Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Interferon G63 Interferon Gamma Induced Transcriptional Regulation Of Ciita The Key Factor Of Mhc Class Ii Expression
Download Interferon G63 Interferon Gamma Induced Transcriptional Regulation Of Ciita The Key Factor Of Mhc Class Ii Expression full books in PDF, epub, and Kindle. Read online Interferon G63 Interferon Gamma Induced Transcriptional Regulation Of Ciita The Key Factor Of Mhc Class Ii Expression ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Interferon-_g63 [Interferon-gamma] Induced Transcriptional Regulation of CIITA, the Key Factor of MHC Class II Expression by : Sven Andrés König Merediz
Download or read book Interferon-_g63 [Interferon-gamma] Induced Transcriptional Regulation of CIITA, the Key Factor of MHC Class II Expression written by Sven Andrés König Merediz and published by . This book was released on 1999 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chromatin Regulation of MHC Class II Expression by :
Download or read book Chromatin Regulation of MHC Class II Expression written by and published by . This book was released on 2007 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eukaryotic cell, DNA is assembled into higher order structure to allow the packaging of genetic material into the confined space within the cell nucleus. Chromatin remodeling must occur too allow transcription factors binding and the activation of gene expression. Class II transactivator (CIITA) is the master regulator of MHC class II expression and it has been shown to participate in chromatin remodeling at the MHC class II promoter. We found that in several tumor cell lines (Colon 26 and RJ2.2.5), MHC class II expression is silenced and can be induced by treatment with the histone deacetylase inhibitor Trichostatin A (TSA) in the absence of CIITA. Although Colon 26 contains an intrinsic, active IFN-[gamma] pathway, TSA pretreatment inhibited the IFN-[gamma] induced STAT-1 phosphorylation suggesting a different TSA activation pathway from that induced by IFN-[gamma]. Chromatin immunoprecipitation (ChIP) assays demonstrated similar patterns of histone modification changes upon IFN-[gamma] (CIITA-dependent) and TSA (CIITA-independent) stimulation. Both IFN-[gamma] and TSA treated cells demonstrated an enhancement of markers associated with active gene expression (Acetylated histone H3 and H4 and trimethylated H3 lysine 4) at the MHC class II promoter while the level of the repressive state marker, trimethylated H3 lysine 9, was decreased. Unlike other histone modifications, enhanced trimethylated H3 lysine 36 was detected at the 3'region but not the promoter of the MHC class II gene in both IFN-[gamma] inducible (HeLa) and TSA inducible (RJ2.2.5) cell lines. Such differential localization of the histone modifications suggests that each mark may be involved in the different phases of the transcription process. H3K79me2 remained unchanged and at low level after IFN-[gamma] (HeLa) or TSA (RJ2.2.5) treatment when compared to the MHC class II expressing cell line Raji. However, H3K79 methylation can be rescued by the reconstitution of CIITA expression in the CIITA deficient cell line RJ2.2.5 by stable transfection. Together, our data suggests that TSA treatment can replace the function of CIITA in activating MHC class II expression. Although IFN-[gamma] and TSA induced MHC class II expression through different regulatory pathways, both resulted in similar patterns of histone modifications and chromatin remodeling. Lastly, CIITA may be crucial for the recruitment of histone methyltransferase to the MHC class II gene.
Book Synopsis Mechanisms by which CIITA Regulates the Expression of MHC Class II Genes and Other Genes of the Immune System by : Tyler James Sisk
Download or read book Mechanisms by which CIITA Regulates the Expression of MHC Class II Genes and Other Genes of the Immune System written by Tyler James Sisk and published by . This book was released on 2001 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Mechanism of Interferon-beta Inhibition of Interferon-gamma-induced MHC Class II Gene Expression by : Hong-Tao Lu
Download or read book Molecular Mechanism of Interferon-beta Inhibition of Interferon-gamma-induced MHC Class II Gene Expression written by Hong-Tao Lu and published by . This book was released on 1996 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of MHC Class II Expression Via CIITA Protein Interactions and Phosphorylation by : Kevin M. Nickerson
Download or read book Regulation of MHC Class II Expression Via CIITA Protein Interactions and Phosphorylation written by Kevin M. Nickerson and published by . This book was released on 2006 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modulation of MHC Antigen Expression and Disease by : G. Eric Blair
Download or read book Modulation of MHC Antigen Expression and Disease written by G. Eric Blair and published by Cambridge University Press. This book was released on 1995-11-09 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.
Book Synopsis Interferon Regulatory Factors—Advances in Research and Application: 2012 Edition by :
Download or read book Interferon Regulatory Factors—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interferon Regulatory Factors—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Interferon Regulatory Factors in a compact format. The editors have built Interferon Regulatory Factors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Interferon Regulatory Factors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Interferon Regulatory Factors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis The Regulation of IFN-[gamma] Inducible MHC Class II Gene Expression by the Retinoblastoma Tumor Suppressor Protein by : Yanmei Lu
Download or read book The Regulation of IFN-[gamma] Inducible MHC Class II Gene Expression by the Retinoblastoma Tumor Suppressor Protein written by Yanmei Lu and published by . This book was released on 1995 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modulation of IFN-[gamma]-induced MHC Class II Gene Expression in Human Vascular Endothelial Cells by Porphyromonas Gingivalis Membrane Vesicles by : Ratchapin Srisatjaluk
Download or read book Modulation of IFN-[gamma]-induced MHC Class II Gene Expression in Human Vascular Endothelial Cells by Porphyromonas Gingivalis Membrane Vesicles written by Ratchapin Srisatjaluk and published by . This book was released on 2001 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Gamma Interferon-Induced Expression of Class II MHC Antigens by Human Keratinocytes: Effects of Conditions of Culture by : Vera B. Morhenn
Download or read book Gamma Interferon-Induced Expression of Class II MHC Antigens by Human Keratinocytes: Effects of Conditions of Culture written by Vera B. Morhenn and published by . This book was released on 1987 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normal human keratinocytes grown in MCDB 153 plus bovine pituitary extract and treated with recombinant gamma interferon (rIFN gamma) express HLA-DR, DP and DQ antigens. The expression of these class II Major Histocompatibility Complex antigens is time dependent: DR and DP appear before DQ. The delay in the HLA-DQ expression is not due to the effects of trypsinization of cultures prior to analysis. Increasing the calcium ion concentration from 0.1 to 1.8 mM does not alter the expression of these antigens. Keratinocytes grown without serum proteins or bovine pituitary extract exhibited markedly delayed expression of DR. By contrast, keratinocytes grown in Dulbecco's modified Eagle's medium (DMEM) plus 10% fetal calf serum express DR and DP but only very small amounts of DQ after treatment with rIFN gamma. Expression of HLA-DR occurs at doses of rIFN gamma that are too low to cause growth inhibition. The cells of the squamous cell line SCL-1, whether grown in MCDB 153 plus bovine pituitary extract or DMEM plus 10% fetal calf serum, express HLA-DQ and DP on only small numbers of cells after treatment with the lymphokine. Thus, the conditions of culture, possibly the presence of a serum factor(s), influence the expression of class II antigens in normal keratinocytes. Furthermore, rIFN gamma does not induce DP and DQ antigens readily in transformed squamous cells cultured in either serum-containing or serum-free medium. (aw).
Book Synopsis Gamma Interferon in Antiviral Defense by : Gunasegaran Karupiah
Download or read book Gamma Interferon in Antiviral Defense written by Gunasegaran Karupiah and published by Landes Bioscience. This book was released on 1997 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of S7, a Subunit of the 19S Proteasome, in the Transcriptional Regulation of MHC II by :
Download or read book The Role of S7, a Subunit of the 19S Proteasome, in the Transcriptional Regulation of MHC II written by and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Induction of an adaptive, or antigen specific, immune response is critical for eliminating most infections. Pathogen clearance is accomplished primarily, by the actions of CD4+ T cells through their ability to recognize foreign antigens presented at the cell surface by major histocompatibility class II (MHC II) molecules. Consequently, the capacity to regulate expression of MHC molecules is essential to control the adaptive immune response. MHC molecules are regulated at the level of transcription by a master regulator, the class II transcriptional activator, CIITA. Thus, the expression of MHC II is directly related to proper CIITA activity. This thesis focuses on the novel role of S7, an ATPase subunit of the 19S proteasome, in the transcriptional regulation of CIITA and MHC II molecules.
Book Synopsis Transcriptional Regulation of Class II Transactivator by Interferon Regulatory Factor-2 by : Hongkang Xi
Download or read book Transcriptional Regulation of Class II Transactivator by Interferon Regulatory Factor-2 written by Hongkang Xi and published by . This book was released on 2001 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization and Mechanism of Action of Interferon-gamma Inhibitory Oligodeoxynucleotides by : Murali Ramanathan
Download or read book Characterization and Mechanism of Action of Interferon-gamma Inhibitory Oligodeoxynucleotides written by Murali Ramanathan and published by . This book was released on 1995 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis MHC Gene Regulation by : Kathleen E. Sullivan
Download or read book MHC Gene Regulation written by Kathleen E. Sullivan and published by . This book was released on 1987 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Interferon Gamma Induces MHC Class I, II Expression on Primary Pancreatic Cancer Cells and Enhances Their Recognition by Autologous Cytotoxic and Helper T-cells by : Luis Vidal Galindo Escobedo
Download or read book Interferon Gamma Induces MHC Class I, II Expression on Primary Pancreatic Cancer Cells and Enhances Their Recognition by Autologous Cytotoxic and Helper T-cells written by Luis Vidal Galindo Escobedo and published by . This book was released on 2006 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Post-transcriptional Regulation of Interferon-gamma Gene Expression by :
Download or read book Post-transcriptional Regulation of Interferon-gamma Gene Expression written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Interferon-_g63 [Interferon-gamma] Induced Transcriptional Regulation of CIITA, the Key Factor of MHC Class II Expression PDF Online Free](https://books.google.com/books/content/images/frontcover/kDEwAAAACAAJ?fife=w200-h370)
![Download The Regulation of IFN-[gamma] Inducible MHC Class II Gene Expression by the Retinoblastoma Tumor Suppressor Protein PDF Online Free](https://books.google.com/books/content/images/frontcover/hjj8tgAACAAJ?fife=w200-h370)
![Download Modulation of IFN-[gamma]-induced MHC Class II Gene Expression in Human Vascular Endothelial Cells by Porphyromonas Gingivalis Membrane Vesicles PDF Online Free](https://books.google.com/books/content/images/frontcover/ldZCOAAACAAJ?fife=w200-h370)
