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Innovations In Modeling And Simulation To Advance Translational Science
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Book Synopsis Innovations in Modeling and Simulation to Advance Translational Science by : Melissa Knothe Tate
Download or read book Innovations in Modeling and Simulation to Advance Translational Science written by Melissa Knothe Tate and published by Frontiers Media SA. This book was released on 2020-12-15 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis Innovations in Biomolecular Modeling and Simulations by : Tamar Schlick
Download or read book Innovations in Biomolecular Modeling and Simulations written by Tamar Schlick and published by Royal Society of Chemistry. This book was released on 2012-05-24 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemical and biological sciences face unprecedented opportunities in the 21st century. A confluence of factors from parallel universes - advances in experimental techniques in biomolecular structure determination, progress in theoretical modeling and simulation for large biological systems, and breakthroughs in computer technology - has opened new avenues of opportunity as never before. Now, experimental data can be interpreted and further analysed by modeling, and predictions from any approach can be tested and advanced through companion methodologies and technologies. This two volume set describes innovations in biomolecular modeling and simulation, in both the algorithmic and application fronts. With contributions from experts in the field, the books describe progress and innovation in areas including: simulation algorithms for dynamics and enhanced configurational sampling, force field development, implicit solvation models, coarse-grained models, quantum-mechanical simulations, protein folding, DNA polymerase mechanisms, nucleic acid complexes and simulations, RNA structure analysis and design and other important topics in structural biology modeling. The books are aimed at graduate students and experts in structural biology and chemistry and the emphasis is on reporting innovative new approaches rather than providing comprehensive reviews on each subject.
Book Synopsis Advances in Modeling and Simulation by : Andreas Tolk
Download or read book Advances in Modeling and Simulation written by Andreas Tolk and published by Springer. This book was released on 2017-08-27 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This broad-ranging text/reference presents a fascinating review of the state of the art of modeling and simulation, highlighting both the seminal work of preeminent authorities and exciting developments from promising young researchers in the field. Celebrating the 50th anniversary of the Winter Simulation Conference (WSC), the premier international forum for disseminating recent advances in the field of system simulation, the book showcases the historical importance of this influential conference while also looking forward to a bright future for the simulation community. Topics and features: examines the challenge of constructing valid and efficient models, emphasizing the benefits of the process of simulation modeling; discusses model calibration, input model risk, and approaches to validating emergent behaviors in large-scale complex systems with non-linear interactions; reviews the evolution of simulation languages, and the history of the Time Warp algorithm; offers a focus on the design and analysis of simulation experiments under various goals, and describes how data can be “farmed” to support decision making; provides a comprehensive overview of Bayesian belief models for simulation-based decision making, and introduces a model for ranking and selection in cloud computing; highlights how input model uncertainty impacts simulation optimization, and proposes an approach to quantify and control the impact of input model risk; surveys the applications of simulation in semiconductor manufacturing, in social and behavioral modeling, and in military planning and training; presents data analysis on the publications from the Winter Simulation Conference, offering a big-data perspective on the significant impact of the conference. This informative and inspiring volume will appeal to all academics and professionals interested in computational and mathematical modeling and simulation, as well as to graduate students on the path to form the next generation of WSC pioneers.
Book Synopsis Advances in Computational Modeling and Simulation by : Rallapalli Srinivas
Download or read book Advances in Computational Modeling and Simulation written by Rallapalli Srinivas and published by Springer Nature. This book was released on 2022-02-15 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents select proceedings of Global meet on ‘Computational Modelling and Simulation, Recent Innovations, Challenges and Perspectives, 2020. This book covers leading-edge technologies from different domains such as computation in optimization and control, multiscale and multiphysics modeling and computation analysis, environmental modeling, modeling approaches to enterprise systems and services, finite element analysis, dependability and security, high-performance computation/cloud computing applications, computational biology and chemistry and computational mechanics. The primary goal of this book is to strengthen pre-eminence in computational modeling and simulation by catalyzing the transformative use of innovative developments in a wide range of disciplines to achieve lasting societal impact. The book discusses on how to perform simulation of large complex dynamic systems in an efficient manner using advanced computational analysis. The inter-disciplinary nature of the book would be a valuable reference for academicians and research scientists, industrialists interested in modelling and simulation driven by computational technology.
Book Synopsis Innovations in Biomolecular Modeling and Simulations by : Tamar Schlick
Download or read book Innovations in Biomolecular Modeling and Simulations written by Tamar Schlick and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two volume set describes innovations in biomolecular modeling and simulation, in both the algorithmic and application fronts.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309494117 Total Pages :109 pages Book Rating :4.3/5 (94 download)
Book Synopsis Enhancing Urban Sustainability with Data, Modeling, and Simulation by : National Academies of Sciences, Engineering, and Medicine
Download or read book Enhancing Urban Sustainability with Data, Modeling, and Simulation written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-10-24 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: On January 30-31, 2019 the Board on Mathematical Sciences and Analytics, in collaboration with the Board on Energy and Environmental Systems and the Computer Science and Telecommunications Board, convened a workshop in Washington, D.C. to explore the frontiers of mathematics and data science needs for sustainable urban communities. The workshop strengthened the emerging interdisciplinary network of practitioners, business leaders, government officials, nonprofit stakeholders, academics, and policy makers using data, modeling, and simulation for urban and community sustainability, and addressed common challenges that the community faces. Presentations highlighted urban sustainability research efforts and programs under way, including research into air quality, water management, waste disposal, and social equity and discussed promising urban sustainability research questions that improved use of big data, modeling, and simulation can help address. This publication summarizes the presentation and discussion of the workshop.
Book Synopsis Advances in Computational Modeling and Simulation by : Rallapalli Srinivas
Download or read book Advances in Computational Modeling and Simulation written by Rallapalli Srinivas and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents select proceedings of Global meet on 'Computational Modelling and Simulation, Recent Innovations, Challenges and Perspectives, 2020. This book covers leading-edge technologies from different domains such as computation in optimization and control, multiscale and multiphysics modeling and computation analysis, environmental modeling, modeling approaches to enterprise systems and services, finite element analysis, dependability and security, high-performance computation/cloud computing applications, computational biology and chemistry and computational mechanics. The primary goal of this book is to strengthen pre-eminence in computational modeling and simulation by catalyzing the transformative use of innovative developments in a wide range of disciplines to achieve lasting societal impact. The book discusses on how to perform simulation of large complex dynamic systems in an efficient manner using advanced computational analysis. The inter-disciplinary nature of the book would be a valuable reference for academicians and research scientists, industrialists interested in modelling and simulation driven by computational technology.
Book Synopsis Innovations in Biomolecular Modeling and Simulations: Personal perspective by : Tamar Schlick
Download or read book Innovations in Biomolecular Modeling and Simulations: Personal perspective written by Tamar Schlick and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two volume set describes innovations in biomolecular modeling and simulation, in both the algorithmic and application fronts.
Book Synopsis Energetic Materials by : Mark J. Mezger
Download or read book Energetic Materials written by Mark J. Mezger and published by CRC Press. This book was released on 2017-07-06 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will take an in-depth look at the technologies, processes, and capabilities to develop and produce "next generation" energetic materials for both commercial and defense applications, including military, mining operations, oil production and well perforation, and construction demolition. It will serve to highlight the critical technologies, latest developments, and the current capability gaps that serve as barriers to military fielding or transition to the commercial marketplace. It will also explain how the processing technologies can be spun out for use in other non-energetics related industries.
Book Synopsis Systems Pharmacology and Pharmacodynamics by : Donald E. Mager
Download or read book Systems Pharmacology and Pharmacodynamics written by Donald E. Mager and published by Springer. This book was released on 2016-11-29 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.
Book Synopsis Journal of the House of Representatives of the United States by : United States. Congress. House
Download or read book Journal of the House of Representatives of the United States written by United States. Congress. House and published by . This book was released on 1973 with total page 1620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some vols. include supplemental journals of "such proceedings of the sessions, as, during the time they were depending, were ordered to be kept secret, and respecting which the injunction of secrecy was afterwards taken off by the order of the House".
Book Synopsis American Clean Energy and Security Act of 2009, June 5, 2009, 111-1 House Report 111-137, Part 1 by :
Download or read book American Clean Energy and Security Act of 2009, June 5, 2009, 111-1 House Report 111-137, Part 1 written by and published by . This book was released on 2009 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Gaming, Simulation and Innovations: Challenges and Opportunities by : Upinder Dhar
Download or read book Gaming, Simulation and Innovations: Challenges and Opportunities written by Upinder Dhar and published by Springer Nature. This book was released on 2022-07-26 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 52nd International Simulation and Gaming Association Conference, ISAGA 2021, held in Indore, India, during September 6–10, 2021. The 24 full papers included in this book were carefully reviewed and selected from 58 submissions. They were organized in topical sections as follows: game design and facilitation; gaming in education; player experience in simulations; and policy formulation and serious games.
Book Synopsis An Investigation Report on Large Public Hospital Reforms in China by : Lulu Zhang
Download or read book An Investigation Report on Large Public Hospital Reforms in China written by Lulu Zhang and published by Springer. This book was released on 2015-12-08 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive understanding of public hospital reform in China, which is a hot topic for China’s new round of health sector reform. The authors use rich data from both health provider side and service user side and conduct a cross-sectional study in China with some comparative analysis between different locations. It provides the audience with a big picture of China’s public hospital and other components of health system as well. The book reviews the main policy measurements in the public hospital reforms and evaluates how these policies influence public hospitals' practices, especially on hospital governance and internal management.
Author :National Science and Technology Council (U.S.). Interagency Working Group on Information Technology Research and Development Publisher : ISBN 13 : Total Pages :64 pages Book Rating :4.3/5 ( download)
Book Synopsis Networking and Information Technology Research and Development by : National Science and Technology Council (U.S.). Interagency Working Group on Information Technology Research and Development
Download or read book Networking and Information Technology Research and Development written by National Science and Technology Council (U.S.). Interagency Working Group on Information Technology Research and Development and published by . This book was released on 2003 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Strengthening a Workforce for Innovative Regulatory Science in Therapeutics Development by : Institute of Medicine
Download or read book Strengthening a Workforce for Innovative Regulatory Science in Therapeutics Development written by Institute of Medicine and published by National Academies Press. This book was released on 2012-05-04 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development and application of regulatory science - which FDA has defined as the science of developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA-regulated products - calls for a well-trained, scientifically engaged, and motivated workforce. FDA faces challenges in retaining regulatory scientists and providing them with opportunities for professional development. In the private sector, advancement of innovative regulatory science in drug development has not always been clearly defined, well coordinated, or connected to the needs of the agency. As a follow-up to a 2010 workshop, the IOM held a workshop on September 20-21, 2011, to provide a format for establishing a specific agenda to implement the vision and principles relating to a regulatory science workforce and disciplinary infrastructure as discussed in the 2010 workshop.
Book Synopsis The Emerging Discipline of Quantitative Systems Pharmacology by : Tarek A. Leil
Download or read book The Emerging Discipline of Quantitative Systems Pharmacology written by Tarek A. Leil and published by Frontiers Media SA. This book was released on 2015-09-07 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems Biology” and “Quantitative Pharmacology”. Systems Biology is the field of biomedical research that seeks to understand the relationships between genes and biologically active molecules to develop qualitative models of these systems; and Quantitative Pharmacology is the field of biomedical research that seeks to use computer aided modeling and simulation to increase our understanding of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, and to aid in the design of pre-clinical and clinical experiments. The purpose of QSP modeling is to develop quantitative computer models of biological systems and disease processes, and the effects of drug PK and PD on those systems. QSP models allow testing of numerous potential experiments “in-silico” to eliminate those associated with a low probability of success, avoiding the potential costs of evaluating all of those failed experiments in the real world. At the same time, QSP models allow us to develop our understanding of the interaction between drugs and biological systems in a more systematic and rigorous manner. As the need to be more cost-efficient in the use of research funding increases, biomedical researchers will be required to gain the maximum insight from each experiment that is conducted. This need is even more acute in the pharmaceutical industry, where there is tremendous competition to develop innovative therapies in a highly regulated environment, combined with very high research and development (R&D) costs for bringing new drugs to market (~$1.3 billion/drug). Analogous modeling & simulation approaches have been successfully integrated into other disciplines to improve the fundamental understanding of the science and to improve the efficiency of R&D (e.g., physics, engineering, economics, etc.). The biomedical research community has been slow to integrate computer aided modeling & simulation for many reasons: including the perception that biology and pharmacology are “too complex” and “too variable” to be modeled with mathematical equations; a lack of adequate graduate training programs; and the lack of support from government agencies that fund biomedical research. However, there is an active community of researchers in the pharmaceutical industry, the academic community, and government agencies that develop QSP and quantitative systems biology models and apply them both to better characterize and predict drug pharmacology and disease processes; as well as to improve efficiency and productivity in pharmaceutical R&D.
