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Download or read book Investigations of the Interaction of Gold Nanoparticles with Proteins, Cells, and Tissues written by and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Masoud Rahman
Publisher : Springer Science & Business Media
ISBN 13 : 3642375553
Total Pages : 95 pages
Book Rating : 4.6/5 (423 download)
Download or read book Protein-Nanoparticle Interactions written by Masoud Rahman and published by Springer Science & Business Media. This book was released on 2013-06-24 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.
Author : Johann Schaller
Publisher : John Wiley & Sons
ISBN 13 : 9780470724361
Total Pages : 538 pages
Book Rating : 4.7/5 (243 download)
Download or read book Human Blood Plasma Proteins written by Johann Schaller and published by John Wiley & Sons. This book was released on 2008-05-23 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Blood Plasma Proteins gives an overview of the proteins found in human blood plasma, with special emphasis on their structure and function and relationship to pathological states and disease. Topics covered include: introduction to blood components and blood plasma proteins blood plasma protein domains, motifs and repeats blood plasma protein families and posttranslational modifications blood coagulation and fibrinolysis the complement system the immune system enzymes inhibitors lipoproteins hormones cytokines and growth factors transport and storage The information of each protein discussed in this book in some detail is summarised at the end of each chapter in a Data Sheet, where one can find the most important data of each protein at one glance. Full cross-referencing to protein databases is given and many of the proteins discussed are accompanied by their 3D structure. Attractively presented in full colour, Human Blood Plasma Proteins is an essential atlas of this proteome for anyone working in biochemistry, protein chemistry and proteomics, structural biology, and medicine.
Author : Gillian Doyle
Publisher :
ISBN 13 :
Total Pages : 101 pages
Book Rating : 4.:/5 (65 download)
Download or read book Surface Plasmon Based Investigations of the Interactions Between Proteins and Gold Nanoparticles Via Time-dependent Mie Scattering Spectroscopy written by Gillian Doyle and published by . This book was released on 2006 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Brian Neil Turner
Publisher :
ISBN 13 :
Total Pages : 213 pages
Book Rating : 4.:/5 (864 download)
Download or read book Kinetic Investigations of Thiolate Protected Gold Nanoparticles written by Brian Neil Turner and published by . This book was released on 2011 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Catherine Louis
Publisher : World Scientific
ISBN 13 : 1848168063
Total Pages : 406 pages
Book Rating : 4.8/5 (481 download)
Download or read book Gold Nanoparticles for Physics, Chemistry and Biology written by Catherine Louis and published by World Scientific. This book was released on 2012 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an introduction to the world of gold nanoparticles. This title traces the history of gold nanoparticles which began in ancient times with red ruby glass, and reached its zenith at the end of the 17th century. It also provides an investigation into the use of gold nanoparticles over the ages.
Author : Jürgen Popp
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110515318
Total Pages : 231 pages
Book Rating : 4.1/5 (15 download)
Download or read book Micro-Raman Spectroscopy written by Jürgen Popp and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-02-10 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Micro-Raman Spectroscopy introduces readers to the theory and application of Raman microscopy. Raman microscopy is used to study the chemical signature of samples with little preperation in a non-destructive manner. An easy to use technique with ever increasing technological advances, Micro-Raman has significant application for researchers in the fields of materials science, medicine, pharmaceuticals, and chemistry.
Author : Ashutosh Kumar
Publisher : Royal Society of Chemistry
ISBN 13 : 1788018532
Total Pages : 310 pages
Book Rating : 4.7/5 (88 download)
Download or read book Nanoparticle–Protein Corona written by Ashutosh Kumar and published by Royal Society of Chemistry. This book was released on 2019-07-26 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticles have numerous biomedical applications including drug delivery, bone implants and imaging. A protein corona is formed when proteins existing in a biological system cover the nanoparticle surface. The formation of a nanoparticle–protein corona, changes the behaviour of the nanoparticle, resulting in new biological characteristics and influencing the circulation lifetime, accumulation, toxicity, cellular uptake and agglomeration. This book provides a detailed understanding of nanoparticle–protein corona formation, its biological significance and the factors that govern the formation of coronas. It also explains the impact of nanoparticle–protein interactions on biological assays, ecotoxicity studies and proteomics research. It will be of interest to researchers studying the application of nanoparticles as well as toxicologists and pharmaceutical chemists.
Download or read book Cat's Away written by and published by . This book was released on 1850* with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Masayoshi Okubo
Publisher : Springer Science & Business Media
ISBN 13 : 9783540229230
Total Pages : 388 pages
Book Rating : 4.2/5 (292 download)
Download or read book Polymer Particles written by Masayoshi Okubo and published by Springer Science & Business Media. This book was released on 2005-02-10 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this special volume on polymer particles, recent trends and developments in the synthesis of nano- to micron-sized polymer particles by radical polymerization (Emulsion, Miniemulsion, Microemulsion, and Dispersion Polymerizations) of vinyl monomers in environmentally friendly heterogeneous aqueous and supercritical carbon dioxide fluid media are reviewed by prominent worldwide researchers. In addition to the important challenges and possibilities with regards to design and preparation of functionalized polymer particles of controlled size, the topics described are of great current interest due to the increased awareness of environmental issues.
Author : Elissa M. Grzincic
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (988 download)
Download or read book Investigating the Impact of Gold Nanoparticles on Cells: from Transcription to Behavior written by Elissa M. Grzincic and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Peter Gehr
Publisher : Springer
ISBN 13 : 3030124614
Total Pages : 344 pages
Book Rating : 4.0/5 (31 download)
Download or read book Biological Responses to Nanoscale Particles written by Peter Gehr and published by Springer. This book was released on 2019-04-16 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book the recent progress accumulated in studies of the interaction of engineered nanoparticles with cells and cellular constituents is presented. The focus is on manufacturing and characterization of nanosized materials, their interactions with biological molecules such as proteins, the mechanisms of transport across biological membranes as well as their effects on biological functions. Fundamental molecular and cellular aspects are in the foreground of the book. A further particularity is the interdisciplinary approach, including fields such as preparatory and analytical chemistry, biophysics and the physics of colloids, advanced microscopy and spectroscopy for in-situ detection of nanoparticles, cellular toxicology and nanomedicine. Nanoscale particles are known to exhibit novel and unprecedented properties that make them different from their corresponding bulk materials. As our ability to control these properties is further advanced, a huge potential to create materials with novel properties and applications emerges. Although the technological and economic benefits of nanomaterials are indisputable, concerns have also been raised that nanoscale structuring of materials might also induce negative health effects. Unfortunately, such negative health effects cannot be deduced from the known toxicity of the corresponding macroscopic material. As a result, there is a major gap in the knowledge necessary for assessing their risk to human health.
Author : Justina Oichi Tam
Publisher :
ISBN 13 :
Total Pages : 274 pages
Book Rating : 4.:/5 (871 download)
Download or read book Interactions of Composite Gold Nanoparticles with Cells and Tissue written by Justina Oichi Tam and published by . This book was released on 2012 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current methods to diagnose and treat cancer often involve expensive, time-consuming equipment and materials that may lead to unwanted side effects and may not even increase a patient's chance of survival. Thus, for a while now, a large part of the research community has focused on developing improved methods to detect, diagnose, and treat cancer on the molecular scale. One of the most recently discovered methods of cancer therapy is targeted therapy. These targeted therapies have potential to provide a patient with a form of personalized medicine because these therapies are biological molecules that specifically target other molecules involved with a cancer's growth. Past trials using these therapeutic molecules, however, have led to controversial results, where certain patients responded better than others to the therapy for unknown reasons. Elucidating the reason behind these mixed results can be accomplished using metal nanoparticle technologies which could provide a bright signal to monitor the path that these therapeutic molecules take in vivo as well as enhance the molecule's efficacy. Literature has shown that presenting targeting molecules in a dense manner to their target will increase these molecules' binding affinity. This concept has been explored here to increase binding affinity of therapeutic molecules by attaching these molecules in a dense manner on the surface of gold nanoparticles, and correlating this increased affinity with therapeutic efficacy. Additionally, gold nanoparticles provide an easy surface for molecules to be functionalized on and have shown to be effective imaging, x-ray, and photothermal therapy agents. A major roadblock to using these gold nanoparticles clinically is their non-degradability and thus potential to cause long-term negative side effects in vivo. A platform for developing biodegradable gold nanoparticles is also explored here to take advantage of the gold nanoparticles' excellent imaging and drug delivery capabilities while still allowing them to be used safely in the long term.
Author : Michael Faraday
Publisher :
ISBN 13 :
Total Pages : 42 pages
Book Rating : 4.B/5 (1 download)
Download or read book Experimental Relations of Gold (and Other Metals) to Light written by Michael Faraday and published by . This book was released on 1857 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Andy Nieto
Publisher : CRC Press
ISBN 13 : 1000377504
Total Pages : 376 pages
Book Rating : 4.0/5 (3 download)
Download or read book Carbon Nanotubes written by Andy Nieto and published by CRC Press. This book was released on 2021-05-18 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This discovery of carbon nanotubes (CNT) three decades ago ushered in the technological era of nanotechnology. Among the most widely studied areas of CNT research is their use as structural reinforcements in composites. This book describes the development of CNT reinforced metal matrix composites (CNT-MMCs) over the last two decades. The field of CNT-MMCs is abundant in fundamental science, rich in engineering challenges and innovations and ripe for technological maturation and commercialization. The authors have sought to present the current state of the-art in CNT-MMC technology from their synthesis to their myriad potential end-use applications. Specifically, topics explored include: • Advantages, limitations, and evolution of processing techniques used to synthesize and fabricate CNT-MMCs • Emphasizes dispersion techniques of CNTs in metallic systems, a key challenge to the successful and widespread implementation of CNT-MMCs. Methods for quantification and improved control of CNT distributions are presented • Methods for quantification and improved control of CNT distributions are presented • Characterization techniques uniquely suited for charactering these nanoscale materials and their many chemical and physical interactions with the metal matrix, including real-time in-situ characterization of deformation mechanisms • Electron microscope images from premier studies enrich discussions on micro-mechanical modeling, interfacial design, mechanical behavior, and functional properties • A chapter is dedicated to the emergence of dual reinforcement composites that seek to enhance the efficacy of CNTs and lead to material properties by design This book highlights seminal findings in CNT-MMC research and includes several tables listing processing methods, associated CNT states, and resulting properties in order to aid the next generation of researchers in advancing the science and engineering of CNT-MMCs. In addition, a survey of the patent literature is presented in order to shed light on what the first wave of CNT-MMC commercialization may look like and the challenges that will have to be overcome, both technologically and commercially.
Download or read book Probing Protein and Organothiol Interactions with Gold Nanoparticles written by and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins and organothiols are known for their high binding affinity to noble metal surface including gold nanoparticles (AuNPs). Numerous reports have been dedicated to AuNP interaction with protein or organothiol alone. Competitive protein and organothiol (OT) interaction is, however, mostly an unexplored area. The research reported here focused on developing a fundamental understanding of sequential and simultaneous protein and organothiol interaction with AuNPs in which protein and OT are added either simultaneously or sequentially into the colloidal AuNP solutions. In studies of OT interactions with bovine serum albumin (BSA) stabilized AuNPs, we found that the protein coating layer is highly porous and permeable for small molecules such as mercaptobenzimidazole (MBI), cysteine (Cys), homocysteine (Hcy), and glutathione (GSH). Based on the amounts of MBI adsorbed and the kinetics of MBI adsorption onto BSA stabilized AuNPs, we were able to get an insight into protein conformational changes on the AuNPs. The competitive and sequential studies of protein and OT interactions with AuNPs involving eight model organothiols showed that the protein and OT co-adsorption onto AuNPs is a kinetically controlled process. The AuNP stability against ligand-adsorption-induced AuNP aggregation differed significantly among the AuNP/OT and AuNP/BSA/OT mixtures where the AuNP stability order increased from (AuNP/OT)/BSA to AuNP/(BSA/OT), and finally (AuNP/BSA)/OT samples (the two components inside the parenthesis are mixed first followed by the addition of the third component). The studies on the role of cysteine in protein-AuNP interactions found that the cysteine has no significant effect on the kinetics of protein adsorption onto AuNPs. However the stability of the protein-AuNP complex against the organothiol-adsorption induced AuNP aggregation increased as the number of cysteine residues increased from zero to two. Besides providing new insights on protein interaction with AuNPs, this research is important for AuNP biological/biomedical applications because AuNPs in biofuids encounter a mixture of proteins and OTs in addition to other molecular species.
Author : Vineet Kumar
Publisher : Elsevier
ISBN 13 : 0128224355
Total Pages : 406 pages
Book Rating : 4.1/5 (282 download)
Download or read book Handbook of Functionalized Nanomaterials written by Vineet Kumar and published by Elsevier. This book was released on 2021-08-23 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Functionalized Nanomaterials: Environmental Health and Safety discusses the reactive properties of FNMs used in a range of applications, and their toxic impact on the environment. Nanomaterials have unique properties that can make them highly reactive. This reactivity can cause unwanted interactions with living cells, an increase in oxidative stress or damage to genetic material - resulting in damage to the environment and local wildlife. This negative impact is often further increased after surface functionalization of nanomaterials with other materials which offer unique properties of their own. To ensure environmental safety and ecological balance, rigorous toxicity testing of functionalized nanomaterials (FNMs) is necessary. This book discusses the toxicological uncertainties of FNMs and the limitations of FNMs in a range of applications. Later chapters propose methods to reliably assess the harm that functionalized nanomaterials can cause to the environment and wildlife, as well covering recent developments in the field of environmental health safety. The book concludes with a discussion on the future prospects of safe functionalized nanomaterials. - Offers a novel, integrated approach, bridging the gap between FNMs and environmental health and safety - Analyses the reactive properties of FNMs and their toxicological potential - Provides an in-depth look at the impact of functionalized nanomaterials on the environment
