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Insulin Related Proteins Structure To Function And Pharmacology
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Book Synopsis Insulin & Related Proteins — Structure to Function and Pharmacology by : Matthias Federwisch
Download or read book Insulin & Related Proteins — Structure to Function and Pharmacology written by Matthias Federwisch and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains contributions presented at the last of the Alcuin Symposia, held in April 2000, as a Festschrift to honour Prof. Axel Wollmer on the occasion of his retirement from the Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen. The Alcuin Symposia were initially held alternatively in York and Aachen, in recent years in Aachen only, as joint workshops on insulin between the groups of Prof. Guy Dodson in York and the groups of Profs Dietrich Brandenburg and Axel Wollmer in Aachen. The Symposium was named after Alcuin, an Anglo-Latin poet, educator and cleric from York, who was invited to join the court of Charlemagne at Aachen. Alcuin’s first 50 years were spent in Yorkshire, were he was first a pupil, later headmaster of the cathedral school of York, the most renowned of its day. Charlemagne was gathering at Aachen the leading Irish, English and Italian scholars of the age. Alcuin was appointed head of the Palatine school, where Charlemagne himself, his family, his friends, and his friends’s sons were taught. Alcuin introduced the traditions of Anglo-Saxon humanism into Western Europe and was the foremost scholar of the revival of learning known as the Carolingian Renaissance. He also promoted the use of the beautiful Carolingian minuscule script, the ancestor of modern Roman typefaces.
Book Synopsis Insulin, chemistry, structure, and function of insulin and related hormones by : Dietrich Brandenburg
Download or read book Insulin, chemistry, structure, and function of insulin and related hormones written by Dietrich Brandenburg and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-05-20 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Insulin, chemistry, structure, and function of insulin and related hormones".
Download or read book Insulin and IGFs written by and published by Academic Press. This book was released on 2009-03-10 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.This volume focuses on insulin and IGFs. Longest running series published by Academic Press Contributions by leading international authorities
Book Synopsis Stability and Characterization of Protein and Peptide Drugs by : Rodney Pearlman
Download or read book Stability and Characterization of Protein and Peptide Drugs written by Rodney Pearlman and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first volume to make available specific case histories of therapeutic proteins and peptides that have been marketed or are currently under clinical testing. The editors have selected a wide range of molecules derived from monoclonal antibodies, recombinant DNA, and natural and chemical sources to provide formulation scientists with practical examples of the development of pharmaceutical products.
Book Synopsis The Nutritional Biochemistry of Chromium(III) by : John Vincent
Download or read book The Nutritional Biochemistry of Chromium(III) written by John Vincent and published by Elsevier. This book was released on 2011-10-13 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromium nutritional supplements are the second best selling mineral supplements after calcium as chromium is found in pills, sports drinks, chewing gums, smoothies, and numerous other products. Chromium has been promoted to promote weight loss and muscle development and most recently to be available to treat the symptoms of type 2 diabetes and related conditions. The aim of The Nutritional Biochemistry of Chromium(III) is to examine the four most controversial areas of chromium nutrition and biochemistry: - is chromium an essential element for humans and are chromium nutritional supplements of value? - what biochemical role, if any, does chromium play in the body - can large doses of chromium(III) be used to treat symptoms of type 2 diabetes, cardiovascular disease, and related medical conditions - is the use of chromium(III) supplements a health concern. Scientific experts, who are recognized leaders in the field, weigh in with their opinions on both sides of these issues in this book.A background review of the field from 1955-1995 by Vincent opens the book and concludes with a summary by Dr. Forrest Nielsen, Center Director of the USDA's Grand Forks Human Nutrition Research Center concludes the book. * Point-counterpoint format, providing both sides of major issues* Complete coverage of current issues, including nutrition, health, biochemical role and toxicology* Authors are recognised experts and leaders in this field
Book Synopsis Encyclopedic Reference of Molecular Pharmacology by : Stefan Offermanns
Download or read book Encyclopedic Reference of Molecular Pharmacology written by Stefan Offermanns and published by . This book was released on 2004 with total page 1152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents current information on the molecular mechanisms of drug action. Provides 159 essays describing groups of drugs and drug targets. Several essays deal with general principles of pharmacology, such as drug tolerance, drug addiction, or drug metabolism.
Book Synopsis Mechanisms of Insulin Action by : Alan R. Saltiel
Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
Book Synopsis Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System by : Mohan Raizada
Download or read book Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System written by Mohan Raizada and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, intercellular communication and the regulation of biological functions of the body have been considered the role of two major and distinct systems: the nervous system and the endocrine system. The classic nervous system transmitted its signal rapidly by using electrical currents, whereas the signals used by the endocrine system were hormones produced by endocrine glands which reached the target tissues via the blood stream. During the past few decades, it has become apparent that these systems of intercellular com munication are not distinct and the signal messenger molecules are not unique to one or the other system. Many classic endocrine hormones are found in and act on nervous tissues and evidence exists for their de novo synthesis by neural related tissues. An exciting development in this area is the possibility that insulin and insulin-like growth factors (IGF) are not only produced by neural tissues but also exert profound physiological and biochemical effects on these tissues. The area of investigation of CNS insulin and IGF has been expanding rapidly and the availability of this book complete with up-to-date reviews on the subject by leaders in the field allows other scientists to utilize the knowledge in planning and adapting the latest ideas for future experiments. In addition, the book provides a collection of up-to-date articles for teachers to be used for the latest instructional material. The first section of the book covers general aspects of insulin receptors and insulin action.
Download or read book Insulin written by Pedro Cuatrecasas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is fourteen years since insulin was last reviewed in The Handbook of Ex perimental Pharmacology, in volume 32. The present endeavor is more modest in scope. Volume 32 appeared in two separate parts, each having its own subeditors, and together the two parts covered nearly all areas of insulin pharmacology. Such comprehensiveness seemed impractical in a new volume. The amount of in formation related to insulin that is now available simply would not fit in a reasonable amount of space. Furthermore, for better or worse, scientists have be come so specialized that a volume providing such broad coverage seemed likely in its totality to be of interest or value to very few individuals. We therefore decided to limit the present volume to the following areas: insulin chemistry and structure, insulin biosynthesis and secretion, insulin receptor, and insulin action at the cellular level. We felt these areas formed a coherent unit. We also felt, perhaps as much because of our own interests and perspectives as any objective reality, that these were the areas in which recent progress has been most dramatic, and yet, paradoxically and tantalizingly, these were the areas in which most has yet to be learned. Even with this limited scope, there are some major gaps in coverage. Regrettably, two important areas, the beta cell ATP-sensitive potassium channel and the glucose transporter, were among these. Nevertheless, the authors who con tributed have done an excellent job, and we would like to thank them for their diligence.
Book Synopsis Insulin Signaling by : George Grunberger
Download or read book Insulin Signaling written by George Grunberger and published by CRC Press. This book was released on 2003-09-02 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from the leading researchers in the field, this volume brings together the latest studies on insulin action and signal transduction to provide a state-of-the-art reference for graduate researchers and students in diabetes and endocrinology. Insulin Signaling is a comprehensive study of the regulation of molecular events by insulin at a cellular level, utilizing experimental techniques ranging from molecular systems through phenotypic expression in transgenic and knockout models.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author :Ashok K. Srivastava Publisher :Springer Science & Business Media ISBN 13 :9780792381136 Total Pages :206 pages Book Rating :4.3/5 (811 download)
Book Synopsis Insulin Action by : Ashok K. Srivastava
Download or read book Insulin Action written by Ashok K. Srivastava and published by Springer Science & Business Media. This book was released on 1998-05-31 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.
Book Synopsis Structure-function Relationships at a Hormone-receptor Interface by : Vijay Pandyarajan
Download or read book Structure-function Relationships at a Hormone-receptor Interface written by Vijay Pandyarajan and published by . This book was released on 2014 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The observation of invariant or highly conserved sites within a protein's primary sequence is a strong indication that throughout the course of the protein's evolutionary history these particular sites have played a fundamental role in maintaining some aspect of the protein's proper function. An understanding of what these evolutionary restraints are may provide insights into protein design and engineering. Insulin is a small protein tractable for such structure/function studies of highly conserved sites. The organization of this thesis is as follows. Chapter 1 is an overview of insulin and the insulin receptor. A discussion of parameters relevant to clinically used insulins is also presented within this chapter. Chapters 2 and 3 provide structure/function studies of a pair of highly conserved insulin residues (PheB24 and TyrB26) and thus serve as the main focus of this thesis. This was accomplished by systematically substituting and testing a range of amino acids at these positions. In nearly every case, mutations which conferred high receptor binding affinity and native-like activity came with biophysical costs. These chapters also further defined what side chain parameters are allowable for substitution into the PheB24 and TyrB26 receptor binding pockets which were recently elucidated by an X-ray crystal structure of a domain-minimized insulin receptor construct (μIR) bound to insulin. Novel insights into insulin structure and function were also gleaned in these studies by the incorporation of the non-standard amino acids cyclohexanylalanine and 3-iodotyrosine. Chapter 4 describes how one such substitution, 3-iodo-TyrB26, can be used to optimize a rapid-acting insulin analog's resistance to fibrillation without the concomitant cost of a reduction in its onset of action; a problem seen in analogs utilizing canonical amino acids. Such properties may in the future be of some therapeutic value. A summary which explores how the principles learned in this thesis can be utilized within the context of protein design as well as future directions are presented in Chapter 5.
Book Synopsis Physiological, Pathological Roles and Pharmacology of Insulin Regulated Aminopeptidase by : Efstratios Stratikos
Download or read book Physiological, Pathological Roles and Pharmacology of Insulin Regulated Aminopeptidase written by Efstratios Stratikos and published by Frontiers Media SA. This book was released on 2021-06-24 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Structure and Function of the Human Insulin Receptor, Quaternary 3D Reconstruction of the Insulin-insulin Receptor Complex and the Structural Localization of the Insulin-binding Site by : Robert Zhao-Tian Luo
Download or read book Structure and Function of the Human Insulin Receptor, Quaternary 3D Reconstruction of the Insulin-insulin Receptor Complex and the Structural Localization of the Insulin-binding Site written by Robert Zhao-Tian Luo and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The elucidation of the mechanism of cellular signal transduction is one of the key challenges in biology. The first step in this pathway has been particularly refractory to study. In the case of insulin action, it is the binding of insulin to its cell surface receptor, a large integral transmembrane glycoprotein. The binding of insulin results in the activation of the cytoplasmic domain of the receptor as a tyrosine kinase. While much is known about the interaction of the activated receptor with its substrates leading to downstream signal transduction, how the binding of insulin to the extracellular domain of the receptor can lead to receptor activation remains unknown. The specific goal of this study is to localize the insulin-binding site of the insulin receptor (IR), and, if possible, to elucidate in molecular details the insulin-IR interaction and the structure-function relationship of the insulin receptor. To achieve this goal with biochemical approach, I used the baculovirus expression system to produce in large quantity the extracellular domain of the human insulin receptor, and used various specific photoaffinity probes to identify the insulin-contacting sites. Peptide identification methods of high sensitivity were developed to detect the labeled IR fragment containing the putative insulin-binding site by HPLC peptide mapping analysis. A small fragment of 1-3 kDa that might contain the putative insulin-binding or contacting site on the receptor à subunit was detected. However, partly due to the lack of an insulin photoprobe with a high efficiency of cross-linking, and a high efficiency peptide mapping method, I failed to obtain a sufficient quantity of the fragment for amino acid sequencing. In an alternative approach, using gold-labeled insulin as a ligand, and sets of electron micrographs obtained by low-dose low temperature dark field scanning transmission electron microscopy (STEM) of the insulin-IR complex, I successfully reconstructed the 3D quaternary structure of the whole 480-kDa human insulin receptor (HIR), complexed with insulin, at a resolution of 20 Å. Contiguous high densities within the 3D structure indicated a two-fold symmetry for this dimeric receptor and the presence of subdomain structures which begin with the extracellular subdomain involved in insulin binding and terminate with the intracellular tyrosine kinase subdomains. These subdomains were confirmed by fitting known high-resolution crystal domain substructures. In addition, the 3D insulin-HIR complex provides evidence for the involvement of only a single insulin molecule in receptor activation. It also explains many of the known characteristics of insulin binding to its receptor and many biochemical findings in the studies of the insulin receptor.
Book Synopsis Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease by : Deric L. Wheeler
Download or read book Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease written by Deric L. Wheeler and published by Springer. This book was released on 2014-11-26 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family. Receptor Tyrosine Kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases. And over the last decade they have become the Number 1 targets of cancer drugs. To be able to conduct fundamental research or to attempt to develop pharmacological agents able to enhance or intercept them, it is essential first to understand the evolutionary origin of the 58 RTKs and their roles in invertebrates and in humans, as well as downstream signaling pathways. The assembly of chapters is written by experts and underscores commonalities between and among the RTKs. It is an ideal companion volume to The Receptor Tyrosine Kinase: Families and Subfamilies, which proceeds, family by family through all of the specific subfamilies of RTKs, along with their unique landmarks.
Book Synopsis The Discovery of Insulin by : Michael Bliss
Download or read book The Discovery of Insulin written by Michael Bliss and published by University of Toronto Press. This book was released on 2017-06-22 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of insulin at the University of Toronto in 1921-22 was one of the most dramatic events in the history of the treatment of disease. Insulin was a wonder-drug with ability to bring patients back from the very brink of death, and it was no surprise that in 1923 the Nobel Prize for Medicine was awarded to its discoverers, the Canadian research team of Banting, Best, Collip, and Macleod. In this engaging and award-winning account, historian Michael Bliss recounts the fascinating story behind the discovery of insulin – a story as much filled with fiery confrontation and intense competition as medical dedication and scientific genius. Originally published in 1982 and updated in 1996, The Discovery of Insulin has won the City of Toronto Book Award, the Jason Hannah Medal of the Royal Society of Canada, and the William H. Welch Medal of the American Association for the History of Medicine.
