4.:/5 (49 download)

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Book Synopsis DEVELOPPEMENT DU COUPLAGE DE LA CHROMATOGRAPHIE LIQUIDE AVEC LA SPECTROMETRIE DE MASSE PAR L'INTERFACE FAB A FLUX CONTINU. CARACTERISATION DES PROTEINES H, T ET L DU COMPLEXE DE LA GLYCINE DECARBOXYLASE DES FEUILLES DE POIS by : VERONIQUE.. LOUVET MERAND

Download or read book DEVELOPPEMENT DU COUPLAGE DE LA CHROMATOGRAPHIE LIQUIDE AVEC LA SPECTROMETRIE DE MASSE PAR L'INTERFACE FAB A FLUX CONTINU. CARACTERISATION DES PROTEINES H, T ET L DU COMPLEXE DE LA GLYCINE DECARBOXYLASE DES FEUILLES DE POIS written by VERONIQUE.. LOUVET MERAND and published by . This book was released on 1994 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: AU COURS DE CE TRAVAIL NOUS AVONS UTILISE DIFFERENTES TECHNIQUES DE SPECTROMETRIE DE MASSE DESTINEES A RESOUDRE DES PROBLEMES ANALYTIQUES DANS LE DOMAINE DE LA STRUCTURE DES PROTEINES. DANS LE BUT DE GAGNER DU TEMPS ET DE LA SENSIBILITE DANS LES ANALYSES, NOUS AVONS DEVELOPPE LE COUPLAGE DE LA CHROMATOGRAPHIE LIQUIDE (HPLC) AVEC LA SPECTROMETRIE DE MASSE (MS) EN MODE FAB FAST ATOM BOMBARDMENT PAR L'INTERFACE FAB A FLUX CONTINU (CF/FAB). CE COUPLAGE A ETE REALISE AVEC DES COLONNES CAPILLAIRES DE DIAMETRE INTERNE 0,25 MM. IL S'EST AVERE ETRE BIEN ADAPTE A L'ETUDE DE MELANGES COMPLEXES DE PEPTIDES DE MASSES INFERIEURES A 5000 DA AVEC UNE SENSIBILITE DE L'ORDRE DE 20 A 200 PMOL POUR UN PEPTIDE DE MASSE 1000 DA. CETTE SENSIBILITE DECROIT AU FUR ET A MESURE QUE NOUS ELEVONS DANS LE DOMAINE DE MASSE. PAR LA SUITE, LES TECHNIQUES DE COUPLAGE DE L'HPLC AVEC LA SPECTROMETRIE DE MASSE, PAR L'INTERFACE CF/FAB MAIS AUSSI PAR L'INTERFACE ELECTROSPRAY (ESI), ONT ETE UTILISEES POUR L'ETUDE DE LA STRUCTURE PRIMAIRE ET DES MODIFICATIONS POST-TRADUCTIONNELLES DES PROTEINES H, T ET L DU COMPLEXE DE LA GLYCINE DECARBOXYLASE DES MITOCHONDRIES DES FEUILLES DE POIS. AINSI, LES ANALYSES DES FRAGMENTS ISSUS DE COUPURES CHIMIQUES OU ENZYMATIQUES DES PROTEINES H (14,1 KDA) ET T (40,9 KDA) ONT PERMIS DE VERIFIER LES SEQUENCES DE CES DEUX PROTEINES ETABLIES A PARTIR DE LEURS ADNC. NOUS AVONS AUSSI LOCALISER LA POSITION EXACTE DU COFACTEUR LIPOATE DE LA PROTEINE H. LA MESURE DE LA MASSE DE LA PROTEINE L (49,7 KDA) CONFIRME LA SEQUENCE DE LA PROTEINE. DE PLUS, ELLE MONTRE QU'IL N'Y A DE LIAISON COVALENTE NI ENTRE LES DEUX SOUS UNITES DE LA PROTEINE, NI ENTRE LA PROTEINE ET SON COFACTEUR, ET QUE LA PROTEINE L CONTIENT UNE MODIFICATION POST-TRADUCTIONNELLE DE 32 DA ENVIRON

Analysis of Peptides and Proteins by Mass Spectrometry

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Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Analysis of Peptides and Proteins by Mass Spectrometry by : C. J McNeal

Download or read book Analysis of Peptides and Proteins by Mass Spectrometry written by C. J McNeal and published by . This book was released on 1988-12-26 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprises the proceedings of the Fourth Texas Symposium on Mass Spectrometry, held at Texas A & M University, April 1988. Twenty-five papers, presented by an international gathering of mass spectroscopists and bioscientists, reveal the state of the art in the application of mass spectrometry to the life sciences. Discussed are instruments that are sensitive to femtomoles, how mass spectrometry can further peptide mapping, monitoring peptide synthesis, peptide sequencing, and much more.

Protein Analysis using Mass Spectrometry

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Publisher : John Wiley & Sons
ISBN 13 : 1119359368
Total Pages : 282 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Protein Analysis using Mass Spectrometry by : Mike S. Lee

Download or read book Protein Analysis using Mass Spectrometry written by Mike S. Lee and published by John Wiley & Sons. This book was released on 2017-05-26 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis

Introduction to Protein Mass Spectrometry

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Publisher : Elsevier
ISBN 13 : 0443139202
Total Pages : 388 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Introduction to Protein Mass Spectrometry by : Pradip K. Ghosh

Download or read book Introduction to Protein Mass Spectrometry written by Pradip K. Ghosh and published by Elsevier. This book was released on 2024-04-22 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Protein Mass Spectrometry, Second Edition provides a comprehensive overview of this increasingly important, yet complex, analytical technique. This book enables readers to understand how determinations about protein identity from mass spectrometric data are made. Coverage begins with the technical basics, including preparations, instruments, and spectrometric analysis of peptides and proteins, before exploring applied use in biological applications, bioinformatics, database, and software resources. This new edition is fully updated to include the latest developments in the field and will feature new content covering recent progress in the areas where there have been the most exciting advances. These include PNNL's multilevel-PCB-based SLIM realization, SLIM-Agilent QQQ field trials; employment of SLIM-IMS-cryo-IR combination in molecular structure determination; proximity-labelling mass spectrometry, and applications in neuroscience. - Offers up-to-date, introductory information for scientists and researchers new to the field, as well as advanced insights into the critical assessment of computer-analyzed mass spectrometric results and their current limitations - Provides examples of commonly used MS instruments from a range of key manufacturers/developers, including Bruker, Applied Biosystems, JEOL, Thermo Scientific/Thermo Fisher Scientific, IU, Waters and PNNL - Includes biological applications and exploration of analytical tools and databases for bioinformatics - Features definitions, case studies, and recent developments in protein mass spectrometry - Includes sections new to this edition on SLIM (Structures for Lossless Ion Manipulation) and mass spectrometry applications in neuroscience, including synaptic biology and Alzheimer's disease

Chromatographie Liquide de Haute Performance en Chimie Des Protéines

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Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Chromatographie Liquide de Haute Performance en Chimie Des Protéines by : Henri Wajcman

Download or read book Chromatographie Liquide de Haute Performance en Chimie Des Protéines written by Henri Wajcman and published by . This book was released on 1984 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: