Insight Into Biological Small Molecule Activation From Enzymes Model Complexes And X Ray Spectroscopy

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Insight Into Biological Small-molecule Activation from Enzymes, Model Complexes, and X-ray Spectroscopy

Author : Julian Avery Rees
Publisher :
ISBN 13 :
Total Pages : 180 pages
Book Rating : 4.:/5 (961 download)

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Book Synopsis Insight Into Biological Small-molecule Activation from Enzymes, Model Complexes, and X-ray Spectroscopy by : Julian Avery Rees

Download or read book Insight Into Biological Small-molecule Activation from Enzymes, Model Complexes, and X-ray Spectroscopy written by Julian Avery Rees and published by . This book was released on 2016 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation covers the investigation of biological strategies for activating inert small molecules. Chapters 1 and 2 respectively present an introduction to some notable biological systems of interest and the X-ray spectroscopic techniques used in their study. Chapter 3 focuses on the application of X-ray spectroscopy and density functional theory to investigate the underlying mechanisms of O-O bond activation by a manganese complex. Chapter 4 presents the discovery of a key structural feature of the vanadium-containing active site of V-dependent nitrogenases, and Chapter 5 provides a detailed comparison of the electronic structures of the Mo- and V-containing nitrogenase cofactors based on spectroscopic characterization of both enzymes and synthetic metallocubane models. Chapter 6 covers a fundamental study of the X-ray absorption and emission spectroscopic features of vanadium ions, providing a basis for the spectroscopic investigation of vanadium-containing enzymes, including nitrogenase. This work contains novel research into the structure-function relationship in both biological and synthetic systems that promote the activation of inert, abundant small molecules. The insight obtained from these studies may help to advance scientific understanding of the complex functions of transition metal ions in biological catalysis.

Activation of Small Molecules

Author : William B. Tolman
Publisher : John Wiley & Sons
ISBN 13 : 3527609377
Total Pages : 382 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Activation of Small Molecules by : William B. Tolman

Download or read book Activation of Small Molecules written by William B. Tolman and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first to combine both the bioinorganic and the organometallic view, this handbook provides all the necessary knowledge in one convenient volume. Alongside a look at CO2 and N2 reduction, the authors discuss O2, NO and N2O binding and reduction, activation of H2 and the oxidation catalysis of O2. Edited by the highly renowned William Tolman, who has won several awards for his research in the field.

Molecular Biology and Biotechnology

Author : Robert Allen Meyers
Publisher : John Wiley & Sons
ISBN 13 : 9780471186342
Total Pages : 1090 pages
Book Rating : 4.1/5 (863 download)

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Book Synopsis Molecular Biology and Biotechnology by : Robert Allen Meyers

Download or read book Molecular Biology and Biotechnology written by Robert Allen Meyers and published by John Wiley & Sons. This book was released on 1995-06-29 with total page 1090 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is one volume 'library' of information on molecular biology, molecular medicine, and the theory and techniques for understanding, modifying, manipulating, expressing, and synthesizing biological molecules, conformations, and aggregates. The purpose is to assist the expanding number of scientists entering molecular biology research and biotechnology applications from diverse backgrounds, including biology and medicine, as well as physics, chemistry, mathematics, and engineering.

Lead: Its Effects on Environment and Health

Author : Astrid Sigel
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110434334
Total Pages : 596 pages
Book Rating : 4.1/5 (14 download)

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Book Synopsis Lead: Its Effects on Environment and Health by : Astrid Sigel

Download or read book Lead: Its Effects on Environment and Health written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2017-04-10 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 17, entitled Lead: Its Effects on Environment and Health of the series Metal Ions in Life Sciences centers on the interrelations between biosystems and lead. The book provides an up-to-date review of the bioinorganic chemistry of this metal and its ions; it covers the biogeochemistry of lead, its use (not only as gasoline additive) and anthropogenic release into the environment, its cycling and speciation in the atmosphere, in waters, soils, and sediments, and also in mammalian organs. The analytical tools to determine and to quantify this toxic element in blood, saliva, urine, hair, etc. are described. The properties of lead(II) complexes formed with amino acids, peptides, proteins (including metallothioneins), nucleobases, nucleotides, nucleic acids, and other ligands of biological relevance are summarized for the solid state and for aqueous solutions as well. All this is important for obtaining a coherent picture on the properties of lead, its effects on plants and toxic actions on mammalian organs. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 17, which are written by 36 internationally recognized experts from 13 nations. The impact of this recently again vibrant research area is manifested in nearly 2000 references, over 50 tables and more than 100 illustrations (half in color). Lead: Its Effects on Environment and Health is an essential resource for scientists working in the wide range from material sciences, inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Molecular Cell Biology

Author : Harvey Lodish
Publisher : Macmillan
ISBN 13 : 9780716743668
Total Pages : 1096 pages
Book Rating : 4.7/5 (436 download)

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Book Synopsis Molecular Cell Biology by : Harvey Lodish

Download or read book Molecular Cell Biology written by Harvey Lodish and published by Macmillan. This book was released on 2004 with total page 1096 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fifth edition provides an authoritative and comprehensive vision of molecular biology today. It presents developments in cell birth, lineage and death, expanded coverage of signaling systems and of metabolism and movement of lipids.

Reactive Oxygen Species

Author : Harald H. H. W. Schmidt
Publisher : Springer Nature
ISBN 13 : 3030685101
Total Pages : 425 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Reactive Oxygen Species by : Harald H. H. W. Schmidt

Download or read book Reactive Oxygen Species written by Harald H. H. W. Schmidt and published by Springer Nature. This book was released on 2021-02-23 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Comprehensive Biophysics

Author :
Publisher : Academic Press
ISBN 13 : 0080957188
Total Pages : 3533 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Comprehensive Biophysics by :

Download or read book Comprehensive Biophysics written by and published by Academic Press. This book was released on 2012-04-12 with total page 3533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource

Optogenetic Tools in the Molecular Spotlight

Author : Tilo Mathes
Publisher : Frontiers Media SA
ISBN 13 : 2889198995
Total Pages : 181 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Optogenetic Tools in the Molecular Spotlight by : Tilo Mathes

Download or read book Optogenetic Tools in the Molecular Spotlight written by Tilo Mathes and published by Frontiers Media SA. This book was released on 2016-08-09 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rise of optogenetics as a standard technique to non-invasively probe and monitor biological function created an immense interest in the molecular function of photosensory proteins. These photoreceptors are usually protein/pigment complexes that translate light into biological information and have become essential tools in cell biology and neurobiology as their function is genetically encoded and can be conveniently delivered into a given cell. Like for fluorescent proteins that quickly became invaluable as genetically encodable reporters in microscopy and imaging, variants of photosensory proteins with customized sensitivity and functionality are nowadays in high demand. In this ebook we feature reviews and original research on molecular approaches from synthetic biology and molecular spectroscopy to computational molecular modelling that all aspire to elucidate the molecular prerequisites for the photosensory function of the given proteins. The principle property of changing activity of biological function simply by application of light is not only very attractive for cell biology, it also offers unique opportunities for molecular studies as excitation can be controlled with high time precision. Especially in spectroscopy the usually fully reversible photoactivation of photosensory proteins allows researchers to to perform time resolved studies with up to femtosecond resolution. In addition, functional variants can be investigated and quickly screened in common biochemical experiments. The insights that are obtained by the here presented various yet complementary methods will ultimately allow us write the script for a molecular movie from excitation of the protein by a photon to activation of its biological function. Such deep understanding does not only provide unique insights into the dynamics of protein function, it will also ultimately enable us to rationally design novel optogenetic tools to be used in cell biology and therapy.

Directory of Graduate Research

Author : American Chemical Society. Committee on Professional Training
Publisher :
ISBN 13 :
Total Pages : 1932 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Directory of Graduate Research by : American Chemical Society. Committee on Professional Training

Download or read book Directory of Graduate Research written by American Chemical Society. Committee on Professional Training and published by . This book was released on 2005 with total page 1932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.

The Chemistry and Biology of Nitroxyl (HNO)

Author : Fabio Doctorovich
Publisher : Elsevier
ISBN 13 : 0128011645
Total Pages : 425 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Chemistry and Biology of Nitroxyl (HNO) by : Fabio Doctorovich

Download or read book The Chemistry and Biology of Nitroxyl (HNO) written by Fabio Doctorovich and published by Elsevier. This book was released on 2016-09-01 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemistry and Biology of Nitroxyl (HNO) provides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity. This useful resource provides the scientific basis to understand the chemistry, biology, and technical aspects needed to deal with HNO. Building on two decades of nitric oxide and nitroxyl research, the editors and authors have created an indispensable guide for investigators across a wide variety of areas of chemistry (inorganic, organic, organometallic, biochemistry, physical, and analytical); biology (molecular, cellular, physiological, and enzymology); pharmacy; and medicine. This book begins by exploring the unique molecule’s structure and reactivity, including important reactions with small molecules, thiols, porphyrins, and key proteins, before discussing chemical and biological sources of nitroxyl. Advanced chapters discuss methods for both trapping and detecting nitroxyl by spectroscopy, electrochemistry, and fluorescent inorganic cellular probing. Expanding on the compound’s foundational chemistry, this book then explores its molecular physiology to offer insight into its biological implications, pharmacological effects, and practical issues. Presents the first book on HNO (nitroxyl or azanone), an increasingly important molecule in biochemistry and pharmaceutical research Provides a valuable coverage of HNO’s chemical structure and significant reactions, including practical guidance on working with this highly reactive molecule Contains high quality content from recognized experts in both industry and academia

X-Ray Absorption and X-Ray Emission Spectroscopy

Author : Jeroen A. van Bokhoven
Publisher : John Wiley & Sons
ISBN 13 : 1118844238
Total Pages : 940 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis X-Ray Absorption and X-Ray Emission Spectroscopy by : Jeroen A. van Bokhoven

Download or read book X-Ray Absorption and X-Ray Emission Spectroscopy written by Jeroen A. van Bokhoven and published by John Wiley & Sons. This book was released on 2016-03-21 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last two decades, remarkable and often spectacular progress has been made in the methodological and instrumental aspects of x–ray absorption and emission spectroscopy. This progress includes considerable technological improvements in the design and production of detectors especially with the development and expansion of large-scale synchrotron reactors All this has resulted in improved analytical performance and new applications, as well as in the perspective of a dramatic enhancement in the potential of x–ray based analysis techniques for the near future. This comprehensive two-volume treatise features articles that explain the phenomena and describe examples of X–ray absorption and emission applications in several fields, including chemistry, biochemistry, catalysis, amorphous and liquid systems, synchrotron radiation, and surface phenomena. Contributors explain the underlying theory, how to set up X–ray absorption experiments, and how to analyze the details of the resulting spectra. X-Ray Absorption and X-ray Emission Spectroscopy: Theory and Applications: Combines the theory, instrumentation and applications of x-ray absorption and emission spectroscopies which offer unique diagnostics to study almost any object in the Universe. Is the go-to reference book in the subject for all researchers across multi-disciplines since intense beams from modern sources have revolutionized x-ray science in recent years Is relevant to students, postdocurates and researchers working on x-rays and related synchrotron sources and applications in materials, physics, medicine, environment/geology, and biomedical materials

X-Ray Spectroscopy

Author : Shatendra K Sharma
Publisher : BoD – Books on Demand
ISBN 13 : 9533079673
Total Pages : 294 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis X-Ray Spectroscopy by : Shatendra K Sharma

Download or read book X-Ray Spectroscopy written by Shatendra K Sharma and published by BoD – Books on Demand. This book was released on 2012-02-01 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The x-ray is the only invention that became a regular diagnostic tool in hospitals within a week of its first observation by Roentgen in 1895. Even today, x-rays are a great characterization tool at the hands of scientists working in almost every field, such as medicine, physics, material science, space science, chemistry, archeology, and metallurgy. With vast existing applications of x-rays, it is even more surprising that every day people are finding new applications of x-rays or refining the existing techniques. This book consists of selected chapters on the recent applications of x-ray spectroscopy that are of great interest to the scientists and engineers working in the fields of material science, physics, chemistry, astrophysics, astrochemistry, instrumentation, and techniques of x-ray based characterization. The chapters have been grouped into two major sections based upon the techniques and applications. The book covers some basic principles of satellite x-rays as characterization tools for chemical properties and the physics of detectors and x-ray spectrometer. The techniques like EDXRF, WDXRF, EPMA, satellites, micro-beam analysis, particle induced XRF, and matrix effects are discussed. The characterization of thin films and ceramic materials using x-rays is also covered.

Solar Energy for Fuels

Author : Harun Tüysüz
Publisher : Springer
ISBN 13 : 3319230999
Total Pages : 333 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Solar Energy for Fuels by : Harun Tüysüz

Download or read book Solar Energy for Fuels written by Harun Tüysüz and published by Springer. This book was released on 2015-10-19 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students

Publications of the National Institute of Standards and Technology ... Catalog

Author : National Institute of Standards and Technology (U.S.)
Publisher :
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Publications of the National Institute of Standards and Technology ... Catalog by : National Institute of Standards and Technology (U.S.)

Download or read book Publications of the National Institute of Standards and Technology ... Catalog written by National Institute of Standards and Technology (U.S.) and published by . This book was released on 1990 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antimicrobial Peptides and Complement – Maximising the Inflammatory Response

Author : Cordula M. Stover
Publisher : Frontiers Media SA
ISBN 13 : 2889197379
Total Pages : 159 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Antimicrobial Peptides and Complement – Maximising the Inflammatory Response by : Cordula M. Stover

Download or read book Antimicrobial Peptides and Complement – Maximising the Inflammatory Response written by Cordula M. Stover and published by Frontiers Media SA. This book was released on 2015-12-18 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial peptides and complement are distinct components of the innate immune defence. While antimicrobial peptides, after cleavage of a preproprotein, have the ability to insert directly in non host membranes, complement requires a sequential enzymatic activation in the fluid phase in order to produce a transmembrane membrane attack complex. Its insertion is controlled by membrane bound regulators. Deficiencies are described for both effectors and relate to increased susceptibility of infection. In addition, however, antimicrobial peptides and complement each influence the activity of inflammatory cells as recent data in the respective research areas shows. This series of articles draws together for the entities of antimicrobial peptides and complement a balance of contributions in the areas of evolution, roles, functions and preclinical applications. By comparing and contrasting antimicrobial peptides and complement, greater cross-disciplinary appreciation will be derived for their individual and overlapping spectra of activity, circumstances of activation and their general ability to more completely inform the inflammatory and cellular response.

Bioinorganic Chemistry of Copper

Author : K.D. Karlin
Publisher : Springer Science & Business Media
ISBN 13 : 940116875X
Total Pages : 510 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Bioinorganic Chemistry of Copper by : K.D. Karlin

Download or read book Bioinorganic Chemistry of Copper written by K.D. Karlin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinorganic Chemistry of Copper focuses on the vital role of copper ions in biology, especially as an essential metalloenzyme cofactor. The book is highly interdisciplinary in its approach--the outstanding list of contributors includes coordination chemists, biochemists, biophysicists, and molecular biologists. Chapters are grouped into major areas of research interest in inorganic copper chemistry, spectroscopy, oxygen chemistry, biochemistry, and molecular biology. The book also discusses basic research of great potential importance to pharmaceutical scientists. This book is based on the first Johns Hopkins University Copper Symposium, held in August 1992. Researchers in chemistry, biochemistry, molecular biology, and medicinal chemistry will find it to be an essential reference on its subject.

Protein Conformational Dynamics

Author : Ke-li Han
Publisher : Springer Science & Business Media
ISBN 13 : 3319029703
Total Pages : 488 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Protein Conformational Dynamics by : Ke-li Han

Download or read book Protein Conformational Dynamics written by Ke-li Han and published by Springer Science & Business Media. This book was released on 2014-01-20 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.