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Interaction Of Translational And Transcriptional Controls In The Regulation Of Gene Expression
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Book Synopsis Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression by : Marianne Grunberg-Manago
Download or read book Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression written by Marianne Grunberg-Manago and published by Elsevier. This book was released on 2012-12-02 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression presents the proceedings of the Fogarty International Conference on Translational/Transcriptional Regulation of Gene Expression, held at the National Institutes of Health in Bethesda, Maryland, on April 7-9, 1982. Speakers discussed the molecular strategies at work during the modulation of gene expression following transcriptional initiation. They also discussed recent developments in a number of key areas in which transcriptional and translational components interact. Organized into five sections encompassing 36 chapters, this volume explores both prokaryotic and eukaryotic systems, as well as structure-function correlations. It begins with an overview of translational/transcriptional controls in prokaryotes, the regulation of gene expression by transcription termination and RNA processing, and the structure and expression of initiation factor genes. It then examines the effect of the codon context on translational fidelity, including mistranslation of messenger RNA; protein synthesis for the construction of cell architecture; regulation of initiation factor activity; and translational regulation in cells. This book is a valuable resource for Fogarty International Scholars who want to broaden their knowledge and contribute their expertise to the National Institutes of Health community.
Book Synopsis Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression by :
Download or read book Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression written by and published by . This book was released on 1982 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Translational Control of Gene Expression by : Nahum Sonenberg
Download or read book Translational Control of Gene Expression written by Nahum Sonenberg and published by CSHL Press. This book was released on 2001 with total page 1034 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translation control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translation machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.
Book Synopsis Post-Transcriptional Control of Gene Expression in Plants by : Witold Filipowicz
Download or read book Post-Transcriptional Control of Gene Expression in Plants written by Witold Filipowicz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: A recent volume of this series (Signals and Signal Transduction Pathways in Plants (K. Palme, ed.) Plant Molecular Biology 26, 1237-1679) described the relay races by which signals are transported in plants from the sites of stimuli to the gene expression machinery of the cell. Part of this machinery, the transcription apparatus, has been well studied in the last two decades, and many important mechanisms controlling gene expression at the transcriptional level have been elucidated. However, control of gene expression is by no means complete once the RNA has been produced. Important regulatory devices determine the maturation and usage of mRNA and the fate of its translation product. Post-transcriptional regulation is especially important for generating a fast response to environmental and intracellular signals. This book summarizes recent progress in the area of post-transcriptional regulation of gene expression in plants. 18 chapters of the book address problems of RNA processing and stability, regulation of translation, protein folding and degradation, as well as intracellular and cell-to-cell transport of proteins and nucleic acids. Several chapters are devoted to the processes taking place in plant organelles.
Book Synopsis Post-transcriptional Control of Gene Expression by : Orna Resnekov
Download or read book Post-transcriptional Control of Gene Expression written by Orna Resnekov and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many important cellular processes rely on posttranscriptional control of gene expression. This book describes the mechanisms of gene expression at this level that occur in the cytoplasm of prokaryotes and eukaryotes. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed. Subsequent chapters discuss protein folding, transport, modification and degradation. The book is an invaluable source of information for both newcomers and those wishing an overview of the field.
Book Synopsis Translational Regulation of Gene Expression 2 by : J. Ilan
Download or read book Translational Regulation of Gene Expression 2 written by J. Ilan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which results from the dramatic increase in interest in the control mechanism employed in gene expression and the importance of the regulated proteins, presents new information not covered in Translational Regulation of Gene Expression, which was published in 1987. It is not a revision of the earlier book but, rather, an extension of that volume witl, special emphasis on mecha nIsm. As the reader will discover, there is enormous diversity in the systems employing genes for translational regulation in order to regulate the appearance of the final product-the protein. Thus, we find that important proteins such as protooncogenes, growth factors, stress proteins, cytokines, lymphokines, iron storage and iron-uptake proteins, and a panorama of prokaryotic proteins, as well as eukaryotic viral proteins, are translationally regulated. Since for some gene products the degree of control is greater by a few orders of magnitude than their transcription, we can state that for these genes, at least, the expression is translationall y controlled. Translational regulation of gene expression in eukaryotes has emerged in the last few years as a major research field. The present book describes mechanisms of translational regulation in bacteria, yeast, and eukaryotic viruses, as well as in eukaryotic genes. In this book we try to provide in-depth coverage by including important examples from each group rather than systematically including all additional systems not described in the previous volume.
Book Synopsis Translational Control in Health and Disease by :
Download or read book Translational Control in Health and Disease written by and published by Academic Press. This book was released on 2009-10-26 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology and translational science. It contains contributions from leaders in their fields and abundant references. This volume focuses on translational control in health and disease. - Contributions from leading scholars and industry experts - Reference guide for researchers involved in molecular biology and related fields
Book Synopsis Transcriptional and Translational Regulation of Stem Cells by : Gary Hime
Download or read book Transcriptional and Translational Regulation of Stem Cells written by Gary Hime and published by Springer Science & Business Media. This book was released on 2013-05-22 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.
Book Synopsis RNA Binding Proteins by : Kathryn Sandberg
Download or read book RNA Binding Proteins written by Kathryn Sandberg and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA binding proteins are an exciting area of research in gene regulation. A multitude of RNA-protein interactions are used to regulate gene expression including pre-mRNA splicing, polyadenylation, editing, transport, cytoplasmic targeting, translation and mRNA turnover. In addition to these post-transcriptional processes, RNA-protein interactions play a key role in transcription as illustrated by the life cycle of retroviruses. Unlike DNA, the structure of RNA is highly variable and conformationally flexible, thus creating a number of unique binding sites and the potential for complex regulation by RNA binding proteins. Although there is a wide range of topics included in this volume, general themes have been repeated, highlighting the overall integrative nature of RNA binding proteins. The chapters have been separated into three different sections: Translational Control; mRNA Metabolism; and Hormonal and Homeostatic Regulation. The chapters of this volume were written with the seasoned investigator and student in mind. Summaries of key concepts are reviewed within each chapter as well as guiding questions that can be used to stimulate class discussions. The Editors of this volume hope that this compendium educates, enthralls, and stimulates the readers to look to the future possibilities in this rapidly evolving field.
Book Synopsis Gene Control, Second Edition by : David Latchman
Download or read book Gene Control, Second Edition written by David Latchman and published by Garland Science. This book was released on 2015-02-20 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of Gene Control has been updated to include significant advances in the roles of the epigenome and regulatory RNAs in gene regulation. The chapter structure remains the same: the first part consists of pairs of chapters that explain the mechanisms involved and how they regulate gene expression, and the second part deals with specific biological processes (including diseases) and how they are controlled by genes. Coverage of methodology has been strengthened by the inclusion more explanation and diagrams.The significant revision and updating will allow Gene Control to continue to be of value to students, scientists and clinicians interested in the topic of gene control.
Book Synopsis mRNA Metabolism & Post-Transcriptional Gene Regulation by : Joe B. Harford
Download or read book mRNA Metabolism & Post-Transcriptional Gene Regulation written by Joe B. Harford and published by John Wiley & Sons. This book was released on 1997-03-28 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION Edited by Joe B. Harford and David R. Morris Gene expression is a process that begins with the transcription ofDNA to an RNA messenger (mRNA), which is then translated into aprotein. Historically, attention has been focused on the regulationof RNA synthesis (transcription); however, there is a growingrecognition of and appreciation for the importance of the manyregulatory mechanisms that take place after RNA synthesis has beencompleted. mRNA Metabolism and Post-Transcriptional Gene Regulation is thefirst comprehensive overview of the various modes of generegulation that exist post-transcriptionally. Collecting studies bysome of the top researchers in the field, this volume provides bothan up-to-date review of the complex "life" of an mRNA molecule andan introduction to current work on the diversity of mechanisms ofpost-transcriptional reactions. Topics covered include: * RNA structure * Mammalian RNA editing * RNA export from the nucleus * The fundamentals of translation initiation * Control of mRNA decay in plants * mRNA metabolism and cancer * Control of mRNA stability during herpes simplex virus infection * Regulation of mRNA expression in HIV-1 and other complexretroviruses * Nucleases * RNA localization A timely contribution to the understanding of genetic regulatorymechanisms, mRNA Metabolism and Post-Transcriptional GeneRegulation provides a basis from which potential therapeuticstrategies may be developed. This book will be of vital interest tocell and molecular biologists at all levels, from graduate studentsto senior investigators, clinical researchers, and professionals inthe pharmaceutical and biotechnology industries.
Book Synopsis Prokaryotic Gene Expression by : Simon Baumberg
Download or read book Prokaryotic Gene Expression written by Simon Baumberg and published by OUP Oxford. This book was released on 1999-05-27 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prokaryotic gene expression is not only of theoretical interest but also of highly practical significance. It has implications for other biological problems, such as developmental biology and cancer, brings insights into genetic engineering and expression systems, and has consequences for important aspects of applied research. For example, the molecular basis of bacterial pathogenicity has implications for new antibiotics and in crop development. Prokaryotic Gene Expression is a major review of the subject, providing up-to-date coverage as well as numerous insights by the prestigious authors. Topics covered include operons; protein recognition of sequence specific DNA- and RNA-binding sites; promoters; sigma factors, and variant tRNA polymerases; repressors and activators; post-transcriptional control and attenuation; ribonuclease activity, mRNA stability, and translational repression; prokaryotic DNA topology, topoisomerases, and gene expression; regulatory networks, regulatory cascades and signal transduction; phosphotransfer reactions; switch systems, transcriptional and translational modulation, methylation, and recombination mechanisms; pathogenicity, toxin regulation and virulence determinants; sporulation and genetic regulation of antibiotic production; origins of regulatory molecules, selective pressures and evolution of prokaryotic regulatory mechanisms systems. Over 1100 references to the primary literature are cited. Prokaryotic Gene Expression is a comprehensive and authoritative review of current knowledge and research in the area. It is essential reading for postgraduates and researchers in the field. Advanced undergraduates in biochemistry, molecular biology, and microbiology will also find this book useful.
Book Synopsis Translational Control by : Michael B. Mathews
Download or read book Translational Control written by Michael B. Mathews and published by . This book was released on 1986 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biophysical Approaches to Translational Control of Gene Expression by : Jonathan D. Dinman
Download or read book Biophysical Approaches to Translational Control of Gene Expression written by Jonathan D. Dinman and published by Springer Science & Business Media. This book was released on 2012-07-27 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights major advances in researching a cell’s molecular machinery through analytical, computational, and imaging methods. It focuses on developing biophysical approaches to studying control of gene expression at the translational level.
Book Synopsis Translational Regulation of Gene Expression by : J. Ilan
Download or read book Translational Regulation of Gene Expression written by J. Ilan and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Untranslated Gene Regions and Other Non-coding Elements by : Lucy W. Barrett
Download or read book Untranslated Gene Regions and Other Non-coding Elements written by Lucy W. Barrett and published by Springer Science & Business Media. This book was released on 2013-06-26 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
