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Intraflagellar Transport In Caenorhabditis Elegans
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Book Synopsis Intraflagellar Transport in Caenorhabditis Elegans by : Peter Nicholas Inglis
Download or read book Intraflagellar Transport in Caenorhabditis Elegans written by Peter Nicholas Inglis and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intraflagellar transport (IFT) is the dynamic bidirectional process required for the biogenesis and maintenance of eukaryotic cilia. Landmark studies exploiting the model organism Chlamydomonas reinhardtii have provided a basic mechanism for the process, although recent research examining IFT in the nematode Caenorhabditis elegans has revealed a greater complexity to the original model of IFT described in Chlamydomonas, which includes the orthologues of several human proteins involved in cilium-associated diseases. The wealth of genomic, bioinformatic, and molecular tools available to C. elegans researchers is exploited in this thesis to uncover and characterise a number of novel proteins involved in the process of IFT, namely DYF-11, MKS-1, MKSR-1, and MKSR-2. DYF-11 localises throughout nematode ciliary structures and acts as a key component of the core IFT subcomplex B. The latter three proteins are members of a previously uncharacterised family of B9-domain containing polypeptides, all of which appear to localise at the base of cilia (basal body/transition zone), where they are found to regulate a cilium-based insulin signalling pathway. The results of this study contribute to the growing realisation in C. elegans cilia research that a network of transition-zone-specific proteins are participating in ciliary processes ranging from subtle modulation of ciliary signalling pathways to the actual biogenesis and maintenance of the organelle. Next, we examine previously isolated nematode strains that are defective in paraquat resistance for impaired retrograde IFT. We identify a retrograde-IFT deficient strain that likely represents a mutation in an IFT component that has not been previously characterised in C. elegans; the mutation maps closely to a highly conserved protein identified as a core component of IFT subcomplex A. Finally, we examine the role played by the IFT-associated Bardet-Biedl syndrome (BBS) proteins in C. elegans thermosensation. bbs mutant worms appear to be slightly defective in responding to both noxious and physiological temperatures. Furthermore, the nature of the physiological temperature defect correlates with a decreased roaming ability that is not the result of impaired locomotion. Altogether, the studies presented in this thesis offer novel insights into both the molecular makeup and physiological functions of IFT in C. elegans.
Book Synopsis Regulation of Intraflagellar Transport in the Sensory Cilia of Caenorhabditis Elegans by : Jan Adrianus Burghoorn
Download or read book Regulation of Intraflagellar Transport in the Sensory Cilia of Caenorhabditis Elegans written by Jan Adrianus Burghoorn and published by . This book was released on 2006 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dissection of the Intraflagellar Transport Protein Machinery in C. Elegans Neurons by : Guangshuo Ou
Download or read book Dissection of the Intraflagellar Transport Protein Machinery in C. Elegans Neurons written by Guangshuo Ou and published by . This book was released on 2006 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ensemble and Single-molecule Dynamics of Intraflagellar Transport in C. Elegans by :
Download or read book Ensemble and Single-molecule Dynamics of Intraflagellar Transport in C. Elegans written by and published by . This book was released on 2018 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis In Vitro Dissection of Intraflagellar Transport in C. Elegans Sensory Cilia by : Mohamed Antar Aziz Mohamed
Download or read book In Vitro Dissection of Intraflagellar Transport in C. Elegans Sensory Cilia written by Mohamed Antar Aziz Mohamed and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanism of Kinesin-II Function in Intraflagellar Transport in Caenorhabditis Elegans Sensory Cilia by : Xiaoyu Pan
Download or read book Mechanism of Kinesin-II Function in Intraflagellar Transport in Caenorhabditis Elegans Sensory Cilia written by Xiaoyu Pan and published by . This book was released on 2008 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Microtubule-based Transport in Ciliated Chemosensory Neurons of Caenorhabditis Elegans by : Dawn Signor
Download or read book Microtubule-based Transport in Ciliated Chemosensory Neurons of Caenorhabditis Elegans written by Dawn Signor and published by . This book was released on 2000 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cilia: Model Organisms and Intraflagellar Transport by :
Download or read book Cilia: Model Organisms and Intraflagellar Transport written by and published by Academic Press. This book was released on 2009-12-01 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia are highly conserved organelles that serve motile functions, sensory functions, or both. These organelles power cell movement, generate fluid flow in various organs, act as sensors of the extracellular environment and have been modified for various specialized tasks such as light reception and smell. Defects in these ubiquitous organelles lead to a broad array of human genetic disorders that range from polycystic kidney disease, retinal degeneration, epilepsy and infertility to developmental defects such as situs inversus and polydactyly. This volume is the third in a three-part series on cilia that focuses on the use of model organisms to gain insight into ciliary function and on the process of intraflagellar transport that is essential for the assembly and maintenance of ciliary structures. Includes both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time Covers forward and reverse genetic analysis of IFT and biochemical methods to define the role of IFT components Methods presented cover molecular, genetic, and biochemical approaches to ciliary function in model organisms
Download or read book Primary Cilia written by and published by Academic Press. This book was released on 2009-11-30 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. Covers protocols for primary cilia across several systems and species Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields
Book Synopsis Molecular Mechanisms of Sensory Receptor Trafficking in Caenorhabditis Elegans by : Young-Kyung Bae
Download or read book Molecular Mechanisms of Sensory Receptor Trafficking in Caenorhabditis Elegans written by Young-Kyung Bae and published by . This book was released on 2008 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cilia and Flagella written by and published by Academic Press. This book was released on 1995-08-31 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella. Key Features* A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher* Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals* Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR* Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures
Download or read book Dyneins written by Stephen M. King and published by Academic Press. This book was released on 2011-08-11 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine. Broad-based up-to-date resource for the dynein class of molecular motors Chapters written by world experts in their topics Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features
Book Synopsis Elucidating the Role of the C. Elegans Nephrocystins in Cilia by : Andrew Jauregui
Download or read book Elucidating the Role of the C. Elegans Nephrocystins in Cilia written by Andrew Jauregui and published by . This book was released on 2007 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Microtubule Dynamics by : Anne Straube
Download or read book Microtubule Dynamics written by Anne Straube and published by Humana Press. This book was released on 2017-04-30 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules are at the heart of cellular self-organization, and their dynamic nature allows them to explore the intracellular space and mediate the transport of cargoes from the nucleus to the outer edges of the cell and back. In Microtubule Dynamics: Methods and Protocols, experts in the field provide an up-to-date collection of methods and approaches that are used to investigate microtubule dynamics in vitro and in cells. Beginning with the question of how to analyze microtubule dynamics, the volume continues with detailed descriptions of how to isolate tubulin from different sources and with different posttranslational modifications, methods used to study microtubule dynamics and microtubule interactions in vitro, techniques to investigate the ultrastructure of microtubules and associated proteins, assays to study microtubule nucleation, turnover, and force production in cells, as well as approaches to isolate novel microtubule-associated proteins and their interacting proteins. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Definitive and practical, Microtubule Dynamics: Methods and Protocols provides the key protocols needed by novices and experts on how to perform a broad range of well-established and newly-emerging techniques in this vital field.
Book Synopsis TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by : Wolfgang B. Liedtke, MD, PH.D.
Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Book Synopsis The Development of Drosophila Melanogaster by : Michael Bate
Download or read book The Development of Drosophila Melanogaster written by Michael Bate and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fruit fly Drosophila melanogaster offers the most powerful means of studying embryonic development in eukaryotes. New information from many different organ systems has accumulated rapidly in the past decade. This monograph, written by the most distinguished workers in the field, is the most authoritative and comprehensive synthesis of Drosophila developmental biology available and emphasizes the insights gained by molecular and genetic analysis. In two volumes, it is a lavishly illustrated, elegantly designed reference work illustrating principles of genetic regulation of embryogenesis that may apply to other eukaryotes.
Book Synopsis Microinjection and Transgenesis by : Angel Cid-Arregui
Download or read book Microinjection and Transgenesis written by Angel Cid-Arregui and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: The establishment of microinjection protocols about 20 years ago for cultured cells and shortly thereafter for the generation of transgenic mice by microinjection of DNA into fertilized mouse eggs greatly influ enced many fields of biology. Not only have the data generated using these approaches contributed to a large extent to our present under standing of gene regulation and cellular function of higher eukaryotic cells, but current knowledge and future developments in this area will certainly have a great impact on basic and applied research for many years to come. This laboratory manual describes the current state of the art in this research area and focuses primarily on both the experimental strategies with an extensive bibliography and the detailed procedures. A large number of studies are presently being performed and a great variety of new experimental designs are rapidly being developed. The book con tains protocols on injection of somatic cells as well as on injection of embryos, the use of similar equipment being a common feature. In the articles dedicated to somatic cells, full descriptions of the manual and automatic injection systems are given as well as the methods for the analysis of injected cells by video-microscopy, electron microscopy or in situ hybridizations. In addition, comprehensive protocols are given for injection experiments with very different purposes, such as to study sig nal transduction or microtubule dynamics.
