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L Dopa And The Serotonergic System
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Book Synopsis L-dopa and the Serotonergic System by : Branden J. Stansley
Download or read book L-dopa and the Serotonergic System written by Branden J. Stansley and published by . This book was released on 2015 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) is characterized by a loss of dopamine neurons in the substantia nigra pars compacta, leading to loss of dopamine neurotransmission in the striatum, and subsequent loss of motor control. L-dopa is often administered to recover motor function in PD patients; however, over time the drug efficacy decreases and debilitating side effects such as dyskinesia, mood disorders, and hallucinations occur. The therapeutic effect as well as some of the side effects of L-dopa has been credited to serotonin (5-HT) neurons. To address the mechanisms underlying the side effects of L-dopa, it was hypothesized that L-dopa forms dopamine within 5-HT neurons to produce oxidative stress and cytotoxicity, leading to 5-HT neurotransmitter deficits as well as behavioral impairments in rats. To directly test this hypothesis, initial experiments utilized serotonergic neuronal cell cultures that were incubated with L-dopa. Results illustrated that dopamine production occurred in serotonergic cells after incubation with L-dopa. Furthermore, L-dopa dose-dependently increased reactive oxygen species production and cell death, both of which were attenuated by amino-acid decarboxylase inhibition, MAO inhibition or incubation with antioxidants. The effects of L-dopa on 5-HT neurons in-vivo were also examined. Male rats were treated chronically for 10 days with L-dopa (6 mg/kg; twice daily) and killed 48 hours after the last injection to investigate the effects on 5-HT neuron number in the dorsal raphe nucleus (DRN) and 5-HT content throughout the brain. L-dopa treatment decreased the number of 5-HT neurons significantly in the caudal-dorsal sub-region of the DRN (28% decrease). Co-treatment with the anti-oxidant ascorbate (400 mg/kg) or MAO-B inhibitor deprenyl (2 mg/kg) prevented the L-dopa induced decreases in 5-HT neurons within the DRN. Furthermore, 5-HT tissue content was decreased significantly in the dorsal DRN and prefrontal cortex (PFC) by L-dopa treatment. These L-dopa-induced 5-HT depletions were blocked by ascorbate co-treatment. Chronic L-dopa also caused significant behavioral impairments in rats. Spatial memory recall was impaired, in addition to a potentiated fear response after L-dopa, both of which were prevented by ascorbate co-treatment. Taken together, results presented in this dissertation provide evidence that L-dopa produces 5-HT neuron loss both in vitro and in vivo, as well as in vivo 5-HT neurochemical depletions and behavioral impairments through an oxidative stress mechanism.
Book Synopsis Serotonin- and Dopamine-mediated Neurotransmission in the Pathophysiology and Treatment of Parkinson's Disease by : Philippe Huot
Download or read book Serotonin- and Dopamine-mediated Neurotransmission in the Pathophysiology and Treatment of Parkinson's Disease written by Philippe Huot and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance by : Giuseppe Di Giovanni
Download or read book Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance written by Giuseppe Di Giovanni and published by Elsevier. This book was released on 2008-11-11 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson's disease. This extremely important topic is of wide interest within the scientific community, with relevance not only to specialists but also to general practitioners and students. The book provides a valuable contribution to the debate on new pharmacological approaches for several psychopathological states, with contributions from expert neuroscientists and pharmacologists who comprehensively survey the most significant currently active areas of dopamine/serotonin interactions. * Provides an understanding of the interaction between Serotonin and Dopamine. * Appeals equally to specialists, general practitioners, students and researchers. * Contributes to the debate on new pharmacological approaches to several psychopathological states * Gives a comprehensive anatomical description plus the physiology and pharmacology of dopaminergic and serotonergic systems * Singles out neuropsychiatric and suggests new therapeutic approaches.
Book Synopsis Role of the Serotonergic System in the Behavioural Pharmacology of Parkinson's Disease and Levodopa-induced Dyskinesia by : Sarah Louise Nicholson
Download or read book Role of the Serotonergic System in the Behavioural Pharmacology of Parkinson's Disease and Levodopa-induced Dyskinesia written by Sarah Louise Nicholson and published by . This book was released on 2005 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hereditary Progressive Dystonia with Marked Diurnal Fluctuation by : Masaya Segawa
Download or read book Hereditary Progressive Dystonia with Marked Diurnal Fluctuation written by Masaya Segawa and published by Parthenon Publishing. This book was released on 1993-01-01 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study examines the condition known as parkinsonism of early onset with diurnal fluctuation (PEDF). It aims to clarify the differences between PEDF and early-onset Parkinson disease, then to compare PEDF with HPD (hereditary progressive dystonia with marked diurnal fluctuation).
Book Synopsis The Plastic Brain by : Rommy von Bernhardi
Download or read book The Plastic Brain written by Rommy von Bernhardi and published by Springer. This book was released on 2017-10-26 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of the many factors that can influence brain plasticity throughout the lifespan. Addresses perinatal plasticity, functional state plasticity, injury-induced plasticity, and stressor-induced plasticity. Because it looks at so many aspects of the field, this volume will serve as a great resource for students as well as researchers interested in expanding their knowledge. The volume comes out as an integrated view based in the expertise of Ibero American neuroscientists working in the field.
Book Synopsis L-DOPA-induced Serotonin Dysfunction and Associated Behavioral Indices in a Bilateral Rat Model of Parkinson's Disease by : Karen Louise Eskow-Jaunarajs
Download or read book L-DOPA-induced Serotonin Dysfunction and Associated Behavioral Indices in a Bilateral Rat Model of Parkinson's Disease written by Karen Louise Eskow-Jaunarajs and published by . This book was released on 2011 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dopamine Handbook by : Leslie L. Iversen
Download or read book Dopamine Handbook written by Leslie L. Iversen and published by . This book was released on 2010 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field.
Book Synopsis NeuroPsychopharmacotherapy by : Peter Riederer
Download or read book NeuroPsychopharmacotherapy written by Peter Riederer and published by Springer Nature. This book was released on 2022-11-04 with total page 4652 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, Japan and China. In addition, it highlights herbal medicine as used in China and Japan, as well as complementary medicine and nutritional aspects. This novel approach offers international readers a global approach in a single dedicated publication and is also a valuable resource for anyone interested in comparing treatments for psychiatric disorders in three different cultural areas. There are three volumes devoted to Basic Principles and General Aspects, offering a general overview of psychopharmacotherapy (Vol. 1); Classes, Drugs and Special Aspects covering the role of psychotropic drugs in the field of psychiatry and neurology (Vol. 2) and Applied Psychopharmacotherapy focusing on applied psychopharmacotherapy (Vol. 3). These books are invaluable to psychiatrists, neurologists, neuroscientists, medical practitioners and clinical psychologists.
Book Synopsis A Synopsis of Parkinson's Disease by : Md, Frcpc, Frcp (hon), Abdul Qayyum Rana
Download or read book A Synopsis of Parkinson's Disease written by Md, Frcpc, Frcp (hon), Abdul Qayyum Rana and published by BoD – Books on Demand. This book was released on 2014-03-26 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinsons disease is a disabling neurological condition with both motor and non-motor symptoms for which no cure is available at this stage. This book is unique in covering the most important topics related to Parkinsons disease. Current research and updates about some non-motor symptoms, as well as surgical treatment of Parkinsons disease, in addition to the long term complications of pharmacological treatments have been presented. This book can be used by physicians, researchers and neuroscientists who want to learn new information about these topics related to Parkinsons disease. Authors of the individual chapters are well known in their fields and the book has been edited by a world renowned Parkinsons disease expert.
Book Synopsis Experimental Models in Serotonin Transporter Research by : Allan V. Kalueff
Download or read book Experimental Models in Serotonin Transporter Research written by Allan V. Kalueff and published by Cambridge University Press. This book was released on 2010-03-04 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. This control over neuronal signalling makes it a prime area of neuroscientific study. In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains. They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human neurobiology. Writing for graduate students and academic researchers, they provide a comprehensive coverage of a wide spectrum of data from animal experimentation to clinical psychiatry, creating the only book exclusively dedicated to this exciting new avenue of brain research.
Book Synopsis Etiology of Parkinson's Disease by : Jonas H. Ellenberg
Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Book Synopsis Neurobiology of Body Fluid Homeostasis by : Laurival Antonio De Luca Jr.
Download or read book Neurobiology of Body Fluid Homeostasis written by Laurival Antonio De Luca Jr. and published by CRC Press. This book was released on 2013-10-01 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely symposium entitled Body-Fluid Homeostasis: Transduction and Integration was held at Araraquara, São Paulo, Brazil in 2011. This meeting was convened as an official satellite of a joint gathering of the International Society for Autonomic Neuroscience (ISAN) and the American Autonomic Society (AAS) held in Buzios, Rio de Janeiro. Broad international participation at this event generated stimulating discussion among the invited speakers, leading to the publication of Neurobiology of Body Fluid Homeostasis: Transduction and Integration. Drawn from the proceedings and filled with rich examples of integrative neurobiology and regulatory physiology, this volume: Provides updated research using human and animal models for the control of bodily fluids, thirst, and salt appetite Explores neural and endocrine control of body fluid balance, arterial pressure, thermoregulation, and ingestive behavior Discusses recent developments in molecular genetics, cell biology, and behavioral plasticity Reviews key aspects of brain serotonin and steroid and peptide control of fluid consumption and arterial pressure The book highlights research conducted by leading scientists on signal transduction and sensory afferent mechanisms, molecular genetics, perinatal and adult long-term influences on regulation, central neural integrative circuitry, and autonomic/neuroendocrine effector systems. The findings discussed by the learned contributors are relevant for a basic understanding of disorders such as heat injury, hypertension, and excess salt intake. A unique reference on the neurobiology of body fluid homeostasis, this volume is certain to fuel additional research and stimulate further debate on the topic.
Book Synopsis Mechanisms of Levodopa Action in the Central Nervous System by : David Buell Goodale
Download or read book Mechanisms of Levodopa Action in the Central Nervous System written by David Buell Goodale and published by . This book was released on 1976 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Obsessive-compulsive Disorder by : Christopher Pittenger
Download or read book Obsessive-compulsive Disorder written by Christopher Pittenger and published by Oxford University Press. This book was released on 2017 with total page 777 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obsessive-compulsive disorder (OCD) affects one person in 40 and can cause great suffering. This volume provides the first comprehensive summary of our understanding of this enigmatic condition, summarizing current work ranging from genetics and neurobiology through cognitive psychology, treatment, personal experiences, and societal implications.
Book Synopsis Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance by : Giuseppe Di Giovanni
Download or read book Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance written by Giuseppe Di Giovanni and published by Elsevier. This book was released on 2008-09-26 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson's disease. This extremely important topic is of wide interest within the scientific community, with relevance not only to specialists but also to general practitioners and students. The book provides a valuable contribution to the debate on new pharmacological approaches for several psychopathological states, with contributions from expert neuroscientists and pharmacologists who comprehensively survey the most significant currently active areas of dopamine/serotonin interactions. - Provides an understanding of the interaction between Serotonin and Dopamine - Appeals equally to specialists, general practitioners, students and researchers - Contributes to the debate on new pharmacological approaches to several psychopathological states - Gives a comprehensive anatomical description plus the physiology and pharmacology of dopaminergic and serotonergic systems - Singles out neuropsychiatric and suggests new therapeutic approaches
Book Synopsis Novel Pharmacological Interventions for Alcoholism by : Claudio A. Naranjo
Download or read book Novel Pharmacological Interventions for Alcoholism written by Claudio A. Naranjo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Pharmacological Interventions for Alcoholism identifies priorities for focusing alcoholism and addiction research efforts during the coming years. A number of important issues concerning methodology, mechanisms, clinical evaluation, and pharmaceutical aspects are discussed. This book is also a plea for a greater degree of collaboration among academics, pharmaceutical physicians and scientists, and drug regulators; it demonstrates that progress in understanding and fighting addiction and alcoholism is possible in the foreseeable future.
