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Author : Hui Gong
Publisher : Frontiers Media SA
ISBN 13 : 2889763587
Total Pages : 155 pages
Book Rating : 4.8/5 (897 download)
Download or read book Ischemic Myocardial Injury and Protection: From Bench to Bedside written by Hui Gong and published by Frontiers Media SA. This book was released on 2022-06-07 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bohuslav Ost'ádal
Publisher : Springer Science & Business Media
ISBN 13 : 147573025X
Total Pages : 198 pages
Book Rating : 4.4/5 (757 download)
Download or read book Cardiac Ischemia: From Injury to Protection written by Bohuslav Ost'ádal and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Ischemia: From Injury to Protection has been divided into six parts. The first part describes the differences between hypoxia and ischemia, animal models, the effects of ischemia on myocardial function and metabolism, and the electrophysiological consequences of ischemia. The second part deals with the mechanisms of cardiomyocyte death in ischemia, structural aspects of irreversible ischemic injury, necrosis and apoptosis of cardiac cells, the role of calcium, and the concept of calcium antagonism. The third chapter is a brief description of reperfusion injury, its clinical relevance, and possible prevention. The fourth part summarizes changes in myocardial vasculature during ischemia and reperfusion. The fifth part is the survey of two main possibilities for increasing cardiac resistance to ischemia and hypoxia, i.e. long-lasting adaptation to chronic hypoxia and short-lasting preconditioning. The last part of the book deals with comparative and ontogenetic aspects of cardiac sensitivity to oxygen deprivation; this chapter also summarizes the ontogenetic differences and limitations in endogenous and exogenous protection of the ischemic/hypoxic heart.
Author : Juan Carlos Kaski
Publisher : Springer Science & Business Media
ISBN 13 : 1849960194
Total Pages : 311 pages
Book Rating : 4.8/5 (499 download)
Download or read book Management of Myocardial Reperfusion Injury written by Juan Carlos Kaski and published by Springer Science & Business Media. This book was released on 2012-07-20 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much has been written about reperfusion injury in the past decade but unfortunately the information has been generally presented in the form of original specialist papers and little if any integral publication exists on the topic, summarising and analysing the clinical impact of the condition and its management. The pathophysiology and molecular mechanisms of reperfusion injury are complex and, regarding diagnosis, individual diagnostic techniques have been proposed but without a proper assessment of the relative values of these methods. A publication dealing with integral diagnostic strategies would be welcome by the managing physician. Management of the condition is also problematic, as strategies that appear to work in the experimental models do not translate into beneficial interventions in patients. There is a need for these issues to be addressed and discussed in a monographic fashion. Management of Myocardial Reperfusion Injury will tackle these issues in a modern and systematic way and the information will be delivered in a fashion that will be appealing to the reader.
Author : Morris Karmazyn
Publisher : Birkhäuser
ISBN 13 : 3034889887
Total Pages : 508 pages
Book Rating : 4.0/5 (348 download)
Download or read book Myocardial Ischemia: Mechanisms, Reperfusion, Protection written by Morris Karmazyn and published by Birkhäuser. This book was released on 2013-03-12 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events in the ischemic, postinfarcted and reperfused myocardium as well as new exciting developments in cardiac protection that involve both novel pharmacological approaches as well as endogenous cardioprotective mechanisms such as preconditioning. Aimed at both the basic and clinical cardiovascular investigator, the book comprehensively reviews the rapid progress made in recent years in understanding the etiology of myocardial ischemia and reperfusion. It will further serve as an authoritative reference for all those interested in learning about the important developments in the treatment of myocardial ischemic and reperfusion disorders.
Author : Bohuslav Ost'ádal
Publisher : Springer
ISBN 13 : 9781441951052
Total Pages : 173 pages
Book Rating : 4.9/5 (51 download)
Download or read book Cardiac Ischemia: From Injury to Protection written by Bohuslav Ost'ádal and published by Springer. This book was released on 2010-12-02 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Ischemia: From Injury to Protection has been divided into six parts. The first part describes the differences between hypoxia and ischemia, animal models, the effects of ischemia on myocardial function and metabolism, and the electrophysiological consequences of ischemia. The second part deals with the mechanisms of cardiomyocyte death in ischemia, structural aspects of irreversible ischemic injury, necrosis and apoptosis of cardiac cells, the role of calcium, and the concept of calcium antagonism. The third chapter is a brief description of reperfusion injury, its clinical relevance, and possible prevention. The fourth part summarizes changes in myocardial vasculature during ischemia and reperfusion. The fifth part is the survey of two main possibilities for increasing cardiac resistance to ischemia and hypoxia, i.e. long-lasting adaptation to chronic hypoxia and short-lasting preconditioning. The last part of the book deals with comparative and ontogenetic aspects of cardiac sensitivity to oxygen deprivation; this chapter also summarizes the ontogenetic differences and limitations in endogenous and exogenous protection of the ischemic/hypoxic heart.
Author : Derek Hausenloy
Publisher : Oxford University Press
ISBN 13 : 019954476X
Total Pages : 138 pages
Book Rating : 4.1/5 (995 download)
Download or read book Cardioprotection written by Derek Hausenloy and published by Oxford University Press. This book was released on 2009-08-20 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronary heart disease (CHD) is the leading cause of death worldwide. Cardioprotection refers to the prevention of CHD and the clinical improvement in patients suffering from cardiovascular problems.
Author : Qian Wang
Publisher : Springer Nature
ISBN 13 : 9819983657
Total Pages : 586 pages
Book Rating : 4.8/5 (199 download)
Download or read book Extracellular Vesicles written by Qian Wang and published by Springer Nature. This book was released on with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tom S. Neuman
Publisher : Elsevier Health Sciences
ISBN 13 : 1437710956
Total Pages : 768 pages
Book Rating : 4.4/5 (377 download)
Download or read book Physiology and Medicine of Hyperbaric Oxygen Therapy E-Book written by Tom S. Neuman and published by Elsevier Health Sciences. This book was released on 2008-07-17 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally recognized leaders in hyperbaric oxygen therapy (HBOT) research and practice, this exciting new book provides evidence-based, practical, useful information for anyone involved in HBOT. It outlines the physiologic principles that constitute the basis for understanding the clinical implications for treatment and describes recent advances and current research, along with new approaches to therapy. This book is an essential tool for anyone who cares for patients with difficult-to-heal wounds, wounds from radiation therapy, carbon monoxide poisoning, and more. Provides comprehensive coverage of pathophysiology and clinically relevant information so you can master the specialty. Covers the relevance of HBOT in caring for diverse populations including critical care patients, infants and pediatric patients, and divers. Features a section on the technical aspects of HBOT to provide insight into the technology and physics regarding HBO chambers. Presents evidence to support the effectiveness of HBOT as well as the possible side effects. Describes situations where HBOT would be effective through indication-specific chapters on chronic wounds, radiation and crush injuries, decompression sickness, and more.
Author : Stéphanie Barrere-Lemaire
Publisher : Frontiers Media SA
ISBN 13 : 2889766535
Total Pages : 219 pages
Book Rating : 4.8/5 (897 download)
Download or read book New Strategies to Inhibit Cell Death in Myocardial Ischemia-Reperfusion Injury: How to succeed? written by Stéphanie Barrere-Lemaire and published by Frontiers Media SA. This book was released on 2022-07-28 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul A. Lapchak
Publisher : Springer
ISBN 13 : 3319453459
Total Pages : 795 pages
Book Rating : 4.3/5 (194 download)
Download or read book Neuroprotective Therapy for Stroke and Ischemic Disease written by Paul A. Lapchak and published by Springer. This book was released on 2017-01-12 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.
Author : José Marín-García
Publisher : Academic Press
ISBN 13 : 0124046428
Total Pages : 935 pages
Book Rating : 4.1/5 (24 download)
Download or read book Post-Genomic Cardiology written by José Marín-García and published by Academic Press. This book was released on 2014-05-09 with total page 935 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs
Author : Johannes Boltze
Publisher : Frontiers Media SA
ISBN 13 : 2889711773
Total Pages : 1044 pages
Book Rating : 4.8/5 (897 download)
Download or read book Cutting-Edge Approaches for CNS Protection and Repair: Focus on Vascular and Degenerative Disorders written by Johannes Boltze and published by Frontiers Media SA. This book was released on 2021-08-19 with total page 1044 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Matthew M. Thompson
Publisher : Oxford University Press
ISBN 13 : 0192534335
Total Pages : 2123 pages
Book Rating : 4.1/5 (925 download)
Download or read book Oxford Textbook of Vascular Surgery written by Matthew M. Thompson and published by Oxford University Press. This book was released on 2016-08-25 with total page 2123 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Textbook of Vascular Surgery draws on the expertise of over 130 specialist contributors to encompass the field of vascular surgery. Through the use of figures, findings of contemporary trials, and additional online content, this textbook is an excellent study material for surgical trainees entering their final two years of training, in addition to serving as an effective reference source for practicing surgeons. This volume discusses the epidemiology, vascular biology, clinical features and management of diseases that affect the vasculature and contains dedicated chapters which address topics such as paediatric surgery, damage control surgery, and amputations. The text follows a logical framework which complements the published Intercollegiate Surgery Curriculum making it particularly useful in preparation for the Intercollegiate Examination. The online version of The Oxford Textbook of Vascular Surgery is free for twelve months to individual purchasers of this book and contains the full text of the print edition, links to external sources and informative videos demonstrating current surgical techniques, making this a valuable resource for practicing surgeons. The field of vascular surgery has advanced rapidly in recent years and has expanded to include the techniques of interventional radiology and cardiology which are also extensively covered in this volume, making it an authoritative modern text. By combining contemporary evidence-based knowledge with informative figures, online resources and links to the current training curriculum, The Oxford Textbook of Vascular Surgery is a highly valuable source of information and will become the standard reference text for all who study vascular disease and its treatment.
Author : Miguel A. Aon
Publisher : Frontiers Media SA
ISBN 13 : 2889452395
Total Pages : 230 pages
Book Rating : 4.8/5 (894 download)
Download or read book Mitochondria: Hubs of Cellular Signaling, Energetics and Redox Balance written by Miguel A. Aon and published by Frontiers Media SA. This book was released on 2017-08-11 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Poised at the convergence of most catabolic and anabolic pathways, mitochondria are the center of heterotrophic aerobic life, representing a hub in the overall metabolic network of cells. The energetic functions performed by mitochondria face the unavoidable redox hurdle of handling huge amounts of oxygen while keeping its own as well as the cellular redox environment under control. Reactive oxygen species (ROS) are produced in the respiratory chain as a result of the energy supplying function of mitochondria. Originally considered an unavoidable by-product of oxidative phosphorylation, ROS have become crucial signaling molecules when their levels are kept within physiological range. This occurs when their production and scavenging are balanced within mitochondria and cells. Mitochondria-generated hydrogen peroxide can act as a signaling molecule within mitochondria or in the cytoplasm, affecting multiple networks that control, for example, cell cycle, stress response, cell migration and adhesion, energy metabolism, redox balance, cell contraction, and ion channels. However, under pathophysiological conditions, excessive ROS levels can happen due to either overproduction, overwhelming of antioxidant defenses, or both. Under oxidative stress, detrimental effects of ROS include oxidation of protein, lipids, and nucleic acids; mitochondrial depolarization and calcium overload; and cell-wide oscillations mediated by ROS-induced ROS release mechanisms. Mitochondrial dysfunction is central in the pathogenesis of numerous human maladies including cardiomyopathies and neurodegeneration. Diseases characterized by altered nutrient metabolism, such as diabetes and cancer, exhibit elevated ROS levels. These may contribute to pathogenesis by increasing DNA mutation, affecting regulatory signaling and transcription, and promoting inflammation. Under metabolic stress, several ionic channels present in the inner and outer mitochondrial membranes can have pro-life and -death effects. In the present E-book, based on the Frontiers Research Topic entitled: "Mitochondria: Hubs of cellular signaling, energetics and redox balance", we address one of the fundamental questions that the field of ROS biology faces today: how do mitochondria accomplish a reliable energy provision and at the same time keep ROS levels within physiological, non-harming, limits but crucial for cellular signaling function? Additionally, and within the perspective of mitochondria as signaling-energetic hubs in the extensive cellular metabolic network, we ask how can their collective dynamics scale from the subcellular to the cellular, tissue and organ levels to affect function in health and disease.
Author : Predrag Sikiric
Publisher : Frontiers Media SA
ISBN 13 : 2832515967
Total Pages : 373 pages
Book Rating : 4.8/5 (325 download)
Download or read book Protection and healing in the digestive system and other tissues: Novel factors, mechanisms, and pharmaceutical targets written by Predrag Sikiric and published by Frontiers Media SA. This book was released on 2023-03-08 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Francisco Purroy
Publisher : Frontiers Media SA
ISBN 13 : 2889765911
Total Pages : 109 pages
Book Rating : 4.8/5 (897 download)
Download or read book Remote Ischemic Conditioning (pre, per, and post) as an Emerging Strategy of Neuroprotection in Ischemic Stroke written by Francisco Purroy and published by Frontiers Media SA. This book was released on 2022-07-18 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : José Marín-García
Publisher : Springer Science & Business Media
ISBN 13 : 1607611473
Total Pages : 460 pages
Book Rating : 4.6/5 (76 download)
Download or read book Heart Failure written by José Marín-García and published by Springer Science & Business Media. This book was released on 2010-06-23 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.
