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Author : Ekaterina E. Klimatcheva
Publisher :
ISBN 13 :
Total Pages : 202 pages
Book Rating : 4.:/5 (431 download)
Download or read book Ion Currents and Proliferation in MCF-7 Human Breast Cancer Cells written by Ekaterina E. Klimatcheva and published by . This book was released on 1997 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jeremy Roy
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (812 download)
Download or read book The Contribution of K+ Ion Channels and the Ca2+-permeable TRPM8 Channel to Breast Cancer Cell Proliferation written by Jeremy Roy and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Elsevier
ISBN 13 : 0443188831
Total Pages : 248 pages
Book Rating : 4.4/5 (431 download)
Download or read book Ion Channels in Cancer written by and published by Elsevier. This book was released on 2023-11-24 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Channels in Cancer, Volume 92 in the Current Topics in Membranes series, highlights advances in the field, including chapters on the Interplay of calcium and potassium signals in cell cycle and cancer, Non-conducting functions of ion channels in cancer and neurological disease, Sodium channels and progression of solid tumors, The Elusive Nav1.7: From Pain to Cancer, Signaling Pathways in cancer: Channels Interactome as a novel therapeutic target, Ion channels in cancer drugs resistance, CLIC1: A potential therapeutic target for malignant glioma, Beyond the Building Blocks: Amino Acids as modulators of ion channels and transporters, and Activation of potassium channels unveils tumor vulnerability. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Current Topics in Membranes Updated release includes the latest information on Ion Channels in Cancer
Author : Malathy Shanmugam
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.3/5 (555 download)
Download or read book Regulation of the Protein Kinase C Delta Isoform by Estrogen in the MCF-7 Human Breast Cancer Cell Line and a Role for Protein Kinase C Delta in Growth Regulation written by Malathy Shanmugam and published by . This book was released on 1997 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Previous evidence in our laboratory demonstrated the ability of estrogen to regulate specifically the protein kinase C (PKC) $\delta$ isoform in the rat and rabbit corpus luteum. The purpose of this study was to evaluate estrogen's ability to regulate PKC, specifically the PKC $\delta$ isoform, in the estrogen responsive, MCF-7 human breast cancer cell line. With the increasingly characterized role of PKC $\delta$ in growth regulation, we were interested to also determine the ability of PKC $\delta$ to regulate growth in the MCF-7 cell line. Treatment of MCF-7 cells with 10$\sp{-10}$ through 10$\sp{-8}$ M estrogen for 7 days down-regulated specifically PKC $\delta$ mRNA and protein; expression of other PKC isoforms was unchanged. These concentrations of estrogen were maximally proliferative for the MCF-7 cells and an inverse correlation between PKC $\delta$ expression and proliferation in MCF-7 cells was observed. PKC $\delta$ protein levels were found to be 10 fold higher in MCF-7 compared to the estrogen receptor-negative, MDA-MB 231 cells which grow aggressively in the absence of estrogen. In view of the inverse correlation between PKC $\delta$ expression and proliferation in MCF-7 cells we wished to determine whether activation of PKC $\delta$ could signal growth inhibition. Phorbol ester treatments that lead to G1 growth arrest and induction of the cyclin-dependent kinase inhibitor p21$\rm\sp{Waf1/Cip1}$ in MCF-7 cells promoted activation of PKC $\delta$, as evidenced in immunecomplex phosphorylation assays. To show that phorbol ester stimulated G1 growth arrest could be mediated by the induction of p21$\rm\sp{Waf1/Cip1}$ by activated PKC $\delta,$ we demonstrated that constitutively active PKC $\delta$ in the absence but not in the presence of dominant negative PKC $\delta$ activated the WAF1/CIP1 promoter-luciferase construct in transient transfection assays. Activated PKC $\delta$ can therefore signal the transcriptional induction of p21$\rm\sp{WAF1/CIP1}.$ Our results are consistent with the hypothesis that modulation of PKC $\delta$ expression and activation state provides a pathway for growth regulation in breast cancer cells.
Author : Regina Brierley
Publisher :
ISBN 13 :
Total Pages : 142 pages
Book Rating : 4.:/5 (413 download)
Download or read book Quantitation of MCF-7 Breast Cancer Cell Proliferation, in Vitro, in Response to Polychlorinated Biphenyl Mixtures Extracted from Human Breast Tissue written by Regina Brierley and published by . This book was released on 1998 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Juliusz Ashot Kozak
Publisher : CRC Press
ISBN 13 : 149875273X
Total Pages : 343 pages
Book Rating : 4.4/5 (987 download)
Download or read book Calcium Entry Channels in Non-Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Author : Phuc Van Pham
Publisher : BoD – Books on Demand
ISBN 13 : 9535129996
Total Pages : 570 pages
Book Rating : 4.5/5 (351 download)
Download or read book Breast Cancer written by Phuc Van Pham and published by BoD – Books on Demand. This book was released on 2017-04-05 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.
Author : Mohamed Chahine
Publisher : Springer
ISBN 13 : 3319902849
Total Pages : 448 pages
Book Rating : 4.3/5 (199 download)
Download or read book Voltage-gated Sodium Channels: Structure, Function and Channelopathies written by Mohamed Chahine and published by Springer. This book was released on 2018-06-04 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.
Author : Dil Afroze
Publisher : BoD – Books on Demand
ISBN 13 : 1789239613
Total Pages : 127 pages
Book Rating : 4.7/5 (892 download)
Download or read book Breast Cancer Biology written by Dil Afroze and published by BoD – Books on Demand. This book was released on 2020-07-08 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive overview of recent developments in the field of breast cancer biology. It is a complete and descriptive reference on motioning pathways and new treatment options for the future transnational scientists and clinicians working on cancer research and treatment. We greatly appreciate the work of all the contributors to this book. They have brought with them tremendous diversity of perspectives and fields, which is truly reflective of the complexity of the topic, and they have come together in this project to serve as the node of multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies, and who have inspired us to gather information to significantly progress knowledge in the field in recent years.
Author : Bernard Fermini
Publisher : Springer Science & Business Media
ISBN 13 : 3540797297
Total Pages : 177 pages
Book Rating : 4.5/5 (47 download)
Download or read book Ion Channels written by Bernard Fermini and published by Springer Science & Business Media. This book was released on 2008-09-04 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases. Following an overview chapter summarizing the current state of ion channel screening technologies, five topics covering areas such as cancer, cardiac arrhythmias, cystic fibrosis, and pain have been selected, and the current state of knowledge is presented by leading experts in their field. Each chapter is structured to cover the biological rationale for the target, the current status in the development of agents to treat the disease, and future prospects and challenges facing each therapeutic area. The reader will receive a critical overview covering the progress made in the rapidly developing and complex field of ion channels and diseases.
Author : Keshav Singh
Publisher : Springer Science & Business Media
ISBN 13 : 0387848355
Total Pages : 294 pages
Book Rating : 4.3/5 (878 download)
Download or read book Mitochondria and Cancer written by Keshav Singh and published by Springer Science & Business Media. This book was released on 2009-04-05 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.
Author : Stuart K. Calderwood
Publisher : Springer Science & Business Media
ISBN 13 : 1402064012
Total Pages : 399 pages
Book Rating : 4.4/5 (2 download)
Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Author : Hong-Gang Wang
Publisher : Springer Science & Business Media
ISBN 13 : 1461465613
Total Pages : 267 pages
Book Rating : 4.4/5 (614 download)
Download or read book Autophagy and Cancer written by Hong-Gang Wang and published by Springer Science & Business Media. This book was released on 2013-03-30 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it.
Author : Peter Ruben
Publisher : Springer
ISBN 13 : 9783642415876
Total Pages : 0 pages
Book Rating : 4.4/5 (158 download)
Download or read book Voltage Gated Sodium Channels written by Peter Ruben and published by Springer. This book was released on 2014-04-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481676911
Total Pages : 367 pages
Book Rating : 4.4/5 (816 download)
Download or read book Ion Channels—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Channels—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Potassium Channels. The editors have built Ion Channels—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Potassium Channels in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Ion Channels—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Fazlul H. Sarkar
Publisher : Springer Science & Business Media
ISBN 13 : 9400726309
Total Pages : 383 pages
Book Rating : 4.4/5 (7 download)
Download or read book Nutraceuticals and Cancer written by Fazlul H. Sarkar and published by Springer Science & Business Media. This book was released on 2011-11-22 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.
