Investigation Of The Roles Of Coq8p A Putative Kinase And Alternate Ring Precursors In Coenzyme Q Biosynthesis

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Investigation of the Roles of Coq8p, a Putative Kinase, and Alternate Ring Precursors in Coenzyme Q Biosynthesis

Author : Letian Xie
Publisher :
ISBN 13 :
Total Pages : 139 pages
Book Rating : 4.:/5 (913 download)

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Book Synopsis Investigation of the Roles of Coq8p, a Putative Kinase, and Alternate Ring Precursors in Coenzyme Q Biosynthesis by : Letian Xie

Download or read book Investigation of the Roles of Coq8p, a Putative Kinase, and Alternate Ring Precursors in Coenzyme Q Biosynthesis written by Letian Xie and published by . This book was released on 2014 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coenzyme Q (ubiquinone or Q) is an essential redox-active, polyisoprenylated benzoquinone lipid essential for electron and proton transport in the mitochondrial respiratory chain. Eleven genes products, Coq1-Coq9, Yah1 and Arh1, are required for Q biosynthesis in yeast Saccharomyces cerevisiae. Chapter 2 details the investigation of the biological function of Coq8 and its human homolog ADCK3. Expression of ADCK3 harboring an amino-terminal yeast mitochondrial leader sequence successfully rescued growth of coq8 mutants on non-fermentable carbon source, partially restored Q biosynthesis and the phosphorylation states of Coq3, Coq5, and Coq7. Chapter 3 investigates the use of over-expression of COQ8 as a tool to study Q biosynthesis pathway in S. cerevisiae. Over-expression of the Coq8 protein restores the steady state levels of the unstable Coq proteins. This stabilization results in the accumulation of several novel Q6 biosynthetic intermediates. Several of the new intermediates contain a C4-amine and provide information on the deamination reaction that takes place when para-aminobenzoci acid is used as a ring precursor in Q biosynthesis. Chapter 4 studies the use of para-aminobenzoic acid, and resveratrol as alternative aromatic ring precursors in Q biosynthesis in E. coli, S. cerevisiae, mouse and human cells. In contrast to S. cerevisiae, neither E. coli nor mammalian cells could utilize pABA as ring precursors in Q biosynthesis. However, E. coli cells labeled with 13C6-pABA generated several novel N-containing early intermediates, suggesting UbiA, UbiD, X, and Ubil are capable of using pABA as substrates. E. coli, S. cerevisiae, human and mouse cells cultured in the presence of 13C6-resveratrol were able to synthesize 13C6-Q. Thus, future evaluation of the physiological and pharmacological responses to dietary polyphenols should consider their metabolism to Q.

Investigation of the Role of Monooxygenases in Coenzyme Q Biosynthesis

Author : Odi Christian Osonkie
Publisher :
ISBN 13 :
Total Pages : 116 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Investigation of the Role of Monooxygenases in Coenzyme Q Biosynthesis by : Odi Christian Osonkie

Download or read book Investigation of the Role of Monooxygenases in Coenzyme Q Biosynthesis written by Odi Christian Osonkie and published by . This book was released on 2009 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Coenzyme Q in Aging

Author : Guillermo López Lluch
Publisher : Springer
ISBN 13 : 9783030456412
Total Pages : 0 pages
Book Rating : 4.4/5 (564 download)

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Book Synopsis Coenzyme Q in Aging by : Guillermo López Lluch

Download or read book Coenzyme Q in Aging written by Guillermo López Lluch and published by Springer. This book was released on 2020-08-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging. The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants. The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice. Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction. The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation. Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.

Microbial Respiration

Author : Walter P. Hempfling
Publisher : Hutchinson Ross Publishing Company
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Microbial Respiration by : Walter P. Hempfling

Download or read book Microbial Respiration written by Walter P. Hempfling and published by Hutchinson Ross Publishing Company. This book was released on 1979 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Cerebellum: Disorders and Treatment

Author :
Publisher : Elsevier
ISBN 13 : 0444641904
Total Pages : 442 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis The Cerebellum: Disorders and Treatment by :

Download or read book The Cerebellum: Disorders and Treatment written by and published by Elsevier. This book was released on 2018-06-08 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cerebellum: Disorders and Treatment, Volume 155 updates readers on the latest and clinically relevant advances in the study of cerebellar diseases in children and adults. It is organized into sections detailing: (1) Disorders (starting from the fetal cerebellum, to adult cerebellum) encountered during daily practice, and (2) Therapy (including insights into innovative drug and rehabilitative approaches). The book's innovative structure discusses cerebellar disorders in children and adults as a continuum, with its companion volume, The Cerebellum: From Embryology to Diagnostic Investigations detailing embryology, anatomy, function and diagnostic investigations and neuroimaging, including conventional sequences, diffusion tensor imaging, functional MRI, and connectivity studies. Provides an in-depth understanding of the cerebellum and its involvement in a wide variety of diseases Explores long-term outcome data of pediatric cerebellar diseases and potential problems in adult life for patients with pediatric cerebellar diseases Features chapters co-authored by two experts, combining expertise in both pediatric and adult cerebellar diseases

The Shikimate Pathway

Author : Edwin Haslam
Publisher : Elsevier
ISBN 13 : 1483161188
Total Pages : 327 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis The Shikimate Pathway by : Edwin Haslam

Download or read book The Shikimate Pathway written by Edwin Haslam and published by Elsevier. This book was released on 2014-05-20 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Shikimate Pathway gives a bird's eye view of the shikimate pathway and its implications for the life of a range of organisms. Topics covered in this book include the chemistry of intermediates in the shikimate pathway; biosynthesis of aromatic amino acids in this pathway; its metabolites; and its role in higher plants. This book is comprised of six chapters and begins by introducing the reader to shikimic acid, a natural product derived from the plant Illicium religiosum, along with the mechanistic and stereochemical aspects of the reactions of the shikimate pathway. The biosynthesis of aromatic amino acids from chorismate is also described, and then the discussion turns to the chemical properties and the detailed stereochemistry of intermediates and enzymes in the shikimate pathway. The next chapter examines the biosynthesis of isoprenoid quinones involved in electron transport and the folic acid group of co-enzymes in the shikimate pathway. The metabolism of the aromatic amino acids in microorganisms and higher organisms is considered, along with the biosynthesis and physiological functions of phenylpropanoid compounds and their derivatives in the shikimate pathway in higher plants. This book will be of general value to practitioners in the many and varied areas of biochemical research associated with metabolism.

Mitochondrial Function in Lung Health and Disease

Author : Viswanathan Natarajan
Publisher : Springer
ISBN 13 : 1493908294
Total Pages : 230 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Mitochondrial Function in Lung Health and Disease by : Viswanathan Natarajan

Download or read book Mitochondrial Function in Lung Health and Disease written by Viswanathan Natarajan and published by Springer. This book was released on 2014-07-26 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Author : M. A. Hayat
Publisher : Academic Press
ISBN 13 : 0128094273
Total Pages : 431 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat

Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2016-12-28 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Genetic Diseases of the Kidney

Author : Richard P. Lifton
Publisher : Academic Press
ISBN 13 : 0080924271
Total Pages : 895 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Genetic Diseases of the Kidney by : Richard P. Lifton

Download or read book Genetic Diseases of the Kidney written by Richard P. Lifton and published by Academic Press. This book was released on 2009-02-25 with total page 895 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic approaches have revolutionized our understanding of the fundamental causes of human disease by permitting the identification of specific genes in which variation causes or contributes to susceptibility to, or protection from, disease. More than 2,000 disease genes have been identified in the last 20 years, providing important new insight into the pathophysiology of diseases in every field of medicine. Genetic Diseases of the Kidney offers expert insight into the role of genetic abnormalities in the pathogenesis of abnormal kidney function and kidney disease. Genetic abnormalities are carefully presented within the appropriate physiologic context so that readers will understand not only which genes are linked to which diseases but also which pathways lead from a genetic “disturbance to the systemic appearance of disease. Lays the essential foundation of mammalian genetics principles for medical professionals with little or no background in genetics Analyzes specific renal diseases – both monogenic disorders confined to the kidney and systemic diseases with renal involvement – and explains their genetic causes World-renowned editors and authors offer expert frameworks for understanding the links between genes and complex clinical disorders (i.e., lupus, diabetes, HIV, and hypertension)

Mitochondrial Case Studies

Author : Russell Saneto
Publisher : Academic Press
ISBN 13 : 0128011491
Total Pages : 340 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mitochondrial Case Studies by : Russell Saneto

Download or read book Mitochondrial Case Studies written by Russell Saneto and published by Academic Press. This book was released on 2015-11-24 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial Case Studies: Underlying Mechanisms and Diagnosis offers the science behind mitochondrial disease with a case studies approach. Since mitochondrial diseases are diverse and influenced by genetic, environmental, and social-economic factors, this publication will help students, physicians, scientists, health care students, and families recognize and accurately diagnose mitochondrial disease and learn about potential treatments. Reviews case studies as a helpful teaching tool to increase awareness and improve diagnosis Provides information on underlying mechanisms of mitochondrial disease Includes basic mitochondrial dysfunction research through patient case studies to best illustrate the entire disease process

Community College Faculty

Author : J. Levin
Publisher : Springer
ISBN 13 : 1403984646
Total Pages : 204 pages
Book Rating : 4.4/5 (39 download)

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Book Synopsis Community College Faculty by : J. Levin

Download or read book Community College Faculty written by J. Levin and published by Springer. This book was released on 2006-01-31 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: John S. Levin, Susan T. Kater, and Richard L. Wagoner collectively argue that as community colleges organize themselves to respond to economic needs and employer demands, and as they rely more heavily upon workplace efficiencies such as part-time labor, they turn themselves into businesses or corporations and threaten their social and educational mission.

Inherited Neuromuscular Diseases

Author : Carmen Espinós
Publisher : Springer Science & Business Media
ISBN 13 : 9048128137
Total Pages : 311 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Inherited Neuromuscular Diseases by : Carmen Espinós

Download or read book Inherited Neuromuscular Diseases written by Carmen Espinós and published by Springer Science & Business Media. This book was released on 2010-03-11 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference on the state-of-the-art of neuromuscular diseases as a whole offers a current review of inherited neuromuscular diseases under different approaches: genetics, pathomechanisms, therapies and treatments.

Feminine Singularity

Author : Ronjaunee Chatterjee
Publisher : Stanford University Press
ISBN 13 : 1503632318
Total Pages : 243 pages
Book Rating : 4.5/5 (36 download)

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Book Synopsis Feminine Singularity by : Ronjaunee Chatterjee

Download or read book Feminine Singularity written by Ronjaunee Chatterjee and published by Stanford University Press. This book was released on 2022-08-09 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: What happens if we read nineteenth-century and Victorian texts not for the autonomous liberal subject, but for singularity—for what is partial, contingent, and in relation, rather than what is merely "alone"? Feminine Singularity offers a powerful feminist theory of the subject—and shows us paths to thinking subjectivity, race, and gender anew in literature and in our wider social world. Through fresh, sophisticated readings of Lewis Carroll, Christina Rossetti, Charles Baudelaire, and Wilkie Collins in conversation with psychoanalysis, Black feminist and queer-of-color theory, and continental philosophy, Ronjaunee Chatterjee uncovers a lexicon of feminine singularity that manifests across poetry and prose through likeness and minimal difference, rather than individuality and identity. Reading for singularity shows us the ways femininity is fundamentally entangled with racial difference in the nineteenth century and well into the contemporary, as well as how rigid categories can be unsettled and upended. Grappling with the ongoing violence embedded in the Western liberal imaginary, Feminine Singularity invites readers to commune with the subversive potentials in nineteenth-century literature for thinking subjectivity today.

Santa Evita

Author : Tomas Eloy Martinez
Publisher : Vintage
ISBN 13 : 0679768149
Total Pages : 385 pages
Book Rating : 4.6/5 (797 download)

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Book Synopsis Santa Evita by : Tomas Eloy Martinez

Download or read book Santa Evita written by Tomas Eloy Martinez and published by Vintage. This book was released on 1997-07-29 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: From one of Latin America's finest writers comes a mesmerizing novel about life of the legendary Eva Peron, the famed wife of an Argentine dictator, told backwards from death to childhood. • Now a 7-part Limited Series on Hulu. Bigger than fiction, Eva Peron was the poor-trash girl who reinvented herself as a beauty, snared Argentina's dictator, reigned as uncrowned queen of the masses, and was struck down by cancer. When her desperate but foxy husband brings Europe's leading embalmer to Eva's deathbed to make her immortal, the fantastical comedy begins. "Finally, this is the novel I always wanted to read." —Gabriel Garcia Marquez

Membrane Protein Protocols

Author : Barry S. Selinsky
Publisher : Springer Science & Business Media
ISBN 13 : 159259400X
Total Pages : 330 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Membrane Protein Protocols by : Barry S. Selinsky

Download or read book Membrane Protein Protocols written by Barry S. Selinsky and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the three-dimensional structure of a protein is absolutely required for the complete understanding of its function. The spatial orientation of amino acids in the active site of an enzyme demonstrates how substrate specificity is defined, and assists the medicinal chemist in the design of s- cific, tight-binding inhibitors. The shape and contour of a protein surface hints at its interaction with other proteins and with its environment. Structural ana- sis of multiprotein complexes helps to define the role and interaction of each individual component, and can predict the consequences of protein mutation or conditions that promote dissociation and rearrangement of the complex. Determining the three-dimensional structure of a protein requires milligram quantities of pure material. Such quantities are required to refine crystallization conditions for X-ray analysis, or to overcome the sensitivity limitations of NMR spectroscopy. Historically, structural determination of proteins was limited to those expressed naturally in large amounts, or derived from a tissue or cell source inexpensive enough to warrant the use of large quantities of cells. H- ever, with the advent of the techniques of modern gene expression, many p- teins that are constitutively expressed in minute amounts can become accessible to large-scale purification and structural analysis.

Integrative Behavioral Couple Therapy: A Therapist's Guide to Creating Acceptance and Change, Second Edition

Author : Andrew Christensen
Publisher : W. W. Norton & Company
ISBN 13 : 0393713644
Total Pages : 416 pages
Book Rating : 4.3/5 (937 download)

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Book Synopsis Integrative Behavioral Couple Therapy: A Therapist's Guide to Creating Acceptance and Change, Second Edition by : Andrew Christensen

Download or read book Integrative Behavioral Couple Therapy: A Therapist's Guide to Creating Acceptance and Change, Second Edition written by Andrew Christensen and published by W. W. Norton & Company. This book was released on 2020-09-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive therapist manual for Integrative Behavioral Couple Therapy (IBCT)—one of the most empirically supported approaches to couple therapy. Andrew Christensen, codeveloper (along with the late Neil Jacobson) of Integrative Behavioral Couple Therapy, and Brian Doss provide an essential manual for their evidence-based practice. The authors offer guidance on formulation, assessment, and feedback of couples’ distress from an IBCT perspective. They also detail techniques to achieve acceptance and deliberate change. In this updated edition of the work, readers learn about innovations to the IBCT approach in the 20+ years since the publication of the original edition—including refinements of core therapeutic techniques. Additionally, this edition provides new guidance on working with diverse couples, complex clinical issues, and integrating technology into a course of treatment.

Modern Sentimentalism

Author : Lisa Mendelman
Publisher : Oxford University Press
ISBN 13 : 0192589717
Total Pages : 256 pages
Book Rating : 4.1/5 (925 download)

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Book Synopsis Modern Sentimentalism by : Lisa Mendelman

Download or read book Modern Sentimentalism written by Lisa Mendelman and published by Oxford University Press. This book was released on 2019-12-17 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Sentimentalism examines how American female novelists reinvented sentimentalism in the modernist period. Just as the birth of the modern woman has long been imagined as the death of sentimental feeling, modernist literary innovation has been understood to reject sentimental aesthetics. Modern Sentimentalism reframes these perceptions of cultural evolution. Taking up icons such as the New Woman, the flapper, the free lover, the New Negro woman, and the divorcée, this book argues that these figures embody aspects of a traditional sentimentality while also recognizing sentiment as incompatible with ideals of modern selfhood. These double binds equally beleaguer the protagonists and shape the styles of writers like Willa Cather, Edith Wharton, Anita Loos, and Jessie Fauset. 'Modern sentimentalism' thus translates nineteenth-century conventions of sincerity and emotional fulfillment into the skeptical, self-conscious modes of interwar cultural production. Reading canonical and under-examined novels in concert with legal briefs, scientific treatises, and other transatlantic period discourse, and combining traditional and quantitative methods of archival research, Modern Sentimentalism demonstrates that feminine feeling, far from being peripheral to twentieth-century modernism, animates its central principles and preoccupations.