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Author : Anthony M. Iacopino
Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.:/5 (229 download)
Download or read book Investigation of the Calcium Binding Protein (calbindin-D28k) Gene written by Anthony M. Iacopino and published by . This book was released on 1990 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anthony Norman
Publisher : Elsevier
ISBN 13 : 0323141420
Total Pages : 650 pages
Book Rating : 4.3/5 (231 download)
Download or read book Calcium-Binding Proteins in Health and Disease written by Anthony Norman and published by Elsevier. This book was released on 2012-12-02 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium-Binding Proteins in Health and Disease includes the papers prepared by the invited speakers as well as many of the free communications. The contributions are grouped according to their general subject matter, based on the classification made by the authors, e.g., Extracellular Metabolism: Calcium Homeostasis; Low-Affinity Calcium-Binding Proteins. There can be little doubt that calcium-binding proteins is a field of scientific endeavor which will continue to produce results of great interest to modern biology. This book is divided into eight sections, the first of which, tackle extracellular calcium metabolism or calcium homeostasis. The next sections focus on topics such as low-affinity calcium-binding proteins; calcium and membranes, channels and transport (pumps); the role of calcium in complex metabolic processes; and gene structure of calcium-binding proteins and their expression. Other chapters cover physical studies on calcium-binding proteins, including X-ray, crystallography, and NMR; structure-function relationships of calcium-binding proteins and their targets; and calcium-binding proteins in health and disease. This book will be of interest to practitioners in the fields of biology and medicine.
Author : Eugene Permyakov
Publisher : John Wiley & Sons
ISBN 13 : 1118099540
Total Pages : 456 pages
Book Rating : 4.1/5 (18 download)
Download or read book Calcium Binding Proteins written by Eugene Permyakov and published by John Wiley & Sons. This book was released on 2011-03-21 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution. Techniques that underlie the description of proteins are discussed, including NMR, circular dichroism, optical rotatory dispersion spectroscopy, calorimetry,and crystallography. The book discusses the patterns of bochmical phenomena such as calcium homeostasis, mineralization, and cell signaling that involve specific proteins. It summarizes ongoing research and presents general hypotheses that help to focus future research, and also provides a conceptual framework and a description of the underlying techniques that permits someone entering the field to become conversant.
Author : Valerie Lynn Leathers
Publisher :
ISBN 13 :
Total Pages : 556 pages
Book Rating : 4.3/5 (121 download)
Download or read book Biophysical Characterization and Functional Studies on Calbindin-D2K, a Vitamin D-induced Calcium Binding Protein written by Valerie Lynn Leathers and published by . This book was released on 1989 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : R. Pochet
Publisher : Springer Science & Business Media
ISBN 13 : 1468457543
Total Pages : 212 pages
Book Rating : 4.4/5 (684 download)
Download or read book Calcium Binding Proteins in Normal and Transformed Cells written by R. Pochet and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the First European Symposium held in Brussels, Belgium, April 20--22, 1989
Author : Constance Hammond
Publisher : Elsevier
ISBN 13 : 0323986137
Total Pages : 602 pages
Book Rating : 4.3/5 (239 download)
Download or read book Cellular and Molecular Neurophysiology written by Constance Hammond and published by Elsevier. This book was released on 2024-06-03 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Neurophysiology, Fifth Edition is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in graduate-level courses on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field. The new edition contains new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction, and a section containing exercises for further learning. This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. Authoritative foundational coverage of basic cellular and molecular neurophysiology Includes new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction Provides fifteen appendices that describe how neurobiological techniques are interspersed in the text Presents enhanced coverage of new methodologies and experimental techniques
Author : Felix Bronner
Publisher : CRC Press
ISBN 13 : 9780849301889
Total Pages : 182 pages
Book Rating : 4.3/5 (18 download)
Download or read book Extra- and Intracellular Calcium and Phosphate Regulation written by Felix Bronner and published by CRC Press. This book was released on 1992-02-21 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical Medicine presents thinking and front-line research addressing calcium and phosphate homeostasis and related clinical problems. Major topics include calcium and phosphate transport in the mammalian body and some of its defects; several aspects of hormonal control of calcium and phosphorus metabolism, including PTH-related peptide; and basic and clinical aspects of bone and bone diseases. Other topics include calcium entry and extrusion mechanisms, secondary osteoporosis, how bone cells translocate phosphate needed to bone mineral, and the culture of renal and intestinal cells capable of transporting calcium in vitro. The book also features two prize-winning contributions; one deals with the characterization of a major calcium transport protein, calbindin D-9K, while the other discusses how the osteoclast, the bone-resorbing cell, is feedback-regulated. Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical Medicine provides plenty of useful information for basic and clinical scientists alike, including biochemists, physiologists, cell biologists, pharmacologists, internists, orthopedic surgeons, dentists, and pathologists.
Author : Juergen K Mai
Publisher : Academic Press
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.3/5 ( download)
Download or read book Atlas of the Human Brain written by Juergen K Mai and published by Academic Press. This book was released on 2008 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying DVD-ROM contains ... "the atlas in electronic format, but also a 3-D visualization software that allows easy browsing of the images, and a feature to allow direct retrieval of brain areas using coordinates obtained in magnetic resonance imaging."--P. [4] of cover.
Download or read book Structural and Functional Characterization of Bacterial Response and Neuroprotective Proteins written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The studies described here involve the structural and functional characterization of two proteins, calbindin-D28k and ComAC. Calbindin-D28k is a calcium binding protein that plays a unique role in eukaryotic cells, acting as both a calcium buffer and sensor. Upon binding calcium, calbindin-D28k transitions from an ordered apo- state into a disordered state as calcium is bound. Once fully loaded with four calcium ions it again takes on an ordered state. The high resolution NMR solution structure of holo- calbindin-D28k has been solved. The structure of the apo- calbindin-D28k, however, remains to be solved. In the absence of a high resolution structure of apo- calbindin-D28k it has not been possible to compare the three-dimensional structure of the two states, making it impossible to analyze how this change affects the function of calbindin-D28k. This study uses differential surface modification analyzed by mass spectrometry to probe the tertiary structural changes that occur upon calcium binding. This comparison provides the first look at the conformational change of calbindin-D28k upon calcium binding. In the second study, the structure and function of the C-terminal DNA binding domain of ComA (ComAC) from Bacillus subtilis was investigated. ComA is a response regulator protein involved in the two-component signal transduction system regulating the development of genetic competence. The protein can be divided into two distinct domains, an N-terminal regulatory domain and a C-terminal effector domain. The C-terminal domain, ComAC, is a DNA binding domain responsible for binding to target operons, including the srfA operon. The transcriptional activation of the srfA operon ultimately controls the expression of the genes responsible for expressing the protein machinery that bind to and take up exogenous DNA. This research determined the high resolution solution structure of ComAC using NMR. This structure was then used in conjunction with SPR, NMR DNA titration studie.
Author : R. Pochet
Publisher : Springer Science & Business Media
ISBN 13 : 9401006881
Total Pages : 746 pages
Book Rating : 4.4/5 (1 download)
Download or read book Calcium: The molecular basis of calcium action in biology and medicine written by R. Pochet and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464932794
Total Pages : 85 pages
Book Rating : 4.4/5 (649 download)
Download or read book Calcium-Binding Proteins: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium-Binding Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Calcium-Binding Proteins in a concise format. The editors have built Calcium-Binding Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Calcium-Binding Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Calcium-Binding Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Charles Gerday
Publisher : Springer Science & Business Media
ISBN 13 : 3642730426
Total Pages : 265 pages
Book Rating : 4.6/5 (427 download)
Download or read book Calcium and Calcium Binding Proteins written by Charles Gerday and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The idea of Professors Bolis and Gilles to gather together for a 3 days' meeting in the splendid environment of Crans-Montana in Switzerland a limited number of people around the subject of calcium and calcium bind ing proteins seemed at first particularly attractive, and when they asked me to take charge of the scientific organization of the symposium, I accepted with enthusiasm. It rapidly became clear that the major problem would be the selection of the topics, since it was impossible to cover completely and in depth such a broad and dynamic area of research. In our view, one imperative was to associate as intimately as possible the structural and the functional aspects of the areas covered. Apart from one whole day focused on the fascinating roles played by calmodulin in cellular activities, the other sessions were devoted to calmodulin-related calcium binding proteins in muscle and non muscle tissues and to some selected biological systems such as mitochondria, secretory cells or sarcoplasmic reticulum in which calcium also plays a crucial role. The presentations were made by leading investigators in their field. Some of them do not, however, appear in the present volume, for which there are two reasons: first, some of the contributions were somewhat outside the scope of the book; second, three speakers, for valid reasons, simply found no opportunity to write a manuscript in the allotted time.
Author :
Publisher : Academic Press
ISBN 13 : 0080552730
Total Pages : 417 pages
Book Rating : 4.0/5 (85 download)
Download or read book Calcium Regulation of Cellular Function written by and published by Academic Press. This book was released on 2000-04-01 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 30 examines the prominent role of calcium as an intracellular second messenger. Leading investigators review a wide variety of studies on how calcium enters and moves through cells, how it interacts with its many binding proteins, and how calcium and its intracellular receptor, calmodulin, control vital cellular processes. Coverage includes a detailed analysis of the mechanisms by which calcium bound to calmodulin regulates contractile proteins in smooth muscle cells. Close attention is given to the roles of calcium and calmodulin-dependent protein kinases and phosphatases in synaptic signal transduction, protein synthesis, gene expression, programmed cell death, activation of T-lymphocytes, and control of cell division cycles. Other chapters discuss studies using genetically manipulable nonmammalian organisms to further proble the functions of calcium and calmodulin.
Author : Juliusz Ashot Kozak
Publisher : CRC Press
ISBN 13 : 149875273X
Total Pages : 343 pages
Book Rating : 4.4/5 (987 download)
Download or read book Calcium Entry Channels in Non-Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Author : John R. Smythies
Publisher : Academic Press
ISBN 13 : 012404722X
Total Pages : 408 pages
Book Rating : 4.1/5 (24 download)
Download or read book The Claustrum written by John R. Smythies and published by Academic Press. This book was released on 2013-11-11 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present day is witnessing an explosion of our understanding of how the brain works at all levels, in which complexity is piled on complexity, and mechanisms of astonishing elegance are being continually discovered. This process is most developed in the major areas of the brain, such as the cortex, thalamus, and striatum. The Claustrum instead focuses on a small, remote, and, until recently, relatively unknown area of the brain. In recent years, researchers have come to believe that the claustrum is concerned with consciousness, a bold hypothesis supported by the claustrum's two-way connections with nearly every other region of the brain and its seeming involvement with multisensory integrations—the hallmark of consciousness. The claustrum, previously in a humble position at the back of the stage, might in fact be the conductor of the brain's orchestra. The Claustrum brings together leading experts on the claustrum from the varied disciplines of neuroscience, providing a state-of-the-art presentation of what is currently known about the claustrum, promising lines of current research (including epigenetics), and projections of new lines of investigation on the horizon. - Develops a unifying hypothesis about the claustrum's role in consciousness, as well as the integration of sensory information and other higher brain functions - Discusses the involvement of the claustrum with autism, schizophrenia, epilepsy, Alzheimer's disease, and Parkinson's disease - Coverage of all aspects of the claustrum, from its evolution and development to promising new lines of research, including epigenetics, provides a platform and point of reference for future investigative efforts
Author : Danielle Pansu
Publisher : Springer
ISBN 13 :
Total Pages : 466 pages
Book Rating : 4.3/5 (91 download)
Download or read book Calcium Transport and Intracellular Calcium Homeostasis written by Danielle Pansu and published by Springer. This book was released on 1990-12-10 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the NATO Advanced Research Workshop on Calcium Transport and Intracellular Calcium Homeostasis held in Lyon, France, March 4-7, 1990
Author : Oriol Bachs
Publisher : Springer Science & Business Media
ISBN 13 : 3662216868
Total Pages : 173 pages
Book Rating : 4.6/5 (622 download)
Download or read book Calcium and Calmodulin Function in the Cell Nucleus written by Oriol Bachs and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the role of calcium and calmodulin in the cell nucleus. Calcium, which is an important second messenger of signal transduction pathways, can also operate in the cell nucleus. Different calcium binding proteins, which are the targets of cellular calcium, have been identified in the nucleus of many different cell types. Prominent among these calcium binding proteins is calmodulin, which appears to be involved in the regulation of major nuclear functions such as gene expression and DNA replication.
