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Author : Paul R. LePlae
Publisher :
ISBN 13 :
Total Pages : 210 pages
Book Rating : 4.:/5 (89 download)
Download or read book Introducing Diversity Into 12-helical Beta-peptides written by Paul R. LePlae and published by . This book was released on 2002 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Matthew G. Woll
Publisher :
ISBN 13 :
Total Pages : 432 pages
Book Rating : 4.:/5 (89 download)
Download or read book Efforts Toward Understanding Secondary and Tertiary Structure in Polypeptides written by Matthew G. Woll and published by . This book was released on 2004 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 740 pages
Book Rating : 4.3/5 (91 download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2004 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bayard Robert Huck
Publisher :
ISBN 13 :
Total Pages : 404 pages
Book Rating : 4.:/5 (89 download)
Download or read book The Development of Novel Β-peptide Foldamers written by Bayard Robert Huck and published by . This book was released on 2002 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Emily Payne English
Publisher :
ISBN 13 :
Total Pages : 288 pages
Book Rating : 4.:/5 (891 download)
Download or read book Development of Beta-peptide Inhibitors of Viral Fusion written by Emily Payne English and published by . This book was released on 2007 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul A Bartlett
Publisher : Royal Society of Chemistry
ISBN 13 : 1847552552
Total Pages : 445 pages
Book Rating : 4.8/5 (475 download)
Download or read book Exploiting Chemical Diversity for Drug Discovery written by Paul A Bartlett and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conceptual and technological advances in chemistry and biology have transformed the drug discovery process. Evolutionary pressure among the diverse scientific and engineering disciplines that contribute to the identification of biologically active compounds has resulted in synergistic improvements at every step in the process. Exploiting Chemical Diversity for Drug Discovery encompasses the many components of this transformation and presents the current state-of-the-art of this critical endeavour. From the theoretical and operational considerations in generating a collection of compounds to screen, to the design and implementation of high-capacity and high-quality assays that provide the most useful biological information, this book provides a comprehensive overview of modern approaches to lead identification. Beginning with an introductory overview, subsequent chapters address topics that include the design of chemical libraries and methods for optimizing their diversity; automated and accelerated chemistry; high throughput assay design and detection techniques; and strategies for data analysis and property optimization. Written by experts in the field, both academic and industrial, and illustrated in full colour, this book provides an excellent overview for current practitioners and will also serve as a stimulating resource for future generations. Researchers in organic and medicinal chemistry, the biological and pharmacological sciences, as well as those interested in allied computational and engineering disciplines will value the comprehensive and up-to-date coverage.
Author : Emilie Ann Porter
Publisher :
ISBN 13 :
Total Pages : 298 pages
Book Rating : 4.:/5 (89 download)
Download or read book Synthesis and Biological Applications of 12-helical Beta-peptides written by Emilie Ann Porter and published by . This book was released on 2003 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Galia Maayan
Publisher : John Wiley & Sons
ISBN 13 : 1118517431
Total Pages : 446 pages
Book Rating : 4.1/5 (185 download)
Download or read book Metallofoldamers written by Galia Maayan and published by John Wiley & Sons. This book was released on 2013-01-18 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metallofoldamers are oligomers that fold into three-dimensional structures in a controlled manner upon coordination with metal ions. Molecules in this class have shown an impressive ability to form single-handed helical structures and other three-dimensional architectures. Several metallofoldamers have been applied as sensors due to their selective folding when binding to a specific metal ion, while others show promise for applications as responsive materials on the basis of their ability to fold and unfold upon changes in the oxidation state of the coordinated metal ion, and as novel catalysts. Metallofoldamers: From Helicates to Biomimetic Architectures describes the variety of interactions between oligomers and metal species, with a focus on non-natural synthetic molecules. Topics covered include: the major classes of foldamers and their folding driving force metalloproteins and metalloenzymes helicates: self-assembly, structure and applications abiotic metallo-DNA metallo-PNA and iDNA metallopeptides interactions of biomimetic oligomers with metal ions applications of metallofoldamers
Author : Zigang Li
Publisher : John Wiley & Sons
ISBN 13 : 3527343458
Total Pages : 242 pages
Book Rating : 4.5/5 (273 download)
Download or read book Cyclized Helical Peptides written by Zigang Li and published by John Wiley & Sons. This book was released on 2021-06-21 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important and timely guide to the progress being made on constrained helical peptides Constraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors noted experts on the topic include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity. The book examines the therapeutic applications of the constraint helices and includes comparison with existing small molecule modulators or antibodies. Designed as a useful resource for both those outside and inside the field. Those new to the field will find a comprehensive introduction to cyclized helical peptide and those inside the field will find a deeper understanding of the topic. This important book: Offers a practical introduction to constrained helical peptides Includes all aspects of constrained helical peptides Includes information on the most recent methods that have emerged Presents a guide to help solve practical problems in the field Written for academics, pharmaceutical professional, Cyclized Helical Peptides is a comprehensive guide to the developments of constrained helical peptides.
Author : Joseph M. Langenhan
Publisher :
ISBN 13 :
Total Pages : 468 pages
Book Rating : 4.:/5 (89 download)
Download or read book Investigations of Strand-forming Foldamers, I. Study of Antiparallel and Parallel Β-peptide Sheet Model Systems, II. Efforts Toward the Design of Sulfonamide Strand Mimics written by Joseph M. Langenhan and published by . This book was released on 2003 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Designing [alpha]/[beta]-peptide Foldamers to Target Diverse Protein Surfaces PDF Online Free](https://books.google.com/books/content/images/frontcover/R3CFAQAACAAJ?fife=w200-h370)
Author :
Publisher :
ISBN 13 :
Total Pages : 1146 pages
Book Rating : 4.:/5 (93 download)
Download or read book Designing [alpha]/[beta]-peptide Foldamers to Target Diverse Protein Surfaces written by and published by . This book was released on 2015 with total page 1146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Huzefa Rangwala
Publisher : John Wiley & Sons
ISBN 13 : 111809946X
Total Pages : 611 pages
Book Rating : 4.1/5 (18 download)
Download or read book Introduction to Protein Structure Prediction written by Huzefa Rangwala and published by John Wiley & Sons. This book was released on 2011-03-16 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: A look at the methods and algorithms used to predict protein structure A thorough knowledge of the function and structure of proteins is critical for the advancement of biology and the life sciences as well as the development of better drugs, higher-yield crops, and even synthetic bio-fuels. To that end, this reference sheds light on the methods used for protein structure prediction and reveals the key applications of modeled structures. This indispensable book covers the applications of modeled protein structures and unravels the relationship between pure sequence information and three-dimensional structure, which continues to be one of the greatest challenges in molecular biology. With this resource, readers will find an all-encompassing examination of the problems, methods, tools, servers, databases, and applications of protein structure prediction and they will acquire unique insight into the future applications of the modeled protein structures. The book begins with a thorough introduction to the protein structure prediction problem and is divided into four themes: a background on structure prediction, the prediction of structural elements, tertiary structure prediction, and functional insights. Within those four sections, the following topics are covered: Databases and resources that are commonly used for protein structure prediction The structure prediction flagship assessment (CASP) and the protein structure initiative (PSI) Definitions of recurring substructures and the computational approaches used for solving sequence problems Difficulties with contact map prediction and how sophisticated machine learning methods can solve those problems Structure prediction methods that rely on homology modeling, threading, and fragment assembly Hybrid methods that achieve high-resolution protein structures Parts of the protein structure that may be conserved and used to interact with other biomolecules How the loop prediction problem can be used for refinement of the modeled structures The computational model that detects the differences between protein structure and its modeled mutant Whether working in the field of bioinformatics or molecular biology research or taking courses in protein modeling, readers will find the content in this book invaluable.
Author : Alessandro Contini
Publisher : Frontiers Media SA
ISBN 13 : 2889630455
Total Pages : 145 pages
Book Rating : 4.8/5 (896 download)
Download or read book Folded Synthetic Peptides for Biomedical Applications written by Alessandro Contini and published by Frontiers Media SA. This book was released on 2019-09-26 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folded peptides - and peptide motifs within proteins - are abundant in living organisms, where they are essential for the biological activities of the peptides and proteins. During the past decades, much research has been dedicated to understanding the rules that govern peptide folding. Simultaneously, a range of strategies have been established for the conformational stabilization of bioactive peptides, as well as for the de novo design of peptides with defined secondary structures. These methods are either based on the chemical modification of the peptide backbone, such as cyclization and stapled peptides, or on the use of a range of non-proteinogenic amino acids that, in a defined sequential arrangement, induce secondary structures peptides. Such building blocks include D- and other non-proteinogenic amino acids, as well as beta- and gamma-amino acids. This Research Topic comprises a collection of papers by an international group of 77 scientists with a background in synthetic, analytical, computational and medicinal chemistry, as well as in biochemistry and pharmacology. Their research is presented here in a total of 11 papers (8 original research reports and 3 reviews), covering diverse aspects of folded synthetic peptides. These studies include the preparation and characterization of new peptide monomers with interesting folding properties, the synthesis and conformational analysis of non-natural peptides, as well as the use of folded peptidomimetics as molecular switches. Additionally, a range of biomedical applications, such as antimicrobial, anti-inflammatory, antiangiogenic and immune-stimulating activities, are also reported. We hope this eBook will be a source of inspiration and knowledge for scientist in various disciplines related to folded peptides and their many applications, as well as for those who want to learn more about this fascinating field of research.
Author : American Chemical Society
Publisher :
ISBN 13 :
Total Pages : 1026 pages
Book Rating : 4.:/5 (334 download)
Download or read book Journal written by American Chemical Society and published by . This book was released on 2004 with total page 1026 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Steven D. Aird
Publisher : MDPI
ISBN 13 : 3039364677
Total Pages : 210 pages
Book Rating : 4.0/5 (393 download)
Download or read book Identification and Functional Characterization of Novel Venom Components written by Steven D. Aird and published by MDPI. This book was released on 2020-12-29 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout most of the 20th century, the toxinological literature consisted largely of pharmacological and functional characterizations of crude venoms and venom constituents, often constituents that could not be identified unambiguously. The advent of amino acid composition analysis in the 1950s enabled the first forays into physical characterizations of purified toxins, though these remained few in number until the 1970s. Then, the tryptic and chymotryptic cleavage of venom proteins coupled with manual Edman degradation began to provide the first complete sequences, particularly of three-finger toxins. Polyacrylamide gel electrophoresis and improved resins for liquid chromatography permitted improved purification and better gross structural characterization of venom components. The early 1980s witnessed the advent of automated Edman degradation, and entire sequences of longer proteins began to be reported in the literature. Then, the molecular biology revolution enabled the generation of cDNA sequences of more and larger proteins, followed by mass-spectrometry-based proteomics and quantitative high-throughput DNA sequencing and genomics. Today, we face an unprecedented situation in which our capacity to generate sequence/structural data has completely overwhelmed our capacity to functionally characterize venom constituents. This Special Issue of Toxins includes 11 publications addressing the discovery and functional characterization of novel venom constituents of vertebrate and invertebrate venoms.
Author : Yasha Hasija
Publisher : Academic Press
ISBN 13 : 0128219734
Total Pages : 453 pages
Book Rating : 4.1/5 (282 download)
Download or read book Translational Biotechnology written by Yasha Hasija and published by Academic Press. This book was released on 2021-01-17 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Biotechnology: A Journey from Laboratory to Clinics presents an integrative and multidisciplinary approach to biotechnology to help readers bridge the gaps between fundamental and functional research. The book provides state-of-the-art and integrative views of translational biotechnology by covering topics from basic concepts to novel methodologies. Topics discussed include biotechnology-based therapeutics, pathway and target discovery, biological therapeutic modalities, translational bioinformatics, and system and synthetic biology. Additional sections cover drug discovery, precision medicine and the socioeconomic impact of translational biotechnology. This book is valuable for bioinformaticians, biotechnologists, and members of the biomedical field who are interested in learning more about this promising field. - Explains biotechnology in a different light by using an application-oriented approach - Discusses practical approaches in the development of precision medicine tools, systems and dynamical medicine approaches - Promotes research in the field of biotechnology that is translational in nature, cost-effective and readily available to the community
Author : William D. Lubell
Publisher : Springer
ISBN 13 : 3319491245
Total Pages : 267 pages
Book Rating : 4.3/5 (194 download)
Download or read book Peptidomimetics II written by William D. Lubell and published by Springer. This book was released on 2016-11-25 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.
