Iron As Therapeutic Targets In Human Diseases Volume 1

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Iron as Therapeutic Targets in Human Diseases

Author : Paolo Arosio
Publisher : MDPI
ISBN 13 : 3039280821
Total Pages : 472 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Iron as Therapeutic Targets in Human Diseases by : Paolo Arosio

Download or read book Iron as Therapeutic Targets in Human Diseases written by Paolo Arosio and published by MDPI. This book was released on 2020-02-11 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc

Download Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc PDF Online Free

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 9780309072793
Total Pages : 804 pages
Book Rating : 4.0/5 (727 download)

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Book Synopsis Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc by : Institute of Medicine

Download or read book Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc written by Institute of Medicine and published by National Academies Press. This book was released on 2002-07-19 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.

Iron as Therapeutic Targets in Human Diseases Volume 1

Author : Paolo Arosio
Publisher :
ISBN 13 : 9783039280834
Total Pages : 472 pages
Book Rating : 4.2/5 (88 download)

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Book Synopsis Iron as Therapeutic Targets in Human Diseases Volume 1 by : Paolo Arosio

Download or read book Iron as Therapeutic Targets in Human Diseases Volume 1 written by Paolo Arosio and published by . This book was released on 2020 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Iron as Therapeutic Targets in Human Diseases

Author : Paolo Arosio
Publisher : MDPI
ISBN 13 : 3039281143
Total Pages : 440 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Iron as Therapeutic Targets in Human Diseases by : Paolo Arosio

Download or read book Iron as Therapeutic Targets in Human Diseases written by Paolo Arosio and published by MDPI. This book was released on 2020-02-11 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Damage-Associated Molecular Patterns in Human Diseases

Author : Walter Gottlieb Land
Publisher : Springer Nature
ISBN 13 : 3030538680
Total Pages : 629 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Damage-Associated Molecular Patterns in Human Diseases by : Walter Gottlieb Land

Download or read book Damage-Associated Molecular Patterns in Human Diseases written by Walter Gottlieb Land and published by Springer Nature. This book was released on 2020-09-19 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a continuance of the topic: “DAMPs in Human Diseases”, the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardiovascular diseases. Our growing understanding of the pathogenetic function of activating DAMPs and suppressive DAMPs (“SAMPs”) is used as a point of departure to explore how these molecules can be used as biomarkers to extend and improve current diagnostic and prognostic modalities. Moreover, this new knowledge about the pathogenetic function of DAMPs and SAMPs is taken as a sound and plausible reason for discussing their implications for present and future treatment of the diseases addressed here. In this context, the focus is on the potential of DAMPs as future therapeutic targets and SAMPs as future therapeutics, applied in strict compliance with safety precautions, as also recommended in this work. The book is intended for professionals from all medical and paramedical disciplines who are interested in applying innovative data from inflammation and immunity research to clinical practice. The readership will include practitioners and clinicians working in the broad field of acute and chronic inflammatory/fibrotic diseases, in particular, traumatologists and intensivists; neurologists and neurosurgeons; cardiologists and cardiac surgeons; pulmonologists and thoracic surgeons; vascular surgeons; nephrologists; gastroenterologists and hepatologists; and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses

Disease Control Priorities, Third Edition (Volume 6)

Author : King K. Holmes
Publisher : World Bank Publications
ISBN 13 : 1464805253
Total Pages : 1027 pages
Book Rating : 4.4/5 (648 download)

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Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes

Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Nutrition and HIV

Author : Saurabh Mehta
Publisher : CRC Press
ISBN 13 : 1351058185
Total Pages : 326 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Nutrition and HIV by : Saurabh Mehta

Download or read book Nutrition and HIV written by Saurabh Mehta and published by CRC Press. This book was released on 2018-05-15 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world continues to lose more than a million lives each year to the HIV epidemic, and nearly two million individuals were infected with HIV in 2017 alone. The new Sustainable Development Goals, adopted by countries of the United Nations in September 2015, include a commitment to end the AIDS epidemic by 2030. Considerable emphasis on prevention of new infections and treatment of those living with HIV will be needed to make this goal achievable. With nearly 37 million people now living with HIV, it is a communicable disease that behaves like a noncommunicable disease. Nutritional management is integral to comprehensive HIV care and treatment. Improved nutritional status and weight gain can increase recovery and strength of individuals living with HIV/AIDS, improve dietary diversity and caloric intake, and improve quality of life. This book highlights evidence-based research linking nutrition and HIV and identifies research gaps to inform the development of guidelines and policies for the United Nations’ Sustainable Development Goals. A comprehensive approach that includes nutritional interventions is likely to maximize the benefit of antiretroviral therapy in preventing HIV disease progression and other adverse outcomes in HIV-infected men and women. Modification of nutritional status has been shown to enhance the quality of life of those suffering HIV/AIDS, both physically in terms of improved body mass index and immunological markers, and psychologically, by improving symptoms of depression. While the primary focus for those infected should remain on antiretroviral treatment and increasing its availability and coverage, improvement of nutritional status plays a complementary role in the management of HIV infection.

Alzheimer's Disease Pathogenesis

Author : Suzanne De La Monte
Publisher : BoD – Books on Demand
ISBN 13 : 9533076909
Total Pages : 706 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Alzheimer's Disease Pathogenesis by : Suzanne De La Monte

Download or read book Alzheimer's Disease Pathogenesis written by Suzanne De La Monte and published by BoD – Books on Demand. This book was released on 2011-09-12 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.

Iron Deficiency Anemia

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309049873
Total Pages : 139 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Iron Deficiency Anemia by : Institute of Medicine

Download or read book Iron Deficiency Anemia written by Institute of Medicine and published by National Academies Press. This book was released on 1994-02-01 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes information related to public health measures on the prevention, detection, and management of iron deficiency anemia. It presents draft guidelines and recommendations related to this area, as applicable in primary health care and public health clinic settings, and it formulates recommendations for research. This volume is intended both to provide a common frame of reference for health professionals in preventing and treating iron deficiency anemia and to enable the U.S. Centers for Disease Control and Prevention to prepare national guidelines and recommendations for the prevention and control of iron deficiency anemia.

Ferroptosis in cancer and beyond

Author : Yanqing Liu
Publisher : Frontiers Media SA
ISBN 13 : 2832513425
Total Pages : 452 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Ferroptosis in cancer and beyond by : Yanqing Liu

Download or read book Ferroptosis in cancer and beyond written by Yanqing Liu and published by Frontiers Media SA. This book was released on 2023-02-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Comparative Quantification of Health Risks: Sexual and reproductive health

Author : Majid Ezzati
Publisher : World Health Organization
ISBN 13 : 9241580313
Total Pages : 2282 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Comparative Quantification of Health Risks: Sexual and reproductive health by : Majid Ezzati

Download or read book Comparative Quantification of Health Risks: Sexual and reproductive health written by Majid Ezzati and published by World Health Organization. This book was released on 2004 with total page 2282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive assessment of the scientific evidence on prevalence and the resulting health effects of a range of exposures that are know to be hazardous to human health, including childhood and maternal undernutrition, nutritional and physiological risk factors for adult health, addictive substances, sexual and reproductive health risks, and risks in the physical environments of households and communities, as well as among workers. This book is the culmination of over four years of scientific equiry and data collection, know as the comparative risk assessment (CRA) project.

Ferroptosis as New Therapeutic Targets in Cancer: from Molecular Mechanisms to Therapeutic Opportunities

Author : Xu Chen
Publisher : Frontiers Media SA
ISBN 13 : 2832504272
Total Pages : 223 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Ferroptosis as New Therapeutic Targets in Cancer: from Molecular Mechanisms to Therapeutic Opportunities by : Xu Chen

Download or read book Ferroptosis as New Therapeutic Targets in Cancer: from Molecular Mechanisms to Therapeutic Opportunities written by Xu Chen and published by Frontiers Media SA. This book was released on 2022-11-08 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Restless Legs Syndrome/Willis Ekbom Disease

Author : Mauro Manconi
Publisher : Springer
ISBN 13 : 1493967770
Total Pages : 291 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Restless Legs Syndrome/Willis Ekbom Disease by : Mauro Manconi

Download or read book Restless Legs Syndrome/Willis Ekbom Disease written by Mauro Manconi and published by Springer. This book was released on 2017-05-07 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the fact that Restless Legs Syndrome/Willis-Ekbom Disease is usually a chronic condition, this book aims to provide physicians with the necessary tools for the long-term management of patients with RLS. The first part of the book addresses the various comorbidities and long-term consequences of RLS on life quality, sleep, cognitive, psychiatric and cardiovascular systems, while the second part focuses on the management of long-term treatment and the drug-induced complications in primary RLS and in special populations. Written by experts in the field, this practical resource offers a high-quality, long-term management of RLS for neurologists, sleep clinicians, pulmonologists and other healthcare professionals.

Field Trials of Health Interventions

Author : Peter G. Smith
Publisher :
ISBN 13 : 0198732864
Total Pages : 479 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Field Trials of Health Interventions by : Peter G. Smith

Download or read book Field Trials of Health Interventions written by Peter G. Smith and published by . This book was released on 2015 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.

Ferroptosis in Stroke, Neurotrauma and Neurodegeneration

Author : Anwen Shao
Publisher : Frontiers Media SA
ISBN 13 : 2889746356
Total Pages : 224 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Ferroptosis in Stroke, Neurotrauma and Neurodegeneration by : Anwen Shao

Download or read book Ferroptosis in Stroke, Neurotrauma and Neurodegeneration written by Anwen Shao and published by Frontiers Media SA. This book was released on 2022-03-09 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Programmed Cell Death and Cardiovascular Disease

Author : Zhi Qi
Publisher : Frontiers Media SA
ISBN 13 : 2889769194
Total Pages : 357 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Programmed Cell Death and Cardiovascular Disease by : Zhi Qi

Download or read book Programmed Cell Death and Cardiovascular Disease written by Zhi Qi and published by Frontiers Media SA. This book was released on 2022-09-12 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hematology E-Book

Author : Ronald Hoffman
Publisher : Elsevier Health Sciences
ISBN 13 : 0323733891
Total Pages : 2886 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Hematology E-Book by : Ronald Hoffman

Download or read book Hematology E-Book written by Ronald Hoffman and published by Elsevier Health Sciences. This book was released on 2022-10-27 with total page 2886 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this rapidly advancing subspecialty. This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy—covering virtually all aspects of hematology in one definitive resource. - Covers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology—in one convenient volume. - Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice. - Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies - Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system. - Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs. - Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches. - Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders. - Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders. - Presents relevant basic science as background for clinical application in later sections. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.