Interfering with Inflammation: Heterogeneous Effects of Interferons in Graft-versus-host Disease of the Gastrointestinal Tract and Inflammatory Bowel Disease

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (126 download)

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Book Synopsis Interfering with Inflammation: Heterogeneous Effects of Interferons in Graft-versus-host Disease of the Gastrointestinal Tract and Inflammatory Bowel Disease by : Eileen Haring

Download or read book Interfering with Inflammation: Heterogeneous Effects of Interferons in Graft-versus-host Disease of the Gastrointestinal Tract and Inflammatory Bowel Disease written by Eileen Haring and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Interferons and graft-versus-host disease

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Publisher : Frontiers Media SA
ISBN 13 : 2832511473
Total Pages : 113 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Interferons and graft-versus-host disease by : Jaebok Choi

Download or read book Interferons and graft-versus-host disease written by Jaebok Choi and published by Frontiers Media SA. This book was released on 2023-01-13 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The European Blood and Marrow Transplantation Textbook for Nurses

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Publisher : Springer
ISBN 13 : 3319500260
Total Pages : 318 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis The European Blood and Marrow Transplantation Textbook for Nurses by : Michelle Kenyon

Download or read book The European Blood and Marrow Transplantation Textbook for Nurses written by Michelle Kenyon and published by Springer. This book was released on 2018-03-14 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

Human Gastrointestinal Development

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Publisher : Raven Press (ID)
ISBN 13 :
Total Pages : 854 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Human Gastrointestinal Development by : Emanuel Lebenthal

Download or read book Human Gastrointestinal Development written by Emanuel Lebenthal and published by Raven Press (ID). This book was released on 1989 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Inflammation and Cancer

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Publisher : Springer
ISBN 13 : 3034808372
Total Pages : 489 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Inflammation and Cancer by : Bharat B. Aggarwal

Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Inflammation, Oxidative Stress, and Cancer

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Publisher : CRC Press
ISBN 13 : 1466503718
Total Pages : 631 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Inflammation, Oxidative Stress, and Cancer by : Ah-Ng Tony Kong

Download or read book Inflammation, Oxidative Stress, and Cancer written by Ah-Ng Tony Kong and published by CRC Press. This book was released on 2016-04-19 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and

Biomedical Index to PHS-supported Research

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Publisher :
ISBN 13 :
Total Pages : 1104 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Biomedical Index to PHS-supported Research by :

Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1991 with total page 1104 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immunopharmacology

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Publisher : Springer Science & Business Media
ISBN 13 : 0387779760
Total Pages : 275 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Immunopharmacology by : Manzoor M. Khan

Download or read book Immunopharmacology written by Manzoor M. Khan and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.

Research Awards Index

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Publisher :
ISBN 13 :
Total Pages : 742 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1989 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hematopoietic Stem Cell Biology

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Publisher : Springer Science & Business Media
ISBN 13 : 1603273476
Total Pages : 260 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Hematopoietic Stem Cell Biology by : Motonari Kondo

Download or read book Hematopoietic Stem Cell Biology written by Motonari Kondo and published by Springer Science & Business Media. This book was released on 2009-12-04 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the summer of 1988, my developmental biology professor announced to the class that hematopoietic stem cells (HSCs) had finally been purified. Somehow, I never forgot the professor’s words. When I started working in Dr. Irv Weissman’s labo- tory at Stanford as a postdoctoral fellow, I realized that the findings mentioned by the professor were from Weissman’s laboratory and had been published in a 1988 edition of the journal Science. It has been over 20 years since the publication of that seminal paper, and since then tremendous advances in understanding the biology and maturation of HSCs, namely the process of hematopoiesis, which includes lymphocyte development, have been made. These discoveries were made possible in part by advancements in technology. For example, recent availability of user friendly fluorescence activated cell sorting (FACS) machines and monoclonal an- bodies with a variety of fluorescent labels has allowed more scientists to sort and analyze rare populations in the bone marrow, such as HSCs. All classes of hematopoietic cells are derived from HSCs. Stem cell biology draws enormous attention not only from scientists, but also from ordinary people because of the tremendous potential for development of new therapeutic application to diseases that currently lack any type of effective therapy. Thus, this type of “regenerative medicine” is a relatively new and attractive field in both basic science and clinical medicine.

Liver Disease in Children

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Publisher : Cambridge University Press
ISBN 13 : 1108911374
Total Pages : 875 pages
Book Rating : 4.1/5 (89 download)

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Book Synopsis Liver Disease in Children by : Frederick J. Suchy

Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.

Signaling Mechanisms Regulating T Cell Diversity and Function

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Publisher : CRC Press
ISBN 13 : 149870509X
Total Pages : 258 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Signaling Mechanisms Regulating T Cell Diversity and Function by : Jonathan Soboloff

Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Inflammasomes: Clinical and Therapeutic Implications

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Publisher : Springer
ISBN 13 : 3319893904
Total Pages : 400 pages
Book Rating : 4.3/5 (198 download)

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Book Synopsis Inflammasomes: Clinical and Therapeutic Implications by : Mario D. Cordero

Download or read book Inflammasomes: Clinical and Therapeutic Implications written by Mario D. Cordero and published by Springer. This book was released on 2018-09-04 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1β has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.

Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2

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Publisher : Springer Science & Business Media
ISBN 13 : 1461553598
Total Pages : 1013 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2 by : David A. Sullivan

Download or read book Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2 written by David A. Sullivan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1013 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past two decades, a significant international research effort has been di rected toward understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays an essential role in maintaining corneal and conjunctival integrity, protecting against microbial challenge, and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in countless individuals throughout the world, may lead to desiccation of the ocular surface, ulceration and perfo ration of the cornea, an increased incidence of infectious disease, and, potentially, pro nounced visual disability and blindness. To promote further progress in this field of vision research, the Second International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance was held at the Southampton Princess Resort in Bermuda November 16-19, 1996. This conference was organized and directed by David A. Sullivan, Ph. D. , codirected by Darlene A. Dartt, Ph. D. , and Michele A. Meneray, Ph. D. , and sponsored by the Schepens Eye Research Institute (Boston, MA), an affiliate of Harvard Medical School. The meeting was designed to assess critically the current knowledge and "state of the art" research on the structure and function of lacrimal tissue, tears, and the ocular sur face in both health and disease.

Selective COX-2 Inhibitors

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Publisher : Springer Science & Business Media
ISBN 13 : 9401148724
Total Pages : 153 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Selective COX-2 Inhibitors by : Sir John R. Vane

Download or read book Selective COX-2 Inhibitors written by Sir John R. Vane and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mainstay of therapy for rheumatoid disease is the non-steroid antiinflammatory drugs (NSAIDs), despite their inherent gastrointestinal toxicity and ability to cause renal damage in susceptible patients. The theory that the beneficial and toxic effects of NSAIDs stem from a reduction in prostanoid production through inhibition of cyclooxygenase implied that particular toxicities were inevitable with NSAIDs and would always be correlated with efficacy. However, over the years, it became apparent that at therapeutic doses, some NSAIDs had greater toxic side-effects than others, a fact not explained by the general theory. A significant clarification arose from the discovery that there are two distinct isoforms of COX, a constitutive enzyme (COX-I) responsible for the production of prostanoids necessary for platelet aggregation and protection of the gastric mucosa and kidney; and an inducible enzyme (COX-2) that is newly synthesized at sites of tissue damage and produces prostaglandins that manifest pathological effects. It became clear that different NSAIDs had greater or lesser effects on COX-I when used in therapeutic doses, explaining the variation in side-effects. ' The elucidation of the crystal structure of these different enzymes and the skills of medicinal chemists have led to the synthesis of new chemicals with a selectivity for the inducible enzyme, and thus with therapeutic efficacy without those toxic effects result ing from inhibition of the constitutive enzyme.

Infections in Pregnancy

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Publisher : Cambridge University Press
ISBN 13 : 1108716636
Total Pages : 215 pages
Book Rating : 4.1/5 (87 download)

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Book Synopsis Infections in Pregnancy by : Adel Elkady

Download or read book Infections in Pregnancy written by Adel Elkady and published by Cambridge University Press. This book was released on 2019-10-24 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides effective diagnosis and management of infectious diseases in pregnant women in a single comprehensive available resource for busy clinicians.

Adaptive Oncogenesis

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Publisher : Harvard University Press
ISBN 13 : 0674545397
Total Pages : 289 pages
Book Rating : 4.6/5 (745 download)

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Book Synopsis Adaptive Oncogenesis by : James DeGregori

Download or read book Adaptive Oncogenesis written by James DeGregori and published by Harvard University Press. This book was released on 2018-03-09 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancerÕs occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the bodyÕs tissues. His theory ties cancerÕs progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genesÑbut not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cellsÕ ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a speciesÕ habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregoriÕs perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissuesÕ natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective.