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Investigations Into The Stereochemical Outcome Of Intramolecular Diels Alder Reactions
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Book Synopsis Investigations Into the Stereochemical Outcome of Intramolecular Diels-Alder Reactions by : Michael John Lilly
Download or read book Investigations Into the Stereochemical Outcome of Intramolecular Diels-Alder Reactions written by Michael John Lilly and published by . This book was released on 1998 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Theoretical and Synthetic Investigations Into the Intramolecular Diels-Alder Reaction by : Tory Nathan Cayzer
Download or read book Theoretical and Synthetic Investigations Into the Intramolecular Diels-Alder Reaction written by Tory Nathan Cayzer and published by . This book was released on 2004 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stereochemical Aspects of the Intramolecular Diels-Alder Reaction by : Herbert Russell Gillis
Download or read book Stereochemical Aspects of the Intramolecular Diels-Alder Reaction written by Herbert Russell Gillis and published by . This book was released on 1982 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Investigations Into the Scope of a Remote Stereocontrolled Asymmetric Intramolecular Diels-Alder Reaction by : Christian A. Clarke
Download or read book Investigations Into the Scope of a Remote Stereocontrolled Asymmetric Intramolecular Diels-Alder Reaction written by Christian A. Clarke and published by . This book was released on 2004 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies on the Intramolecular Diels-Alder Reaction by : Geoff T. Halvorsen
Download or read book Studies on the Intramolecular Diels-Alder Reaction written by Geoff T. Halvorsen and published by . This book was released on 2012 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intramolecular Diels-Alder reaction is widely recognized as a powerful and versatile method for the assembly of complex bicyclic structures in synthetic organic chemistry and has been utilized as a key step in the total syntheses of a number of interesting biologically active natural products. We have studied the use of siloxacyclopentene constrained trienes as a method to control diastereofacial selectivity in the intramolecular Diels-Alder reaction. The siloxacyclopentene constraints could be formed under mild conditions and attached to either the diene or dienophile units of a variety of trienes. These constrained trienes underwent intramolecular Diels-Alder reactions to give cycloadducts with the oxygen contained in the siloxacyclopentene exclusively in an anti-configuration relative to the ring fusion proton. Suitably chosen dienophile activating groups and optimized conditions for cyclization allowed for high levels of selectivity for either cis - or trans -fused cycloadducts in the case of siloxacyclopentenes contained within the diene, while siloxacyclopentenes constraints attached at the dienophile gave exclusively the trans-fused cycloadducts. A siloxacyclopentene constrained tetraene was then utilized in a concise, stereoselective synthesis of the decahydrofluorene core common to the hirsutellones. Synthetic efforts targeting the completion of the hirsutellones via a common biosynthetic intermediate were pursued utilizing a macrobenzannulation strategy. This strategy was abandoned due to inability to prepare a suitable benzannulation precursor. Later a strategy of first forming a five membered ring containing analogue was also pursued, but failed due to an inability to convert a suitable ester to the corresponding furan or thiophene.
Book Synopsis Intramolecular Diels-Alder and Alder Ene Reactions by : Douglass F. Taber
Download or read book Intramolecular Diels-Alder and Alder Ene Reactions written by Douglass F. Taber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Diels-Alder reaction has long been a powerful tool in organic synthesis. In recent years, the Alder ene reaction has also achieved some prominence. From the beginning, it was apparent that the intramolecular variants of these reactions would be feasible. Many such have been reported, but the results are widely scattered in the chemical literature. This volume is an attempt to synthesize results observed to date, and to suggest directions for future development. One of the limiting factors in the application of the intramolecular Diels Alder reaction has been the development of methods for the preparation of the requisite trienes. The fIrst chapter of this volume summarizes methods for the preparation of dienes and dienophiles. Examples representative of every general approach to 1,3-dienes and to dienophilic functional group combinations have been included. There are two questions one might ask in considering the prospective cyclization of a given triene: what are the factors that govern the rate of cyclization? and, for cyclizations that lead to the creation of one or more new chiral centers, what are the factors that govern diastereoselectivity? These questions are addressed in Chapter Two. The third chapter is devoted to the all-carbon intramolecular Alder ene reaction. The tables in that chapter summarize all examples that could be found in the literature through 1981, with several additional examples from 1982. Leading references to heterocyclic ene reactions are also included in this chapter.
Book Synopsis The Diels-Alder Reaction by : Francesco Fringuelli
Download or read book The Diels-Alder Reaction written by Francesco Fringuelli and published by John Wiley & Sons. This book was released on 2002-01-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: 70 Jahre Forschung an der Diels-Alder-Reaktion: Dieses Buch fasst die wichtigsten und beeindruckendsten Ergebnisse in einzigartiger Weise zusammen! Zunächst werden die Grundprinzipien der Reaktion klar und verständlich anhand übersichtlicher Graphiken erläutert. Spezielle Vorschriften und gegebenenfalls ihre industrielle Umsetzung werden anschließend erklärt. Einen Schwerpunkt bilden auch physikalische und katalytische Verfahren zur Steigerung der Selektivität der Reaktion. Cycloadditionen in konventionellen und unkonventionellen Medien werden vorgestellt. Mit über 1.000 Literaturverweisen!
Book Synopsis Intramolecular Diels-alder Reactions in Organic Synthesis by : Nicholas Blandford Luke Sizemore
Download or read book Intramolecular Diels-alder Reactions in Organic Synthesis written by Nicholas Blandford Luke Sizemore and published by . This book was released on 2014 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intramolecular Diels-Alder (IMDA) reactions are an important class of reactions in synthetic organic chemistry for the rapid construction of polycyclic frameworks. Three classes of IMDA reactions were investigated synthetically and computationally: 1) all-carbon type 1 IMDA reactions, 2) N-acylnitroso type 2 IMDA reactions, and 3) cyano-azadiene IMDA reactions. The first class was implemented in research toward the total synthesis of maoecrystal Z and isopalhinine A. The second class was studied computationally to understand the origins of regio- and stereochemistry in these reactions. The third class was investigated in the context of indolizine and quinolizidine synthesis.
Book Synopsis Investigation of the Intramolecular Diels-Alder Reaction in the Synthesis of Cis- and Trans-fused Decalins by : Joshua Gigax McCoy
Download or read book Investigation of the Intramolecular Diels-Alder Reaction in the Synthesis of Cis- and Trans-fused Decalins written by Joshua Gigax McCoy and published by . This book was released on 2006 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stereochemically Controlled Intramolecular Diels-Alder Reactions by : B. A. Moloney
Download or read book Stereochemically Controlled Intramolecular Diels-Alder Reactions written by B. A. Moloney and published by . This book was released on 1987 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Intramolecular Diels-Alder Reactions of Alkenylboranes & a Hetero Diels-Alder Approach to the Total Synthesis of Martinelline by : Denny Lin
Download or read book Intramolecular Diels-Alder Reactions of Alkenylboranes & a Hetero Diels-Alder Approach to the Total Synthesis of Martinelline written by Denny Lin and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Deeper Understanding of the Diels-Alder Reaction by : William James Lording
Download or read book A Deeper Understanding of the Diels-Alder Reaction written by William James Lording and published by . This book was released on 2010 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Diels-Alder reaction was discovered in 1928 and has become the most efficient and practical method for the synthesis of six-membered carbocyclic and heterocyclic rings. This thesis comprises three chapters of results and discussion with the Diels-Alder reaction as a theme. Chapter 2 details an investigation of endo:exo selectivity in the Diels-Alder reactions of 1,3-butadiene. Chapter 3 explores aspects of the intramolecular Diels-Alder reactions of some substituted 1,3,8-nonatrienes, and Chapter 4 describes the domino Diels-Alder reactions of 1,4-diiodo-1,3-butadiene. The Diels-Alder reaction is powerful, general, and widely used in chemical synthesis, and it is well known that many Diels-Alder reactions exhibit endo selectivity, in accord with Alder's empirical rule. The origins of endo:exo selectivity in the Diels-Alder reaction, however, are not completely understood and there is a dearth of experimental evidence concerning the Diels-Alder reactions of the archetypal 1,3-diene, 1,3-butadiene. Chapter 2 describes a study of the Diels-Alder reactions of an isotopically labelled 1,3-butadiene with a range of simple dienophiles, allowing the endo:exo selectivities of these important reactions to be determined for the first time. The experimental data shed light on the origins of endo:exo selectivity in the Diels-Alder reaction and will serve as an important reference for future computational investigations in this area. The intramolecular Diels-Alder reaction shares many of the virtues of its intermolecular counterpart, however its use in chemical synthesis is limited because intramolecular Diels-Alder reactivity and stereoselectivity are often governed by subtle factors, and can be very difficult to predict. As part of a comprehensive experimental and computational collaboration, Chapter 3 describes an investigation of the heat and Lewis acid promoted intramolecular Diels-Alder reactions of some ether tethered 1,3,8-nonatrienes. Also presented are the results of a rate study and a kinetic isotope effect study involving the intramolecular Diels-Alder reactions of some 1,3,8-nonatrienes. The experimental data are analysed and compared with predicted stereoselectivities, activation barriers and kinetic isotope effects obtained from computational modelling. Increased efficiency in chemical synthesis conserves resources, reduces waste, and saves time and money. Domino reactions are particularly efficient processes, which can generate complex products from simple reactants. Chapter 4 describes an investigation of the domino Diels-Alder reactions of (1E,3E)-1,4-diiodo-1,3-butadiene with maleimide dienophiles, through which a family of bicyclo[2.2.2]oct-2-ene derivatives are produced in one high yielding and stereoselective synthetic step.
Book Synopsis Investigations of the Type II Intramolecular Diels-Alder Reaction Directed Toward Natural Product Synthesis by : Andrew Clive Muscroft-Taylor
Download or read book Investigations of the Type II Intramolecular Diels-Alder Reaction Directed Toward Natural Product Synthesis written by Andrew Clive Muscroft-Taylor and published by . This book was released on 2006 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Classics in Stereoselective Synthesis by : Erick M. Carreira
Download or read book Classics in Stereoselective Synthesis written by Erick M. Carreira and published by John Wiley & Sons. This book was released on 2009-02-09 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Die wichtigsten und nützlichsten Methoden der modernen stereoselektiven Synthese sind in diesem Band zusammengefasst. Viele anschauliche Beispiele für die Darstellung von Wirkstoffen und Naturstoffen regen zur gezielten Abwandlung und Integration in eigene Synthesewege an. Dabei geht es den Autoren weniger darum, das Gebiet in seiner Gesamtheit darzustellen; vielmehr versuchen sie, die wirklich grundlegenden Ansätze auszuwählen, die jeder organische Synthesechemiker kennen und anwenden sollte.
Book Synopsis Synthetic Studies of the Intramolecular Diels-Alder Reaction by : Joseph Scott Warmus Warmus
Download or read book Synthetic Studies of the Intramolecular Diels-Alder Reaction written by Joseph Scott Warmus Warmus and published by . This book was released on 1990 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Chirality written by and published by Newnes. This book was released on 2012-12-31 with total page 5635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs. Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding. The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems. Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.
Book Synopsis Stereochemical Studies Related to the Diels-Alder Reaction by : Glenn Earl Palmer
Download or read book Stereochemical Studies Related to the Diels-Alder Reaction written by Glenn Earl Palmer and published by . This book was released on 1962 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
