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Author : Chun Yat Leung
Publisher :
ISBN 13 :
Total Pages : 76 pages
Book Rating : 4.:/5 (112 download)
Download or read book Investigating Dissolution Kinetics and Cytotoxicity of Zinc Oxide Nanomaterials written by Chun Yat Leung and published by . This book was released on 2019 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lifetime and Dissolution Kinetics of Zinc Oxide Nanoparticles in Aqueous Media written by and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Marek Kosmulski
Publisher : CRC Press
ISBN 13 : 9780585418049
Total Pages : 774 pages
Book Rating : 4.4/5 (18 download)
Download or read book Chemical Properties of Material Surfaces written by Marek Kosmulski and published by CRC Press. This book was released on 2001-07-18 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: A discussion of the adsorption of inorganics from aqueous solution on inorganic adsorbents. It emphasizes the relationship between adsorption and surface charging, highlighting simple and complex adsorption systems sorted by the adsorbent as well as the adsorbate. The author includes a comprehensive collection of pristine PZC of different materials - covering crystallographic structure, methods of preparation, impurities in the solid, temperature and ionic composition of the solution, experimental methods to determine PZC, and the correlation between zero points and other physical quantities.
Author : M. Munawar
Publisher : Springer Science & Business Media
ISBN 13 : 9400918968
Total Pages : 663 pages
Book Rating : 4.4/5 (9 download)
Download or read book Environmental Bioassay Techniques and their Application written by M. Munawar and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the First International Conference held in Lancaster, England, July 11-14, 1988
Author : Vyom Sharma
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (89 download)
Download or read book An Investigation Into the Mechanism of Toxicity of Zinc Oxide Nanoparticles written by Vyom Sharma and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The wide scale use of ZnO nanoparticles (NPs) in the world consumer market has resulted in likelihood of exposure to human beings. The present study was aimed to assess the in vitro and in vivo interactions of ZnO NPs in the mammalian system and to elucidate the possible mechanism of their toxicity. Our in vitro results using human epidermal cells (A431), primary human epidermal keratinocytes and human liver cells (HepG2) demonstrated that cells exposed to ZnO NPs exhibit a decrease in cell viability which was independent of NP dissolution. ZnO NPs also induced oxidative DNA damage as evidenced by an increase in the Fpg sensitive sites. The reactive oxygen species triggered a decrease in mitochondrial membrane potential and an increase in the ratio of Bax/Bcl2 leading to apoptosis through the intrinsic pathway. In addition, ZnO NPs induced phosphorylation of JNK, P38 and P53ser15. The results from our in vivo studies using a mouse model showed that ZnO NPs induce lipid peroxidation, oxidative DNA damage and apoptosis in liver which further confirmed our in vitro findings. The data from the present study provide valuable insights into the cellular interactions of ZnO NPs and the underlying molecular mechanism of their toxicity. The results also stress the need for a comprehensive environmental health and safety assessment of engineered nanomaterials to ensure safer nanotechnology based products.
Author : Donald L. Sparks
Publisher :
ISBN 13 :
Total Pages : 460 pages
Book Rating : 4.:/5 (318 download)
Download or read book Mineral-water Interfacial Reactions written by Donald L. Sparks and published by . This book was released on 1998 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clearly explains how to more effectively decipher and predict contaminant fate in the environment by combining kinetic methods and molecular-scale spectroscopic and microscopic techniques to analyze mineral/water interfacial reactions in situ. The book begins with a broad overview, then continues with three sections written by internationally known expert. The first deals specifically with spectroscopic/microscopic techniques that can be used in combination with macroscopic approaches to glean mechanistic information on mineral/water reactions and processes. The second section emphasizes computer models that are used to elucidate surface mediated reaction mechanisms. The remainder of the volume is organized around reaction type, including sorption/desorption of inorganic species, sorption/desorption of organic species, precipitation/dissolution processes, heterogeneous electron transfer reactions, photochemically driven reactions, and microbially mediated reactions. Mineral-Water Interfacial Reactions will be a valuable resource for environmental scientists, geochemists, soil chemists, microbiologists, and marine engineers who need to be familiar with the most current and effective methods for testing and controlling the mobility, speciation, and bioavailability of contaminants in the environment.
Author : Catherine Binns Anders
Publisher :
ISBN 13 :
Total Pages : 256 pages
Book Rating : 4.:/5 (114 download)
Download or read book The Physicochemical Properties and Cellular Toxicity of Variably Synthesized Zinc Oxide Nanoparticles written by Catherine Binns Anders and published by . This book was released on 2017 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nanotechnology has grown exponentially since its inception in the early 1970's. Since then, bionanotechnological devices and treatment options have significantly improved disease treatments and patient outcomes; however, this rapid growth in consumer related products has also prompted concern. Zinc oxide nanoparticles (nZnO), known for their inherent toxicity and prevalent global use in consumer products and medical applications, have received much of this attention. Significant research efforts have focused on both toxicity remediation through material property modification and the exploitation of these same factors to create potential cancer therapeutics. There is general agreement that the physicochemical properties of nZnO strongly contribute to NP-induced toxicity; however, inconsistencies in the material property characterization methods employed, and an understanding of how those properties influence cytotoxicity in mammalian cells has led to discrepancies in the literature. Additionally, more research is needed to connect the material properties of nZnO to downstream cellular responses. Here, a panel of variably synthesized nZnO was utilized to thoroughly investigate the material properties of the particles as they relate to cytotoxicity, oxidative stress, and transcriptome changes in different mammalian cell types. The goals of this study are three-fold: i) reduce NP agglomeration and sedimentation tendencies within complex media and achieve dispersion stability, ii) define which material property interactions have the greatest potential to affect cellular toxicity, and to iii) examine the preferential toxicity of nZnO towards Jurkat leukemic cells through genetic expression studies. Chapter 2 highlights the importance of dispersion stability and the effect of fetal bovine serum (FBS) proteins on the dispersion stability, dosimetry and NP-induced cytotoxicity of nZnO in suspension and adherent in vitro cell culture models. The presence of surface adsorbed proteins from the FBS on the nZnO decreased agglomeration and sedimentation potential. Furthermore, FBS-stabilized nZnO dispersions resulted in toxicity increases in suspension cells when compared to unstable dispersions; however, toxicity was decreased in adherent cell models with stable dispersions. These observations indicate that improved dispersion stability leads to increased NP bioavailability for suspension cells and reduced NP sedimentation onto adherent cell layers resulting in more accurate in vitro toxicity assessments. In Chapter 3, we utilized an expanded panel of nZnO synthesized through wet chemical and high temperature methods, followed by thorough characterization to examine the importance of material property changes in NP-induced toxicity. We found our diverse set of nZnO displayed significant differences in surface reactivity, dissolution potential and cytotoxicity towards cancerous and primary T cells. Additionally, principal component analysis (PCA) suggested that the synthesis procedure conferred unique material properties, and can be a determinant of cellular cytotoxicity. Furthermore, we showed that attributing NP-induced toxicity to one specific material property is shortsighted and that complex interactions between these properties needs to be considered. Finally, Chapter 4 introduces future work dedicated to investigating transcriptome changes in cancerous and primary T cells exposed to nZnO. Both cell types demonstrated significant up- and down-regulation of genes in a dose-dependent manner. Many significant differentially expressed genes (SDEGs) corresponded to proteins involved in the sequestration and transport of ionic zinc confirming the importance of nZnO in the cytotoxic response. Additional analysis will focus on the importance of specific SDEGs involved in the regulation of oxidative stress pathways, cellular metabolism, inflammation, T cell activation, and protein misfolding in the NP-induced toxicity mechanism."--Boise State University ScholarWorks.
Author : Muharrem Ince
Publisher : BoD – Books on Demand
ISBN 13 : 178984696X
Total Pages : 232 pages
Book Rating : 4.7/5 (898 download)
Download or read book Biochemical Toxicology written by Muharrem Ince and published by BoD – Books on Demand. This book was released on 2020-07-29 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical Toxicology - Heavy Metals and Nanomaterials provides an overview of biochemical contamination, nanomaterials and toxic metals, and measurement techniques. It explains and clarifies important studies and compares and develops new and groundbreaking measurement techniques in the fields of organic and inorganic pollution and nanoscience. It is highly recommended for professionals and readers interested in the environment and human health.
Author : Elza Neelima Mathew
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (129 download)
Download or read book Investigating the Biophysical, Biochemical, and Biological Activity of Anti-cancer Zinc Oxide Nanoparticle and Its Physiometacomposite (PMC) Nanoparticles written by Elza Neelima Mathew and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Combating melanoma, the most lethal form of skin cancer, our research group works towards assessing the anticancer potential of zinc oxide (ZnO) nanoparticle and its different physiological metal oxide nanoparticles or physiometacomposite (PMC) nanoparticles. Among these, the antimelanoma cytotoxic activity of zinc oxide nanoparticle (ZnO NP; 100 nm) has been extensively demonstrated. The objective of the proposed study is to elucidate the biophysical, biochemical, and biological mechanisms of the anti-cancer activity of ZnO NP and its PMCs. For biophysical and biochemical characterization, dynamic light scattering (DLS), two-dimensional fluorescence difference spectroscopy (2-D FDS), transmission electron microscopy (TEM) and inductively coupled plasma mass spectrometry (ICP-MS) have been used. The biological activity of the different nanoparticles was investigated in NIH3T3 mouse fibroblast cells and B16F10 mouse melanoma cells followed by in vivo investigation in a mouse model. The behavior of the nanoparticles in different mouse tissues was also monitored ex vivo. This dissertation presents the significant findings of this study. Chapter 1 gives a general introduction to the dissertation and an overview of ZnO NP, its anti-cancer activity, in vivo behavior, and a brief outline on melanoma particularly drug resistant and rarer forms. Chapter 2 is a detailed review of the anticancer activity of zinc oxide nanoparticles and combining ZnO NPs with nucleic acid therapeutic and protein delivery against metastatic melanoma. Chapter 3 investigates the immunological activity of zinc oxide nanoparticle and its anticancer peptide and RNA complexes. Chapter 4 characterizes the biochemical activities of ZnO NP and its PMCs in terms of inhibition of enzyme activities and associations of enzymes involved in the RAS pathway of metastatic progression. In Chapter 5, the interaction of ZnO NP with proteins using Ras binding Domain (RBD) as the model protein is investigated. In chapter 6, the combinatory anti-melanoma potential of ZnO NP and LL-37, an antimicrobial peptide, which is currently in clinical trials against melanoma is investigated. Chapter 7 summarizes the main findings from the previous chapters. An in-depth investigation of the cellular mechanisms and in vivo physiological/pathological effects is expected to help in molding new therapeutic targets and approaches. Demonstration of precise mechanisms of action is expected to help with the development of further therapeutic approaches utilizing ZnO NP.
Author : Chaudhery Mustansar Hussain
Publisher : John Wiley & Sons
ISBN 13 : 1119592968
Total Pages : 580 pages
Book Rating : 4.1/5 (195 download)
Download or read book The ELSI Handbook of Nanotechnology written by Chaudhery Mustansar Hussain and published by John Wiley & Sons. This book was released on 2020-03-31 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook focuses on the recent advancements in Safety, Risk, Ethical Society and Legal Implications (ESLI) as well as its commercialization of nanotechnology, such as manufacturing. Nano is moving out of its relaxation phase of scientific route, and as new products go to market, organizations all over the world, as well as the general public, are discussing the environmental and health issues associated with nanotechnology. Nongovernmental science organizations have long since reacted; however, now the social sciences have begun to study the cultural portent of nanotechnology. Societal concerns and their newly constructed concepts, show nanoscience interconnected with the economy, ecology, health, and governance. This handbook addresses these new challenges and is divided into 7 sections: Nanomaterials and the Environment; Life Cycle Environmental Implications of Nanomanufacturing; Bioavailability and Toxicity of Manufactured Nanoparticles in Terrestrial Environments; Occupational Health Hazards of Nanoparticles; Ethical Issues in Nanotechnology; Commercialization of Nanotechnology; Legalization of Nanotechnology.
Author : Clint Edwin Johnson
Publisher :
ISBN 13 :
Total Pages : 212 pages
Book Rating : 4.:/5 (748 download)
Download or read book In Vitro Toxicity Assessment of Silver and Zinc Oxide Nanoparticles written by Clint Edwin Johnson and published by . This book was released on 2009 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotoxicology is a nascent field of study concerned with the potential for nanotechnology to adversely impact human health or result in ecological damage. Nanomaterials can display unique physicochemical properties not present in the parent bulk material and it is these properties that may be a potential source of toxicity. There are a growing number of examples of nanomaterials functioning differently in biosystems compared to the parent bulk material. With the rapid growth of nanotechnology and increasing exposure of people to novel nanomaterials there is an urgent need to evaluate the toxicity of nanomaterials. In this study the toxicities of silver and zinc oxide nanoparticles were assessed. The effects of size and surface coating on the cytotoxicity and immunogenicity of silver nanoparticles were investigated, with cytotoxicity found to be inversely proportional to nanoparticle size. The subcutaneous penetration of zinc oxide nanoparticles was assessed to determine whether this material can be safely used as a UV filter in sunscreens and cosmetics. No dermal penetration was detected using a porcine in vitro model. Zinc oxide nanoparticles were also used as a model material to investigate nano-specific toxicity by comparing cytotoxicity and changes to gene expression with bulk scale zinc oxide. In both cases cytotoxicity and changes to gene expression were greater for zinc oxide nanoparticles. Methods and techniques to test the toxicity of nanomaterials in vitro and the implication for in vivo toxicity are only beginning to be elucidated. The methods and techniques used in this study, particularly nanomaterial stabilization in biofluids and toxicity testing using blood cell cultures, may assist the establishment of standard in vitro testing protocols for nanomaterials.
Author : Eun Ji Chung
Publisher : Elsevier
ISBN 13 : 0128166630
Total Pages : 442 pages
Book Rating : 4.1/5 (281 download)
Download or read book Nanoparticles for Biomedical Applications written by Eun Ji Chung and published by Elsevier. This book was released on 2019-11-19 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticles for Biomedical Applications: Fundamental Concepts, Biological Interactions and Clinical Applications brings into one place information on the design and biomedical applications of different classes of nanoparticles. While aspects are dealt with in individual journal articles, there is not one source that covers this area comprehensively. This book fills this gap in the literature. - Outlines an in-depth review of biomedical applications of a variety of nanoparticle classes - Discusses the major techniques for designing nanoparticles for use in biomedicine - Explores safety and regulatory aspects for the use of nanoparticles in biomedicine
Author : Eleonora Spisni
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (12 download)
Download or read book Toxicity Assessment of Industrial- and Sunscreen-derived ZnO Nanoparticles written by Eleonora Spisni and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the present case study is investigating the toxic effects derived from nanosized zinc oxide nanoparticles toward the marine life. In particular, the present study evaluates for the first time the growth inhibition induced by both industrial-derived and sunscreen self-extracted zinc oxide nanoparticles on the diatom Thalassiosira pseudonana. The experiments, performed at the Environmental Engineering Laboratory of the University of Miami, showed that the toxic effects induced by nano-ZnO were influenced by the type of nanoparticle, as well as their concentration in aqueous media and the exposure time. Specifically, smaller, industrial-derived nano-ZnO induced a greater growth inhibition compared to sunscreen-derived ones, especially at lower nanoparticle concentration in the aqueous media. This behavior might indicate that at higher nanoparticle concentration the toxicity is controlled by nanoparticle aggregation (regardless of nanoparticle size), whereas at lower nanoparticle concentration the toxicity is influenced by the nanoparticle size, as well as nanoparticle type and exposure time. The aim of the present case study is investigating the toxic effects derived from nanosized zinc oxide nanoparticles toward the marine life. In particular, the present study evaluates for the first time the growth inhibition induced by both industrial-derived and sunscreen self-extracted zinc oxide nanoparticles on the diatom Thalassiosira pseudonana. The experiments, performed at the Environmental Engineering Laboratory of the University of Miami, showed that the toxic effects induced by nano-ZnO were influenced by the type of nanoparticle, as well as their concentration in aqueous media and the exposure time. Specifically, smaller, industrial-derived nano-ZnO induced a greater growth inhibition compared to sunscreen-derived ones, especially at lower nanoparticle concentration in the aqueous media. This behavior might indicate that at higher nanoparticle concentration the toxicity is controlled by nanoparticle aggregation (regardless of nanoparticle size), whereas at lower nanoparticle concentration the toxicity is influenced by the nanoparticle size, as well as nanoparticle type and exposure time.
Author : Magnus Willander
Publisher : CRC Press
ISBN 13 : 9814411345
Total Pages : 225 pages
Book Rating : 4.8/5 (144 download)
Download or read book Zinc Oxide Nanostructures written by Magnus Willander and published by CRC Press. This book was released on 2014-07-22 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zinc oxide (ZnO) in its nanostructured form is emerging as a promising material with great potential for the development of many smart electronic devices. This book presents up-to-date information about various synthesis methods to obtain device-quality ZnO nanostructures. It describes both high-temperature (over 100 C) and low-temperature (under
Author : Suresh C. Pillai
Publisher :
ISBN 13 : 9780429265471
Total Pages : 0 pages
Book Rating : 4.2/5 (654 download)
Download or read book Toxicity of Nanomaterials written by Suresh C. Pillai and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Choice Recommended Title, April 2020 This comprehensive book, edited by two leading experts in nanotechnology and bioengineering with contributions from a global team of specialists, provides a detailed overview of the environmental and health impacts associated with the toxicology of nanomaterials. Special attention is given to nanomaterial toxicity during synthesis, production and application, and chapters throughout are focused on key areas that are important for future research and development of nanomaterials. This book will be of interest to advanced students studying biomedical engineering and materials science, PhD researchers, post-docs and academics working in the area of nanotechnology, medicine, manufacturing and regulatory bodies. Features: Collates and critically evaluates various aspects of the toxicology of nanomaterials in one comprehensive text Discusses the various effects of nanocrystals including the morphologies on cytotoxicity, in addition to the environmental and cytotoxicity risks of graphene and 2D nanomaterials Explores practical methods of detection and quantification, with applications in the environmental and healthcare fields
Author : Andreia Ferreira de Castro Gomes
Publisher : BoD – Books on Demand
ISBN 13 : 9535139398
Total Pages : 174 pages
Book Rating : 4.5/5 (351 download)
Download or read book Unraveling the Safety Profile of Nanoscale Particles and Materials written by Andreia Ferreira de Castro Gomes and published by BoD – Books on Demand. This book was released on 2018-03-21 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: As nanomaterials become increasingly present in our daily lives, pertinent questions regarding their safety arise. Nanomaterial risk assessment, as in other areas, directs much of the effort worldwide in defining guidelines that may be translated into national or international directives. Nanomaterials encompass different entities, from nanoparticles to nanostructured materials, with specific effects over cells, tissues, organisms and ecosystems depending on their biophysical characteristics. Such interactions will directly affect the impact of novel nanotechnologies. This book aims to provide the reader with a comprehensive overview of the current state of the art in nanotoxicology, featuring the most important developments and critical issues regarding the use of and exposure to nanoparticles.
Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher : World Health Organization
ISBN 13 : 9283212819
Total Pages : 434 pages
Book Rating : 4.2/5 (832 download)
Download or read book Man-made Vitreous Fibres written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 2002 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This publication represents the views and expert opinions of an IARC working group on the evaluation of carcinogenic risks to humans, which met in Lyon, 9-16 October 2001."
