Iron As Therapeutic Targets In Human Diseases

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Iron as Therapeutic Targets in Human Diseases

Author : Paolo Arosio
Publisher : MDPI
ISBN 13 : 3039281143
Total Pages : 440 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Iron as Therapeutic Targets in Human Diseases by : Paolo Arosio

Download or read book Iron as Therapeutic Targets in Human Diseases written by Paolo Arosio and published by MDPI. This book was released on 2020-02-11 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Iron as Therapeutic Targets in Human Diseases

Author : Paolo Arosio
Publisher : MDPI
ISBN 13 : 3039280821
Total Pages : 472 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Iron as Therapeutic Targets in Human Diseases by : Paolo Arosio

Download or read book Iron as Therapeutic Targets in Human Diseases written by Paolo Arosio and published by MDPI. This book was released on 2020-02-11 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Iron as Therapeutic Targets in Human Diseases Volume 1

Author : Paolo Arosio
Publisher :
ISBN 13 : 9783039280834
Total Pages : 472 pages
Book Rating : 4.2/5 (88 download)

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Book Synopsis Iron as Therapeutic Targets in Human Diseases Volume 1 by : Paolo Arosio

Download or read book Iron as Therapeutic Targets in Human Diseases Volume 1 written by Paolo Arosio and published by . This book was released on 2020 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Iron as Therapeutic Targets in Human Diseases Volume 2

Author : Paolo Arosio
Publisher :
ISBN 13 : 9783039281152
Total Pages : 440 pages
Book Rating : 4.2/5 (811 download)

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Book Synopsis Iron as Therapeutic Targets in Human Diseases Volume 2 by : Paolo Arosio

Download or read book Iron as Therapeutic Targets in Human Diseases Volume 2 written by Paolo Arosio and published by . This book was released on 2020 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Iron Chelation Therapy

Author : Chaim Hershko
Publisher : Springer Science & Business Media
ISBN 13 : 1461505933
Total Pages : 275 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Iron Chelation Therapy by : Chaim Hershko

Download or read book Iron Chelation Therapy written by Chaim Hershko and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).

Nutrition and HIV

Author : Saurabh Mehta
Publisher : CRC Press
ISBN 13 : 1351058185
Total Pages : 326 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Nutrition and HIV by : Saurabh Mehta

Download or read book Nutrition and HIV written by Saurabh Mehta and published by CRC Press. This book was released on 2018-05-15 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world continues to lose more than a million lives each year to the HIV epidemic, and nearly two million individuals were infected with HIV in 2017 alone. The new Sustainable Development Goals, adopted by countries of the United Nations in September 2015, include a commitment to end the AIDS epidemic by 2030. Considerable emphasis on prevention of new infections and treatment of those living with HIV will be needed to make this goal achievable. With nearly 37 million people now living with HIV, it is a communicable disease that behaves like a noncommunicable disease. Nutritional management is integral to comprehensive HIV care and treatment. Improved nutritional status and weight gain can increase recovery and strength of individuals living with HIV/AIDS, improve dietary diversity and caloric intake, and improve quality of life. This book highlights evidence-based research linking nutrition and HIV and identifies research gaps to inform the development of guidelines and policies for the United Nations’ Sustainable Development Goals. A comprehensive approach that includes nutritional interventions is likely to maximize the benefit of antiretroviral therapy in preventing HIV disease progression and other adverse outcomes in HIV-infected men and women. Modification of nutritional status has been shown to enhance the quality of life of those suffering HIV/AIDS, both physically in terms of improved body mass index and immunological markers, and psychologically, by improving symptoms of depression. While the primary focus for those infected should remain on antiretroviral treatment and increasing its availability and coverage, improvement of nutritional status plays a complementary role in the management of HIV infection.

Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc

Download Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc PDF Online Free

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 9780309072793
Total Pages : 804 pages
Book Rating : 4.0/5 (727 download)

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Book Synopsis Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc by : Institute of Medicine

Download or read book Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc written by Institute of Medicine and published by National Academies Press. This book was released on 2002-07-19 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.

Iron and Human Disease

Author : R.B. Lauffer
Publisher :
ISBN 13 : 9781351073899
Total Pages : 550 pages
Book Rating : 4.0/5 (738 download)

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Book Synopsis Iron and Human Disease by : R.B. Lauffer

Download or read book Iron and Human Disease written by R.B. Lauffer and published by . This book was released on 2017 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Iron and Human Disease is the first book to cover the three key aspects of human iron metabolism: the accumulation of iron in adults, iron as a limiting factor for tumor and infectious cell growth, and iron as a catalyst for oxygen free radical production. The book describes the hypotheses and findings related to the role of iron in cardiovascular disease (including reperfusion injury), cancer, aging, and autoimmune and neurodegenerative diseases. Other topics covered include the molecular biology and biochemistry of iron, the general principles governing iron balance, iron in the immune system and acute phase response, and new preventive and therapeutic strategies. Iron and Human Disease will be a useful reference for biomedical investigators, physicians, nutritionists, and public health officials."--Provided by publisher.

Brain Iron Metabolism and CNS Diseases

Author : Yan-Zhong Chang
Publisher : Springer Nature
ISBN 13 : 9811395896
Total Pages : 194 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Brain Iron Metabolism and CNS Diseases by : Yan-Zhong Chang

Download or read book Brain Iron Metabolism and CNS Diseases written by Yan-Zhong Chang and published by Springer Nature. This book was released on 2019-08-27 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.

Nutritional Anemia in Preschool Children

Author : Anil Gupta
Publisher : Springer
ISBN 13 : 981105178X
Total Pages : 233 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Nutritional Anemia in Preschool Children by : Anil Gupta

Download or read book Nutritional Anemia in Preschool Children written by Anil Gupta and published by Springer. This book was released on 2017-08-05 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book highlights intricate predisposing factors for pathogenesis of nutritional anemia. It delivers valuable information related to this public health hazard influencing the nutritional health of preschool children. The book is valuable for readers in diverse fields to gain insight of the concept of nutritional anemia in preschool children. Additionally, book furnishes clinical and laboratory methods in a comparative way to assess nutritional anemia. Impact of the disorder on health of preschool children has been covered in a simple language. The book mentions need for interventional strategies for the management of nutritional anemia. Infants, preschool children and women during pregnancy and lactation are highly susceptible to dietary deficiency of iron, folic acid and cyanocobalamin leading to comparatively, higher predisposition to development of nutritional anemia. The condition has myriad of ill effects on nutritional health of preschool children.

Restless Legs Syndrome/Willis Ekbom Disease

Author : Mauro Manconi
Publisher : Springer
ISBN 13 : 1493967770
Total Pages : 287 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Restless Legs Syndrome/Willis Ekbom Disease by : Mauro Manconi

Download or read book Restless Legs Syndrome/Willis Ekbom Disease written by Mauro Manconi and published by Springer. This book was released on 2017-05-07 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the fact that Restless Legs Syndrome/Willis-Ekbom Disease is usually a chronic condition, this book aims to provide physicians with the necessary tools for the long-term management of patients with RLS. The first part of the book addresses the various comorbidities and long-term consequences of RLS on life quality, sleep, cognitive, psychiatric and cardiovascular systems, while the second part focuses on the management of long-term treatment and the drug-induced complications in primary RLS and in special populations. Written by experts in the field, this practical resource offers a high-quality, long-term management of RLS for neurologists, sleep clinicians, pulmonologists and other healthcare professionals.

Iron Deficiency Anemia

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309049873
Total Pages : 139 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Iron Deficiency Anemia by : Institute of Medicine

Download or read book Iron Deficiency Anemia written by Institute of Medicine and published by National Academies Press. This book was released on 1994-02-01 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes information related to public health measures on the prevention, detection, and management of iron deficiency anemia. It presents draft guidelines and recommendations related to this area, as applicable in primary health care and public health clinic settings, and it formulates recommendations for research. This volume is intended both to provide a common frame of reference for health professionals in preventing and treating iron deficiency anemia and to enable the U.S. Centers for Disease Control and Prevention to prepare national guidelines and recommendations for the prevention and control of iron deficiency anemia.

Anemia in Inflammatory Bowel Diseases

Author : Christoph Gasche
Publisher : Uni-Med
ISBN 13 : 9781848151246
Total Pages : 95 pages
Book Rating : 4.1/5 (512 download)

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Book Synopsis Anemia in Inflammatory Bowel Diseases by : Christoph Gasche

Download or read book Anemia in Inflammatory Bowel Diseases written by Christoph Gasche and published by Uni-Med. This book was released on 2008 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammatory bowel diseases are increasingly common and complex. Modern therapeutic strategies involve infusion therapy and the use anti-TNF or other biologicals as well as intravenous iron preparations. This book covers the pathophysiology and treatment of anemia in inflammatory bowel diseases and discusses controversial aspects specifically when it comes to iron therapy.

Anemia in the Elderly

Author : Lodovico Balducci
Publisher : Springer Science & Business Media
ISBN 13 : 0387495053
Total Pages : 148 pages
Book Rating : 4.3/5 (874 download)

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Book Synopsis Anemia in the Elderly by : Lodovico Balducci

Download or read book Anemia in the Elderly written by Lodovico Balducci and published by Springer Science & Business Media. This book was released on 2007-09-10 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anemia in the elderly, known as the silent epidemic, afflicts 3 million people in the U.S. ages 65 or older. This reference, complete with the most recent findings, answers all the crucial questions regarding anemia in the elderly.

Chelation Therapy in the Treatment of Metal Intoxication

Author : Jan Aaseth
Publisher : Academic Press
ISBN 13 : 0128030739
Total Pages : 388 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Chelation Therapy in the Treatment of Metal Intoxication by : Jan Aaseth

Download or read book Chelation Therapy in the Treatment of Metal Intoxication written by Jan Aaseth and published by Academic Press. This book was released on 2016-04-18 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Parkinson's Disease and Related Disorders

Author : Peter Riederer
Publisher : Springer Science & Business Media
ISBN 13 : 3211452958
Total Pages : 484 pages
Book Rating : 4.2/5 (114 download)

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Book Synopsis Parkinson's Disease and Related Disorders by : Peter Riederer

Download or read book Parkinson's Disease and Related Disorders written by Peter Riederer and published by Springer Science & Business Media. This book was released on 2006-11-23 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a comprehensive overview on current clinical and basic research issues related to Parkinson’s disease and its related disorders. The book is the result of the 16th International Congress of Parkinson’s Disease and Related disorders congress 2005. Its contents are suitable for neurologists, psychiatrists, neurosurgeons, basic researchers, geneticians and patients as well as their relatives.

Prevention of Micronutrient Deficiencies

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 030906029X
Total Pages : 222 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Prevention of Micronutrient Deficiencies by : Institute of Medicine

Download or read book Prevention of Micronutrient Deficiencies written by Institute of Medicine and published by National Academies Press. This book was released on 1998-03-24 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Micronutrient malnutrition affects approximately 2 billion people worldwide. The adverse effects of micronutrient deficiencies are profound and include premature death, poor health, blindness, growth stunting, mental retardation, learning disabilities, and low work capacity. Preventing Micronutrient Deficiencies provides a conceptual framework based on past experience that will allow funders to tailor programs to existing regional/country capabilities and to incorporate within these programs the capacity to address multiple strategies (i.e., supplementation/fortification/food-based approaches/public health measures) and multiple micronutrient deficiencies. The book does not offer recommendations on how to alleviate specific micronutrient deficienciesâ€"such recommendations are already available through the publications of diverse organizations, including the U.S. Agency for International Development, the Micronutrient Initiative, World Bank, United Nations Childrens' Fund, and the World Health Organization. Instead, this volume examines key elements in the design and implementation of micronutrient interventions, including such issues as: The importance of iron, vitamin A, and iodine to health. Populations at risk for micronutrient deficiency. Options for successful interventions and their cost. The feasibility of involving societal sectors in the planning and implementation of interventions. Characteristics of successful interventions. The book also contains three in-depth background papers that address the prevention of deficiencies of iron, vitamin A, and iodine.