Integrative Approaches For Mining High Throughput Genomic Data

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Knowledge-Based Bioinformatics

Author : Gil Alterovitz
Publisher : John Wiley & Sons
ISBN 13 : 1119995833
Total Pages : 306 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Knowledge-Based Bioinformatics by : Gil Alterovitz

Download or read book Knowledge-Based Bioinformatics written by Gil Alterovitz and published by John Wiley & Sons. This book was released on 2011-04-20 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an increasing need throughout the biomedical sciences for a greater understanding of knowledge-based systems and their application to genomic and proteomic research. This book discusses knowledge-based and statistical approaches, along with applications in bioinformatics and systems biology. The text emphasizes the integration of different methods for analysing and interpreting biomedical data. This, in turn, can lead to breakthrough biomolecular discoveries, with applications in personalized medicine. Key Features: Explores the fundamentals and applications of knowledge-based and statistical approaches in bioinformatics and systems biology. Helps readers to interpret genomic, proteomic, and metabolomic data in understanding complex biological molecules and their interactions. Provides useful guidance on dealing with large datasets in knowledge bases, a common issue in bioinformatics. Written by leading international experts in this field. Students, researchers, and industry professionals with a background in biomedical sciences, mathematics, statistics, or computer science will benefit from this book. It will also be useful for readers worldwide who want to master the application of bioinformatics to real-world situations and understand biological problems that motivate algorithms.

Integrative Omics

Author : Manish Kumar Gupta
Publisher : Elsevier
ISBN 13 : 0443160937
Total Pages : 434 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Integrative Omics by : Manish Kumar Gupta

Download or read book Integrative Omics written by Manish Kumar Gupta and published by Elsevier. This book was released on 2024-05-03 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrative Omics: Concepts, Methodology and Applications provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference includes a range of chapters in a systemic 'step by step' manner, which begins with the basic concepts from Omic to Multi Integrative Omics approaches, followed by their full range of approaches, applications, emerging trends, and future trends. All key areas of Omics are covered including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics as well as omics technology policy and society research. Integrative Omics: Concepts, Methodology and Applications highlights the recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science. The book bridges the gap between biological sciences, physical sciences, computer science, statistics, data science, information technology and mathematics by presenting content specifically dedicated to mathematical models of biological systems. - Provides a holistic, integrated view of a defining and applying network approach, integrative tools, and methods to solve problems for rationalization of genotype to phenotype relationships - Offers an interdisciplinary approach to Databases, data analytics techniques, biological tools, network construction, analysis, modeling, prediction and simulation of biological systems leading to 'translational research', i.e., drug discovery, drug target prediction, and precision medicine - Covers worldwide methods, concepts, databases, and tools used in the construction of integrated pathways

Modeling the 3D Conformation of Genomes

Author : G. Tiana
Publisher : CRC Press
ISBN 13 : 9780367780456
Total Pages : 370 pages
Book Rating : 4.7/5 (84 download)

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Book Synopsis Modeling the 3D Conformation of Genomes by : G. Tiana

Download or read book Modeling the 3D Conformation of Genomes written by G. Tiana and published by CRC Press. This book was released on 2021-03-31 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, and predicting 3D genome structur

Big Data Analytics in Genomics

Author : Ka-Chun Wong
Publisher : Springer
ISBN 13 : 3319412795
Total Pages : 426 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Big Data Analytics in Genomics by : Ka-Chun Wong

Download or read book Big Data Analytics in Genomics written by Ka-Chun Wong and published by Springer. This book was released on 2016-10-24 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume explores the emerging intersection between big data analytics and genomics. Recent sequencing technologies have enabled high-throughput sequencing data generation for genomics resulting in several international projects which have led to massive genomic data accumulation at an unprecedented pace. To reveal novel genomic insights from this data within a reasonable time frame, traditional data analysis methods may not be sufficient or scalable, forcing the need for big data analytics to be developed for genomics. The computational methods addressed in the book are intended to tackle crucial biological questions using big data, and are appropriate for either newcomers or veterans in the field.This volume offers thirteen peer-reviewed contributions, written by international leading experts from different regions, representing Argentina, Brazil, China, France, Germany, Hong Kong, India, Japan, Spain, and the USA. In particular, the book surveys three main areas: statistical analytics, computational analytics, and cancer genome analytics. Sample topics covered include: statistical methods for integrative analysis of genomic data, computation methods for protein function prediction, and perspectives on machine learning techniques in big data mining of cancer. Self-contained and suitable for graduate students, this book is also designed for bioinformaticians, computational biologists, and researchers in communities ranging from genomics, big data, molecular genetics, data mining, biostatistics, biomedical science, cancer research, medical research, and biology to machine learning and computer science. Readers will find this volume to be an essential read for appreciating the role of big data in genomics, making this an invaluable resource for stimulating further research on the topic.

Gene Quantification

Author : Francois Ferre
Publisher : Springer Science & Business Media
ISBN 13 : 1461241642
Total Pages : 379 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Gene Quantification by : Francois Ferre

Download or read book Gene Quantification written by Francois Ferre and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Geneticists and molecular biologists have been interested in quantifying genes and their products for many years and for various reasons (Bishop, 1974). Early molecular methods were based on molecular hybridization, and were devised shortly after Marmur and Doty (1961) first showed that denaturation of the double helix could be reversed - that the process of molecular reassociation was exquisitely sequence dependent. Gillespie and Spiegelman (1965) developed a way of using the method to titrate the number of copies of a probe within a target sequence in which the target sequence was fixed to a membrane support prior to hybridization with the probe - typically a RNA. Thus, this was a precursor to many of the methods still in use, and indeed under development, today. Early examples of the application of these methods included the measurement of the copy numbers in gene families such as the ribosomal genes and the immunoglo bulin family. Amplification of genes in tumors and in response to drug treatment was discovered by this method. In the same period, methods were invented for estimating gene num bers based on the kinetics of the reassociation process - the so-called Cot analysis. This method, which exploits the dependence of the rate of reassociation on the concentration of the two strands, revealed the presence of repeated sequences in the DNA of higher eukaryotes (Britten and Kohne, 1968). An adaptation to RNA, Rot analysis (Melli and Bishop, 1969), was used to measure the abundance of RNAs in a mixed population.

Data Analysis and Visualization in Genomics and Proteomics

Author : Francisco Azuaje
Publisher : John Wiley & Sons
ISBN 13 : 0470094400
Total Pages : 284 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Data Analysis and Visualization in Genomics and Proteomics by : Francisco Azuaje

Download or read book Data Analysis and Visualization in Genomics and Proteomics written by Francisco Azuaje and published by John Wiley & Sons. This book was released on 2005-06-24 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data Analysis and Visualization in Genomics and Proteomics is the first book addressing integrative data analysis and visualization in this field. It addresses important techniques for the interpretation of data originating from multiple sources, encoded in different formats or protocols, and processed by multiple systems. One of the first systematic overviews of the problem of biological data integration using computational approaches This book provides scientists and students with the basis for the development and application of integrative computational methods to analyse biological data on a systemic scale Places emphasis on the processing of multiple data and knowledge resources, and the combination of different models and systems

Biomat 2013 - International Symposium On Mathematical And Computational Biology

Author : Rubem P Mondaini
Publisher : World Scientific
ISBN 13 : 981460223X
Total Pages : 427 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis Biomat 2013 - International Symposium On Mathematical And Computational Biology by : Rubem P Mondaini

Download or read book Biomat 2013 - International Symposium On Mathematical And Computational Biology written by Rubem P Mondaini and published by World Scientific. This book was released on 2014-04-02 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a book of a series on interdisciplinary topics on the Biological and Mathematical Sciences. The chapters correspond to selected papers on special research themes, which have been presented at BIOMAT 2013 International Symposium on Mathematical and Computational Biology which was held in the Fields Institute for Research in Mathematical Sciences, Toronto, Ontario, Canada, on November 04 - 08, 2013. The treatment is both pedagogical and advanced in order to motivate research students as well as to fulfill the requirements of professional practitioners. There are comprehensive reviews written by prominent scientific leaders of famous research groups.

Intelligent Computing Theories and Application

Author : De-Shuang Huang
Publisher : Springer
ISBN 13 : 3030269698
Total Pages : 810 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Intelligent Computing Theories and Application by : De-Shuang Huang

Download or read book Intelligent Computing Theories and Application written by De-Shuang Huang and published by Springer. This book was released on 2019-07-31 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set of LNCS 11643 and LNCS 11644 constitutes - in conjunction with the volume LNAI 11645 - the refereed proceedings of the 15th International Conference on Intelligent Computing, ICIC 2019, held in Nanchang, China, in August 2019. The 217 full papers of the three proceedings volumes were carefully reviewed and selected from 609 submissions. The ICIC theme unifies the picture of contemporary intelligent computing techniques as an integral concept that highlights the trends in advanced computational intelligence and bridges theoretical research with applications. The theme for this conference is “Advanced Intelligent Computing Methodologies and Applications.” Papers related to this theme are especially solicited, including theories, methodologies, and applications in science and technology.

Molecular Pathway Analysis Using High-Throughput OMICS Molecular Data

Author : Anton Buzdin
Publisher : Elsevier
ISBN 13 : 0443155690
Total Pages : 359 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Molecular Pathway Analysis Using High-Throughput OMICS Molecular Data by : Anton Buzdin

Download or read book Molecular Pathway Analysis Using High-Throughput OMICS Molecular Data written by Anton Buzdin and published by Elsevier. This book was released on 2024-10-26 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field molecular pathway analysis evolves rapidly, and many progressive methods have recently been discovered. Molecular Pathway Analysis Using High-Throughput OMICS Data contains the largest collections of molecular pathways. For the first time, guidelines on how to do genomic, epigenetic, transcriptomic, proteomic, and metabolomic data analysis in real-world research practice are given. Molecular Pathway Analysis Using High-Throughput OMICS Molecular Data also focuses on the pathway analysis applications for solving tasks in biotechnology, pharmaceutics, and molecular diagnostics It demonstrates how pathway analysis can be applied for the research and treatment of chronic and acute diseases, for next-generation molecular diagnostics, for drug design and preclinical testing; relevant real-world examples, molecular tests, and web resources will be reviewed in-depth. The book shows a tendency of erasing the borders between chemistry, physics, informatics, mathematics, biology, and medicine by means of novel research approaches and instruments, providing a truly multidisciplinary approach. - Provides theoretical insights, links to available resources and their descriptions, and protocols related to multiple possibilities and options of the molecular pathway analysis - Elucidates unique instruments (i) for the quantitative pathway analysis using metabolomic data, and (ii) for algorithmic hypothesis-free reconstruction and functional annotation of the molecular pathways that have a strong potential to revolutionize the field - Includes intuitive practical guidelines on the analysis of genomic, epigenetic, transcriptomic, proteomic, and metabolomic data at the molecular pathway level for non-bioinformaticians - Provides state-of-the art in the field of Big molecular data analysis for research, medicine, biotechnology, pharmaceutics, and next-generation molecular diagnostics

Biological Data Mining in Protein Interaction Networks

Author : Li, Xiao-Li
Publisher : IGI Global
ISBN 13 : 1605663999
Total Pages : 448 pages
Book Rating : 4.6/5 (56 download)

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Book Synopsis Biological Data Mining in Protein Interaction Networks by : Li, Xiao-Li

Download or read book Biological Data Mining in Protein Interaction Networks written by Li, Xiao-Li and published by IGI Global. This book was released on 2009-05-31 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The goal of this book is to disseminate research results and best practices from cross-disciplinary researchers and practitioners interested in, and working on bioinformatics, data mining, and proteomics"--Provided by publisher.

Systems Biology Approaches for Host-Pathogen Interaction Analysis

Author : Mohd. Tashfeen Ashraf
Publisher : Elsevier
ISBN 13 : 0323958915
Total Pages : 317 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Systems Biology Approaches for Host-Pathogen Interaction Analysis by : Mohd. Tashfeen Ashraf

Download or read book Systems Biology Approaches for Host-Pathogen Interaction Analysis written by Mohd. Tashfeen Ashraf and published by Elsevier. This book was released on 2024-02-16 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: System Biology Approaches for Microbial Pathogenesis Interaction Analysis aids biological researchers to expand their research scope using piled up data generated through recent technological advancement. In addition, it also opens avenues for bioinformatics and computer science researchers to utilize their expertise in biological meaningful ways. It also covers network biology approaches to decipher complex multiple host-pathogen interactions in addition to giving valuable coverage of artificial intelligence. The host-pathogen interactions are generally considered as highly specific interactions leading to a variety of consequences. The utilization of data science approaches has revolutionized scientific research including host-pathogen interaction analyses. Data science approaches coupled with network biology has taken host-pathogen interaction analysis from specific interaction to a new paradigm of understanding consequences of these interaction in the biological network. Unfortunately, basic biological researchers are mostly unaware of these advancements. In contrast, data scientists are not familiar with biological aspects of such data. System Biology Approaches for Microbial Pathogenesis Interaction Analysis will bridge these gaps through a new paradigm of understanding consequences of interaction in biological networks. • Cover approaches to decipher complex multiple host–pathogen interactions• Gives biological researcher an insight into the utilization of technological advancements in the field of host–pathogen interaction analyses in their work• Provides a new paradigm of understanding the consequences of host–pathogen interaction in biological systems

Omics Data Integration towards Mining of Phenotype Specific Biomarkers in Cancer - Volume II

Author : Liang Cheng
Publisher : Frontiers Media SA
ISBN 13 : 2832507387
Total Pages : 793 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Omics Data Integration towards Mining of Phenotype Specific Biomarkers in Cancer - Volume II by : Liang Cheng

Download or read book Omics Data Integration towards Mining of Phenotype Specific Biomarkers in Cancer - Volume II written by Liang Cheng and published by Frontiers Media SA. This book was released on 2022-11-29 with total page 793 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Microbial Functional Genomics

Author : Jizhong Zhou
Publisher : John Wiley & Sons
ISBN 13 : 9780471071907
Total Pages : 624 pages
Book Rating : 4.0/5 (719 download)

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Book Synopsis Microbial Functional Genomics by : Jizhong Zhou

Download or read book Microbial Functional Genomics written by Jizhong Zhou and published by John Wiley & Sons. This book was released on 2004-03-19 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial Functional Genomics offers a timely summary of the principles, approaches, and applications. It presents a comprehensive review of microbial functional genomics, covering microbial diversity, microbial genome sequencing, genomic technologies, genome-wide functional analysis, applied functional genomics, and future directions. An introduction will offer a definition of the field and an overview of the historical and comparative genomics aspects.

Systems Analysis of Human Multigene Disorders

Author : Natalia Maltsev
Publisher : Springer Science & Business Media
ISBN 13 : 1461487781
Total Pages : 134 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Systems Analysis of Human Multigene Disorders by : Natalia Maltsev

Download or read book Systems Analysis of Human Multigene Disorders written by Natalia Maltsev and published by Springer Science & Business Media. This book was released on 2013-11-29 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

Comparative Genomics

Author : D. Sankoff
Publisher : Springer Science & Business Media
ISBN 13 : 9780792365846
Total Pages : 586 pages
Book Rating : 4.3/5 (658 download)

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Book Synopsis Comparative Genomics by : D. Sankoff

Download or read book Comparative Genomics written by D. Sankoff and published by Springer Science & Business Media. This book was released on 2000-09-30 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive account of genomic rearrangement, focusing on the mechanisms of inversion, translocation, gene and genome duplication and gene transfer and on the patterns that result from them in comparative maps. Includes analyses of genomic sequences in organelles, prokaryotes and eukaryotes as well as comparative maps of the nuclear genomes in higher plants and animals. The book showcases a variety of algorithmic and statistical approaches to rearrangement and map data.

Data Mining and Statistical Methods for Knowledge Discovery in Diseases Based on Multimodal Omics

Author : Jiajie Peng
Publisher : Frontiers Media SA
ISBN 13 : 2889761746
Total Pages : 160 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Data Mining and Statistical Methods for Knowledge Discovery in Diseases Based on Multimodal Omics by : Jiajie Peng

Download or read book Data Mining and Statistical Methods for Knowledge Discovery in Diseases Based on Multimodal Omics written by Jiajie Peng and published by Frontiers Media SA. This book was released on 2022-06-06 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Methodologies of Multi-Omics Data Integration and Data Mining

Author : Kang Ning
Publisher : Springer Nature
ISBN 13 : 9811982104
Total Pages : 173 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Methodologies of Multi-Omics Data Integration and Data Mining by : Kang Ning

Download or read book Methodologies of Multi-Omics Data Integration and Data Mining written by Kang Ning and published by Springer Nature. This book was released on 2023-01-15 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features multi-omics big-data integration and data-mining techniques. In the omics age, paramount of multi-omics data from various sources is the new challenge we are facing, but it also provides clues for several biomedical or clinical applications. This book focuses on data integration and data mining methods for multi-omics research, which explains in detail and with supportive examples the “What”, “Why” and “How” of the topic. The contents are organized into eight chapters, out of which one is for the introduction, followed by four chapters dedicated for omics integration techniques focusing on several omics data resources and data-mining methods, and three chapters dedicated for applications of multi-omics analyses with application being demonstrated by several data mining methods. This book is an attempt to bridge the gap between the biomedical multi-omics big data and the data-mining techniques for the best practice of contemporary bioinformatics and the in-depth insights for the biomedical questions. It would be of interests for the researchers and practitioners who want to conduct the multi-omics studies in cancer, inflammation disease, and microbiome researches.