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Author : Clifford J. Steer
Publisher : CUP Archive
ISBN 13 : 9780521361200
Total Pages : 798 pages
Book Rating : 4.3/5 (612 download)
Download or read book Intracellular Trafficking of Proteins written by Clifford J. Steer and published by CUP Archive. This book was released on 1991-07-18 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nava Segev
Publisher : Springer Science & Business Media
ISBN 13 : 038793877X
Total Pages : 459 pages
Book Rating : 4.3/5 (879 download)
Download or read book Trafficking Inside Cells written by Nava Segev and published by Springer Science & Business Media. This book was released on 2010-05-30 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Author : Y. Peng Loh
Publisher : CRC Press
ISBN 13 : 9780849368707
Total Pages : 312 pages
Book Rating : 4.3/5 (687 download)
Download or read book Mechanisms of Intracellular Trafficking and Processing of Proproteins written by Y. Peng Loh and published by CRC Press. This book was released on 1992-10-23 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Intracellular Trafficking and Processing of ProProteins provides an in-depth discussion of the cellular organization and current views of the molecular mechanisms underlying the trafficking, sorting, and processing of various classes of proproteins. The book covers the mechanisms of pro-protein translocation across the rough endoplasmic reticulum (RER) membrane and subsequent transport to the Golgi apparatus, molecular sorting and retention signals involved in directing pro-proteins to various cellular compartments, and the specific enzymes mediating different posttranslational modification steps. It is the only book that covers the principles of intracellular trafficking and processing of proproteins using examples representative of different classes of proproteins in the cell. New classes of enzymes, especially proteases with unique specificities, are examined as well. Mechanisms of Intracellular Trafficking and Processing of ProProteins presents a wealth of information valuable to cell biologists, endocrinologists, neurobiologists, enzymologists, and biochemists. Students studying molecular endocrinology, neurobiology, and cell biology will also find the book to be a useful text.
Author : Maria C. Pedroso De Lima
Publisher : Springer Science & Business Media
ISBN 13 : 3642795471
Total Pages : 366 pages
Book Rating : 4.6/5 (427 download)
Download or read book Trafficking of Intracellular Membranes: written by Maria C. Pedroso De Lima and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the lectures presented at the NATO Advanced Study Institute (ASI) on "Trafficking of Intracellular Membranes: From Molecular Sorting to Membrane Fusion", held in Espinho, Portugal, from June 19 to June 30,1994. The objective of this Institute was to survey recent developments and to discuss future directions in the rapidly advancing field of membrane cell biology, with particular emphasis on the dynamical properties and intracellular flow of membranes. A wide range of interrelated topics around the central theme of intracellular trafficking of membranes was covered, including lipid flow, membrane fusion, dynamics of membrane components, protein folding and assembly, vesicular transport in membrane biogenesis, exocytosis and endocytosis. A large variety of experimental techniques and systems, including the application of viruses and model systems, to study these processes was also considered. Membrane cell biology is a broad discipline which encompasses many scientific areas including cell biology, biochemistry, biophysics, virology, immunonology and genetics. Indeed, recent advances in the cell biology of membranes could not have been made without this multidisciplinary approach. Significant progress achieved during the last few years in understanding how newly synthesized lipids and proteins find their way to the cell organelles, how molecular sorting and the continuous flow of membranes allow each cellular membrane to maintain its own distinct molecular composition, and, thereby, the individuality of the various intracellular compartments, was discussed in considerable detail in this Institute.
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Silvana Zanlungo
Publisher : Frontiers Media SA
ISBN 13 : 2832509940
Total Pages : 237 pages
Book Rating : 4.8/5 (325 download)
Download or read book Cell compartments and intracellular trafficking of lipids and proteins: Impact on biomedicine written by Silvana Zanlungo and published by Frontiers Media SA. This book was released on 2022-12-30 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Richard A. Kahn
Publisher : Springer Science & Business Media
ISBN 13 : 1402017197
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)
Download or read book ARF Family GTPases written by Richard A. Kahn and published by Springer Science & Business Media. This book was released on 2004-02-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.
Author : Eric Wong
Publisher : Axolotl Academic Publishing
ISBN 13 : 0985226110
Total Pages : 283 pages
Book Rating : 4.9/5 (852 download)
Download or read book Cells: Molecules and Mechanisms written by Eric Wong and published by Axolotl Academic Publishing. This book was released on 2009 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.
Author : T.Y. Chang
Publisher : Springer Science & Business Media
ISBN 13 : 1461551137
Total Pages : 298 pages
Book Rating : 4.4/5 (615 download)
Download or read book Intracellular Cholesterol Trafficking written by T.Y. Chang and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: INTRODUCTION AND RATIONALE FOR INTRACELLULAR CHOLESTEROL TRAFFICKING This volume is an elaboration of an earlier small meeting held in St. Louis, Missouri. In April 1997, many of the authors met for a two-day meeting devoted entirely to intracellular cholesterol trafficking. The rationale for this meeting was that investigators interested in this topic worked in a variety of fields, and rarely, if ever, all met together. Everybody knew each other's papers but mostly worked in isolation from one another. Understanding of cholesterol trafficking also appeared to have reached the point where it would start to rapidly expand beyond these few laboratories. Understanding of cholesterol trafficking was moving from a largely descriptive science into the molecular age. It seemed a good time to get together and see how much we agreed upon up to this point. More authors contributed to this volume than attended the St. Louis meeting. That meeting was generously funded by grants from Bristol-Myers Squibb, Merck and Company and Parke-Davis, however, the total funding available limited the size of the meeting. For the book, we are not so limited and have tried to be as inclusive as possible and pretty much invited everyone who is presently active in this area. We were quite fortunate to successfully recruit the authors we sought for each of these chapters. The authors and their contributions can be organized by particular interests and particular areas of expertise.
Author : Rina Glozman
Publisher :
ISBN 13 :
Total Pages : 126 pages
Book Rating : 4.:/5 (61 download)
Download or read book Characterization of a Novel Ubiquitin-like Protein Family Involved in Intracellular Trafficking written by Rina Glozman and published by . This book was released on 2004 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Martin Chalfie
Publisher : John Wiley & Sons
ISBN 13 : 0471739480
Total Pages : 486 pages
Book Rating : 4.4/5 (717 download)
Download or read book Green Fluorescent Protein written by Martin Chalfie and published by John Wiley & Sons. This book was released on 2005-11-18 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of the gene for green fluorescent protein (GFP), derived from jellyfish, this protein that emits a green glow has initiated a revolution in molecular biosciences. With this tool, it is now possible to visualize nearly any protein of interest in any cell or tissue of any species. Since the publication of the first edition, there have been tremendously significant technological advances, including development of new mutant variants. Proteins are now available in yellow and blue, and Novel Fluorescent Proteins (NFPs) have expanded their utility in developing biosensors, biological markers, and other biological applications. This updated, expanded new edition places emphasis on the rise of NFPs, including new chapters on NFP properties with detailed protocols, applications of GFPs and NFPs in industry research, and biosensors. This book provides a solid theoretical framework, along with detailed, practical guidance on use of GFPs and NFPs with discussion of potential pitfalls. The expert contributors provide real examples in showing how to tailor GFP/NFP to specific systems, maximize expression, and enhance detection.
Author : Ralph A. Bradshaw
Publisher : Academic Press
ISBN 13 : 0080920918
Total Pages : 3188 pages
Book Rating : 4.0/5 (89 download)
Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field
Author : Andrew J. Bean
Publisher : Elsevier
ISBN 13 : 0080465897
Total Pages : 466 pages
Book Rating : 4.0/5 (84 download)
Download or read book Protein Trafficking in Neurons written by Andrew J. Bean and published by Elsevier. This book was released on 2006-10-27 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases. Provides a comprehensive examination of membrane/protein movement in neuronal function Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease Includes a focus on Molecular Mechanisms Illustrated with color summary pictures The only book examining protein trafficking and its functional implications, written by leaders in the field
Author : Stefan Offermanns
Publisher : Springer Science & Business Media
ISBN 13 : 3540389164
Total Pages : 1515 pages
Book Rating : 4.5/5 (43 download)
Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Author : S. Damjanovich
Publisher : CRC Press
ISBN 13 : 1351091573
Total Pages : 673 pages
Book Rating : 4.3/5 (51 download)
Download or read book Mobility and Proximity in Biological Membranes written by S. Damjanovich and published by CRC Press. This book was released on 2018-01-18 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell surface membranes have long been characterized as two-dimensional fluids whose mobile components are randomized by diffusion in the plane of the membrane bilayer. Recent research has indicated that cell surface membranes are highly organized and ordered and that important functional units of membranes appear as arrays of interacting molecules rather than as single, freely diffusing molecules. Mobility and Proximity in Biological Membranes provides an overview of the results obtained from biophysical methods for probing the organization of cell surface membranes. These results are presented in the context of detailed treatments of the theory and the technical demands of each of the methods. The book describes a versatile and easily applied mode for investigating molecular proximities in plasma membranes in a flow cytometer. Its analysis of lipid fluidity and viscosity of membranes and the rotational mobility of proteins offers intimate insight into the physical chemistry of biological membranes. The electrophysiology of lymphocytes is presented with focus on its importance in different diseases. New techniques are described, and new data, new possibilities, and future trends are presented by world experts. This book's chapters can serve both as guides to the existing literature and as starting points for new experiments and approaches associated with problems in membrane function.
Author : Kathleen FitzGerald
Publisher :
ISBN 13 :
Total Pages : 172 pages
Book Rating : 4.:/5 (795 download)
Download or read book An Investigation of the Intracellular Trafficking of Two Pathological Proteins written by Kathleen FitzGerald and published by . This book was released on 2004 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocytosis is a process whereby cargo is transported to and from the plasma membrane, and between organelles, in membrane-bound vesicles. The HIV encoded Nef protein is immunosuppressive and substantially contributes to the overall state of immune dysfunction associated with acquired immune deficiency syndrome. The pathological Nef protein has been implicated in modifying the receptor-mediated endocytic pathway. The transmissible spongiform encephalopathies caused by the infectious prion protein from a group of fatal neurodegenerative disorders that affect both animals and human. The trafficking of the prion protein is considered to play an essential role in its pathogenic conversion while the route and mechanism of the pathological prion protein remain controversial. The objective of this work was to investigate the intracellular trafficking of these two pathological proteins, Nef and prion, with emphasis on the localization and effects of Nef on proteins associated with the receptor-mediated endocytic pathway and emphasis on the cellular trafficking of the prion protein. Nef localizes primarily to the early sorting endosome and shows dramatic effects on the redistribution of the recycling compartment-associated proteins, Rab 11 and REM-1. Expression of the Nef mutant E160A, which is disrupted in its' ability to recruit the adaptor protein complex AP-3, resulted in a redistribution of the Rab11-positive compartment while having no effect on the localization of the RME-1 positive tubules. In contrast, expression of the Nef mutant LL164/165AA, which is disrupted in its' ability to recruit AP-1 and AP-3, results in a normal recycling compartment phenotype. These results suggest that Nefs' effect on the receptor-mediated endocytic pathway relies on its' ability to interact with adaptor protein complexes. A proportion of the pathological prion protein localized to the Rab4-positive early sorting endosome and recycling compartment. Analysis of the Rab4-positive compartment revealed that the form of the prion protein present was unglycosylated. Subsequently it was shown that trafficking of the prion protein through the caveolar pathway converged with the receptor-mediated endocytic pathway. The cause and significance of two distint pathways converging, with respect to prion protein trafficking, remains to be determined. This work raises the possibility that conversion may take place in the Rab4-positive compartment as it is consistent with previous data stating that conversion from normal to infectious prion protein takes place in an acidic environment similar to that found in endosomes and that conversion of the prion protein favours the unglycosylated form of the protein.
Author : J. Soll
Publisher : Springer Science & Business Media
ISBN 13 : 9780792352372
Total Pages : 410 pages
Book Rating : 4.3/5 (523 download)
Download or read book Protein Trafficking in Plant Cells written by J. Soll and published by Springer Science & Business Media. This book was released on 1998-08-31 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The highly structured eucaryotic cell with its complex division of biochemical labour requires a distinct protein complement in each cellular structure and compartment. Nuclear coded and cytosolically synthesized polypeptides are specifically sorted to every corner of the cell in a post- or co-translational manner. The presence of separate genomes and protein translation machineries in plastids and mitochondria requires further coordination not only on the transcriptional, translational but also most likely on the protein import level. Numerous different protein transport systems have developed and coexist within plant cells to ensure the specific and selective composition of every sub-cellular compartment. This volume summarizes the current knowledge on protein trafficking in plant cells. Aside from the fundamental aspects in cell biology of how specific pre-protein sorting and translocation across biological membranes is achieved, a major focus is on transport, modification and deposition of plant storage proteins. The increasing use of plants as bioreactors to provide custom-designed proteins of different usage requires detailed understanding of these events. This text is directed not only at students and professionals in plant cell and molecular biology but also at those involved in horticulture and plant breeding. It is intended to serve as a text and guide for graduate-level courses on plant cell biology and as a valuable supplement to courses in plant physiology and development. Scientists in other disciplines who wish to learn more about protein translocation in plants will also find this text an up-to-date source of information and reference.
