Ion Source For High Precision Mass Spectrometry

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Applications in High Resolution Mass Spectrometry

Author : Roberto Romero-González
Publisher : Elsevier
ISBN 13 : 0128096489
Total Pages : 362 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Applications in High Resolution Mass Spectrometry by : Roberto Romero-González

Download or read book Applications in High Resolution Mass Spectrometry written by Roberto Romero-González and published by Elsevier. This book was released on 2017-03-07 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications of High Resolution Mass Spectrometry: Food Safety and Pesticide Residue Analysis is the first book to offer complete coverage of all aspects of high resolution mass spectrometry (HRMS) used for the analysis of pesticide residue in food. Aimed at researchers and graduate students in food safety, toxicology, and analytical chemistry, the book equips readers with foundational knowledge of HRMS, including established and state-of-the-art principles and analysis strategies. Additionally, it provides a roadmap for implementation, including discussions of the latest instrumentation and software available. Detailed coverage is given to the application of HRMS coupled to ultra high-performance liquid chromatography (UHPLC-HRMS) in the analysis of pesticide residue in fruits and vegetables and food from animal origin. The book also discusses extraction procedures and the challenges of sample preparation, gas chromatography coupled to high resolution mass spectrometry, flow injection-HRMS, ambient ionization, and identification of pesticide transformation products in food. Responding to the fast development and application of these new procedures, this book is an essential resource in the food safety field. - Arms researchers with an in-depth resource devoted to the rapid advances in HRMS tools and strategies for pesticide residue analysis in food - Provides a complete overview of analytical methodologies and applications of HRMS, including UHPLC-HRMS, HRMS coupled with time of flight (TOF) and/or GC-Orbitrap, and flow injection-HRMS - Discusses the current international regulations and legislation related to the use of HRMS in pesticide residue analysis - Features a chapter on the hardware and software available for HRMS implementation - Offers separate chapters on HRMS applied to pesticide residue analysis in fruits and vegetables and in food from animal origin

Mass Spectrometry for the Clinical Laboratory

Author : Hari Nair
Publisher : Academic Press
ISBN 13 : 0128009926
Total Pages : 306 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mass Spectrometry for the Clinical Laboratory by : Hari Nair

Download or read book Mass Spectrometry for the Clinical Laboratory written by Hari Nair and published by Academic Press. This book was released on 2016-11-02 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Encyclopedia of Geochemistry

Author : William M. White
Publisher : Springer
ISBN 13 : 9783319393117
Total Pages : 1680 pages
Book Rating : 4.3/5 (931 download)

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Book Synopsis Encyclopedia of Geochemistry by : William M. White

Download or read book Encyclopedia of Geochemistry written by William M. White and published by Springer. This book was released on 2018-07-24 with total page 1680 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia is a complete and authoritative reference work for this rapidly evolving field. Over 200 international scientists, each experts in their specialties, have written over 330 separate topics on different aspects of geochemistry including geochemical thermodynamics and kinetics, isotope and organic geochemistry, meteorites and cosmochemistry, the carbon cycle and climate, trace elements, geochemistry of high and low temperature processes, and ore deposition, to name just a few. The geochemical behavior of the elements is described as is the state of the art in analytical geochemistry. Each topic incorporates cross-referencing to related articles, and also has its own reference list to lead the reader to the essential articles within the published literature. The entries are arranged alphabetically, for easy access, and the subject and citation indices are comprehensive and extensive. Geochemistry applies chemical techniques and approaches to understanding the Earth and how it works. It touches upon almost every aspect of earth science, ranging from applied topics such as the search for energy and mineral resources, environmental pollution, and climate change to more basic questions such as the Earth’s origin and composition, the origin and evolution of life, rock weathering and metamorphism, and the pattern of ocean and mantle circulation. Geochemistry allows us to assign absolute ages to events in Earth’s history, to trace the flow of ocean water both now and in the past, trace sediments into subduction zones and arc volcanoes, and trace petroleum to its source rock and ultimately the environment in which it formed. The earliest of evidence of life is chemical and isotopic traces, not fossils, preserved in rocks. Geochemistry has allowed us to unravel the history of the ice ages and thereby deduce their cause. Geochemistry allows us to determine the swings in Earth’s surface temperatures during the ice ages, determine the temperatures and pressures at which rocks have been metamorphosed, and the rates at which ancient magma chambers cooled and crystallized. The field has grown rapidly more sophisticated, in both analytical techniques that can determine elemental concentrations or isotope ratios with exquisite precision and in computational modeling on scales ranging from atomic to planetary.

Methods in Systems Biology

Author : Daniel Jameson
Publisher : Academic Press
ISBN 13 : 0123851181
Total Pages : 775 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Methods in Systems Biology by : Daniel Jameson

Download or read book Methods in Systems Biology written by Daniel Jameson and published by Academic Press. This book was released on 2011-09-26 with total page 775 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems biology is a term used to describe a number of trends in bioscience research and a movement that draws on those trends. This volume in the Methods in Enzymology series comprehensively covers the methods in systems biology. With an international board of authors, this volume is split into sections that cover subjects such as machines for systems biology, protein production and quantification for systems biology, and enzymatic assays in systems biology research. This volume in the Methods in Enzymology series comprehensively covers the methods in systems biology With an international board of authors, this volume is split into sections that cover subjects such as machines for systems biology, protein production and quantification for systems biology, and enzymatic assays in systems biology research

Direct Analysis in Real Time Mass Spectrometry

Author : Yiyang Dong
Publisher : John Wiley & Sons
ISBN 13 : 3527341846
Total Pages : 370 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Direct Analysis in Real Time Mass Spectrometry by : Yiyang Dong

Download or read book Direct Analysis in Real Time Mass Spectrometry written by Yiyang Dong and published by John Wiley & Sons. This book was released on 2018-04-09 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clear, comprehensive, and state of the art, the groundbreaking book on the emerging technology of direct analysis in real time mass spectrometry Written by a noted expert in the field, Direct Analysis in Real Time Mass Spectrometry offers a review of the background and the most recent developments in DART-MS. Invented in 2005, DART-MS offers a wide range of applications for solving numerous analytical problems in various environments, including food science, forensics, and clinical analysis. The text presents an introduction to the history of the technology and includes information on the theoretical background, for exampleon the ionization mechanism. Chapters on sampling and coupling to different types of mass spectrometers are followed by a comprehensive discussion of a broad range of applications. Unlike most other ionization methods, DART does not require laborious sample preparation, as ionization takes place directly on the sample surface. This makes the technique especially attractive for applications in forensics and food science. Comprehensive in scope, this vital text: -Sets the standard on an important and emerging ionization technique -Thoroughly discusses all the relevant aspects from instrumentation to applications -Helps in solving numerous analytical problems in various applications, for example food science, forensics, environmental and clinical analysis -Covers mechanisms, coupling to mass spectrometers, and includes information on challenges and disadvantages of the technique Academics, analytical chemists, pharmaceutical chemists, clinical chemists, forensic scientists, and others will find this illuminating text a must-have resource for understanding the most recent developments in the field.

Handbook of Ion Sources

Author : Bernhard Wolf
Publisher : CRC Press
ISBN 13 : 9780849325021
Total Pages : 558 pages
Book Rating : 4.3/5 (25 download)

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Book Synopsis Handbook of Ion Sources by : Bernhard Wolf

Download or read book Handbook of Ion Sources written by Bernhard Wolf and published by CRC Press. This book was released on 1995-08-31 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Ion Sources delivers the data needed for daily work with ion sources. It also gives information for the selection of a suitable ion source and ion production method for a specific application. The Handbook concentrates on practical aspects and introduces the principle function of ion sources. The basic plasma parameters are defined and discussed. The working principles of various ion sources are explained, and examples of each type of ion source are presented with their operational data. Tables of ion current for various elements and charge states summarize the performance of different ion sources. The problems related to the production of ions of non-gaseous elements are detailed, and data on useful materials for evaporation and ion source construction are summarized. Additional chapters are dedicated to extraction and beam formation, ion beam diagnosis, ion source electronics, and computer codes for extraction, acceleration, and beam transport. Emittance and brilliance are described and space charge effects and neutralization discussed. Various methods for the measurement of current, profile, emittance, and time structure are presented and compared. Intensity limits for these methods are provided for different ion energies. Typical problems related to the operation of ion source plasmas are discussed and practical examples of circuits are given. The influence of high voltage on ion source electronics and possibilities for circuit protection are covered. The generation of microwaves and various microwave equipment are described and special problems related to microwave operation are summarized. The Handbook of Ion Sources is a valuable reference on the subject, of benefit to practitioners and graduate students interested in accelerators, ion implantation, and ion beam techniques.

Neuroproteomics

Author : Oscar Alzate
Publisher : CRC Press
ISBN 13 : 1420076264
Total Pages : 356 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Neuroproteomics by : Oscar Alzate

Download or read book Neuroproteomics written by Oscar Alzate and published by CRC Press. This book was released on 2009-10-26 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg

Analyzing Biomolecular Interactions by Mass Spectrometry

Author : Jeroen Kool
Publisher : John Wiley & Sons
ISBN 13 : 3527334645
Total Pages : 402 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Analyzing Biomolecular Interactions by Mass Spectrometry by : Jeroen Kool

Download or read book Analyzing Biomolecular Interactions by Mass Spectrometry written by Jeroen Kool and published by John Wiley & Sons. This book was released on 2015-05-04 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph reviews all relevant technologies based on mass spectrometry that are used to study or screen biological interactions in general. Arranged in three parts, the text begins by reviewing techniques nowadays almost considered classical, such as affinity chromatography and ultrafiltration, as well as the latest techniques. The second part focusses on all MS-based methods for the study of interactions of proteins with all classes of biomolecules. Besides pull down-based approaches, this section also emphasizes the use of ion mobility MS, capture-compound approaches, chemical proteomics and interactomics. The third and final part discusses other important technologies frequently employed in interaction studies, such as biosensors and microarrays. For pharmaceutical, analytical, protein, environmental and biochemists, as well as those working in pharmaceutical and analytical laboratories.

Principles of Forensic Toxicology

Author : Barry Levine
Publisher : Amer. Assoc. for Clinical Chemistry
ISBN 13 : 9781890883874
Total Pages : 406 pages
Book Rating : 4.8/5 (838 download)

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Book Synopsis Principles of Forensic Toxicology by : Barry Levine

Download or read book Principles of Forensic Toxicology written by Barry Levine and published by Amer. Assoc. for Clinical Chemistry. This book was released on 2003 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Physical Vapor Deposition (PVD) Processing

Author : D. M. Mattox
Publisher : Cambridge University Press
ISBN 13 : 0080946585
Total Pages : 947 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Handbook of Physical Vapor Deposition (PVD) Processing by : D. M. Mattox

Download or read book Handbook of Physical Vapor Deposition (PVD) Processing written by D. M. Mattox and published by Cambridge University Press. This book was released on 2014-09-19 with total page 947 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all aspects of physical vapor deposition (PVD) process technology from the characterizing and preparing the substrate material, through deposition processing and film characterization, to post-deposition processing. The emphasis of the book is on the aspects of the process flow that are critical to economical deposition of films that can meet the required performance specifications. The book covers subjects seldom treated in the literature: substrate characterization, adhesion, cleaning and the processing. The book also covers the widely discussed subjects of vacuum technology and the fundamentals of individual deposition processes. However, the author uniquely relates these topics to the practical issues that arise in PVD processing, such as contamination control and film growth effects, which are also rarely discussed in the literature. In bringing these subjects together in one book, the reader can understand the interrelationship between various aspects of the film deposition processing and the resulting film properties. The author draws upon his long experience with developing PVD processes and troubleshooting the processes in the manufacturing environment, to provide useful hints for not only avoiding problems, but also for solving problems when they arise. He uses actual experiences, called ""war stories"", to emphasize certain points. Special formatting of the text allows a reader who is already knowledgeable in the subject to scan through a section and find discussions that are of particular interest. The author has tried to make the subject index as useful as possible so that the reader can rapidly go to sections of particular interest. Extensive references allow the reader to pursue subjects in greater detail if desired. The book is intended to be both an introduction for those who are new to the field and a valuable resource to those already in the field. The discussion of transferring technology between R&D and manufacturing provided in Appendix 1, will be of special interest to the manager or engineer responsible for moving a PVD product and process from R&D into production. Appendix 2 has an extensive listing of periodical publications and professional societies that relate to PVD processing. The extensive Glossary of Terms and Acronyms provided in Appendix 3 will be of particular use to students and to those not fully conversant with the terminology of PVD processing or with the English language.

Ambient Ionization Mass Spectrometry

Author : Marek Domin
Publisher : Royal Society of Chemistry
ISBN 13 : 1849739269
Total Pages : 528 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Ambient Ionization Mass Spectrometry by : Marek Domin

Download or read book Ambient Ionization Mass Spectrometry written by Marek Domin and published by Royal Society of Chemistry. This book was released on 2014-11-25 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.

Chinmedomics

Author : Xijun Wang
Publisher : Academic Press
ISBN 13 : 0128031182
Total Pages : 408 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Chinmedomics by : Xijun Wang

Download or read book Chinmedomics written by Xijun Wang and published by Academic Press. This book was released on 2015-07-15 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future. - Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method - Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications - Edited by the leading experts of research related to Chinmedomics

Essentials of Pharmaceutical Analysis

Author : Muhammad Sajid Hamid Akash
Publisher : Springer Nature
ISBN 13 : 9811515476
Total Pages : 235 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Essentials of Pharmaceutical Analysis by : Muhammad Sajid Hamid Akash

Download or read book Essentials of Pharmaceutical Analysis written by Muhammad Sajid Hamid Akash and published by Springer Nature. This book was released on 2019-12-17 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in the pharmaceutical sciences and biotechnology have facilitated the production, design, formulation and use of various types of pharmaceuticals and biopharmaceuticals. This book provides detailed information on the background, basic principles, and components of techniques used for the analysis of pharmaceuticals and biopharmaceuticals. Focusing on those analytical techniques that are most frequently used for pharmaceuticals, it classifies them into three major sections and 19 chapters, each of which discusses a respective technique in detail. Chiefly intended for graduate students in the pharmaceutical sciences, the book will familiarize them with the components, working principles and practical applications of these indispensable analytical techniques.

TOF-MS Within Food and Environmental Analysis

Author : Amadeo Rodriguez Fernandez-Alba
Publisher : Elsevier
ISBN 13 : 0444538100
Total Pages : 452 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis TOF-MS Within Food and Environmental Analysis by : Amadeo Rodriguez Fernandez-Alba

Download or read book TOF-MS Within Food and Environmental Analysis written by Amadeo Rodriguez Fernandez-Alba and published by Elsevier. This book was released on 2012-09-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: New developments in mass spectrometry have allowed routine identification and lowered limits of detection at levels only imagined a decade ago. Thousands of contaminants and residues in the food supply and the environment are now being reported. Between 2005 and 2010, more than 5,000 publications covering TOF-MS and environmental and food analysis were published, showing the importance of the technique in these applications. This book covers the basic principles of method development in GC- and LC-TOF-MS as well as the main operational parameters related to TOF-MS. The second part focuses on the relevant environmental applications, including quality control aspects as well as data collection. The third part is devoted to relevant applications in food analysis, including validation procedures for screening analysis as well as relevant databases. Outlines basic concepts and principles of gas and liquid chromatography TOF-MS and its application in food analysis Includes quality control and data collection techniques Focuses on environmental implications and safety concerns

An Introduction to Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and its Application to Materials Science

Author : Sarah Fearn
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1681740885
Total Pages : 67 pages
Book Rating : 4.6/5 (817 download)

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Book Synopsis An Introduction to Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and its Application to Materials Science by : Sarah Fearn

Download or read book An Introduction to Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and its Application to Materials Science written by Sarah Fearn and published by Morgan & Claypool Publishers. This book was released on 2015-10-16 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the application of Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) for high-resolution surface analysis and characterization of materials. While providing a brief overview of the principles of SIMS, it also provides examples of how dual-beam ToF-SIMS is used to investigate a range of materials systems and properties. Over the years, SIMS instrumentation has dramatically changed since the earliest secondary ion mass spectrometers were first developed. Instruments were once dedicated to either the depth profiling of materials using high-ion-beam currents to analyse near surface to bulk regions of materials (dynamic SIMS), or time-of-flight instruments that produced complex mass spectra of the very outer-most surface of samples, using very low-beam currents (static SIMS). Now, with the development of dual-beam instruments these two very distinct fields now overlap.

Introduction to Mass Spectrometry

Author : J. Throck Watson
Publisher : John Wiley & Sons
ISBN 13 : 1118681584
Total Pages : 972 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Introduction to Mass Spectrometry by : J. Throck Watson

Download or read book Introduction to Mass Spectrometry written by J. Throck Watson and published by John Wiley & Sons. This book was released on 2013-07-09 with total page 972 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, this text provides an easy-to-read guide to the concept of mass spectrometry and demonstrates its potential and limitations. Written by internationally recognised experts and utilising "real life" examples of analyses and applications, the book presents real cases of qualitative and quantitative applications of mass spectrometry. Unlike other mass spectrometry texts, this comprehensive reference provides systematic descriptions of the various types of mass analysers and ionisation, along with corresponding strategies for interpretation of data. The book concludes with a comprehensive 3000 references. This multi-disciplined text covers the fundamentals as well as recent advance in this topic, providing need-to-know information for researchers in many disciplines including pharmaceutical, environmental and biomedical analysis who are utilizing mass spectrometry

Modern Techniques for Food Authentication

Author : Da-Wen Sun
Publisher : Academic Press
ISBN 13 : 0128142650
Total Pages : 808 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Modern Techniques for Food Authentication by : Da-Wen Sun

Download or read book Modern Techniques for Food Authentication written by Da-Wen Sun and published by Academic Press. This book was released on 2018-07-25 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Techniques for Food Authentication, Second Edition presents a comprehensive review of the novel techniques available to authenticate food products, including various spectroscopic technologies, methods based on isotopic analysis and chromatography, and other techniques based on DNA, enzymatic analysis and electrophoresis. This new edition pinpoints research and development trends for those working in research, development and operations in the food industry, giving them readily accessible information on modern food authentication techniques to ensure a safe and authentic food supply. It will also serve as an essential reference source to undergraduate and postgraduate students, and for researchers in universities and research institutions. - Presents emerging imaging techniques that have proven to be powerful, non-destructive tools for food authentication - Includes applications of hyperspectral imaging to reflect the current trend of developments in food imaging technology for each topic area - Provides pixel level visualization techniques needed for fast and effective food sample testing - Contains two new chapters on Imaging Spectroscopic Techniques